Category: bromides-buliding-blocks

Electric Literature of 1073-06-9, The chemical industry reduces the impact on the environment during synthesis 1073-06-9, name is 1-Bromo-3-fluorobenzene, I believe this compound will play a more active role in future production and life.

1)3 Grignard reagent was prepared from 3-bromofluorobenzene (8.20 mL, 75.0 mmol) and magnesium (1.9095 g, 78.5 mmol) in dry THF (120 mL) in virtually quantitative yield. To a solution of ethyl formate (2.42 mL, 30.0 mmol) in dry THF (60 mL) a solution of Grignard reagent solution was slowly added at 0 C. After 1 h warming to room temperature, the reaction mixture was quenched with sat. NH4Cl aq. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layer was dried over MgSO4, and filtered. The filtrate was concentrated in vacuo. The resulting residue was purified by column chromatography on silica gel (hexane/ ethyl acetate = 30/1) to afford bis(3-fluorophenyl)methanol. Yellow oil (6,6738g, quant.). 1H NMR (500 MHz, CDCl3) delta 7.34-7.27 (m, 2H), 7.17-7.04 (m, 4H), 7.02-6.93 (m, 2H), 5.81 (d, J = 3.5 Hz, 1H), 2.32 (d, J = 3.5 Hz, 1H) 4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-3-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tanaka, Kenta; Kishimoto, Mami; Hoshino, Yujiro; Honda, Kiyoshi; Tetrahedron Letters; vol. 59; 19; (2018); p. 1841 – 1845;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7073-94-1, name is 1-Bromo-2-isopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 7073-94-1

7 g of 2,4,6-trimethylaniline, 10 g of 2-chlorotoluene, 11 g of sodium t-butoxide, 75 mL of toluene was added to the flask, And the mixture was thoroughly stirred under a nitrogen stream. here, Palladium acetate 24 mg, 85 mg of 1,3-bis (2,6-diisopropylphenyl) imidazolium chloride was added, The reaction solution was raised to 110 C., And the mixture was stirred for 3 hours. The obtained reaction solution was cooled and poured into water, And extracted with ethyl acetate. The obtained organic phase was dried over sodium sulfate, After concentration, purification by silica gel column chromatography (developing solution: ethyl acetate / hexane = 1/20) gave 10 g of intermediate 403A.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7073-94-1.

Reference:
Patent; FUJIFILM CORPORATION; YAGI, KAZUNARI; TATEISHI, KEIICHI; (89 pag.)JP2017/66208; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16518-62-0, name is 3-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 3-Bromo-N,N-dimethylaniline

TO A MIXTURE OF] [PALLADIUM (II)] acetate (3 mg, 5 [MOLpercent),] [2-DICYCLOHEXYLPHOSPHINO-2APOS;- (N,] N- dimethylamino) biphenyl (10 mg, 5 molpercent) and lithium bis (trimethylsilyl) amide (0.55 mL, 0.55 mmol, 1.1 equiv, 1.0 M solution in tetrahydrofuran) in toluene (0.5 mL) under nitrogen at-10 [¡ãC,] was added a solution of [3- [5- (3, 4-DICHLORO-] [PHENYL)-1-(2, 4-DICHLORO-PHENYL)-1H-PYRAZOL-3-YL]-PROPIONIC] acid tert-butyl ester (243 mg, 0.50 mmol, 1.0 equiv) in toluene (1.0 mL). This mixture was stirred at [- 10 ¡ãC] for 10 min, then (3-bromo-phenyl)-dimethyl-amine (42 mg, 0.21 mmol, 0.45 equiv) in toluene (0.5 mL) was added. The resulting solution was allowed to warm to room temperature then was heated to 80 [¡ãC] for 3 h. The reaction mixture was cooled to room temperature, and the reaction was quenched with satd aq ammonium chloride (1.0 mL). Water (10.0 mL) was added, and the resulting mixture was extracted with diethyl ether (2 x 10 mL). The combined extracts were washed with brine (10 mL), dried [(NA2SO4),] and concentrated under reduced pressure. The crude material was purified by reversed-phase HPLC to afford the desired aryl acetic acid ester (20 mg, 16percent). MS [(ESI)] : mass [CALCULATED FOR C30H29CI4N302,] 603.10 ; [M/Z] found, 604.1 [M+H] [+.]

The synthetic route of 16518-62-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2004/7463; (2004); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 452-74-4, name is 1-Bromo-2-fluoro-4-methylbenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6BrF

A: A mixture of 4-bromo-3-fluorotoluene (39.4 g, 0.21 mol), NBS (38.1 g, 0.22 mol) and ADBN (5 g, 0.03 mol) in 250 mL CH2Cl2 was heated at reflux for 6 h. After cooling to room temperature, the reaction mixture was filtered, and the filtrate was washed with water, brine, and concentrated under vacuum to afford l-bromo-4-(bromomethyl)-2-fluorobenzene, which was used without further purification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MERCK & CO., INC.; WO2008/51404; (2008); A2;,
Bromide – Wikipedia,
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Synthetic Route of 583-75-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-75-5, name is 4-Bromo-2-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 192 1,2-Dihydro-6-(3-nitrophenyl)-2,2,4,8-tetramethylquinoline (Compound 292, structure 86 of Scheme XXII, where R1 =R3-5 =H, R2 =nitro) 4-Bromo-2-methylaniline (5.58 g, 30 mmol) was treated with iodine (0.2 g, 0.9 mmol) and acetone (150 mL) in a sealed tube at 80 C. for 24 h to provide 6-bromo-1,2-dihydro-8-methylquinoline (Compound 85 of Scheme XXII) in 9 % yield as a yellow oil (0.70g). Most of the aniline (>80%) was recovered.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5696133; (1997); A;,
Bromide – Wikipedia,
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Electric Literature of 583-70-0,Some common heterocyclic compound, 583-70-0, name is 2,4-Dimethylbromobenzene, molecular formula is C8H9Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a three-necked, 50mLflask equipped with a magnetic stirring bar, 15mL of THF, 2.5mmol of ester(1 equiv), 0.375mmol of CuO (15%equiv), 7.5 mmol of aryl halides and magnesium chips (3 equiv) or 15mmol ofalkyl bromides and magnesium chips(6 equiv) were added. The reaction mixturewas heated at 65 Cfor 4 h. Theprogress of the reaction was monitored by TLC. Then, the reaction was quenchedby saturated aqueous NH4Cl (5 mL), extracted with AcOEt (10 mL ¡Á 3),dried over sodium sulfate, filtered, and evaporated to give the raw product.Pure product could be obtained by TLC with petroleum /AcOEt = 5/1 as eluent

The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gao, Fei; Deng, Xiang-Jun; Tang, Yu; Tang, Jin-Peng; Yang, Jun; Zhang, Yuan-Ming; Tetrahedron Letters; vol. 55; 4; (2014); p. 880 – 883;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 460-00-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 460-00-4, name is 1-Bromo-4-fluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: 7a was prepared by reacting compound 6 (4.00g, 18.1mmol) with 4-bromoanisole (3.38g, 18.1mmol) in the presence of Pd(PPh3)4 and Na2CO3 (6.40g, 60mmol) in THF (80mL containing 10% water). After refluxing for 15h at 368K, the product was extracted with CH2Cl2. The organic layer was dried over MgSO4, filtrated, and evaporated. Column chromatography on SiO2 with petroleum ether as the eluent afforded 3.99g of 7a as a yellowish solid in 78% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Liu, Hongliang; Pu, Shouzhi; Liu, Gang; Chen, Bing; Dyes and Pigments; vol. 102; (2014); p. 159 – 168;,
Bromide – Wikipedia,
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Application of 418762-26-2,Some common heterocyclic compound, 418762-26-2, name is 4-Bromo-2-fluoro-5-methylaniline, molecular formula is C7H7BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 4-bromo-2-fluoro-5-methylaniline (1.10 g, 5.39 mmol), ethyl 4-(3-methylbutanoyl)benzoate (1.26 g, 5.39 mmol) and Et3N (2.25 ml, 16.2 mmol) in DCM (100 ml) was added TiCl4 (2.7 ml, 2.7 mmol) dropwise and the reaction was monitored by TLC. The mixture was kept stirring at room temperature for 16 h, then 5N NaOH was added to adjust pH = 14, extracted with DCM and the organic layer was washed with brine, dried and concentrated. The resulting residue was used for the next step reaction directly.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-fluoro-5-methylaniline, its application will become more common.

Reference:
Article; Song, Fengbin; Xu, Guozhang; Gaul, Michael D.; Zhao, Baoping; Lu, Tianbao; Zhang, Rui; DesJarlais, Renee L.; DiLoreto, Karen; Huebert, Norman; Shook, Brian; Rentzeperis, Dennis; Santulli, Rosie; Eckardt, Annette; Demarest, Keith; Bioorganic and Medicinal Chemistry Letters; vol. 29; 15; (2019); p. 1974 – 1980;,
Bromide – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4766-33-0 as follows. Safety of 5-Bromonaphthalen-1-amine

General procedure: To a stirred solution of 3-chloro-6-nitrobenzo[d]isothiazole 1,1-dioxide (2) 1 mmol) in THF (15 mL), triethylamine (3 mmol) and aromatic amine (1 mmol) were added. The mixture was stirred at room temperature for 4~6 h. The solvent was eliminated in vacuo and the resulting residual was recrystallised from ethyl acetate/hexane to give the title compounds in mediate to high over yield.

According to the analysis of related databases, 4766-33-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shang, Erchang; Wu, Yiran; Liu, Pei; Liu, Ying; Zhu, Wei; Deng, Xiaobing; He, Chong; He, Shan; Li, Cong; Lai, Luhua; Bioorganic and Medicinal Chemistry Letters; vol. 24; 12; (2014); p. 2764 – 2767;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 19190-91-1,Some common heterocyclic compound, 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, molecular formula is C12H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5,6-Dibromo-1,2-dihydroacenaphthylene, its application will become more common.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary