Category: bromides-buliding-blocks

Improved resistive switching WORM memory behavior in D-π-A architectures by modifying the terminal donor units was written by Harshini, Deivendran;Angela, Varghese Maria;Devibala, Paneerselvam;Imran, Predhanekar Mohamed;Bhuvanesh, Nattamai S. P.;Nagarajan, Samuthira. And the article was included in ACS Applied Electronic Materials in 2022.Recommanded Product: 128-08-5 This article mentions the following:

A series of D-π-A, D-π-D, and A-π-A based push-pull compounds with triarylamine and benzophenone were designed and synthesized for nonvolatile memory applications. All of the compounds showed good solubility in common organic solvents, which permits solution processability. D-π-A based compounds exhibited write-once-read-many (WORM) memory applications, and the compound with a methoxyphenyl substituent exhibited switching with a low threshold voltage of -0.82 V, an ON/OFF current ratio of 10², and a long-lasting retention time of 10³ s. The effect of differently functionalized triarylamines on memory behavior was explored by optical, electrochem., and computational studies. The highest HOMO levels of around 5̃.0 eV and irreversible anodic peaks (0.7-1.3 V) obtained for the compounds facilitate charge injection and switching behavior. Besides, electrochem. and d. functional theory studies disclose the charge-transfer mechanism of the D-π-A systems, which is related to the bistability of the devices. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Comparative Molecular Moment Analysis (CoMMA): 3D-QSAR without Molecular Superposition was written by Silverman, B. D.;Platt, Daniel. E.. And the article was included in Journal of Medicinal Chemistry in 1996.Safety of 3-(Bromomethyl)benzoic acid This article mentions the following:

3D-QSAR procedures utilize descriptors that characterize mol. shape and charge distributions responsible for the steric and electrostatic nonbonding interactions intimately involved in ligand-receptor binding. Comparative mol. moment anal. (CoMMA) utilizes moments of the mol. mass and charge distributions up to and including second order in the development of mol. similarity descriptors. As a consequence, two Cartesian reference frames are then defined with respect to each mol. structure. One frame is the principal inertial axes calculated with respect to the center-of-mass. For neutrally charged mol. species, the other reference frame is the principal quadrupolar axes calculated with respect to the mol. “center-of-dipole”. QSAR descriptors include quantities that characterize shape and charge independently as well as quantities that characterize their relationship. 3D-QSAR partial least squares (PLS) cross-validation procedures are utilized to predict the activity of several training sets of mols. previously investigated. This is the first time that mol. electrostatic quadrupolar moments have been utilized in a 3D-QSAR anal., and it is shown that descriptors involving the quadrupolar moments and related quantities are required for the significant cross-validated predictive r²‘s obtained. CoMMA requires no superposition step, i.e., no step requiring a comparison between two mols. at any stage of the 3D-QSAR calculation In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Safety of 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Safety of 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Efficient synthesis of alkylboronic esters via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides was written by Shegavi, Mahadev L.;Agarwal, Abhishek;Bose, Shubhankar Kumar. And the article was included in Green Chemistry in 2020.Recommanded Product: 57293-19-3 This article mentions the following:

We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Recommanded Product: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Novel metal complexes of pyridineimine derivative used as auxiliary electron acceptor of D-(A-π-A)₂ motif dye sensitizer: synthesis and photovoltaic application was written by Tian, Yong;Wang, Kaixuan;Wu, Xianming;Tang, Shiyu;Zhang, Houpeng;Zhong, Chaofan. And the article was included in Journal of Solid State Electrochemistry in 2022.Quality Control of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The auxiliary acceptors of metal complexes can easily regulate the electron-withdrawing ability of electron acceptor and adjust the balance of push-pull electron of D-A-π-A motif dye sensitizers. Two series of the D-(A-π-A)₂ motif dye sensitizer (BDTT-i.m.-Co, BDTT-i.m.-Cu, BDTT-i.m.-Zn, BDTT-i.m.-Cd and FL-i.m.-Co, FL-i.m.-Cu, FL-i.m.-Zn, FL-i.m.-Cd) which use metal complexes of pyridineimine derivative as auxiliary acceptor were designed, synthesized, and characterized. The photovoltaic test of eight complex-based dye sensitized solar cells (DSSCs) showed that the short-circuit photocurrent d. (J_SC) and the power conversion efficiency (PCE) of two series dye sensitizers are sequentially increased. BDTT-i.m.-Cd have the highest J_SC of 15.58 mA cm^-2 and the PCE of 9.13% under AM 1.5 irradiation, which may be due to that electron-withdrawing ability of the auxiliary acceptor metal complexes of pyridineimine derivative can be changed by the strength of coordination bond of the complexes. They also show good terminal stability with decomposition temperatures (T_d) higher than 300 °C. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Quality Control of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bis(4â€?tert-butylbiphenyl-4-yl)aniline (BBA)-substituted A₃B zinc porphyrin as light harvesting material for conversion of light energy to electricity was written by Duvva, Naresh;Gangada, Suneel;Chitta, Raghu;Giribabu, Lingamallu. And the article was included in Journal of Porphyrins and Phthalocyanines in 2020.Name: 4-Bromo-4′-tert-butylbiphenyl This article mentions the following:

Limited synthetic steps via low-cost starting materials are needed to develop large-scale light-active materials for efficient solar cells. Here, novel bis(4â€?tert-butylbiphenyl-4-yl)aniline (BBA) based A3B zinc porphyrin (GB) is synthesized and applied as a light harvesting/electron injection material in dye-sensitized solar cells. The GB sensitizer was characterized by various spectroscopic techniques and the optimized device shows JSC of 10.98 ± 0.37 mA/cm² and power conversion efficiency (PCE) of 3.34 ± 0.26%. In addition, performance is enhanced up to _~3.9% by the addition of co-adsorbent 3a,7a-dihydroxy-5b-cholic acid (chenodeoxycholic acid, CDCA) to minimize π-π staking of the planar porphyrin macrocycles. These results demonstrate that novel broad-absorbing light-active material (GB) could be used for indoor solar panels. In the experiment, the researchers used many compounds, for example, 4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1Name: 4-Bromo-4′-tert-butylbiphenyl).

4-Bromo-4′-tert-butylbiphenyl (cas: 162258-89-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 4-Bromo-4′-tert-butylbiphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Carboarylation of Alkynes via Vinyl Cations was written by Walkinshaw, Andrew J.;Xu, Wenshu;Suero, Marcos G.;Gaunt, Matthew J.. And the article was included in Journal of the American Chemical Society in 2013.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Copper-catalyzed arylation of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalent that react with pendant arene nucleophiles to form all carbon tetrasubstituted alkenes, e.g. I. The new process streamlines the synthesis of important medicinally relevant mols. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The Effect of Surface Polarity on the Electrochemical Double Layer and Its Influence on the Measurement of the Standard Rate Constant of Electron Transfer was written by Eggers, Paul K.;Hibbert, D. Brynn;Paddon-Row, Michael N.;Gooding, J. Justin. And the article was included in Journal of Physical Chemistry C in 2009.Product Details of 56523-59-2 This article mentions the following:

The influence of surface polarity and, hence, the elec. double layer on long-range electron transfer was studied using 35 different electrode constructs. These constructs were prepared using 5 different lengths of ferrocene-modified alkanethiols (of general formula HS(CH₂)_nCONHCH₂Fc where n was 7, 10, 11, 14, and 15 and Fc refers to ferrocene) mixed with an appropriate ratio of hydroxyl-terminated to Me-terminated alkanethiols as diluents. The mixtures of diluents in different ratios served not only to sep. and dilute the redox-active species but also to control the surface polarity of the self-assembled monolayer (SAM). The ratios of the 3 components in each SAM were 1:20:0, 1:16.6:3.4, 1:13.4:6.6, 1:10:10, 1:6.6:13.4, 1:16.6:3.4, and 1:0:20 of the ferrocene-, hydroxyl-, and Me-terminated species, resp. The formal redox potential and electron transfer rate constant were measured for each construct. It was found, 1st, that formal potentials changed according to the theory of interfacial potential distribution and, 2nd, that rate constants measured using cyclic voltammetry are strongly influenced by the Stern layer of the elec. double layer, which forms at the SAM-solution interface. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Product Details of 56523-59-2).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 56523-59-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and antiproliferative activity of marine bromotyrosine purpurealidin I and its derivatives was written by Bhat, Chinmay;Ilina, Polina;Tilli, Irene;Voracova, Manuela;Bruun, Tanja;Barba, Victoria;Hribernik, Nives;Lillsunde, Katja-Emilia;Maki-Lohiluoma, Eero;Ruffer, Tobias;Lang, Heinrich;Yli-Kauhaluoma, Jari;Kiuru, Paula;Tammela, Paivi. And the article was included in Marine Drugs in 2018.Formula: C8H6Br2O2 This article mentions the following:

The first total synthesis of the marine bromotyrosine purpurealidin I (1) using trifluoroacetoxy protection group and its dimethylated analog (29) is reported along with 16 simplified bromotyrosine derivatives lacking the tyramine moiety. Their cytotoxicity was evaluated against the human malignant melanoma cell line (A-375) and normal skin fibroblast cells (Hs27) together with 33 purpurealidin-inspired simplified amides, and the structure-activity relationships were investigated. The synthesized simplified analogs without the tyramine part retained the cytotoxic activity. Purpurealidin I (1) showed no selectivity but its simplified pyridin-2-yl derivative (36) had the best improvement in selectivity (Selectivity index 4.1). This shows that the marine bromotyrosines are promising scaffolds for developing cytotoxic agents and the full understanding of the elements of their SAR and improving the selectivity requires further optimization of simplified bromotyrosine derivatives In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Formula: C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intrinsic Turn-On Response of Thioflavin T in Complexes was written by Kung, Jocky C. K.;Vurgun, Nesrin;Chen, JoAnn C.;Nitz, Mark;Jockusch, Rebecca A.. And the article was included in Chemistry – A European Journal in 2020.SDS of cas: 53784-83-1 This article mentions the following:

The fluorescence enhancement (“turn-on”) response of the amyloid-sensing dye thioflavin T (ThT) is examined in vacuo, where solvent interactions are absent. “Upon the complexation of ThT with a derivatized β-cyclodextrin, heptakis-[6-deoxy-6-(3-sulfanylpropanoic acid)]-β-cyclodextrin, turn-on responses in both the gas phase and solution phase were observed In contrast, turn-on response was not detected when ThT was bound to gaseous cucurbit[7]uril or human telomeric DNA 22AG, whereas clear turn-on response occurs in solution The observed difference in turn-on response in the gas phase emphasizes the key interplay between chromophore, host and solvent and demonstrates the utility of gas-phase spectroscopy to tease out the balance among intermol. forces driving the behavior of important chromophores in solution In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1SDS of cas: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-β-Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase was written by Volkov, Oleg A.;Brockway, Anthony J.;Wring, Stephen A.;Peel, Michael;Chen, Zhe;Phillips, Margaret A.;De Brabander, Jef K.. And the article was included in Journal of Medicinal Chemistry in 2018.Recommanded Product: 96558-78-0 This article mentions the following:

New therapeutic options are needed for treatment of human African trypanosomiasis (HAT) caused by protozoan parasite Trypanosoma brucei. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine pathway of T. brucei. Previous attempts to target this enzyme were thwarted by the lack of brain penetration of the most advanced series. Herein, the authors describe a T. brucei AdoMetDC inhibitor series based on a pyrimidineamine pharmacophore that the authors identified by target-based high-throughput screening. The pyrimidineamines showed selectivity for T. brucei AdoMetDC over the human enzyme, inhibited parasite growth in whole-cell assay, and had good predicted blood-brain barrier penetration. The medicinal chem. program elucidated structure-activity relationships within the series. Features of the series that were required for binding were revealed by determining the x-ray crystal structure of TbAdoMetDC bound to one analog. The pyrimidineamine series provides a novel starting point for an anti-HAT lead optimization. In the experiment, the researchers used many compounds, for example, 3-Bromo-5-chlorophenylamine (cas: 96558-78-0Recommanded Product: 96558-78-0).

3-Bromo-5-chlorophenylamine (cas: 96558-78-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 96558-78-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary