Category: bromides-buliding-blocks

2′- and 3′- cholesterol-conjugated adenosine and cytosine nucleoside building blocks: synthesis of lipidic nucleic acids was written by Manoharan, Muthiah;Inamati, Gopal;Tivel, Kathleen L.;Conklin, Boyd;Ross, Bruce S.;Cook, P. Dan. And the article was included in Nucleosides & Nucleotides in 1997.Name: N-(5-Bromopentyl)phthalimide This article mentions the following:

2′- And 3′- cholesterol-conjugated adenosine and cytosine nucleoside building blocks for lipidic nucleic acids were prepared Large scale synthesis and purification of two oligonucleotides were completed in 100 mg scale. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Name: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol was written by Shen, Cong;Zhu, Yuhang;Jin, Shuqi;Xu, Kejie;Luo, Shuxin;Xu, Lixia;Zhong, Guofu;Zhong, Liangjun;Zhang, Jian. And the article was included in Organic Chemistry Frontiers in 2022.Synthetic Route of C8H6BrFO2 This article mentions the following:

N,N-bidentate-chelation-assisted 浼? and 灏?olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction In the experiment, the researchers used many compounds, for example, Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9Synthetic Route of C8H6BrFO2).

Methyl 2-bromo-4-fluorobenzoate (cas: 653-92-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C8H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Multifunctional electron-transporting indolizine derivatives for highly efficient blue fluorescence, orange phosphorescence host and two-color based white OLEDs was written by Wan, Jing;Zheng, Cai-Jun;Fung, Man-Keung;Liu, Xiao-Ke;Lee, Chun-Sing;Zhang, Xiao-Hong. And the article was included in Journal of Materials Chemistry in 2012.Safety of 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl This article mentions the following:

Derivatives of 1-azaindolizine are 1st used as electron-transporting host materials for hybrid fluorescence/phosphorescence white organic LEDs (F/P-WOLED). Of the azaindolizine derivatives, a blue fluorescent material BPPI (3-(4,4′-biphenyl)-2-diphenyl-1-azaindolizine) has: (1) blue emission with high quantum yields, (2) good morphol. and thermal stabilities, (3) electron-transporting properties, and (4) a sufficiently high triplet energy level to act as a host for red or yellow-orange phosphorescent dopants. The multifunctional BPPI enables adaptation of several simplified device configurations. For example, a nondoped blue fluorescent device exhibits good performance with an external quantum efficiency of 3.16% and Commission Internationale de l’Eclairage coordinates of (0.15, 0.07). A high-performance orange phosphorescent device has a high current efficiency of 23.9 cd A^-1. Using BPPI, a F/P-WOLED with a simplified structure, stable emissions and respectable performance (current and external quantum efficiencies of 17.8 cd A^-1 and 10.7%, resp.) was demonstrated. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Safety of 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photochromic dihetarylethenes 3. Synthesis and photochromic properties of 1,2-bis[2-methyl-5-(benzoxazol-2-yl)thien-3-yl]hexafluorocyclopentene was written by Krayushkin, M. M.;Stoyanovich, F. M.;Zolotarskaya, O. Yu.;Martynkin, A. Yu.;Ivanov, V. L.;Uzhinov, B. M.. And the article was included in Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya) in 1999.Application of 29421-99-6 This article mentions the following:

The title compound, i.e., 2,2′-[(3,3,4,4,5,5-hexafluoro-1-cyclopentene-1,2-diyl)di-(2-methyl-3,5-thiophenediyl)]bis[benzoxazole] was prepared and its photochromic properties were studied. The compound thus prepared did not exhibit fluorescent properties in either open or cyclic form. In the experiment, the researchers used many compounds, for example, 4-Bromo-5-methylthiophene-2-carboxylic acid (cas: 29421-99-6Application of 29421-99-6).

4-Bromo-5-methylthiophene-2-carboxylic acid (cas: 29421-99-6) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Application of 29421-99-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thiazolidinedione “Magic Bullets” Simultaneously Targeting PPAR绾?and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects was written by Tilekar, Kalpana;Hess, Jessica D.;Upadhyay, Neha;Bianco, Alessandra Lo;Schweipert, Markus;Laghezza, Antonio;Loiodice, Fulvio;Meyer-Almes, Franz-Josef;Aguilera, Renato J.;Lavecchia, Antonio;C S, Ramaa. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 615-55-4 This article mentions the following:

Monotargeting anticancer agents suffer from resistance and target nonspecificity concerns, which can be tackled with a multitargeting approach. The combined treatment with HDAC inhibitors and PPAR绾?agonists has displayed potential antitumor effects. Based on these observations, this work involves design and synthesis of mols. I (Ar = Ph, pyridin-2-yl, benzo[d]thiazol-2-yl, etc.) that can simultaneously target PPAR绾?and HDAC. Several out of 25 compounds inhibited HDAC4, and six compounds acted as dual-targeting agents. Compound I (Ar = 2-bromo-4,6-difluorophenyl) was the most potent, with activity toward PPAR绾?EC₅₀ = 0.245娓璏 and HDAC4 IC₅₀ = 1.1娓璏. Addnl., compounds I (Ar = 4-methylphenyl, 2-bromo-4,6-difluorophenyl) were cytotoxic to CCRF-CEM cells (CC₅₀ = 2.8 and 9.6娓璏, resp.), induced apoptosis, and caused DNA fragmentation. Furthermore, compound I (Ar = 4-methylphenyl) modulated the expression of c-Myc, cleaved caspase-3, and caused in vivo tumor regression in CCRF-CEM tumor xenografts. Thus, this study provides a basis for the rational design of dual/multitargeting agents that could be developed further as anticancer therapeutics. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Research in the azole series. XXVI. Nuclear magnetic resonance study and the reaction of 1,2,3-triazole with halo nitrobenzenes was written by Elguero, Jose;Gonzalez, Emmanuel;Jacquier, Robert. And the article was included in Bulletin de la Societe Chimique de France in 1967.Formula: C3H4BrN3 This article mentions the following:

Nucleophilic aromatic substitution of 1,2,3-triazole (I) is studied. An equimolar mixture of I and p-fluoronitrobenzene is heated 2 hrs. at 210鎺?in the presence of anhydrous KF to give a mixture of II, m. 206鎺? and III, m. 185鎺? With 1-fluoro-2,4-dinitrobenzene refluxed 6 hrs. with an equimolar amount of I, the only product isolated is IV, m. 127鎺? The same reaction with 1-chloro-2,4,6-trinitrobenzene leads only to V, m. 230鎺? The products are studied by N.M.R. in CDCl3, C6H6, Me2SO, (NMe2)3PO, C5D5N, CF3CO2H, and H2NNH2 solution, together with 1-methyl-1,2,3-triazole and 1-methyl-1,2,5-triazole. The chem. shifts are compared with calculated electron densities. 13C-1H coupling constants are determined for I and for its 1-Me derivative In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Formula: C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design of novel carbamate acetylcholinesterase inhibitors based on the multiple sites of acetylcholinesterase was written by Zhao, Qianfei;Yang, Guoquan;Mei, Xiangdong;Yuan, Huizhu;Ning, Jun. And the article was included in Journal of Pesticide Science (Tokyo, Japan) in 2008.Quality Control of N-(5-Bromopentyl)phthalimide This article mentions the following:

This work describes the design, synthesis, AChE inhibitory activity, and structure-activity relationship of compounds related to a recently discovered series of AChE inhibitors: phthalimide alkyloxyphenyl N-methylcarbamates. The influence of structural variations on inhibitory potency was carefully investigated by modifying different alkyloxy chain lengths and positions between phthalimide and Ph N-methylcarbamate. The biol. properties of the series were investigated in some detail by considering their activity on isolated enzymes. All of the newly synthesized derivatives, when tested on isolated AChE from the brain of the housefly (Musca domestica), were more active than Ph N-methylcarbamate. In particular, compound I1 displayed the best AChE inhibition (352-fold higher than Ph N-methylcarbamate, and 29-fold higher than metolcarb), which suggested that the phthalimide group of I1 bound strongly to the residues lining the gorge, and Ph N-methylcarbamate bound at the catalytic sites. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Quality Control of N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Variation of the alkyl side chain in 铻?sup>8-THC was written by Huffman, John W.;Lainton, Julia A. H.;Dai, Dong;Jordan, Robert D.;Duncan, Sammy G. Jr.. And the article was included in Life Sciences in 1995.Category: bromides-buliding-blocks This article mentions the following:

The synthesis of (2’RS)-2′-methyl-, (3’RS)-, (3’S)-3′-methyl-, and 4′-methyl-铻?sup>8-THC has been carried out, and the pharmacol. of all four compounds has been investigated. All four compounds showed typical cannabinoid activity both in vitro and in vivo. The 2′-Me compound is somewhat more active than 铻?sup>8-THC, while the 4′-Me isomer is less active. The 3′-methyl-铻?sup>8-THC has approx. the same activity as the parent cannabinoid. In the experiment, the researchers used many compounds, for example, Isopentyltriphenylphosphonium bromide (cas: 28322-40-9Category: bromides-buliding-blocks).

Isopentyltriphenylphosphonium bromide (cas: 28322-40-9) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells was written by Valente, Sergio;Lepore, Ilaria;Dell’Aversana, Carmela;Tardugno, Maria;Castellano, Sabrina;Sbardella, Gianluca;Tomassi, Stefano;Di Maro, Salvatore;Novellino, Ettore;Di Santo, Roberto;Costi, Roberta;Altucci, Lucia;Mai, Antonello. And the article was included in Biochimie in 2012.Related Products of 108940-96-1 This article mentions the following:

Chem. manipulations undertaken on some bis(bromo- and dibromo-phenol) compounds previously reported by us as wide-spectrum epigenetic inhibitors let us to identify bis (bromo- and dibromo-methoxyphenyl) derivatives highly selective for PR-SET7 and EZH2 (compounds 4, 5, 9, and 10). Western blot analyses were carried out in U937 cells to determine the effects of such compounds on the Me marks related to the tested enzymes (H3K4me1, H3K9me2, H4H20me1, and H3K27me3). The 1,5-bis(3-bromo-4-methoxyphenyl)penta-1,4-dien-3-one 4 (EC₅₀ vs EZH2 = 74.9 娓璏), tested in U937 cells at 50 娓璏, induced massive cell death and 28% of granulocytic differentiation, highlighting the potential use of EZH2 inhibitors in cancer. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Related Products of 108940-96-1).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 108940-96-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Substituted 6-Anilinouracils and Their Inhibition of DNA Polymerase IIIC and Gram-Positive Bacterial Growth was written by Zhi, Chengxin;Long, Zheng-Yu;Gambino, Joseph;Xu, Wei-Chu;Brown, Neal C.;Barnes, Marjorie;Butler, Michelle;LaMarr, William;Wright, George E.. And the article was included in Journal of Medicinal Chemistry in 2003.Related Products of 615-55-4 This article mentions the following:

Certain substituted 6-anilinouracils are potent and selective inhibitors of Gram+ bacterial DNA polymerase IIIC (pol IIIC). In addition, analogs with 3-substituents in the uracil ring have potent antibacterial activity against Gram+ organisms in culture. In an attempt to find optimal anilino substituents for pol IIIC binding and optimal 3-substituents for antibacterial activity, several series of 3-substituted-6-aminouracils were prepared and assayed their activity against pol IIIC from Bacillus subtilis and a panel of Gram+ and Gram- bacteria in culture. The 6-(3-ethyl-4-methylanilino) group and closely related substituent patterns maximized pol IIIC inhibition potency. Among a series of 3-(substituted-butyl)-6-(3-ethyl-4-methylanilino)uracils, basic amino substituents increased pol IIIC inhibition, but decreased antibacterial activity. The most potent antibacterials were simple hydroxybutyl and methoxybutyl derivatives, and hydrophobically substituted piperidinylbutyl derivatives In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Related Products of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary