Category: bromides-buliding-blocks

Related Products of 626-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-39-1, name is 1,3,5-Tribromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,3,5-tribromobenzene (3.11 g, 10 mmol), pyridine-3-boronic acid (2.71 g, 22 mmol), tetrakis(triphenylphosphine)palladium(1.56 g, 1 mmol) and potassium carbonate (5.52 g, 40 mmol) were added to the reaction flask.The nitrogen was exchanged three times (10 min/time). Injecting solvent under nitrogen protection(toluene: ethanol: water = 8:1:1), after the completion of the injection, the reaction was refluxed at 120 C for 8 h;Extract, concentrate, make powder,Purification by column chromatography gave white solid product 1 in 65% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3,5-Tribromobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; South China University of Technology; Tang Benzhong; Zhao Zujin; Hu Shimin; Qin Anjun; Hu Rongrong; Wang Zhiming; (24 pag.)CN109593079; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 393-36-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of [6-CHLORO-4-ISOPROPYL-N- (TETRAHYDROPYRAN-4-YLMETHYL)-NICOTINAMIDE] (Description 8) (100mg), [4-BROMO-3-TRIFLUOROMETHYL-] (ex Lancaster, 162mg), [METHANESULFONIC] acid [(44NL)] in 1,4-dioxane [(1MI)] was irradiated under microwave conditions at [180FOR] 30 minutes. After removal of the 1,4-dioxane under reduced pressure, the mixture was partitioned between ethyl acetate [(5ML)] and brine [(2ML)] and the aqueous layer separated. The organic layer was evaporated under reduced pressure and the residue purified using the Biotage Horizon system. Purification afforded the title compound as a white solid (47mg). NMR [(DMSO-D6)] [No.1. ]16-1.23 (8H, d, m), 1.60-1. 63 (2H, d), 1.75 (1H, m), 3.10 (2H, t), 3.28 (2H, t), 3.41 (1H, m), 3.85 (2H, d), 6.80 (1H, s), 7.73 (1H, d), 7.83 (1H, d), 8.16 (1H, s), 8.38-8. 42 (2H, m), 9.70 (1H, s). LC/MS t = 3.5 min, [MH+] 500, consistent with molecular formula [C22H2579BR F3N302]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/29026; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24358-62-1, Application In Synthesis of 1-(4-Bromophenyl)ethylamine

To a solution of 2-bromoacetamide 6 (827mg, 5.88 mmol), and 4-bromobenzylethylamine 15 (1.00 g, 4.90 mmol) in MeOH (5ml) and CH2Cl2 (5ml) at room temperature was added Hunig’s base (5ml). The mixture was stirred at 50-60 C for 16h. Water (30mL) was added and the mixture was extracted with CH2Cl2 (4 x 30ml) and dried over Na2SO4 to provide 1.27 g amide 16 as white crystals in 100% yield. This product was used without further purification in the next step. 1HNMR (300 MHz, CDCl3, ppm): delta 7.38 (d, J=8Hz, 2H), 7.09 (d, J=8Hz, 1H), 6.77 (s br, 1H), 5.69 (s br, 1H), 3.67 (q, J=7Hz, 1H), 3.07 (s, 2H), 1.29 (d, J=7Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Bromophenyl)ethylamine, and friends who are interested can also refer to it.

Reference:
Patent; RIB-X PHARMACEUTICALS, INC.; WO2005/12270; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 615-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 615-54-3, name is 1,2,4-Tribromobenzene, This compound has unique chemical properties. The synthetic route is as follows.

6.296 (0.02 mol) 1,2,4-tribromobenzene and 8.671 g (0.05 mol)3-aminobenzeneboronic acidHydrochlorideAdd to a 500 mL three-necked flask, add 400 mL of tetrahydrofuran (THF), and add 45 mL of 2 mol/L potassium carbonate solution.And add an appropriate amount of aliquat336, magnetically stirred and argon gas, after heating to 75 C in the oil bath,0.020 g of tetrakistriphenylphosphine palladium was added, and the reaction was refluxed for 24 hours, and the reaction liquid was poured into water to precipitate a large amount. The mixture was filtered with a funnel, and the solvent was evaporated under reduced pressure.The product was purified by column chromatography using dichloromethane: n-hexane = 2:1 (volume ratio) as mobile phase as the stationary phase. The product was collected and dried.Drying in a vacuum at 90 C for 24 h,The target product was obtained 5.834 g,The yield was 83%.

The chemical industry reduces the impact on the environment during synthesis 1,2,4-Tribromobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hunan University of Technology; Ke Shenghai; Liu Yiwu; Tan Jinghua; Zhu Heping; (19 pag.)CN108976138; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1003-98-1, These common heterocyclic compound, 1003-98-1, name is 2-Bromo-4-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 10: methyl [(lR)-6-fluoro-8-(methylsulfonyl)-2, 3,4, 9-tetrahydro-lH-carbazol-l- yl] acetate Step 1: 2-(2-bromo-4-fluorophenyl) hydraziniumchloride To a suspension of 2-bromo-4-fluoroaniline in concentrated HCI (1. 5M) at-10 C was slowly added a 10. 0M aqueous solution of NaNO2 (1.1 eq). The mixture was stirred at 0 C for 2.5 hrs. A cold (-30 C) solution of SnCl2 (3. 8M) in concentrated HCI was then slowly added while maintaining the internal temperature below 10 C. The resulting mixture was stirred mechanically for 20 min at 0, then at room temperature for 1 hr. The thick slurry was filtered and the solid was air dried overnight. The solid was resuspended in cold HCI and filtered again. The dried material was suspended in Et2O, stirred for 10 min, filtered and air dried overnight to give the title compound as a beige solid.

Statistics shows that 2-Bromo-4-fluoroaniline is playing an increasingly important role. we look forward to future research findings about 1003-98-1.

Reference:
Patent; MERCK FROSST CANADA & CO.; WO2005/56527; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 1074-24-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1074-24-4 as follows.

Iodine (78 mg, 0.33 mmol) was added to p-xylene (6.13 mL, 50.0 mmol), the mixture was cooled to 0 °C, and bromine (5.20 mL, 101 mmol) was added dropwise over 10 min. The ice bath was removed and the reaction stirred at rt for 16 h in the absence of light. The reaction was quenched with 20percent aq. KOH and stirred for 15 min while the solution became colorless. The solid precipitate was filtered and rinsed 2 x with 100 mL of H2O. The solids were recrystallized in ethanol to afford a white solid (9.19 g, 70percent). 1H NMR (CDCl3): delta 7.40 (s, 2H), 2.34 (s, 6H). 1,4?dibromo-2,5-dimethylbenzene (5.93 g, 22.5 mmol) and KMnO4 (15.72 g, 99.5 mmol) were added to 80 mL of t-BuOH:H2O (1:1). Celite (14 g) was added to the flask and the reaction was refluxed for 18 h. The reaction mixture was cooled to rt, filtered over celite and the filter was washed with hot H2O (100mL) and EtOAc (50mL). The filtrate was then acidified to pH=1 with conc. HCl. The white suspension was then extracted 3x with 100 mL of EtOAc. The combined organic extracts were dried over MgSO4 and excess solvent was removed under vacuum to obtain a white solid (3.06 g, 42percent) which was not purified further. 1H NMR (DMSO-d6): delta 8.01 (s, 2H). 2,5?dibromoterephthalic acid (2.04 g, 6.30 mmol) dissolved in 35 mL of MeOH and refluxed for 30 min. Thionyl chloride (9.00 mL, 124 mmol) was then carefully added and the reaction was refluxed 12 hours. The reaction flask was cooled to room temperature, 50 mL of water was carefully added, and the reaction was extracted 3x with 75 mL of Et2O. The combined organics were washed with 3 x with 50 mL of sat. NaHCO3 and dried with MgSO4. The solvent was removed under vacuum and the solids recrystallized in MeOH to yield a white crystalline solid (1.65g, 74percent), mp = 134-136 C (lit.3 mp 134-137 C). 1H NMR (CDCl3): delta 8.06 (s, 2H), 3.96 (s, 6H). The 1H NMR matches the known spectrum.3

According to the analysis of related databases, 1074-24-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dressler, Justin J.; Miller, Sarah A.; Meeuwsen, Brian T.; Riel, Asia Marie S.; Dahl, Bart J.; Tetrahedron; vol. 71; 2; (2015); p. 283 – 292;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 626-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-39-1 name is 1,3,5-Tribromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1,3,5-Tribromobenzene (20 g, 62 mmol), Pd(PPh3)4 (3.57 g, 3.1mmol) were added to 300 mL of dry THF solution, thenphenylbronic acid (32 g, 155 mmol) and 2 M K2CO3 solution (50 mL), which was dissolved in H2O, was added to the reaction mixture. The reaction mixture was heated to 65C for 5 h under nitrogen. After the reaction was finished,extracted with diethyl ether and water. The organic layer was dried with anhydrous MgSO4 and filterd. The solvent was evaporated. The product was isolated by silica gel column chromatography using CHCl3:hexane (1:15) eluent to afforda white solid (Yield 61%). 1H NMR (300 MHz, CDCl3) delta 7.7(s, 3H), 7.6 (d, 4H), 7.45 (t, 4H), 7.4 (t, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Tribromobenzene, and friends who are interested can also refer to it.

Reference:
Article; Shin, Hwangyu; Kang, Hyeonmi; Kim, Beomjin; Park, Youngil; Yu, Young-Jun; Park, Jongwook; Bulletin of the Korean Chemical Society; vol. 35; 10; (2014); p. 3041 – 3046;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937046-98-5, Quality Control of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

To a dry, argon purged round bottom flask (100 mL) were added 7-bromo- pyrrolo[2, 1 -f] [ 1 ,2,4]triazin-4-ylamine (234 mg, 1.10 mmol) (prepared according to WO2007056170) and anhydrous THF (1.5 mL). TMSCI (276 mu, 2.2 mmol) was then added and the reaction mixture stirred for 2 h. The flask was placed into a dry ice/acetone bath (~ -78 C) and BuLi (2.5 mL, 4.0 mmol, 1.6M in hexanes) was added dropwise. After lh, a solution of If (432.5 mg, 1.0 mmol) in THF was cooled to 0 C and then added to the reaction flask dropwise. After 1 h of stirring at -78 C, the flask was warmed to 0 C and sat. NH4C1 (5 mL) was added to quench the reaction. The organics were extracted using EtOAc (3 10 mL) and the combined organic layers were dried using MgS04. The solvent was removed under reduced pressure and the crude material was purified using flash chromatography (hexanes / EtOAc). 560 mg (90 %) of 2a was isolated as a mixture of two anomers. LC/MS = 567.2 (M + H+). ]H NMR (300 MHz, CDC13): delta 7.85 (m, IH), 7.27 (m, 15H), 7.01 (m, 1H), 6.51 (m, 1H), 4.66 (m, 8H), 4.40 (m, 2H), 3.79 (m, 3H), 1.62 (s, 2′-CH3 from the one anomer), 1.18 (s, 2′-CH3 from the other anomer).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; CHO, Aesop; CLARKE, Michael, O’neil Hanrahan; WOLCKENHAUER, Scott, Alan; GILEAD SCIENCES, INC.; WO2012/12465; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 141474-37-5, name is 2,4-Dibromo-6-fluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Safety of 2,4-Dibromo-6-fluoroaniline

2,4-dibromo-6-fluoro-phenylamine 2.69 g (10.0 mmol), phenylboronic acid 2.68 g (22.0 mmol), Pd(PPh3)4 (Tetrakis(triphenylphosphine)palladium(0)) 0.58 g ( 0.5 mmol) and K2CO3 6.21 g (45.0 mmol) were dissolved in 40 mL of a THF (tetrahydrofuran)/H20 (2/1) mixed solution, and stirred at 80C for 5 hours. After cooling the reaction solution to room temperature, it was extracted 3 times with 40 mL of water and 40 mL of diethyl ether. The organic layer obtained therefrom was dried over magnesium sulfate, and the residue obtained by evaporating the solvent was separated and purified through silica gel column chromatography to obtain intermediate I-2 (2.26 g, 86% yield).

According to the analysis of related databases, 141474-37-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samsung Display Co., Ltd.; Kim Su-yeon; Hwang Seok-hwan; Kim Yeong-guk; Jeong Hye-jin; Im Jin-o; Han Sang-hyeon; Jeong Eun-jae; Park Jun-ha; Lee Eun-yeong; Lee Jong-hyeok; (74 pag.)KR102105076; (2020); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1154740-48-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1154740-48-3, name is 6-Bromo-5-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A well stirred DMF (15 ml.) solution of the arylbromide 5e (0.50 g, 2.19 mmol, 1 eq), potassium acetate (0.728 g, 7.67 mmol, 3.5 eq) and bis(pinacolato)diborane (0.83 g, 3.3 mmol, 1.5 eq) is degassed by bubbling Ar through the solution for about 20 min. PdCI2(dppf)-DCM (320 mg, 0.44 mmol, 0.20 eq) is added and degassing is continued for about 15 min. The system is sealed (teflon screw cap vessel) under Ar and heated to ~90C for about 5 h. The reaction mixture is allowed to cool to RT, dilute with EtOAc (150 ml_), washed with brine (3 x 100 ml_) and water (2 x 100 ml_), dried over anhydrous MgSO4, filtered and concentrated to dryness. The residue is purified by CombiFlash Companion (EtOAc/hexanes) to give the desired boronate 5f (389 mg, 65% yield) as a yellowish waxy solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromo-5-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GmbH; WO2009/62308; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary