Category: bromides-buliding-blocks

3814-30-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3814-30-0, name is (Bromomethyl)cyclopentane, A new synthetic method of this compound is introduced below.

Example 19A Di-tert-butyl-{2-[5-(cyclopentylmethoxy)-1-benzofur-2-yl]-2-oxoethyl}[2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)ethyl]malonate To a mixture of 750 mg (1.33 mmol) of the compound from Example 7A and 552 mg (3.99 mmol) of potassium carbonate in 10 ml

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BECK, Hartmut; LI, Volkhart Min-Jian; CANCHO GRANDE, Yolanda; TIMMERMAN, Andreas; BROHM, Dirk; JOeRIssEN, Hannah; BOGNER, Pamel

Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (24 pag.)CN109232538; (2019); A;,
B

Patent; Kwansei Gakuin Educational Foundation; JNC Corporation; HATAKEYAMA, Takuji; KONDO, Yasuhiro; NAKAMOTO, Keiichi; YANAI, Motoki; (190 pag.)US2018/94000; (2018); A1;,
Author tianliPosted on November 25, 2020Categories 28342-75-8, bromides-buliding-blocksTags M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., 40161-54-4

Step D 8-(2-Fluoro-4-trifluoromethyl-phenyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one A sealed tube was charged with 4-bromo-3-fluorobenzotrifluoride (40 mg, 0.16 mmol), 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Ackermann, Jean; Conte, Aurelia; Hunziker, Daniel; Neidhart, Werner; Nettekoven, Matthias; Schulz-Gasch, Tanja; Wertheimer, Stanley; US2012/41013; (2012); A1;

937046-98-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 937046-98-5 as follows.

Intermediate Rl-A: 7-Bromo-5-iodopyrrolo[2,l-f][l,2,4]triazin-4-amine (Rl-A) To a solution of 7-bromopyrrolo[2,l-f][l,2,4]triazin-4-amine (4 g, 18.78 mmol) in anhydrous DMF (200 mL) was added NIS (4.65 g, 20.65 mmol) and the mixture was stirred in the dar

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 937046-98-5, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; RUAN, Zheming; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; DHAR, T.G. Murali; GONG, Hua; MARCOUX, David; POSS, M

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 142808-15-9 name is 4-Bromo-2-fluorobenzotrifluoride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 142808-15-9

Preparatory Example27 (3-Fluoro-4- (trifluoromethyl) phenyl) (1-methylcyclopropyl) methanone (Scheme 7): To a solution of 4-bromo-2-fluoro-1- (trifluoromethyl) benzene (0.34 g, 1.4 mmol) in THF (5 mL) at -78under N2was added a solution of isopropylmagnesi

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-fluorobenzotrifluoride, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO. LTD.; SHEN, Dong-Ming; DWYER, Michael; SINZ, Christopher J.; WANG, Deping; STACHEL, Shawn; PAONE, Daniel;

61326-44-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61326-44-1, name is 1,1,2,2-Tetrakis(4-bromophenyl)ethene, A new synthetic method of this compound is introduced below.

The 1- (4- (4- (1H-1,2,4-triazol-1-yl) phenoxy) phenyl) -1H-1,2,4-triazoleThe preparation method,Its characteristics in the use of “one pot”In DMF polar solvents,1,1,2,2-tetrakis (4-bromophenyl) ethylene, triazole,The molar ratio of 4,4′-dibromodiphenyl e

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Tianjin Normal University; Wang, Ying; (11 pag.)CN104557985; (2017); B;,
Bromide – Wikipedia,

A common compound: 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 67567-26-4

Step 1: Preparation of N-(4-bromo-2,6-difluorophenyl)-4-chlorobutanamide. [0804] To a solution of 4-bromo-2,6-difluoroaniline (5.00 g, 24.0 mmol) and EbN (5.0 mL, 36 mmol) in anhydrous THF (50 mL) was added 4-chlorobutanoyl chloride (3.5 mL, 31 mmol) drop

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 67567-26-4, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PETRA PHARMA CORPORATION; LINDSTROeM, Johan; PERSSON, Lars Boukharta; VIKLUND, Jenny; KESICKI, Edward A.; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Ale

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-70-0, name is 2,4-Dimethylbromobenzene, A new synthetic method of this compound is introduced below., 583-70-0

To a solution of magnesium (1.17 g, 48.0 mmol) and lithium chloride (2.20 g, 60.0 mmol) in THF (40 ml) at room temperature was added 1 -bromo-2,4-dimethylbenzene (5.4 mE, 40.0 mmol) and the reaction was heated gently to reflux with a heat gun. The reaction was cooled to room temperature over 1 hr. The reaction was then cooled to 0 C., and Fe(acac)3 (0.71 g, 2.00 mmol) dissolved inS mE of THF was added. After 5 minutes, allyl chloride (4.23 mE, 52.0mmol) was added and the reaction was stirred at 0 C. for 30 mm. The mixture was warmed to room temperature over 1 hr and was heated at 70 C. overnight. The reaction was cooled to 0 C. and quenched by the addition of a saturated NaHCO3 solution (50 mE). The mixture was extracted with hexane (3×40 mE), the combined organic phases were washed with brine (50 mE), dried over Na2 SO4 and carefully concentrated (25 C., 250 mbar). The residue was purified by Isco chromatography (100% hexane as the eluent) to provide i-allyl-2,4-dimethylbenzene (2.75 g, 15.04 mmol, 38% yield) as a colorless oil. ?H NMR (400 MHz, CDC13) oe 7.11-6.87 (m, 3H), 5.93 (ddt, J=i6.6, 10.1, 6.4 Hz, iH), 5.19-4.85 (m, 2H), 3.33 (dd, J=6.4, 1.5 Hz, 2H), 2.29 (s, 3H),2.25 (s, 3H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Dow AgroSciences LLC; Loy, Brian A.; Rigoli, Jared W.; Sam, Brannon; Meyer, Kevin G.; Yao, Chenglin; (32 pag.)US2018/186743; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

699-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of (S)-2-{(4-morpholin-4-yl-benzyl)-[3-(6-trifluoromethyl-pyridin-3-yl)-acryloyl]- amino}-3-phenyl-propionic acid (4.00 g, 7.41 mmol), TBTU (4.76 g, 14.83 mmol), and cat. DMAP in dry DCM (45 ml.) was added DIPEA (3.8 ml_, 22.24 mmol). The resulting mixture was stirred at rt for 10 min and then (4-bromo-benzyl)-methyl-amine (1.48 g, 7.41 mmol) was added. The reaction mixture was stirred at rt overnight under nitrogen atmosphere, then concentrated in vacuo. The resulting residue was taken up in EA. The organic layer was washed with water (5x) and brine, dried (MgSO4), filtered and concentrated under reduced pressure. FC (n-heptane/EA 5:5) afforded the N-{1-[(4-bromo-benzyl)-methyl- carbamoyl]-2-phenyl-ethyl}-N-(4-morpholin-4-yl-benzyl)-3-(6-trifluoromethyl-pyridin-3-yl)- acrylamide as a yellow foam (2.38 g, 44%).LC-MS (analytic A, Zorbax SB-AQ column, acidic conditions): tR = 1.16 min; [M+H]+ = 722.76

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CORMINBOEUF, Olivier; FRANTZ, Marie-Celine; GRISOSTOMI, Corinna; WO2010/58353; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary