Category: bromides-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-(tert-butyl)benzene

A typical procedure of the electroreductive coupling of aryl bromide1 with catalytic amounts of [OctV2+][Tf2N]2 and Pd species isas follows. Into an undivided cell fitted with a Zn anode(1.5 1 cm2) and a Pt cathode (1.5 1 cm2) was added a DMF(3 mL) solution of 4-bromopropiophenone (1a, 0.25 mmol),[Bu4N+][Tf2N] (0.3 mmol), [OctV2+][Tf2N]2 (0.075 mmol,30 mol %), and PdCl2(PPh3)2 (0.0125 mmol, 5 mol %). The wholemixture was electrolyzed at 60 C under constant current(10 mA) conditions until 2 F/mol-1a of electricity was passed.The reaction mixture was poured into 5% aq HCl and extractedwith AcOEt. Purification by column chromatography (SiO2, toluene/AcOEt = 10/1) afforded 4,40-dipropanoylbiphenyl (2a) in 94%yield

The synthetic route of 3972-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kuroboshi, Manabu; Shiba, Takuya; Tanaka, Hideo; Tetrahedron Letters; vol. 54; 28; (2013); p. 3666 – 3668;,
Bromide – Wikipedia,
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348-57-2, name is 1-Bromo-2,4-difluorobenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C6H3BrF2

EXAMPLE 16 Preparation of 4-(2,4-difluorophenyl)-anisole from 4-methoxyphenylmagnesiumbromide and palladium acetate/triphenylphosphine (0.1percent) A suspension of magnesium turnings (13.5 g; 555 mmoles–Janssen) in tetrahydrofuran (132.9 g) was heated at 65¡ã C. under stirring and under nitrogen. Then, iodine (0.35 g) and, after 30 minutes, 4-bromoanisole (102.65 g; 549 mmoles), in 1 hour, were added to the reaction mixture. At the end of the addition, the reaction mixture was kept at 75¡ã C. for 1 hour and, then, decanted obtaining a solution of 4-methoxyphenylmagnesiumbromide (solution A). A mixture of 1-bromo-2,4-difluorobenzene (100 g; 518 mmoles), palladium acetate (0.11644 g; 0.519 mmoles–Janssen) and triphenylphosphine (0.54356 g; 2.07 mmoles–Fluka) was de-aerated by vacuum/nitrogen at 25¡ã C. The mixture was heated at 85¡ã C., kept under stirring for 15 minutes and, then, solution A was added in 6 hours. At the end of the addition, the reaction mixture was kept at 85¡ã C. for 30 minutes. After cooling at 60¡ã C., a solution of 37percent hydrochloric acid (17.5 ml) in water (88 ml) was added in 20 minutes. The mixture was cooled at 40¡ã C. and the phases were separated. The solvent of the organic phase was evaporated under reduced pressure obtaining the desired compound (113 g; HPLC titre 93.71percent; 93percent yield).

The synthetic route of 348-57-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zambon Group S.p.A.; US5312975; (1994); A;,
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Synthetic Route of 58971-11-2, The chemical industry reduces the impact on the environment during synthesis 58971-11-2, name is 3-Bromophenethylamine, I believe this compound will play a more active role in future production and life.

To a solution of methanesulfonyl chloride(1.60 mmol, 0.12 mL, 1.0 equiv) in ethanol (3 mL), 2-(3-bromophenyl)ethan-1-amine (3.20 mmol, 639mg, 2.0 equiv) was added and the mixture was stirred at room temperature. The reaction wasmonitored by TLC. After completion the solvent was removed under reduced pressure and theremaining solid dissolved in a small amount of water. The solution was applied to a C18 precolumnbefore purification on a 60 g C18 column with a gradient of acetonitrile in water (10-80%). The titlecompound (1.07 mmol, 295 mg, 66%) was obtained as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Akhter, Sundus; Lund, Bjarte Aarmo; Ismael, Aya; Langer, Manuel; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.; Bayer, Annette; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 634 – 648;,
Bromide – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 10485-09-3, name is 2-Bromoindene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10485-09-3, Quality Control of 2-Bromoindene

n a fully dried, argon purged 100 mL reactor,JP-A-2012-206997 2. 4-g 2- (5-methyl-2-furyl) -1-indene synthesized by the method described in the publicationCharge (15.0 mmol) and 20 mL of tetrahydrofuran,n-Butyllithium solution 9.70 mL(Hexane solution, 1.55 M, 15.0 mmol) is added,Stir at room temperature for 2 hours. This reaction solution is9.00 mL (75.3 mmol) of dimethylsilyl dichloride in 10 mL of n-hexane diluted solutionAdd slowly while cooling at -78 C,Stirring was continued for 20 hours while returning to room temperature.After the solvent of the reaction solution and unreacted dimethylsilyl dichloride were distilled off, 20 mL of tetrahydrofuran and 1.50 mL (16.0 mmol) of 1,3-dimethyl-2-imidazolidinone were added to the residue.In a fully dried, argon purged 200 mL reactor, 1.45 g (59.8 mmol) of magnesium pieces are charged,Stir vigorously for 30 minutes while heating under reduced pressure.After cooling to room temperature, attach a reflux condenser,A piece of iodine and 10 mL of tetrahydrofuran were charged and stirred.After dropwise addition of 1.0 mL of a dilute solution of 2.93 g (15.0 mmol) of 2-bromoindene in 10 mL of tetrahydrofuran,Heat to reflux until the iodine color disappears in the dryer,After the reaction starts, the remaining droplets areAfter completion of the dropwise addition, the mixture was stirred at room temperature for 2 hours.This solution isAdd dropwise to the previous reaction residue dilution solution cooled to -78 C,Stirring was continued for 19 hours while slowly warming to room temperature.Add saturated aqueous ammonium chloride solution,The soluble fraction is extracted with n-hexane and the obtained fraction is saturated.Washed with Japanese salt water and dried over anhydrous magnesium sulfate.After filtering the magnesium sulfate,The residue obtained by distilling off the filtrate is purified by silica gel column chromatography,Target object shown by the following formula (A-3L)(Hereafter referred to as the compound (A-3L))Was obtained as an isomer mixture of 2.55 g (46% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoindene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsui Chemicals, Inc.; Prime Polymer Co., Ltd.; Tanaka, Yoichi; Harada, Yoichi; Tamura, Naoya; Hato, Ikki; Tsuchiya, Hiroko; (55 pag.)JP2019/59724; (2019); A;,
Bromide – Wikipedia,
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Electric Literature of 201138-91-2, A common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

10.43 g (32 mmol) of B-(9-phenyl-9H-carbazole-3-yl)boronic acid, 8.9 g (31.6 mmol) of 4,6-dibromodibenzofuran and 31 mL (63 mmol) of Na2CO3 (2 M solution) was then suspended in 120 mL of toluene and 120 mL ethanol. To this suspension, it was added 0.73 g (0.63 mmol) of Pd(PPh3)4 and heat the reaction mixture for 16 hours under reflux. After cooling, remove the organic phase, after filtration, washed three times with 200 mL through silica gel, and concentrated until dry. Recrystallization of the residue from toluene. The yield for the 73% of theory, 11.4 g

The synthetic route of 201138-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck patent GmbH; Hussain, Farham Amir; Martinopa, Irina; Yachi, Anya; Avelluley, Thomas; Kuriba, JonasFallentine; (111 pag.)KR2016/38006; (2016); A;,
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Reference of 103977-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103977-79-3 as follows.

A mixture of 106 2,2-dimethyl-1,3-dioxane-4,6-dione (7.62 g, 52.88 mmol) in 107 trimethoxymethane (26.3 mL, 240.38 mmol) was heated at 85 C. and stirred for 1.5 h. 498 3-Bromo-2,4-difluoroaniline (10 g, 48.08 mmol) in 33 ethanol (42.4 mL) was added and the reaction mixture was stirred at 85 C. for 3 h. The mixture was cooled with the resulting solid was filtered and washed with IPA (2¡Á50 mL) and diethyl ether (4¡Á50 mL). The solid was dried under vacuum overnight to afford 499 5-[(3-bromo-2,4-difluoroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (14.62 g, 84%) as a beige solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.69 (6H, s), 7.33-7.43 (1H, m), 7.86-7.97 (1H, m), 8.56-8.64 (1H, m), 11.24 (1H, s); m/z: ES+ [M+H]+ 362.0.

According to the analysis of related databases, 103977-79-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937046-98-5, Application In Synthesis of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

To a solution of 2-1 (3.85 g, 18.1 mmol, WO 2007/64931, published June 7, 2007) in anhydrous DMF (30 mL) was added NaH (1.08 g, 27.1 mmol) at 0 C. The reaction was stirred under N2 for 0.5 h. MMTrCl (6.14 g, 19.9 mmol) was added. The mixture was stirred at RT for 2 h. Water was added to quench the reaction. The mixture was extracted with EA (3 X 100 mL). The organic phase was combined and then dried over Na2SO4. After filtration, the solution was concentrated in vacuo to give a residue which was further purified by column chromatograph (PE:EA = 20: 1) to give 2-2 (3.8 g, 45%) as a white solid. ESI-LCMS: m/z 485.2 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALIOS BIOPHARMA, INC.; BEIGELMAN, Leonid; WANG, Guangyi; ZHONG, Minghong; (249 pag.)WO2017/156262; (2017); A1;,
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Synthetic Route of 88223-35-2, These common heterocyclic compound, 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of benzoyl chloride (1.05 ml; 13.5 mmol), AlCl3 (2 g; 15 mmol) and2-bromo-9,9-dibutyl-9H-fluorene (4.0 g; 9.0 mmol) in CS2 (80 mL) was prepared and purged with argon. Themixture was stirred for 16 h under argon. After the solvent was evaporated, the aqueous layer was extractedwith DCM. The combined organic layer was washed with water and dried over MgSO4. The residue waspurified by column chromatography on silica gel (hexane : DCM = 1 : 1).Yield: white solid (415 mg; 9.0 mmol; 99 %).1H-NMR (300 MHz, DMSO-d6): delta 7.84-7.73 (m, 5H), 7.65-7.58 (m, 2H), 7.52-7.48 (m, 4H), 2.07-1.89 (m, 4H),1.16-1.03 (m, 4H), 0.68 (t, 6H), 0.66-0.54 (m, 4H).

Statistics shows that 2-Bromo-9,9-dibutyl-9H-fluorene is playing an increasingly important role. we look forward to future research findings about 88223-35-2.

Reference:
Article; Wada, Atsushi; Nishida, Jun-Ichi; Maitani, Masato M.; Wada, Yuji; Yamashita, Yoshiro; Chemistry Letters; vol. 43; 3; (2014); p. 296 – 298;,
Bromide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100189-84-2, name is 2,5-Dibromo-1,3-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H8Br2

Step 1: A solution of 2,5-dibromoxylene (2.0 g, 7.6 mmol) in DCM (20 ml) was treated with n-BuLi (2.5 M solution in hexane, 3 ml, 1.0 equiv.) at -78C. After stirring for 1h, DMF (1.8 ml, 23 mmol, 3 eq.) was added and the solution was allowed to warm to room temperature. It was acidified to pH 2 with 5% hydrochloric acid and extracted with diethyl ether (3×50 ml). The combined organic phase was dried and evaporated and the residue was purified by column chromatography using PE:EA = 10:1 as eluent to give 4-bromo-3,5-dimethylbenzaldehyde (0.76 g, yield: 47%).

According to the analysis of related databases, 100189-84-2, the application of this compound in the production field has become more and more popular.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-04-7, name is 1-Bromo-2,3,4,5,6-pentafluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 344-04-7

C5F5Br (12.35 gm, 0.05 mol) dissolved in dry ether, was added drop wise to Mg (1.2 gm, 0.05 mol) turnings at 0C. The resulting Grignard solution was cooled to -100C and (3.78 gm, 0.0165 mol) SbCl3 dissolved in dry ether slowly added with constant stirring. This mixture was stirred30 for an additional hour at room temperature and subsequently refluxed for one hour more. The mixture was then cooled to 0C and treated with ice water containing NH4Cl and subsequently followed by the addition of 4 N HCl (1 ml) and stirred to make the solution acidic. The ether layer was separated and dried over Na2SO4 and evaporated to give (C6Fs)3Sb. Yield 3.11 gm, 30 %, m.p. 74C (found C; 34.5: Sb; 19.32) (calculated for Ci8Fi5Sb: C; 34.7: Sb; 19.54) The brownish layer was extracted with CHCl3 and after working up it in usual manner give another crop of (C6F5)3Sb. Yield 3.63 gm, 35 %, m.p. 74C (found C; 34.49:Sb ; 19.34) ( calculated for Ci8Fi5Sb: C; 34.7: Sb; 19.54)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 344-04-7.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; CHANDRASHEKAR, Krishnappa; BEHL, Hari, Mohan; KUMAR, Vishal; SIDHU, Om, Prakash; PUSHPANGADAN, Palpu; RAO, Chandana, Venkateswara; SHUKLA, Sanjeev, Kumar; RANJAN, Ashok; SAXENA, Arvind, Kumar; KANT, Ravi; SINGHAL, Kiran; RAJ, Prem; WO2006/67800; (2006); A1;,
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