Category: bromides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H6Br2N2

To a solution of methyl (S)-4-(2-(2-formylbenzoyl)-5,5,8a-trimethyl-1,2,3,5,8,8a- hexahydroisoquinolin-6-yl)benzoate (50 mg, 0.113 mmol) and 4,5-dibromobenzene-1,2- diamine (30 mg, 0.113 mmol) in DMF (2 ml) was added sodium metabisulfite (24 mg, 0.124 mmol). The mixture was stirred at 60 C overnight. The mixture was concentrated in vacuo. The residue was partitioned between EtOAc (20 ml) and H2O (20 ml). The separated aqueous layer was extracted with EtOAc (20 ml). The combined organic layers were washed brine (20 ml), dried over Na2S04, and concentrated in vacuo. The crude product was purified by silica gel column eluted with 35 % EtOAc / hexanes to give the desired product (62 mg, 80 %) as a solid. LC/MS m/z 688.10 (M+H)+, 2.91 min (Method 2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 49764-63-8.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; CHEN, Jie; MEANWELL, Nicholas A.; REGUEIRO-REN, Alicia; SIT, Sing-Yuen; SWIDORSKI, Jacob; (267 pag.)WO2018/2848; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 2550-36-9, name is (Bromomethyl)cyclohexane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks

1H-indole-6-carboxylic acid methyl ester (300mg, 1.71mmol) was dissolved in dimethyl formamide (7ml). Bromomethyl cyclohexane (0.5ml, 3.42mmol) and sodium hydride (150mg, 3.42mmol) were added dropwise thereto at 0, and then the mixture was stirred for 8 hours at room temperature. 1N hydrochloric acid solution was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate and filtered. Filtrate was distilled under reduced pressure and separated by column chromatography to obtain the title compound (150mg, 32%). [611] NMR:1H-NMR(400HMz, CDCl3); delta 7.29-7.39 (m, 2H), 7.19 (d, 1H), 7.13 (m, 1H), 7.00-7.09 (m, 2H), 6.66 (m, 1H), 4.83 (s, 2H), 2.06 (s, 3H)

The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LG LIFE SCIENCES LTD.; LEE, Sung Bae; PAEK, Seung Yup; YOON, Sook Kyung; YOON, Seung Hyun; CHOI, Jeung Soon; WO2014/73904; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 3972-64-3, A common heterocyclic compound, 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-(3-(Tert-butyl)phenyl)ethanol To a vial was added the 1-bromo-3-(tert-butyl)benzene (0.107 g, 0.502 mmol) and dry THF. The reaction was then cooled to -78¡ã C. and the BuLi (0.221 mL, 0.552 mmol) (2.5 M in hexanes) was added dropwise and the reaction stirred for 30 min at -78¡ã C. and then ethylene oxide (0.502 mL, 1.255 mmol) (2.5-3.3M solution in THF) was added dropwise and the reaction stirred for 10 minutes at -78¡ã C. then warmed to rt and stirred for 1 h. The reaction was then quenched with 1.0 M HCl (2 mL) and extracted with EtOAc (3*5 mL). The EtOAc layer was combined, concentrated and purified by reverse-phase MPLC (10-100percent MeCN:water) to produce pure 2-(3-(tert-butyl)phenyl)ethanol (0.035 g, 0.196 mmol, 39percent yield). 1H NMR (400 MHz, CDCl3): delta 7.31-7.27 (m, 3H), 7.10-7.07 (m, 1H), 3.90 (t, J=6.6 Hz, 2H), 2.91 (t, J=6.5 Hz, 2H), 1.52 (br s, 1H), 1.36 (s, 9H).

The synthetic route of 3972-64-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITY OF ROCHESTER; UNIVERSITY OF KANSAS; Dunman, Paul M.; Krysan, Damian J.; Flaherty, Daniel P.; US2015/238473; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 6274-57-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6274-57-3 name is 1-(4-Bromophenyl)-N,N-dimethylmethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: At room temperature, organic carbonyl acid 3 (R-COOH, 0.5 mmol) was added into a reaction tube equipped with a small magnet. Then a solution of tertiary amine 1 (R1CH2-NR2R3, 0.5 mmol ) in DCM (2.5 mL) was added dropwise in 2 min. After the mixture was stirred at room temperature for a few minutes, 1 equivalents of dimethyl acetylenedicarboxylate (DMAD, 2) was added. The reaction was stirred overnight at room temperature, and then monitored by TLC with silica gel coated plates. After being stirred for 14 h, the solvent was removed and the residue was purified by a flash column chromatography with silica gel with ethyl acetate/hexane (1:25-30) as eluent to give the desired products 4, 5, and 7. Most of compounds are known and confirmed by NMR, ESI-MS, IR.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-(4-Bromophenyl)-N,N-dimethylmethanamine, and friends who are interested can also refer to it.

Reference:
Article; Shen, Hao; Lu, Xing; Jiang, Ke-Zhi; Yang, Ke-Fang; Lu, Yixin; Zheng, Zhan-Jiang; Lai, Guo-Qiao; Xu, Li-Wen; Tetrahedron; vol. 68; 43; (2012); p. 8916 – 8923;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1195-33-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1195-33-1 as follows.

General procedure: A sealable reaction tube equipped with a magnetic stirrer bar was charged with 2-(allyloxy)benzaldehyde (0.2mmol), benzenesulfinic acid (3.0 equiv.), Na2-Eosin Y (4 mol%), K2S2O8 (3.0 equiv.), DMF_H2O=1:1 (2 ml), 8W blue. The reaction vessel was carried out room temperature. After completion, it was diluted with ethylacetate, washed with water. After the solvent was removed under reduced pressure, the residue was purified bycolumn chromatography on silica gel to afford the corresponding product.

According to the analysis of related databases, 1195-33-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chen, De-Mao; Han, Qing-Qing; Li, Guang-Hui; Sun, Yuan-Yuan; Wang, Zu-Li; Xu, Xin-Ming; Yu, Xian-Yong; Chinese Chemical Letters; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 583-70-0, The chemical industry reduces the impact on the environment during synthesis 583-70-0, name is 2,4-Dimethylbromobenzene, I believe this compound will play a more active role in future production and life.

(Diethylamino)-bis(2,4-dimethylphenyl)phosphine (B46): A solution of 2.92 ml (21.61 mmol) of 4-bromo-1,3-dimethylbenzene in 3 ml of Et2O were added at 0 C. to a suspension of 0.5 g (20.56 mmol) of magnesium turnings in 7 ml of THF and 7 ml of Et2O and also a crystal of iodine. The mixture was heated to room temperature, stirred further overnight and slowly added dropwise at 0 C. to a solution of 1.5 ml (10.31 mmol) of Et2NPCl2 in 8 ml of THF. The mixture was heated to 5-10 C., stirred for a further 2 hours and the solvent was subsequently removed under reduced pressure. After adding 60 ml of hexane, the mixture was filtered through Celite under argon and the solvent was subsequently removed under reduced pressure. Yield: 1.37 g (59% of theory). 1H NMR (400 MHz, CDCl3) delta, 6.9 (m, 6H), 3.03 (m, 4H, CH2), 2.20 (s, 12H, CH3), 0.81 (t, 3J=7.0 Hz, 6H, CH3) 31P NMR (161.9 MHz, CDCl3) delta, 47.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dimethylbromobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Meseguer, Benjamin; Militzer, Hans-Christian; Castillon, Sergio; Claver, Carmen; Diaz, Yolanda; Aghmiz, Mohamed; Guiu, Ester; Aghmiz, Ali; Masdeu, Anna; US2005/80047; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3814-30-0, The chemical industry reduces the impact on the environment during synthesis 3814-30-0, name is (Bromomethyl)cyclopentane, I believe this compound will play a more active role in future production and life.

General procedure: To a stirred solution of ethyl 2-(4-aminophenoxy)-2-methylpropanoate 12 (1 equiv) and anhydrous potassium carbonate(0.5 equiv) in dry DMF was slowly added the corresponding alkyl bromides (1 equiv), and then heated to 80 C until the reaction completed. The mixture was added ethyl acetate and washed with water and brine successively, dried, filtered and concentrated under reduced pressure. The residue was purified by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclopentane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Yongqiang; Tian, Kang; Qin, Aifang; Zhang, Lijian; Huo, Lianchao; Lei, Lei; Shen, Zhufang; Song, Hongrui; Feng, Zhiqiang; European Journal of Medicinal Chemistry; vol. 76; (2014); p. 182 – 192;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 698-00-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 698-00-0, name is 2-Bromo-N,N-dimethylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 1512-{4-[4-(2-methoxyphenyl)piperazin- I -yI]-1 H-pyrazolo[3,4-d]pyrimidin- I -yI}-N,Ndimethylaniline 80 mg (0.26 mmo[) 4-[4-(2-methoxypheny[)piperazin-1 -y[]-1 H-pyrazo[o[3,4-d]pyrimidine, 77.4 mg (0.39 mmo[) 2-bromo-N,N-dimethy[ani[ine, 14.7 mg (0.08mmo[) copper(I) iodide, 115 mg (0.54 mmo[) tripotassium phosphate and 22mg (0.16mmo[) trans-N,N?-dimethy[cyc[ohexane-1,2-diamine in 3 mL anhydrous NMP wereheated under microwave irradiation at 180CC for 8 h. The reaction mixture waspoured into water and extracted three times with ethy[ acetate. The combinedorganic phases were washed with 0.5 M aqueous EDTA so[ution and three times with water, dried over magnesium su[fate and concentrated. The residue was purified by HPLC affording 3 mg (3%) product.LC-MS (ana[ytica[ method 3): R = 1 .09 mm, MS (ESipos): mlz = 430 (M+H).1H-NMR (300MHz, CHLOROFORM-d): 6 [ppm]= 2.52 (5, 6H), 3.25 – 3.33 (m, 4H), 3.96 (5, 3H), 4.22 – 4.30 (m, 4H), 6.92 – 7.16 (m, 6H), 7.31 (d, 1H), 7.36 – 7.45 (m, 1H), 8.25 (5, 1H), 8.45 (5, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HEISLER, Iring; MUeLLER, Thomas; GOLZ, Stefan; TELSER, Joachim; REHWINKEL, Hartmut; SIEBENEICHER, Holger; BUCHMANN, Bernd; ZORN, Ludwig; EIS, Knut; KOPPITZ, Marcus; LINDNER, Niels; HEROULT, Melanie; NEUHAUS, Roland; WO2013/182612; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 55289-36-6, These common heterocyclic compound, 55289-36-6, name is 3-Bromo-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of triphosgene (2.249 g, 7.58 mmol) in toluene (26.9 mL) was stirred on an ice-water bath and treated slowly with a solution of 3-bromo-2-methylaniline (3 g,16.12 mmol) and DIEA (5.63 mL, 32.2 mmol) in toluene (5.37 mL). The resulting suspension was stirred at room temperature for 2 h, filtered, and the precipitate was washed with EtOAc. The combined filtrates were washed quickly with brine, dried and concentrated to provide 1 -bromo-3 -isocyanato-2-methylbenzene as a brown solid/oil mixture (3.36 g). Treatment of a portion of this crude material with ethanol provided 1-(3-bromo-2-methylphenyl)-3-ethylurea as an off-white solid. Mass spectrum m/z 357,259 (M+H). ?H NMR (400 MHz, DMSO-d6) oe 7.80 (s, 1H), 7.75 (d, J=7.5 Hz, 1H), 7.24(dd,J7.9, 0.9 Hz, 1H), 7.04 (t,J8.0 Hz, 1H), 6.50 (t,J5.4 Hz, 1H), 3.11 (qd,J=7.2,5.6 Hz, 2H), 1.07 (t, J7.3 Hz, 3H).

Statistics shows that 3-Bromo-2-methylaniline is playing an increasingly important role. we look forward to future research findings about 55289-36-6.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; AHMAD, Saleem; BATT, Douglas G.; LIU, Qingjie; MACOR, John E.; TINO, Joseph A.; WATTERSON, Scott Hunter; NAIR, Satheesh Kesavan; MAISHAL, Tarun Kumar; (247 pag.)WO2016/65236; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5433-01-2, name is 1-Bromo-3-isopropylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 5433-01-2

Example 3; N-{1-(3,5-Difluoro-bthetanzyl)-3-[1-ethyl-4-(3-isopropyl-phe?yl)-2-oxo-pipbetaridin-4- ylami?o]-2-hydroxy-propyl}-acbetatamide ( alternate synthesis ); Referring to Scheme 1c, intermediate compounds 14,16, 23, 24, 25, 26, 27 and the Me ester of 17 were prepared according to the following procedures:; In a 250 ml round bottom flask with reflux condenser and N2 cap, a solution of 25 gm (125.6 mmol) 1-bromo-3-isopropylbenzene and 45 gm (502.5 mmol) copper cyanide in 50 ml of pyridine was heated in a 150 0C oil bath for 2 hr where upon a dark brown homogeneous solution was formed. The reaction mixture was heated at this temperature for 11 hrs. The refluxing solution was treated with benzene and allowed to cool. The reaction mixture was partitioned between 400 ml cone NH4OH and 200 ml of benzene and was then stirred for 30 min. The mixture was poured through a small pad of silica to remove any remaining solids. The organic phase was removed and the aqueous layer was washed several times with methylene chloride. The combined organic layers were washed with saturated brine and then dried and evaporated to afford 18 gm (100%) of 3-isopropylbenzonitrile. NMR (400 MHz, CDCI3) delta 7.5-7.2 (m, 3H), 2.9 (m, 1H), 1.2 (d, 6H) ppm

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5433-01-2.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/60526; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary