Category: bromides-buliding-blocks

Lerman, L. S. published the artcileSymposium on molecular action of mutagenic and carcinogenic agents. Acridine mutagens and DNA structure, Recommanded Product: Dimidium bromide, the publication is Journal of Cellular and Comparative Physiology (1964), 64(2;Pt. II;Suppl. 1), 1-13, discussion 13-18, database is CAplus.

Evidence for intercalation of acridine compounds between 2 otherwise sequential base pairs was obtained by studies of sedimentation, low angle x-ray scattering, flow dichroism, flow-polarized fluorescence, and chem. reactivity. Such binding requires a local untwisting and extension of the double helix. The intercalated mols. have a decreased chem. reactivity. They increase the stability of the double helix as shown by an increase in the thermal transition temperature Intercalation into complexes formed between polyadenylic and polyuridylic acids makes the double helix more stable than the triple. Intercalation seems to be a prerequisite for mutagenicity of the insertion-deletion type but the acridine structure is not essential and not all intercalating mols. are mutagenic.

Journal of Cellular and Comparative Physiology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Chang-chun published the artcileSelective bromination of p-hydroxybenzaldehyde, COA of Formula: C10H16Br3N, the publication is Huaxue Shijie (2008), 49(8), 481-483, database is CAplus.

The selective bromination of 4-hydroxybenzaldehyde (HBD) with benzyltrimethylammonium tribromide in dichloromethane-methanol was studied. A method for the synthesis of 3-bromo-4-hydroxybenzaldehyde is reported here. The effects of reaction conditions were determined When the mol ratio of 4-hydroxybenzaldehyde to benzyltrimethylammonium tribromide was 1.0:1.05, volume ratio of dichloromethane to methanol was 5:1, reaction temperature was 30° and reaction time was 1 h, the yield of monobromide reached 92.5% and the selectivity of monobromide reached 99%.

Huaxue Shijie published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, COA of Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Yu-Cheng published the artcileFree radical reaction. Reaction of Grignard reagents with 2-bromo-2,3-dimethylbutane and with 1-chloro-1-methylcyclohexane in the presence of cobaltous halides, Application In Synthesis of 594-81-0, the publication is Acta Chim. Sinica (1956), 104-11, database is CAplus.

cf. C.A. 51, 14569e. CHMe₂CBrMe₂ (I) decomp, when treated with PhMgBr (II) and CoBr₂ (III) to give 35% CHMe₂CHMe₂ (IV), 31% CHMe₂CMe:CH₂ (V), and 2% CMe₂:CMe₂ (VI). I (0.45 mole) added dropwise to 0.5 mole freshly prepared II in 250 ml. Et₂O containing III with stirring, stirred with cooling several hrs., the product poured into ice H₂O, 30 ml. AcOH added, the Et₂O layer separated, washed neutral, dried, and fractionally distilled to 80° gave 25.8 g. fraction, b. 53-8°, n²⁰_D 1.3822, containing some V (infrared spectrum), mainly IV as shown by oxidation with O₃ in CCl₄ at 0° to CH₂O (IV derivative with saturated 5,5-dimethyldihydroresorcinol, m. 192-3°) and some Me₂CHCOMe; 2,4-(O₂N)₂C₆H₃NHNH₂ derivative, m. 114-15°. The fraction b. 71.5° (0.7 g.) proved to be VI, m. 165° (sublimation). The residue gave 33 g. biphenyl, m. 70-2°, on steam-distillation Treatment of 9.7 g. I with 11.2 g. KOH in 50 ml. glycol at 100-10° 1.5 hrs. gave 4.1 g. distillate, n²⁰_D 1.4076, a mixture of 79% VI and 21% V. Bromination of 0.5 g. of this mixture in CCl₄ yielded 61% CBrMe₂CBrMe₂, m. 170-5°. 1-Methylcyclohexyl chloride (VII) (0.2 mole) in 100 ml. absolute Et₂O added dropwise to 0.3 moles MeMgBr (VIII) in 320 ml. Et₂O with frequent addition (6.5 g. total) of III and stirring continued an addnl. hr. after complete evolution of the gas gave as the main distillate, b. 100-3°, n²⁰_D 1.4371, 62% mixture of C₆H₁₁Me, 1-methylcyclohexene (IX), and methylenecyclohexane. The % unsaturation of bromate-bromide titration and catalytic hydrogenation with Pt was 51, infrared absorption spectrum showed the presence of C:CH, and group oxidation with O₃ gave cyclohexanone; 2,4-dinitrophenylhydrazone, m. 158.5-9.5°. VII (26.5 g.) in 40 ml. absolute Et₂O with 0.4 mole iso-PrMgBr in 200 ml. Et₂O in the presence of 2.6 g. III in the same way as above gave 11.3 g. distillate, b. 100-3°, n²⁰_D 1.4348, % unsaturation = 42, a mixture of the same products as from VII and VIII. VII (5 g.) and 25 ml. 4N NaOH refluxed on a steam-bath 3 hrs., extracted with Et₂O, and distilled, gave 2.4 g. IX, b. 107-8°, n²⁰_D 1.4364. It is therefore suggested the disproportionation of alkyl radicals in solution is probably a bimol. reaction and the number of α-H atoms has a directive influence upon the orientation of olefin formation.

Acta Chim. Sinica published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Application In Synthesis of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Logusch, Eugene W. published the artcileA simple preparation of S-alkyl homocysteine derivatives: S-phosphonomethyl homocysteines as inhibitors of glutamine synthetase, Name: Diethyl (bromomethyl)phosphonate, the publication is Tetrahedron Letters (1988), 29(47), 6055-8, database is CAplus.

A facile synthesis of S-alkyl homocysteines is described which features the coupling of sodium alkyl thiolates with Me 4-bromo-2-phthalimidobutyrate, followed by hydrolysis. This approach is exemplified by the synthesis of H₂O₃PCH₂SO₂CH₂CH₂CH(NH₂)CO₂H, a new inhibitor of the enzyme glutamine synthetase.

Tetrahedron Letters published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Name: Diethyl (bromomethyl)phosphonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Malamas, Michael S. published the artcileFacile synthesis of novel spiro[azetidine-2,4′(1’H)-isoquinoline-1′,3′,4(2’H)-triones], Application of (4-Bromo-2-fluorophenyl)methanamine hydrochloride, the publication is Journal of Heterocyclic Chemistry (1994), 31(2), 565-8, database is CAplus.

A convenient general method for the synthesis of a new heterocycle, spiro[azetidine-2,4′(1’H)-isoquinoline-1′,3′,4(2’H)-trione] (I, R¹ = H, halo; R² = Me, CH₂C₆H₃FBr-2,4) is described. The key intermediate II (R = Cl) was prepared by direct halogenation of position-4 of acid II (R = H) with thionyl chloride, and subsequent treatment of the generated 4-Cl, 4-acetyl chloride derivative with a THF/NH₃ solution at low temperature

Journal of Heterocyclic Chemistry published new progress about 147181-08-6. 147181-08-6 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Salt,Amine,Benzene, name is (4-Bromo-2-fluorophenyl)methanamine hydrochloride, and the molecular formula is C7H8BrClFN, Application of (4-Bromo-2-fluorophenyl)methanamine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mellander, Alfred published the artcileStereoisomers of α-alkylmercapto- and α-alkylsulfonepropionic acids, Product Details of C4H7BrO2, the publication is Arkiv. Kemi, Mineral. Geol. (1937), 12A(No. 16), 32 pp., database is CAplus.

The dl-form of α-propylmercaptopropionic acid, MeCH (SPr) CO₂H, was prepared by the addition of PrI (185 g.) to 106 g. α-thiolactic acid, 143 g. Na₂CO₃.10H₂O in 150 cc. H₂O and 41 g. caustic soda in 130 cc. H₂O. The α-iso-Pr derivative was similarly prepared Data are given for the following alkyl-mercapto derivatives (m. and b. ps. corrected): Me, m. 17.3°, b₉ 106.5°, d₄²⁰ 1.1464, n_D²⁰ 1.4843, M_D (mol. refraction by Lorenz-Lorentz’s formula) 29.99, k₂₅ (affinity constant by conductivity measurement) 1.73 × 10^-4; Et, b₉ 115.5°, d₄²⁰ 1.1087, n_D²⁰ 1.4798, M_D 34.35, k₂₅ 1.60 × 10^-4; Pr, b₈ 128.5°, d₄²⁰ 1.0595, n_D²⁰ 1.4765, M_D 39.47, k₂₆ 1.53 × 10^-3; isd-Pr, b₉ 121.4°, m. 14.6°, d₄²⁰ 1.0482, n_D²⁰ 1.4724, M_D 39.61, k₂₅ 1.67 × 10^-4. The corresponding sulfones, CH₃CH(SO₂R)CO₂H, were prepared by oxidation of the sulfides with KMnO₄ in alk. solution Their data follow: Me, m. 96.6°, k₂₅ 3.6 × 10^-3; Et, m. 62.6°, k₂₅ 3.25 × 10^-3; Pr, m. 59.5°; k₂₅ 3.11 × 10^-3; iso-Pr, m. 105.0°; k₂₅ 3.01 × 10^-3. Addition of Br to the sulfones gave the corresponding α-bromo-α-alkylsulfonepropionic acids as follows: Me, m. 173° (decomposition); Et, m. 96.5°; Pr, m. 125.4°; iso-Pr, m. 64.3°. Reduction of the Br derivatives with N₂H₄ gave the corresponding unsubstituted α-alkyl-sulfonepropionic acids. Resolution of dl-α-MeCH(SEt)CO₂H by crystallization of the brucine salt gave the l-form, [α]_D -111.8°, [α]_Hg -132.6°. Crystallization of the quinidine salt, m. 66-7°, from the mother liquor gave the d-form, [α]_D 111.8°, [α]_Hg 132.6°. The quinine salt of the l-Pr acid, m. 92.5-94°; the l-acid [α]_D -106.0°, [α]_Hg -126.0°. The d-acid was not isolated. d-Iso-Pr acid, [α]_D 113.7°, [α]_Hg 135.4°, was obtained by crystallization of the brucine salt, m. 76-77.5°. l-Acid, [α]_D -113.8°, [α]_Hg -135.5°, was prepared through the quinine salt, m. 132.2-4.4°. The above values of [α] were obtained by graphic interpolation of [α] values for a series of aqueous solutions of concentrations varying around 1%. The sp. rotation in aqueous solutions decreases on dilution, indicating that the undissociated acid has greater rotatory power than the ion. Distillation of the active form of the acids results in racemization. The active forms of the α-alkylsulfonepropionic acids were prepared by oxidation of the corresponding active sulfides, using KMnO₄ and phosphate buffer (p_H 6.98). The pure active forms could not be prepared by resolution of the dl-sulfones. The interpolated values of [α] for the sulfones are: l-Me [α]_D -24.5°, [α]_Hg -29.6°; d-Me [α]_D 24.5°, [α]_Hg 29.7°; l-Et [α]_D -32.7°, [α]_Hg -39.2°; d-Et [α]_D 32.6°, [α]_Hg 39.2°; l-Pr [α]_D -33.6°, [α]_Hg -40.6°; l-iso-Pr [α]_D -36.5°, [α]_Hg -44.2°; d-iso-Pr [α]_D 36.5°, [α]_Hg 44.2°.

Arkiv. Kemi, Mineral. Geol. published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Product Details of C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Miyagawa, Ichiro published the artcileStudies on internal rotation by the measurement of dipole moments. IV. The dipole moments of some halogenated hydrocarbons, Product Details of C6H12Br2, the publication is Nippon Kagaku Kaishi (1921-47) (1954), 1162-5, database is CAplus.

cf. C.A. 48, 13297h. The dipole moments of 2,3-dichloro-2,3-dimethylbutane, 2,3-dibromo-2,3-dimethylbutane, 1,2-dibromo-2-methylpropane, and 1,1,2-tribromoethane were measured in heptane at -20° to 50°. The energy difference between a trans and a gauche form and the moment of the gauche form were calculated The moment of 1,1,2-tribromoethane is independent of temperature The moment of this compound corresponds to that of the gauche form rather than to that of the C_s form.

Nippon Kagaku Kaishi (1921-47) published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Product Details of C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Moritz, A. G. published the artcileHydrogen bonding in N-(2-hydroxybenzyl)aniline, Computed Properties of 53484-26-7, the publication is Spectrochimica Acta (1959), 242-8, database is CAplus.

The O-H and N-H stretching frequencies (3200 to 3600 cm.^-1) of a number of N-benzylanilines and N-(2-hydroxybenzyl)anilines were measured in dilute CCl₄ solution and attempts made to relate the observed spectra to the known effects of substituents. The results indicate that rotational isomerism probably occurs in the N-benzylanilines and that the intramol. H bond in the N-(2-hydroxybenzyl)aniline is responsible for a change in hybridization on the N atom.

Spectrochimica Acta published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H7BrN2O2, Computed Properties of 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Phillips, Montague A. published the artcileAction of hydrobromic acid on certain arsonic acids, Name: 4-Bromo-N-methyl-2-nitroaniline, the publication is Journal of the Chemical Society (1930), 2400-1, database is CAplus.

Boiling the following benzenearsonic acids with 3-4 times their weight of HBr (d. 1.445) gives the following products: 3,4-O₂N(H₂N), 4,2-Br-(O₂N)C₆H₃NH₂ (97%); 4,3-O₂N(H₂N), 5,2-Br(O₂N)C₆H₃NH₂ (96%); 3,4-O₂N(MeNH), 4,2-Br(O₂N)C₆H₃NHMe (92%); 4-nitro-3-methylamino, yellow plates, 5,2-Br(O₂N)C₆H₃NHMe (80%); 3,4-O₂N(HO), mixture of polybrominated nitrophenols, from which 20% of 2,4,6-Br₂(O₂N)C₆H₂OH was isolated; 3,4-H₂N(HO), 4,2-Br(H₂N)C₆H₃OH (about 20%); 3,4-AcNH(HO), the same product as before; 4,3,5-H₂N(O₂N)2, 4,2,6-Br(O₂N)₂C₆H₂NH₂ (96%). No decompn, occurred with the 6,3-O₂N(H₂N) derivative The 4,3-O₂N(HO) and 2,3-O₂N(HO) derivatives gave mixtures which could not be separated

Journal of the Chemical Society published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H7BrN2O2, Name: 4-Bromo-N-methyl-2-nitroaniline.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ryley, J. F. published the artcileThe chemotherapy of Babesia infections, Computed Properties of 518-67-2, the publication is Annals of Tropical Medicine & Parasitology (1957), 38-49, database is CAplus and MEDLINE.

A screening test is described for anti-Babesia drugs by using mice infected with B. rodhaini. The maximum tolerated dose and min. effective dose (as mg./20 g. × 3) are, resp.: acapron, 0.1 and 0.01; dimidium bromide, 0.5 and 0.01; ethidium bromide, 1 and 0.025; pentamidine (as base), 0.75 and 0.25; propamidine (as base), 0.5 and >0.5; stilbamidine (as base), 0.75 and 0.1; trypan blue, >5 and >5; acriflavine, 0.5 and 0.1; berenil, 0.25 and 0.1; antrycide dimethyl sulfate, 0.5 and 0.1; 4-amino-6-(2-amino-1,6-dimethyl-4-pyrimidinylamino)-2-phenyl-1-methylquinolinium dichloride (Compound 10,073), 0.5 and 0.005; bis(1,2-dimethyl-4-methylamino-6-quinolyl)-amine bis(methyl sulfate) (Compound 14,911), 1 and 0.005. Mepacrine, chloroquine, paludrine, and Daraprim had no effect against B. rodhaini. Compound 10,073, in doses up to 8 mg./kg., was effective in treating B. bovis in calves with no apparent toxicity. Reversible toxic symptoms were elicited with 10 mg./kg.

Annals of Tropical Medicine & Parasitology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Computed Properties of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary