Category: bromides-buliding-blocks

Production of halogenated compounds by Bjerkandera adusta was written by Spinnler, H.-E.;de Jong, E.;Mauvais, G.;Semon, E.;le Quere, J.-L.. And the article was included in Applied Microbiology and Biotechnology in 1994.Synthetic Route of C8H6Br2O2 This article mentions the following:

The white-rot fungus Bjerkandera adusta produces volatile chlorinated Ph compounds The main compounds identified were 3-chloro-4-methoxybenzaldehyde (3-chloro-p-anisaldehyde), 3-chloro-4-methoxybenzyl alc. (3-chloro-p-anisyl alc.), 3,5-dichloro-4-methoxybenzaldehyde (3,5-dichloro-p-anisaldehyde), and 3,5-dichloro-4-methoxybenzyl alc. (3,5-dichloro-p-anisyl alc.). P-Anisaldehyde, veratraldehyde, and the corresponding alcs., p-anisyl alc. and veratryl alc., were produced simultaneously. Even with a very low concentration of Cl^– in the medium (<10^-5 M), chlorinated aromatic compounds were still observed Addition of Br^– to the culture medium led to the production of brominated compounds: 3-bromo-4-methoxybenzaldehyde, 3-bromo-4-methoxybenzyl alc., 3,5-dibromo-4-methoxybenzaldehyde, and 3-bromo-5-chloro-4-methoxybenzaldehyde. These brominated compounds have not previously been reported as natural products. Although iodo-aromatic compounds were not produced by supplementation of the medium with I^–, isovanillin was found in the culture broth under these conditions. This compound may be formed by substitution of the I intermediate by an OH group on C3 of the ring. CH₂I₂ or CH₂ClI were also found. This is the 1st time that the production of halomethane has been related to the production of halogenated aromatic compounds All the strains tested have these capabilities. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Synthetic Route of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Synthetic Route of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Transition Metal Free Stannylation of Alkyl Halides: The Rapid Synthesis of Alkyltrimethylstannanes was written by Li, Songyi;Lian, Chang;Yue, Guanglu;Zhang, Jianning;Qiu, Di;Mo, Fanyang. And the article was included in Journal of Organic Chemistry in 2022.Related Products of 4457-67-4 This article mentions the following:

A transition metal free stannylation reaction of alkyl bromides and iodides with hexamethyldistannane was developed. This protocol is operationally convenient and features a rapid reaction and good functional group tolerance. A wide range of functionalized primary and secondary alkyl and benzyl tri-Me stannanes were prepared in moderate to excellent yields. The success of the gram-scale procedure and tandem Stille coupling reaction has allowed this protocol to demonstrate potential for application in organic synthesis. Both exptl. and theor. studies reveal the mechanistic details of this stannylation reaction. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Related Products of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Halogenation using quaternary ammonium polyhalides. VI. Bromination of aromatic amines by use of benzyltrimethylammonium tribromide was written by Kajigaeshi, Shoji;Kakinami, Takaaki;Inoue, Kazuhisa;Kondo, Manabu;Nakamura, Hiroko;Fujikawa, Masahiro;Okamoto, Tsuyoshi. And the article was included in Bulletin of the Chemical Society of Japan in 1988.Category: bromides-buliding-blocks This article mentions the following:

The reaction of aromatic amines with benzyltrimethylammonium tribromide in dichloromethane-methanol containing calcium carbonate powder for 0.5 h at room temperaturegave bromo-substituted aromatic amines in good yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7Category: bromides-buliding-blocks).

2-Bromo-4-methyl-6-nitroaniline (cas: 827-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fluorine-Substituted Pyrrolo[2,3-d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis was written by Ravindra, Manasa;Wilson, Mike R.;Tong, Nian;OConnor, Carrie;Karim, Mohammad;Polin, Lisa;Wallace-Povirk, Adrianne;White, Kathryn;Kushner, Juiwanna;Hou, Zhanjun;Matherly, Larry H.;Gangjee, Aleem. And the article was included in Journal of Medicinal Chemistry in 2018.Synthetic Route of C8H6BrFO2 This article mentions the following:

Novel fluorinated 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidine analogs were synthesized and tested for selective cellular uptake by folate receptors (FRs) α and β or the proton-coupled folate transporter (PCFT) and for antitumor efficacy. Compounds I (n = 0, 1) and II (n = 0, 1) showed increased in vitro anti-proliferative activities (âˆ?1-fold) over the nonfluorinated analogs toward engineered Chinese hamster ovary and HeLa cells expressing FRs or PCFT. Compounds I (n = 0, 1) and II (n = 0, 1) also inhibited proliferation of IGROV1 and A2780 epithelial ovarian cancer cells; in IGROV1 cells with knockdown of FRα, I (n = 0) and II (n = 0, 1) showed sustained inhibition associated with uptake by PCFT. All compounds inhibited glycinamide ribonucleotide formyltransferase, a key enzyme in the de novo purine biosynthesis pathway. Mol. modeling studies validated in vitro cell-based results. NMR evidence supports the presence of an intramol. fluorine-hydrogen bond. Potent in vivo efficacy of II (n = 1) was established with IGROV1 xenografts in severe compromised immunodeficient mice. In the experiment, the researchers used many compounds, for example, Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2Synthetic Route of C8H6BrFO2).

Methyl 4-bromo-2-fluorobenzoate (cas: 179232-29-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Analytical chemistry of the platinum metals. VIII. Application of phosphonium and arsonium salts to the gravimetric determination of osmium was written by Neeb, R.. And the article was included in Fresenius’ Zeitschrift fuer Analytische Chemie in 1960.Electric Literature of C23H26BrP This article mentions the following:

Solubility determinations are reported of halo-osmates of substituted phosphonium and arsonium compounds, and several are investigated for determining Os. Those recommended are tetraphenylarsonium chloride and benzyltriphenylphosphonium chloride in HCl solution, and tetraphenylarsonium and tetraphenylphosphonium chlorides in HBr solution In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Electric Literature of C23H26BrP).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Electric Literature of C23H26BrP

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Glycerol-Based Bicontinuous Cubic Lyotropic Liquid Crystal Monomer System for the Fabrication of Thin-Film Membranes with Uniform Nanopores was written by Carter, Blaine M.;Wiesenauer, Brian R.;Hatakeyama, Evan S.;Barton, John L.;Noble, Richard D.;Gin, Douglas L.. And the article was included in Chemistry of Materials in 2012.Formula: C15H29BrO2 This article mentions the following:

This article present a new imidazolium-based gemini Lyotropic liquid crystal (LLC) monomer that forms a cross-linkable Q₁-phase with the low volatility and environmentally benign solvent, glycerol, instead of water. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Formula: C15H29BrO2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Formula: C15H29BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors was written by Congdon, Molly D.;Kharel, Yugesh;Brown, Anne M.;Lewis, Stephanie N.;Bevan, David R.;Lynch, Kevin R.;Santos, Webster L.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Name: 1-Bromo-4-methoxybutane This article mentions the following:

The two isoforms of sphingosine kinase (SphK1 and SphK2) are the only enzymes that phosphorylate sphingosine to sphingosine-1-phosphate (S1P), which is a pleiotropic lipid mediator involved in a broad range of cellular processes including migration, proliferation, and inflammation. SphKs are targets for various diseases such as cancer, fibrosis, and Alzheimer’s and sickle cell disease. Herein, the authors disclose the structure-activity profile of naphthalene-containing SphK inhibitors, e.g. I, and mol. modeling studies that reveal a key mol. switch that controls SphK selectivity. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Constructing Soluble Anthracene-Based Blue Emitters Free of Electrically Inert Alkyl Chains for Efficient Evaporation- and Solution-Based OLEDs was written by Noda, Taito;Sasabe, Hisahiro;Owada, Tsukasa;Sugiyama, Ryo;Arai, Ayato;Kumada, Kengo;Tsuneyama, Hisaki;Saito, Yu;Kido, Junji. And the article was included in ChemPlusChem in 2022.Application of 128-08-5 This article mentions the following:

Anthracene derivatives are one of the most promising blue emitters employed in organic light-emitting devices (OLEDs) because of their electrochem. and thermal stabilities. However, their high crystallinity owing to their large π-planar structures severely impedes the progress in the development of solution-based systems. In this work, we developed two types of highly soluble multifunctional anthracene derivatives terminated with ortho-biphenyl and triphenylamine moieties and showed high solubility in general organic solvents such as toluene, THF, and cyclohexanone at high concentrations (>10 mg mL-1), and showed blue emission with a peak wavelength of âˆ?65 nm and a high photoluminescence quantum yield that ranges up to 81 %. Notably, these emitters are suitable for fabricating both evaporation- and solution-based systems. The evaporation-based system OLED achieved a high external quantum efficiency (EQE) of 5.4 %. While the solution-processed system realized 4.8 %, exhibiting the best performance among the anthracene-based solution-processed OLEDs so far. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells was written by Hampel, Sonja M.;Sidibe, Assitan;Gunaratnam, Mekala;Riou, Jean-Francois;Neidle, Stephen. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.COA of Formula: C13H14BrNO2 This article mentions the following:

A series of tetrasubstituted naphthalene diimide compounds I (n = 2-4) with N-methylpiperazine end groups has been synthesized and evaluated as G-quadruplex ligands. They have high affinity and selectivity for telomeric G-quadruplex DNA over duplex DNA. CD studies show that they induce formation of a parallel G-quadruplex topol. They inhibit the binding of hPOT1 and topoisomerase IIIα to telomeric DNA and inhibit telomerase activity in MCF7 cells. I has potent activity in a panel of cancer cell lines, with typical IC₅₀ values of âˆ?.1 μM, and up to 100-fold lower toxicity in a normal human fibroblast cell line. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4COA of Formula: C13H14BrNO2).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.COA of Formula: C13H14BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gold(I)-Catalyzed Tandem Transformation with Diynes: Rapid Access to Linear Cyclopentenone-Fused Polycyclic Molecules was written by Yu, Congjun;Chen, Bin;Zhou, Tian;Tian, Qingshan;Zhang, Guozhu. And the article was included in Angewandte Chemie, International Edition in 2015.Electric Literature of C8H4BrF3O This article mentions the following:

An efficient and convenient synthesis of useful linear cyclopentenone-fused polycyclic compounds has been achieved through a novel gold(I)-catalyzed transformation of diynes. The method demonstrates high product yields and tolerates of a wide variety of important functional groups. Gold-vinylidene formation, methoxy group migration, and Nazarov-type cyclization are proposed to be the key steps in the reaction pathway. The synthetic utility of this method is demonstrated by converting the product to eight-membered-ring-fused compound In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Electric Literature of C8H4BrF3O).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Electric Literature of C8H4BrF3O

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary