Category: bromides-buliding-blocks

Li, Penghui published the artcileDesign, synthesis and biological evaluation of benzimidazole-rhodanine conjugates as potent topoisomerase II inhibitors, Category: bromides-buliding-blocks, the publication is MedChemComm (2018), 9(7), 1194-1205, database is CAplus and MEDLINE.

In this study, a series of benzimidazole-rhodanine conjugates were designed, synthesized and investigated for their topoisomerase II (Topo II) inhibitory and cytotoxic activities. The results from Topo II-mediated pBR322 DNA relaxation and cleavage assays showed that the synthesized compounds might act as Topo II catalytic inhibitors. Certain compounds displayed potent Topo II inhibition at 10 muM. The cytotoxic activities of these compounds against HeLa, A549, Raji, PC-3, MDA-MB-201, and HL-60 cancer cell lines were evaluated. The results indicated that these compounds exhibited strong antiproliferative activity. A good relationship was observed between the Topo II inhibitory potency and the cytotoxicity of these compounds The structure-activity relationship revealed that the electronic effects, the Ph group, and the rhodanine moiety were particularly important for the Topo II inhibitory potency and cytotoxicity.

MedChemComm published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Jiang, Hong published the artcileSynthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(8), 1320-1323, database is CAplus and MEDLINE.

In this study, a series of carbazole-rhodanine conjugates was synthesized and evaluated for their Topoisomerase II inhibition potency as well as cytotoxicity against a panel of four human cancer cell lines. Among these thirteen compounds, I (R = 2-F-4-Br, 4-NO₂, 4-CN, 4-CF₃) possessed Topoisomerase II inhibition potency at 20μM. Mechanism study revealed that these compounds may function as Topo II catalytic inhibitors. It was found that the electron-withdrawing groups on the Ph ring of compounds played an important role on enhancing both enzyme inhibition and cytotoxicity.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sha, Wanxing published the artcilePhotoredox-Catalyzed Cascade Difluoroalkylation and Intramolecular Cyclization for Construction of Fluorinated γ-Butyrolactones, Product Details of C4H6BrFO2, the publication is Journal of Organic Chemistry (2017), 82(18), 9824-9831, database is CAplus and MEDLINE.

A cascade visible-light photocatalytic difluoroalkylation and intramol. cyclization reaction was developed for the synthesis of difluoroalkylated oxygen heterocycles. The reaction was carried out under mild conditions, affording fluorinated isobenzofuran-1-ones, lactone, and cyclic ethers with up to 97% chem. yields. Furthermore, several types of bromofluoroalkane precursors bearing ester, keto, amido, and phosphate groups could all work well in this reaction, which provides an easy method for the preparation of functionalized difluoroalkylated oxygen heterocycles.

Journal of Organic Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C9H6N2O2, Product Details of C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fan, Xiaozhong published the artcileEnantioselective Atropisomeric Anilides Synthesis via Cu-Catalyzed Intramolecular Adjacent C-N Coupling, Safety of 2-Bromo-5-methoxybenzene boronic acid, the publication is ACS Catalysis (2019), 9(3), 2286-2291, database is CAplus.

Catalytically asym. synthesis of atropisomeric compounds is an important research area in organic synthesis. However, in comparison with C-C atropisomers, the atropisomers caused by the restricted rotation of C-N single bonds have been given less attention because of the limited methods for accessing these compounds Herein we report a Cu-catalyzed enantioselective intramol. Ullmann-type amination reaction for the synthesis of C-N atropisomers. The C-N axial chirality was induced highly efficiently by the intramol. adjacent C-N cross-coupling. The readily prepared N,N’-(cyclohexane-1,2-diyl)dipicolinamides showed high efficacy and stereoinduction (up to 99% ee).

ACS Catalysis published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Safety of 2-Bromo-5-methoxybenzene boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fang, Di published the artcileRadical C(sp³)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols, Synthetic Route of 111-83-1, the publication is Organic Letters (2022), 24(10), 2050-2054, database is CAplus and MEDLINE.

The first radical C(sp³)-H Heck-type reaction of aliphatic alcs. for selective δ- and ε-alkenol I [R = H, Ph, 4-FC₆H₄, etc.; R¹ = Me, n-Bu, Bn, etc.; R² = H, Me; R¹R² = cyclohexyl, cyclopentyl, 2,3-dihydro-1H-inden-2-yl; Ar = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; X = CH₂, O] and II [Ar¹ = Ph, 4-CNC₆H₄, 4-MeOC₆H₄, etc.] synthesis by photoredox catalysis. N-Alkoxybenzimidoyl chlorides were developed as novel alkoxyl radical precursors with tunable redox potentials. Various alkenols could be constructed by the inert C(sp³)-H Heck-type reaction of 4-cyano-N-alkoxybenzimidoyl chlorides with styrene derivatives under redox-neutral conditions, which could be performed on the gram scale and can be easily derivatized.

Organic Letters published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Synthetic Route of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zu, Pengjiao published the artcileStructure design and performance investigation of 2-mercapto-5-methyl thiadiazole based ionic liquids as lubricants and corrosion inhibitors, Safety of 1-Bromooctane, the publication is Tribology International (2022), 107682, database is CAplus.

2-Mercapto-5-methyl-1,3,4-thiadiazole (MMT) based ionic liquids were synthesized, their corrosion inhibition behavior and tribol. performance were systematically evaluated. Electrochem. experiments showed MMT based ILs exhibited surprising corrosion inhibition efficiencies. The ILs adsorption behavior obeys Langmuir isotherm. Friction tests demonstrated MMT based ILs performed excellent lubrication properties, compared to [BMIM][BF4]. Combining with anal. of SEM and XPS, it can be concluded that the prominent lubrication performance ascribed to the coexistence of adsorption layer and tribo-film. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting performance and excellent lubricating properties. This work is instructive for structure design of multifunctional ILs and will promote industrial application of MMT based ILs in the future.

Tribology International published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C6H6N2O, Safety of 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zu, Pengjiao published the artcileStructure design and performance investigation of 2-mercapto-5-methyl thiadiazole based ionic liquids as lubricants and corrosion inhibitors, Application of 1-Bromododecane, the publication is Tribology International (2022), 107682, database is CAplus.

2-Mercapto-5-methyl-1,3,4-thiadiazole (MMT) based ionic liquids were synthesized, their corrosion inhibition behavior and tribol. performance were systematically evaluated. Electrochem. experiments showed MMT based ILs exhibited surprising corrosion inhibition efficiencies. The ILs adsorption behavior obeys Langmuir isotherm. Friction tests demonstrated MMT based ILs performed excellent lubrication properties, compared to [BMIM][BF4]. Combining with anal. of SEM and XPS, it can be concluded that the prominent lubrication performance ascribed to the coexistence of adsorption layer and tribo-film. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting performance and excellent lubricating properties. This work is instructive for structure design of multifunctional ILs and will promote industrial application of MMT based ILs in the future.

Tribology International published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C7H16ClNO2, Application of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mu, Bin published the artcilePositional Isomerism-Mediated Copolymerization Realizing the Continuous Luminescence Color-Tuning of Liquid-Crystalline Polymers, Synthetic Route of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(13), 5332-5341, database is CAplus.

Liquid crystals with color-tunable light emission are important for a variety of applications; however, achieving multicolor light-emitting liquid crystals whose emission colors can be fine-tuned remains challenging because the limited derivatization of mesogenic fluorophores disfavors the diversity of the emission. Here, we present a positional isomerism-mediated copolymerization strategy to obtain liquid-crystalline polymers with continuous luminescence color-tuning ability. The introduced α-/β-cyanostilbene positional isomers possess very similar mol. structures, thus reducing the risk of assembly heterogeneity and facilitating the formation of a homogeneous and consistent liquid crystal mesophase. Meanwhile, a significant electronic effect was caused for fluorophores with positional isomerization, allowing the efficient tuning of emission colors via copolymerization Especially with a gradual change in the composition of the copolymers, the emission color shift behaved in a continuous manner from blue to green. These cyanostilbene-based liquid-crystalline polymers also showed reversible photochromic fluorescence switching ability. This approach highlights the value of positional isomers to prepare color-tunable solid-state light-emitting materials, allowing control and fine-tuning of the emission property while maintaining the ordered assembly ability.

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Synthetic Route of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Weng, Wei published the artcileSynthesis and electrochemical property of sulfone-functionalized imidazolium ionic liquid electrolytes, Safety of 2-Bromoethyl Methyl Sulfone, the publication is Electrochimica Acta (2013), 392-396, database is CAplus.

Sulfone-functionalized imidazolium ionic liquids were synthesized from direct nucleophilic substitution for the 1st time. Detailed NMR anal. of the products revealed the competition pathways of classic S_N2 substitution and E2 elimination in the synthesis reaction. Impurities from E2 elimination can easily be overlooked during the conventional method of ionic liquid preparation via S_N2 substitution. Initial electrochem. examination of the synthesized ionic liquids shows good compatibility with Li_1.1(Ni_1/3Co_1/3Mn_1/3)_0.9O₂ cathode material.

Electrochimica Acta published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C6H20Cl2N4, Safety of 2-Bromoethyl Methyl Sulfone.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shao, Jiahui published the artcileHumic acid rejection and flux decline with negatively charged membranes of different spacer arm lengths and charge groups, Formula: C3H6BrNaO3S, the publication is Journal of Membrane Science (2013), 38-45, database is CAplus.

A series of novel charged ultrafiltration membranes that differed in spacer arm length and charge group were generated by covalent attachment of neg. charged group to a com. available regenerated cellulose membrane. Rejection of humic acid and flux decline were compared with essentially neutral and neg. charged versions of regenerated cellulose membranes of different spacer arm lengths and charge groups. Effects of membrane mol. weight cut-off and solution pH on humic acid removal and flux decline on neutral and neg. charged membranes of different spacer arm lengths were also compared. The membrane with larger spacer arm length has better rejection of humic acid and less membrane fouling compared to that with smaller spacer arm length. The modified neg. charged membrane with a strongly acidic (sulfonic acid) functional group has better rejection of humic acid and less membrane fouling than that with a weakly acidic (carboxylic acid) functional group. These exptl. results are consistent with the larger charge of the membranes having larger spacer arm length and sulfonic acid group. This study confirms that the appropriate design of membrane charge functionality could be an effective way for better removal of humic acid and reduction of membrane fouling due to the electrostatic interactions with the combination effect of membrane pore size.

Journal of Membrane Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C8H8O3, Formula: C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary