Category: bromides-buliding-blocks

Hu, Essa published the artcileDiscovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2008), 51(11), 3065-3068, database is CAplus and MEDLINE.

Inhibition of c-Kit has the potential to treat mast cell associated fibrotic diseases. We report the discovery of several aminoquinazoline pyridones that are potent inhibitors of c-Kit with greater than 200-fold selectivity against KDR, p38, Lck, and Src. In vivo efficacy of pyridone 16 (I)by dose-dependent inhibition of histamine release was demonstrated in a rodent pharmacodynamic model of mast cell activation.

Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uchikawa, Yuki published the artcileSynthesis and demethylation of 4,22-dimethoxy[2.10]metacyclophan-1-yne with BBr₃ to afford a novel [10](2,9)-5a,11a-benzofuro-5a-bora-11-bromochromenophane, Category: bromides-buliding-blocks, the publication is Canadian Journal of Chemistry (2012), 90(5), 441-449, database is CAplus.

4,22-Dimethoxy[2.10]metacyclophan-1-yne was prepared by bromination of [2.10]metacyclophan-1-ene followed by the dehydrobromination of the bromine adduct with KOBu-t. Treatment of 4,22-Dimethoxy[2.10]metacyclophan-1-yne with BBr₃ in CH₂Cl₂ at room temperature led to the demethylation and a successive intramol. cyclization reaction to afford a novel [10](2,9)-5a,11a-benzofuro-5a-11-bromochromenophane in good yield. Similar treatment of a mixture of the corresponding meso- and dl-1,2-dibromo-4,22-dimethoxy[2.10]metacyclophane with BBr₃ in CH₂Cl₂ under the same conditions described above afforded cis-4b,9b-dihydro[10]benzofuro[3,2-b]benzofuranophane in 83% yield.

Canadian Journal of Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C13H9ClN2O4, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Griffiths, W. Richard published the artcileThe mass spectra of phosphonyl compounds. Part 3. Dimethyl- and diethylalkane and substituted-methane phosphonates, Name: Diethyl (bromomethyl)phosphonate, the publication is Phosphorus and Sulfur and the Related Elements (1978), 5(1), 101-6, database is CAplus.

The electron impact spectra of 28 related phosphonates were determined Et, Me₂CH, and Me₃C groups which are bound directly to P, fragment to the corresponding alkenes; similar Me₂CH, Me₃C groups in the di-Me esters also fragment to ethylene and propene, resp., i.e., the P-alkyl rearranges with transfer of the elements of a Me group to the P ion. The di-Et alkenephosphonates undergo double H rearrangements of an ethoxy group to give dihydroxyphosphonium ions. The di- and trihydroxyphosphonium ions have a characteristic fragmentation which involves loss of water. This characteristic has been used as evidence for the rearrangement of a phosphacylium ion to a dihydroxyphosphonium ion.

Phosphorus and Sulfur and the Related Elements published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Name: Diethyl (bromomethyl)phosphonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bovonsombat, Pakorn published the artcileRegioselective monobromination of aromatics via a halogen bond acceptor-donor interaction of catalytic thioamide and N-bromosuccinimide, Formula: C10H6Br2, the publication is Tetrahedron (2017), 73(46), 6564-6572, database is CAplus.

Regioselective monobromination of various aromatics was achieved at room temperature using N-bromosuccinimide and 5 mol% of thioamides in acetonitrile. With thiourea as catalyst, activated aromatics, such as anisole, acetanilide, benzamide and phenol analogs containing electron donating or withdrawing groups, were brominated with high regioselectivity. Room temperature brominations of weakly activated aromatics and deactivated 9-fluorenone were accomplished by 5 mol% thioacetamide, higher substrates concentrations and longer reaction times. A backbonding of the bromine lone pairs with the π^*of C=S group and a halogen bond between the halogen bond donor bromine and the halogen bond acceptor sulfur of the thioamide are thought to be the principal interactions and cause of N-bromosuccinimide activation.

Tetrahedron published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Formula: C10H6Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rawale, Dattatraya Gautam published the artcileLinchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins, Formula: C13H17BrO3, the publication is Chemical Science (2021), 12(19), 6732-6736, database is CAplus and MEDLINE.

The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chem. space to enable site-selectivity for histidine and aspartic acid modifications overcoming the pre-requisite of chemoselectivity.

Chemical Science published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C13H17BrO3, Formula: C13H17BrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hernandez, Andres S. published the artcileEnantiospecific Synthesis of (+)- and (-)-Ferruginine from L-Glutamic Acid. Synthesis of Tropanes via Intramolecular Iminium Ion Cyclization, Category: bromides-buliding-blocks, the publication is Journal of Organic Chemistry (1996), 61(1), 314-23, database is CAplus.

Iminium ions, generated by decarbonylation of N-benzyl-5-[1-(methoxycarbonyl)-4-oxopentyl]prolines, undergo intramol. cyclization to afford 2,4-disubstituted tropanes in good yields. This transformation is also shown to be a stereospecific reaction. The value of these substituted tropanes has been demonstrated by functional group manipulation, leading to the enantiospecific synthesis of (+)-ferruginine, an alkaloid isolated from Darlinga ferruginea, and its unnatural enantiomer, (-)-ferruginine.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caldirola, P. published the artcileSynthesis of [³H]-VUF 4576: a new radiolabeled calcium antagonist, Product Details of C9H8BrF3, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (1992), 31(12), 987-93, database is CAplus.

The new radiolabeled [³H]-VUF 4576 (I) was prepared by an easy procedure using com. available C³H₃I. The new radiolabeled ligand [³H]-VUF 4576 belongs to a subclass of prenylamine analogs which interfere with calcium regulated pathways. The compound has been synthesized in order to study the interaction of other compounds with these mechanisms and in particular the site of action of this subclass of calcium entry blockers and calmodulin antagonists (phosphodiesterase inhibitors).

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Product Details of C9H8BrF3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ho, Hien The published the artcileA post-polymerization functionalization strategy for the synthesis of sulfonyl (trifluoromethanesulfonyl)imide functionalized (co)polymers, Category: bromides-buliding-blocks, the publication is Polymer Chemistry (2017), 8(37), 5660-5665, database is CAplus.

The synthesis of a series of potassium sulfonyl (trifluoromethanesulfonyl)imide (STFSI) derivatives, bearing at one extremity the STFSI group and at the other extremity either bromo, azido or amine groups, is reported. The resultant STFSI derivatives were subsequently used in the post-polymerization functionalization of (co)polymers to yield functionalized (co)polymers by exploiting the highly efficient coupling reactions, namely alkylation, amidation and alkyne-azide cycloaddition

Polymer Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Kenan published the artcileAB-Versus AA+BB-Suzuki Polycondensation: A Palladium/Tris(tert-butyl)phosphine Catalyst Can Outperform Conventional Catalysts, Name: 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Macromolecular Rapid Communications (2020), 41(1), 1900521, database is CAplus and MEDLINE.

A Pd/Pt-Bu₃ catalyst having bulky, electron-rich ligands significantly outperforms conventional “step-growth catalysts” Pd(PPh₃)₄ and Pd(Po-Tol₃)₃ in the suzuki polycondensation of the AB-type arylene-based monomers, such as some of the substituted fluorenes, carbazoles, and phenylenes. In the AA+BB polycondensation, Pd/Pt-Bu₃ also performs better under homogeneous reaction conditions, in combination with the organic base Et₄NOH. The superior performance of Pd/Pt-Bu₃ is discussed in terms of its higher reactivity in the oxidative addition step and inherent advantages of the intramol. catalyst transfer, which is a key step joining catalytic cycles of the AB-polycondensation. These findings are applied to the synthesis of a carbazole-based copolymer designed for the use as a hole conductor in solution-processed organic light-emitting diodes.

Macromolecular Rapid Communications published new progress about 401797-04-4. 401797-04-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic acid and ester, name is 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C5H7NO, Name: 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cardenas, Mariel M. published the artcileEnantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution, Related Products of bromides-buliding-blocks, the publication is Organic Letters (2018), 20(7), 2037-2041, database is CAplus and MEDLINE.

The catalytic enantioselective synthesis of 3-aryl-substituted pyrrolopyrimidines (PPYs), a common motif in drug discovery, is achieved through a kinetic resolution via quaternary ammonium salt-catalyzed nucleophilic aromatic substitution (S_NAr). Both enantioenriched products and starting materials can be functionalized with no observed racemization to give enantiodivergent access to diverse chiral analogs of an important class of kinase inhibitor. One of the compounds was found to be a potent and selective inhibitor of breast tumor kinase.

Organic Letters published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary