Category: bromides-buliding-blocks

Reactivity of thienopyrroles. Synthesis of isomeric nitro and bromothienopyrroles was written by Eras, J.;Galvez, C.;Garcia, F.. And the article was included in Journal of Heterocyclic Chemistry in 1984.HPLC of Formula: 18791-79-2 This article mentions the following:

The isomeric thienopyrroles I and II (R = H, Br) were prepared by thermal cyclization of the azidothienylacrylates III and IV. III and IV were prepared from the corresponding thiophenecarboxaldehydes and N₃CH₂CO₂Et. I and II (R = NO₂) were prepared by nitration of I and II (R = H). In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2HPLC of Formula: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Studies on the Formal [3 + 2] Cycloaddition of Aziridines with Alkenes for the Synthesis of 1-Azaspiroalkanes was written by Martinand-Lurin, Elodie;Gruber, Raymond;Retailleau, Pascal;Fleurat-Lessard, Paul;Dauban, Philippe. And the article was included in Journal of Organic Chemistry in 2015.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

The Lewis acid-mediated [3+2] cycloaddition of N-sulfonyl- and N-sulfamoylaziridines with alkenes provides a rapid and efficient access to 1-azaspiro[4.n]alkanes. Exptl. studies have been combined with DFT calculations to explore the mechanism of the reaction. They demonstrate that the nature of the electron-withdrawing nitrogen protecting group has a very limited influence on the course of the reaction and, particularly, on the initial formation of the 1,3-zwitterionic species through C-N bond cleavage, which has been found to be the rate-determining step. Compared to N-sulfonylaziridines, N-sulfamoylaziridines have proved to be more synthetically useful synthons that afford crystalline polycyclic structures in good yields. A short sequence of catalytic C(sp³)-H amination-cyclization-[3+2] cycloaddition has then been successfully designed to afford the homolog 1-azaspiro[5.n]alkanes, thereby illustrating the higher versatility of sulfamates in these cycloadditions In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fabrication and performance of all-solid-state dye-sensitized solar cells using synthetic carboxylated and pyridylated chlorophyll derivatives was written by Cui, Yuxiao;Zhao, Wenjie;Ogasawara, Shin;Wang, Xiao-Feng;Tamiaki, Hitoshi. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2018.Electric Literature of C8H7BrO2 This article mentions the following:

All-solid-state dye-sensitized solar cells (DSSCs) based on a mesoporous TiO₂ electrode were fabricated using synthetic chlorophyll derivatives as a photosensitizer and 2,2閳?7,7閳?tetrakis[N,N-di(4-methoxyphenyl)amino]-9,9閳?spirobifluorene as a hole-transport material. Me pyropheophorbides-a possessing a carboxy group in the C3-substituent as the anchoring moiety to the TiO₂ surface were effective DSSCs. Direct conjugation of the COOH group with the terminus of the C3-vinyl group gave the highest solar energy-to-electricity conversion efficiency (鐣? of 2.25%. Insertion of a 1,3-phenylene group in the connection partially suppressed the efficiency by 25% (鐣?= 1.68%), whereas insertion of an isomeric 1,4-phenylene moiety decreased to one third (0.75%). A pyridyl group was not useful as the sensitizer anchor due to its low binding affinity to the TiO₂ electrode. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Electric Literature of C8H7BrO2).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Electric Literature of C8H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Base strengths of (锠?methoxyalkyl)triphenyl- and (锠?methoxyalkyl)diphenylmethylsilanes was written by Bellama, Jon M.;Harmon, Linda A.. And the article was included in Inorganic Chemistry in 1978.Quality Control of 1-Bromo-4-methoxybutane This article mentions the following:

The basicity of MeO(CH₂)_nSiPh₃ (I) and of MeO(CH₂)_nSiMePh₂ (II), determined from the difference between their IR in Et₂O or MeOH-CCl₄, is n = 1 << n = 2 > n = 3. A combination of inductive, steric, hyperconjugative, and conjugative effects is responsible for this basicity order. The mass spectral fragmentation of I and II involved rearrangements of the O atom to Si. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Quality Control of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Quality Control of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Preparation and Reactions of CF₃-Containing Phthalides was written by Mitobe, Kana;Terashima, Kyu;Kawasaki-Takasuka, Tomoko;Agou, Tomohiro;Kubota, Toshio;Yamazaki, Takashi. And the article was included in European Journal of Organic Chemistry in 2018.Formula: C10H8Br2O4 This article mentions the following:

We have demonstrated that reactions of aromatic 1,2-diesters and the Ruppert-Prakash reagent (TMSCF₃) afforded hitherto unknown phthalides with both trifluoromethyl (CF₃) and alkoxy groups at the 3 position. Their unique transformation was also investigated in detail to attain construction of a variety of very rare types of compounds, such as 1,3-dihydroisobenzofurans as well as indanones with a CF₃ moiety, whose behavior was completely different from the structurally similar hydroxy compound In the experiment, the researchers used many compounds, for example, Dimethyl 4,5-dibromophthalate (cas: 859299-66-4Formula: C10H8Br2O4).

Dimethyl 4,5-dibromophthalate (cas: 859299-66-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C10H8Br2O4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodoxybenzoic acid (IBX) was written by Cheng, Huicheng;Pei, Yu;Leng, Faqiang;Li, Jingya;Liang, Apeng;Zou, Dapeng;Wu, Yangjie;Wu, Yusheng. And the article was included in Tetrahedron Letters in 2013.Name: 5-Bromothiophene-3-carbaldehyde This article mentions the following:

A 2-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcs. were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amounts of K₂CO₃. The trifluoromethyl alcs. were then oxidized conveniently and efficiently by 2-iodoxybenzoic acid (IBX) under mild conditions to give the desired functionalized aryl and heteroaryl trifluoromethyl ketones. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Name: 5-Bromothiophene-3-carbaldehyde).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 5-Bromothiophene-3-carbaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Domino Direct Arylation and Cross-Aldol for Rapid Construction of Extended Polycyclic 锜?Scaffolds was written by Nitti, Andrea;Bianchi, Gabriele;Po, Riccardo;Swager, Timothy M.;Pasini, Dario. And the article was included in Journal of the American Chemical Society in 2017.Synthetic Route of C10H11BrO2 This article mentions the following:

Five-membered aromatic heterocycles are a ubiquitous skeleton of 锜?conjugated organic compounds, and their incorporation requires synthetic protocols that are not easily industrially sustainable or scalable. Improved methodologies for their insertion into 锜?scaffolds are therefore necessary. We report an efficient and scalable protocol involving a one-pot cross-Aldol direct arylation reaction protocol for the rapid construction of thiophene- and furan-based 锜?extended organic materials. In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Synthetic Route of C10H11BrO2).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C10H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regulation of Protein Binding Capability of Surfaces via Host-Guest Interactions: Effects of Localized and Average Ligand Density was written by Shi, Xiujuan;Zhan, Wenjun;Chen, Gaojian;Yu, Qian;Liu, Qi;Du, Hui;Cao, Limin;Liu, Xiaoli;Yuan, Lin;Chen, Hong. And the article was included in Langmuir in 2015.Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

The protein binding capability of biomaterial surfaces can significantly affect subsequent biol. responses, and appropriate ligand presentation is often required to guarantee the best functions. Herein, a new facile method for regulating this capability by varying the localized and average ligand d. is presented. Binding between lysine and plasminogen relevant to a fibrinolysis system was chosen as a model. We integrated different lysine-modified 灏?cyclodextrin (灏?CD) derivatives onto bioinert copolymer brushes via host-guest interactions. The localized and average lysine d. can be conveniently modulated by changing the lysine valency on 灏?CD scaffolds and by diluting lysine-persubstituted 灏?CD with pure 灏?CD, resp. Both the plasminogen adsorption and the plasminogen binding affinity were enhanced by lysine-persubstituted 灏?CD compared with those of lysine-monosubstituted 灏?CD, which is possibly due to the higher localized lysine d. and the multivalent binding of plasminogen on lysine-persubstituted 灏?CD surfaces. With a change in the ratio of lysine-persubstituted 灏?CD to 灏?CD, the average lysine d. can be tuned, leading to the linear regulation of the adsorption of plasminogen on surfaces. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of 浼?Aryl Esters and Nitriles: Deaminative Coupling of 浼?Amino-Esters and 浼?Aminoacetonitriles with Arylboronic Acids was written by Wu, Guojiao;Deng, Yifan;Wu, Chaoqiang;Zhang, Yan;Wang, Jianbo. And the article was included in Angewandte Chemie, International Edition in 2014.Related Products of 2178-24-7 This article mentions the following:

Transition-metal-free synthesis of 浼?aryl esters and nitriles using arylboronic acids with 浼?amino esters and 浼?(amino)acetonitrile derivatives, resp., as starting materials has been developed. The reaction represents a rare case of converting C(sp³)-N bonds (carbon-nitrogen bonds) into C(sp³)-C(sp²) bonds (carbon-carbon bonds). The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. The synthesis of the target compounds was achieved using glycine ester hydrochloride, leucine ester hydrochloride, aspartate ester hydrochloride, alanine ester hydrochloride as starting materials in a reaction with (aryl)boronic acids. The title compounds thus formed included benzeneacetic acid esters, 1-naphthaleneacetic acid ester, benzenepropanoic acid esters, 浼?phenyl-1H-indole-3-propanoic acid ester, benzenebutanoic acid ester and similar substances. A reaction of (aryl)boronic acids with 浼?(amino)acetonitrile gave 浼?(alkyl)benzeneacetonitrile derivatives Nitriles included 浼?(hexyl)benzeneacetonitrile, 浼?phenyl-3-thiophenepropanenitrile and similar compounds In the experiment, the researchers used many compounds, for example, Ethyl (2-bromophenyl)acetate (cas: 2178-24-7Related Products of 2178-24-7).

Ethyl (2-bromophenyl)acetate (cas: 2178-24-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 2178-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Remarkably High Reactivity of Pd(OAc)₂/Pyridine Catalysts: Nondirected C-H Oxygenation of Arenes was written by Emmert, Marion H.;Cook, Amanda K.;Xie, Yushu J.;Sanford, Melanie S.. And the article was included in Angewandte Chemie, International Edition in 2011.Name: 3-Bromophenyl acetate This article mentions the following:

The rational optimization and general applicability of the catalytic system Pd(OAc)₂/pyridine is described (see scheme). The catalyst shows excellent reactivity in the C-H oxygenation of simple aromatic substrates. The Pd/pyridine ratio is critical as the use of one equivalent of pyridine per Pd center leads to dramatic enhancements in both reactivity and site selectivity in comparison to Pd(OAc)₂ alone. In the experiment, the researchers used many compounds, for example, 3-Bromophenyl acetate (cas: 35065-86-2Name: 3-Bromophenyl acetate).

3-Bromophenyl acetate (cas: 35065-86-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 3-Bromophenyl acetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary