Category: bromides-buliding-blocks

RAFT polymerization of bromotyramine-based 4-acryloyl-1,2,3-triazole: a functional monomer and polymer family through click chemistry was written by Andjouh, Sofyane;Bressy, Christine;Blache, Yves. And the article was included in RSC Advances in 2016.Electric Literature of C10H13BrO This article mentions the following:

Four new functional acryloyl-triazole monomers derived from bromotyramine were successfully synthesized. These monomers were prepared in an efficient way from organic azides and propargyl acrylate via a copper catalyzed 1,3-dipolar cycloaddition Polymers containing bromotyramine as a pendant group were obtained via reversible addition-fragmentation chain transfer (RAFT) polymerization The influence of the chain transfer agent (CTA), solvent, temperature and the length of the linker between the triazole and bromotyramine groups on the polymerization kinetics was studied. It was found that triazoles containing acrylate monomers are characterized by fast polymerization and polymers with controlled molar masses (20 000 g mol^-1) and low dispersities (DM < 1.5) can be prepared Glass transition temperatures of these acrylic polymers ranged from 48 °C to 20 °C by controlling the length of the linker between the bromotyramine side groups and the backbone. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Electric Literature of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Electric Literature of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 3-phenylethynylphenol. (A novel high-temperature phenyl acetylene endcapper for arylene ethers) was written by Jayaraman, S.;Srinivasan, R.;McGrath, J. E.. And the article was included in Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) in 1993.Safety of 3-Bromophenyl acetate This article mentions the following:

PhCCH was condensed with m-XC₆H₄OAc (X = Br, I) to give 3-(phenylethynyl)phenyl acetate, which was methanolyzed to provide 3-(phenylethynyl)phenol, an endcapping agent for aromatic polyethers. 3-Ethynylphenol was similarly obtained. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Safety of 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Safety of 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and gas permeation properties of poly(diarylacetylene)s having substituted and twisted biphenyl moieties was written by Hu, Yanming;Shimizu, Toshiyuki;Hattori, Kyohei;Shiotsuki, Masashi;Sanda, Fumio;Masuda, Toshio. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2010.Computed Properties of C16H17Br This article mentions the following:

Diarylacetylene monomers containing substituted biphenyl (1a-f) and anthryl (1g) groups were synthesized and then polymerized with TaCl₅-n-Bu₄Sn catalyst to produce the corresponding poly(diarylacetylene)s (2a-g). Polymers 2a-f were soluble in common organic solvents such as cyclohexane, toluene, and chloroform. According to thermogravimetric anal., the onset temperatures of weight loss of the polymers were over 400° in air, indicating considerably high thermal stability. Free-standing membranes 2a and 2c-e were prepared by the solution casting method. Desilylation of Si-containing membrane 2c was carried out with trifluoroacetic acid to afford 3c. All the polymer membranes, especially those having twisted biphenyl groups, exhibited high gas permeability; for example, their oxygen permeability (PO₂) values ranged from 130 to 1400 barriers. Membrane 2d having two chlorine atoms in the biphenyl group showed the highest gas permeability (PO₂ = 1400 barriers) among the present polymers. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Computed Properties of C16H17Br).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C16H17Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Polysubstituted 2-Naphthols by Palladium-Catalyzed Intramolecular Arylation/Aromatization Cascade was written by Cai, Jinhui;Wang, Zhen-Kai;Zhang, Yun-Hao;Yao, Fei;Hu, Xu-Dong;Liu, Wen-Bo. And the article was included in Advanced Synthesis & Catalysis in 2020.Reference of 61150-57-0 This article mentions the following:

A palladium-catalyzed intramol. α-arylation and defluorinative aromatization strategy for the synthesis of polysubstituted 2-naphthols, e.g., 1-(3-hydroxynaphthalen-2-yl)ethan-1-one, is reported. With ortho-bromobenzyl-substituted α-fluoroketones RCH₂C(F)(C(O)R²)C(O)R¹ (R = 2-bromophenyl, 2-bromopyridin-3-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc., R¹ = Me, Et, Ph, R² = Et, OMe, OEt, Ot-Bu) as the substrates and palladium acetate/triphenylphosphine as the catalyst system, this method features good functional group tolerance, readily available catalyst and starting materials, and high yields. The applications of the strategy are demonstrated by the synthesis of useful building blocks, such as naphtha[2,3-b]furan, naphthol AS-D, and ligands/catalysts. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Reference of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Reference of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors was written by Soliman, Beatrice;Wang, Ning;Zagotto, Giuseppe;Pockes, Steffen. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2019.Related Products of 954-81-4 This article mentions the following:

Imidazolylbutyl cyanoguanidines, such as N-cyano-N’-4-(4-imidazolyl)butyl-N”-2-(phenylthio)ethylguanidine, previously identified as highly potent agonists at the human histamine H₄ receptor (hH₄R), display certain drawbacks in pharmacokinetics, which led to the attempt to replace the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and N-methylpiperazine) as potential bioisosteres. Besides these changes, a variation of the spacer length (C₃-C₅) connecting the heterocycle and the cyanoguanidine moiety was made to possibly trigger the selectivity towards the resp. HRs. Investigations in radioligand-binding assays of the synthesized compounds I [X = CH₂, O, S, NMe; Y = CH₂, S; Z = (CH₂)_n; n = 1-3] exhibited only very weak activity at the hH₁R and hH₃R, while nearly all compounds were inactive at the hH₂R and hH₄R. In the case of piperidine-containing compounds, moderate affinities at the hH₃R over the single-digit micromolar range were detected. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Related Products of 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Many-membered heterocyclic compounds. XII. Formation of 15-pentadecanolide from 15-bromopentadecanoic acid was written by Stoll, M.. And the article was included in Helvetica Chimica Acta in 1947.Product Details of 56523-59-2 This article mentions the following:

Because the method of Kerschbaum (C.A. 21, 2118) for the lactonization of higher ω-Br fatty acids, using their Ag salts, gives very low yields, this reaction is studied in detail, using other salts and various solvents and concentrations The results are given in a table. The best results are obtained when the K 15-bromopentadecanoate is lactonized in a specially designed apparatus in MeCOEt, giving 85% 15-pentadecanolide (I), b_0.1 122°, m. 32-6°. Using the method of Hunsdiecker, et al. (French 839,188), with and without K₂CO₃, yields of 82.8% I are obtained in both cases. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Product Details of 56523-59-2

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Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and study of the antioxidant activity of symmetrical and unsymmetrical sulfides based on 3-[4-hydroxy(methoxy)aryl]-1-bromopropanes was written by Prosenko, A. E.;Terakh, E. I.;Gorokh, E. A.;Khomchenko, A. S.;Panferov, M. A.. And the article was included in Neftekhimiya in 2003.Category: bromides-buliding-blocks This article mentions the following:

Synthesis of structural analogs of bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propyl]sulfide (stabilizer SO-3) – sym. and unsym. sulfides with different number of tert-Bu ortho-substituents in the structure of phenol fragments. A comparative study of the antioxidant activity of the synthesized compounds in model reactions of the autoxidation of lard and vaseline oil was carried out. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Macrocyclic 2,2′-Bibenzimidazole Ruthenium(II) Chromophore as a Versatile Building Block for Supramolecular Devices was written by Sorsche, Dieter;Rau, Sven. And the article was included in European Journal of Inorganic Chemistry in 2014.Computed Properties of C7H7BrN2O2 This article mentions the following:

The authors present the synthesis of a macrocyclic Ru(II) complex I(PF₆)₂ that combines the versatile photophysics and supramol. chem. of biimidazole Ru(II) chromophores with a macrocyclic geometry that allows for its introduction into mech. interlocked frameworks. Structural information on the core framework was gained from a solid-state structure. The new supramol. building block shows that the principal photophysics of the Ru chromophore, i.e., the cation-driven light-switch effect, are retained during the formation of the macrocycle. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Computed Properties of C7H7BrN2O2).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C7H7BrN2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

From hexa-peri-hexabenzocoronene to “superacenes” was written by Iyer, Vivekanantan S.;Wehmeier, Mike;Brand, J. Diedrich;Keegstra, Menno A.;Mullen, Klaus. And the article was included in Angewandte Chemie, International Edition in English in 1997.Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl This article mentions the following:

The polyphenylene I was prepared and characterized. Intramol. cyclodehydration of I with AlCl₃ and copper triflate in CS₂ afforded a black solid, which gave a broad mass spectral peak in the mass range expected for the analogous C₂₂₂ graphite unit. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A Direct and Efficient Total Synthesis of the Tubulin-Binding Agents Ceratamine A and B; Use of IBX for a Remarkable Heterocycle Dehydrogenation was written by Coleman, Robert S.;Campbell, Erica L.;Carper, Daniel J.. And the article was included in Organic Letters in 2009.HPLC of Formula: 108940-96-1 This article mentions the following:

The total synthesis of the tubulin-binding agents (no biol. testing data presented) ceratamines A and B I (R = Me, H, resp., R¹ = Me) was reported, along with des-Me analogs I (R = Me, H, R¹ = H), via a synthetic route that is high-yielding and operationally efficient. The synthetic route involved a Beckmann rearrangement to form an azepine ring precursor, a Knoevenagel condensation to install the benzylic side chain, and an effective imidazole annulation onto an α-aminoketone precursor with a protected S-methylisothiourea. Final dehydrogenation proved remarkably facile using IBX. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1HPLC of Formula: 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary