Category: bromides-buliding-blocks

Synthesis of N-sulfenylimines from disulfides and primary methanamines was written by Kawecki, Robert. And the article was included in Journal of Organic Chemistry in 2022.Reference of 128-08-5 This article mentions the following:

N-sulfenylimines (sulfenimines, thiooximes, N-alkylidenesulfenamides) were efficiently synthesized through the reaction of primary amines and disulfides with NBS or bromine. This reaction can be carried out in an open flask at room temperature without the need for any transition metal-containing additives. The use of thiols instead of disulfides gave similar results. A wide range of amines were reacted with aryl and alkyldisulfides, resulting in the formation of sulfenimines in a yield of 44-99%. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Reference of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Reference of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly selective electroreductive linear dimerization of electron-deficient vinylarenes was written by Ning, Shulin;Zheng, Lianyou;Bai, Ya;Wang, Shutao;Wang, Siyu;Shi, Lingling;Gao, Qiansong;Che, Xin;Zhang, Zhuoqi;Xiang, Jinbao. And the article was included in Tetrahedron in 2021.HPLC of Formula: 474709-71-2 This article mentions the following:

A direct electroreductive dimerization of electron-deficient vinylarenes R¹R²C:CR³R⁴ (R¹ = Ph, 4-NCC₆H₄, pyridin-4-yl, etc., R² = R³ = R⁴ = H; R¹ = 4-EtO₂CC₆H₄, R² = Me, Ph, R³ = R⁴ = H; R¹ = 4-MeO₂CC₆H₄, R² = H, R³ = Me, R⁴ = H, Me; etc.) for the synthesis of 1,4-diarylbutanes R¹R²CH-CR³R⁴-CR³R⁴-CHR¹R² as been developed using a simple undivided cell with inexpensive carbon electrodes at room temperature The control and deuterium-labeling experiments of electroreductive dimerization suggest that the hydrogen source comes from the solvent CH₃CN. This protocol provides a mild and efficient route for the construction of C-C bond in moderate to good yields with high regioselectivity and broad substrate scope. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2HPLC of Formula: 474709-71-2).

Ethyl 4-bromo-2-fluorobenzoate (cas: 474709-71-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 474709-71-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Substituent effects on the mass spectra of substituted phenyl acetates was written by Gamble, A. A.;Gilbert, J. R.;Tillett, J. G.. And the article was included in Organic Mass Spectrometry in 1971.Category: bromides-buliding-blocks This article mentions the following:

The mass spectra of a series of meta- and para-substituted phenyl acetates were examined Substituent effects were correlated with Δ(AP-IP) values (AP = appearance potential; IP = ionization potential) and by using the Harrison and Chin approach. The bond-cleavage and rearrangement reactions of Ph acetates are compared with the corresponding reactions of acetanilides and the differences attributed to the degree of transmission of polar effects in the 2 systems. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Category: bromides-buliding-blocks).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates was written by Craig, Sandra. And the article was included in Bioorganic Chemistry in 2012.HPLC of Formula: 166821-88-1 This article mentions the following:

Carbohydrates in various forms play a vital role in numerous critical biol. processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the design, synthesis and evaluation of three bisboronic acid fluorescent probes, each having about ten linear steps in its synthesis. Among these compounds that were evaluated, 9b was shown to selectively label HepG2, liver carcinoma cell line within a concentration range of 0.5-10 μM in comparison to COS-7, a normal fibroblast cell line. In the experiment, the researchers used many compounds, for example, 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1HPLC of Formula: 166821-88-1).

2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 166821-88-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 166821-88-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

De Novo Synthesis of Phenols and Naphthols through Oxidative Cycloaromatization of Dienynes was written by Rong, Ming-Guang;Qin, Tian-Zhu;Liu, Xin-Rui;Wang, Hong-Fa;Zi, Weiwei. And the article was included in Organic Letters in 2018.Related Products of 85118-24-7 This article mentions the following:

In this work, a rhodium-catalyzed oxidative cycloaromatization of dienynes, which provides a highly straightforward and efficient way to access polysubstituted naphthols and phenols under mild conditions, is described. Challenged electron-withdrawing groups are well tolerated in this protocol, and late-stage Ph ring formation is demonstrated. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Related Products of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. design, synthesis, and enzymatic BACE-1 and cell assays was written by Garino, Cedrik;Tomita, Taisuke;Pietrancosta, Nicolas;Laras, Younes;Rosas, Roselyne;Herbette, Gaetan;Maigret, Bernard;Quelever, Gilles;Iwatsubo, Takeshi;Kraus, Jean-Louis. And the article was included in Journal of Medicinal Chemistry in 2006.Computed Properties of C13H14BrNO2 This article mentions the following:

Twenty novel β-secretase inhibitors containing biarylpiperazine moieties belonging to naphthyl and coumarinyl series were designed for their potential use in Alzheimer’s disease therapy. Enzymic and cell-based assays have been carried out. The biol. results clearly demonstrate that specific substituents located at the N₄-position of the piperazine ring result in excellent in vitro inhibitory potency (IC₅₀ values ranging between 40 and 70 nM). Variable temperature NMR and modeling studies are consistent with the obtained biol. data, since these studies confirmed that introduction at the N₄-position of the piperazine ring allows productive interactions within the BACE-1 active site, which appear to be determinative for high BACE-1 inhibitory activity. These results are of particular interest since some of the new analogs belonging to the naphthyl series are almost one log more active than the best inhibitor of the similar family recently reported. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Computed Properties of C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of the Hammett relation to tetrasubsituted thiophenes. Kinetics of piperidino-debromination of 5-substituted 2-bromo-3-nitrothiophenes and 2-bromo-4-methyl-3-nitrothiophenes in methanol was written by Spinelli, D.;Consiglio, G.;Corrao, A.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1972.SDS of cas: 38239-45-1 This article mentions the following:

The kinetics of piperidino-debromination of six 5-substituted 2-bromo-3-nitrothiophenes and six 2-bromo-4-methyl-3-nitrothiophenes in MeOH were determined The results were correlated with σp- values (ρ = 3.21 for the trisubstituted and 3.24 for the tetrasubstituted thiophenes). In the experiment, the researchers used many compounds, for example, 5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1SDS of cas: 38239-45-1).

5-Bromo-3-methylthiophene-2-carboxylic acid (cas: 38239-45-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 38239-45-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chiral Chalcogenide-Catalyzed Enantioselective Electrophilic Hydrothiolation of Alkenes was written by Liang, Yaoyu;Jiao, Hui;Zhang, Hang;Wang, You-Qing;Zhao, Xiaodan. And the article was included in Organic Letters in 2022.Related Products of 128-08-5 This article mentions the following:

A new strategy for the construction of chiral sulfides by catalytic enantioselective hydrothiolation of alkenes via an electrophilic pathway has been developed. Using this strategy, cyclic and acyclic unactivated alkenes efficiently afforded various chiral products in the presence of electrophilic sulfur reagents and silanes through chiral chalcogenide catalysis. The obtained products were easily transformed into other types of valuable chiral sulfur-containing compounds Mechanistic studies revealed that the superior construction of chiral thiiranium ion intermediate is the key to achieving such a transformation. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Related Products of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Aromatic components analysis of fresh and rotten Penacus orientalis by HS-SPME and GC-MS was written by Xue, Yu-ping;Lan, Xin. And the article was included in Shipin Gongye (Shanghai, China) in 2014.Application of 56523-59-2 This article mentions the following:

The aromatic components of fresh and rotten Penacus orientalis were extracted by HS-SPME and identified by GC-MS. Then 100 μm PDMS microextraction fibers were used for sample pretreatment, with result that fresh prawn meat had 34 kinds of flavor composition, while rotten prawn meat had 48 kinds and quantified them. The result of the flavor characteristics and sensory evaluation were consistent. The results showed that the HS-SPME-GC-MS was suitable for anal. of prawn meat flavor composition method, which could be used in the anal. of volatile compounds as a quality indicator, with sensory evaluation for products quality evaluation, products classification, etc. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Application of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and anti-proliferative activity evaluation of N3-acyl-N5-aryl-3,5-diaminoindazole analogues as anti-head and neck cancer agent was written by Lee, Jinho;Kim, Jina;Hong, Victor Sukbong;Park, Jong-Wook. And the article was included in Daru, Journal of Pharmaceutical Sciences in 2014.Product Details of 1130165-74-0 This article mentions the following:

Head and neck squamous cell carcinoma (HNSCC) is the 11th leading cancer by incidence worldwide. Surgery and radiotherapy were the major treatment for patients with HNSCC while chemotherapy become an important treatment option for locally advanced HNSCC. Understanding of the mol. mechanisms underlying HNSCC impelled the development of targeted therapeutic agents. The development and combinations of targeted therapies in different cellular pathways may be needed to fulfill the unmet needs of current HNSCC chemotherapy. A series of N3-acyl-N5-aryl-3,5-diaminoindazoles were synthesized and their antiproliferative activities were evaluated against human cancer cell lines, Caki, A549, AMC-HN1, AMC-HN3, AMC-HN4, AMC-HN6, and SNU449. The cellular selectivity of compound was obtained by the modification of substituent at N5-aryl group of 3,5-diaminoindazole. The compounds 2-(4-ethoxyphenyl)-N-{5-[2-fluoro-4-(morpholine-4-carbonyl)phenylamino]-1H-indazol-3-yl}acetamide and 2-(4-ethoxyphenyl)-N-{5-[2-fluoro-4-(4-methylpiperazine-1-carbonyl)phenylamino]-1H-indazol-3-yl}acetamide showed more than 7-fold selectivity for AMC-HN4 and AMC-HN3, resp. 3-Acylamino-N-arylaminoindazole analogs were used as hits in the development of anticancer drug for HNSCC. In the experiment, the researchers used many compounds, for example, Ethyl 4-bromo-3-fluorobenzoate (cas: 1130165-74-0Product Details of 1130165-74-0).

Ethyl 4-bromo-3-fluorobenzoate (cas: 1130165-74-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 1130165-74-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary