Category: bromides-buliding-blocks

Babgi, Bandar A. published the artcileSynthesis, structures, DNA-binding, cytotoxicity and molecular docking of CuBr(PPh₃)(diimine), Category: bromides-buliding-blocks, the publication is Polyhedron (2020), 114847, database is CAplus.

The copper(I) coordination compounds of general formula [CuBr(PPh₃)(N^ΛN)] (N^ΛN = 2,2′-bipyridine (1), 1,10-phenanthroline (2), 4,4′-dimethyl-2,2′-bipyridine (3), 4,4′-dimethoxy-2,2′-bipyridine (4), 3-(2-pyridyl)-4,5-diphenyl-1,2,4-triazine (5), 4,7-diphenyl-1,10-phenanthroline (6), 5-nitro-1,10-phenanthroline (7), dipyrido[3,2-a:2′,3′-c]phenazine(8)) have been synthesized and characterized by elemental anal., ³¹P NMR spectroscopy and mass spectrometry. The structure of 5 and 7 were confirmed by X-ray crystallog. 5 Is the second example to be reported with an unusual 4 N-triazine-ligated coordination mode of the 3-(2-pyridyl)-4,5-diphenyl-1,2,4-triazine. Calculated energies of the two possible bidentate modes of the ligand (2 N- and 4 N-triazine) at the copper center showed no significant difference, consistent with the absence of the steric hindrance at the metal center. Preliminary biol. studies were conducted, highlighting the effect of the diimine ligands. 5 And 8 exhibited good cytotoxicity against prostate (PC-3), leukemia (MOLT-4) and breast (MCF-7) cancer cell lines, consistent with the presence of nitrogen heteroatoms and extended delocalized systems correlating with strong cytotoxic performance. Binding affinity studies against ct-DNA and docking studies with B-DNA and MDM2 protein highlighted the strong π interactions of 5 and 8, with the planarity of the diimine ligand of the latter contributing to its better binding and cytotoxicity. The present results afford structural design requirements for new copper(I) coordination compounds with enhanced biol./physiochem. properties.

Polyhedron published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Perera, Tharushi A. published the artcilePhotoreduction of Pt(IV) Chloro Complexes: Substrate Chlorination by a Triplet Excited State, Formula: C6H12Br2, the publication is Inorganic Chemistry (2014), 53(14), 7608-7621, database is CAplus and MEDLINE.

The Pt(IV) complexes trans-Pt(PEt₃)₂(Cl)₃(R) (2; R = Cl, Ph, 9-phenanthryl, 2-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-perylenyl) were prepared by chlorination of the Pt(II) complexes trans-Pt(PEt₃)₂(R)(Cl) (1) with Cl₂ gas or PhICl₂. Mixed bromo-chloro complexes trans,trans-Pt(PEt₃)₂(Cl)₂(Br)(R) (R = 9-phenanthryl, 4-trifluoromethylphenyl), trans,cis-Pt(PEt₃)₂(Cl)₂(Br)(4-trifluoromethylphenyl), trans,trans-Pt(PEt₃)₂(Br)₂(Cl)(R) (R = 9-phenanthryl), and trans,cis-Pt(PEt₃)₂(Br)₂(Cl)(4-trifluoromethylphenyl) were obtained by halide exchange or by oxidative addition of Br₂ to 1 or Cl₂ to trans-Pt(PEt₃)₂(R)(Br). Except for 2 (R = Ph, 4-trifluoromethylphenyl), all of the Pt(IV) complexes are photosensitive to UV light and undergo net halogen reductive elimination to give Pt(II) products, trans-Pt(PEt₃)₂(R)(X) (X = Cl, Br). Chlorine trapping experiments with alkenes indicate a reductive-elimination mechanism that does not involve mol. chlorine and is sensitive to steric effects at the Pt center. DFT calculations suggest a radical pathway involving ³LMCT excited states. Emission from a triplet is observed in glassy 2-methyltetrahydrofuran at 77 K where photoreductive elimination is markedly slowed.

Inorganic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zang, Yu published the artcileSynthesis and Oxygen Permeation of Well-Defined Multistranded Copolymers from Monomers Having Two Different Polymerizable Groups, Synthetic Route of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(13), 5699-5710, database is CAplus.

Four multistranded copolymers were synthesized by two-step selective polymerization of monomers having an acetylene and two olefins. Their second main chains, which were formed at the postpolymn. between the olefin groups in the template acetylene polymers, are categorized into two types, i.e., helical conformations along with the conformations of their template helical polymers and nonhelical conformations parallel to the direction of the main chain of their precursor polymers. The numbers of the strands are two, four, and seven when supramol. strands by hydrogen bonds are included. Since the copolymers were all soluble, they could be fully characterized and fabricated to self-standing membranes. The conversions of the postpolymns. were high. The degree of the postpolymn. could be controlled by changing conditions. Oxygen permselectivies of these multistranded copolymers were better than the corresponding template polymers. The more the number of the strands was, the higher their oxygen permselectivity showed.

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C7H16Cl2Si, Synthetic Route of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Negishi, Eiichi published the artcileSelective carbon-carbon bond formation via transition metal catalysis. 35. A convenient synthesis of unsymmetrical bibenzyls, homoallylarenes, and homopropargylarenes via palladium-catalyzed cross coupling, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Tetrahedron Letters (1983), 24(36), 3823-4, database is CAplus.

The Pd-catalyzed homobenzyl-aryl, homobenzyl-alkenyl, homoallyl-aryl, and homopropargyl-aryl cross coupling reactions provide the desired coupling products, 2-MeC₆H₄CH₂CH₂Ph, (E)-PhCH₂CH₂CH:CMe(CH₂)₅Me, 4-NCC₆H₄CH₂CH₂CH:CH₂, Me₃SiCCCH₂CH₂Ph, in high yields. Similar reactions involving alkynyl halides lead to low product yields.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hintz, Sandra published the artcileRegio- and stereoselective cyclization reactions of unsaturated silyl enol ethers by photoinduced electron transfer. Mechanistic aspects and synthetic approach, Product Details of C7H13BrSi, the publication is European Journal of Organic Chemistry (1998), 1583-1596, database is CAplus.

Oxidative photoinduced electron transfer (PET) reactions were performed with various silyl enol ethers and silyloxy-2H-chromones bearing an olefinic or silylacetylenic side-chain. The reactions result in regioselective ring-closure with the formation of bi- to tetracyclic ring systems with a well-defined ring juncture, e.g. perhydrophenanthrenones or benzo-annelated xanthenones. Our investigations have focussed on the optimization of this cyclization method with regard to irradiation time and product yield. The irradiation times could be reduced by using the cosensitized PET method. Modifying the substrate at the silyl group led to enhanced yields. In addition, it was found that solvent and pressure dependences are important tools, allowing control of the regiochem. Both the synthesis of 6-endo products by radical cationic reaction pathways as well as 5-exo ring-closure by radical intermediates was achieved. Mechanistic details, including findings from deuterium labeling experiments, are discussed.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rinderhagen, Heiko published the artcileSynthetic applications in radical/radical cationic cascade reactions, COA of Formula: C7H13BrSi, the publication is Chemistry – A European Journal (2004), 10(4), 851-874, database is CAplus and MEDLINE.

Oxidative photoinduced electron transfer (PET) reactions have been performed with various cyclic cyclopropyl(vinyl) silyl ethers bearing an olefinic or acetylenic side chain. The reactions result in bi- to tetracyclic ring systems via a fragmentation-radical/radical cationic addition reaction pathway with well defined ring juncture. The mode of cyclization (endo/exo) can be partially controlled by addition of nucleophiles due to the suppression of radical cationic reaction pathways. Quantum chem. calculation of the cyclization transition states underline the exptl. found selectivities. Addnl. mechanistic studies concerning the saturation step reveal that the final radical is saturated mostly by the solvent and traces of water in the solvent.

Chemistry – A European Journal published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Camp, David published the artcileDevelopment of a Synthetic Process towards a Hepatitis C Polymerase Inhibitor, SDS of cas: 76283-09-5, the publication is Organic Process Research & Development (2006), 10(4), 814-821, database is CAplus.

The synthesis of clin. candidate 2-(4-{2-[(2R)-2-Cyclopentyl-5-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylmethyl)-4-hydroxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-ethyl}-2-fluoro-phenyl)-2-methyl-propionitrile (I) on multikilogram scale is described. Initial synthesis of I, clin. candidate for inhibition of the hepatitis C viral polymerase (HCVP) protein, was executed via a racemic synthetic route coupled with chiral HPLC separation Due to the achiral route and instability of key intermediates, the initial route was determined to be unsuitable for large-scale manufacture An alternate route was developed utilizing a convergent Heck coupling, resolution of a carboxylic acid via diastereomeric salt formation, and an efficient chem. recycling of the undesired enantiomer.

Organic Process Research & Development published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, SDS of cas: 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bauer, Adriano published the artcileChemoselective formal β-functionalization of substituted aliphatic amides enabled by a facile stereoselective oxidation event, Safety of 7-Bromohept-1-yne, the publication is Chemical Science (2019), 10(42), 9836-9840, database is CAplus and MEDLINE.

A facile and stereoselective dehydrogenation event enabling the functionalization of aliphatic amides, e.g., 1-(indolin-1-yl)-2-methylpropan-1-one at different positions in a one-pot fashion has been described. Derivatives of relevant pharmaceuticals were formally functionalized in the β-position in late-stage manner. A single-step synthesis of incrustoporine from a simple precursor further showcases the potential utility of this approach.

Chemical Science published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Safety of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mathey, Francois published the artcilePyrolysis of some phosphorus trihalide-diene addition compounds, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques (1969), 268(21), 1902-4, database is CAplus.

Pyrolysis of H2C:-CMeCMe:CH2.PBr3, H2C:CMeCMe:CH2.PCl3, and H2C:-CMeCH:CH2.PBr3 in vacuo at <200° gave, resp., PBr3 or PCl3 and Me2CBrCBrMe2, ClCH2CHMeCClMe2 or BrCH2CH2CBrMe2 together with polymeric residues. The products were identified by their N.M.R. spectra, which are discussed.

Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uslu, Azize Gizem published the artcileBenzimidazole derivatives as potent and isoform selective tumor-associated carbonic anhydrase IX/XII inhibitors, Recommanded Product: 4-Bromo-N-methyl-2-nitroaniline, the publication is Bioorganic Chemistry (2020), 103544, database is CAplus and MEDLINE.

We describe the synthesis of a series of 2-arylbenzimidazole derivatives bearing sulfonamide functionality (4a-d, 7a-c and 10) as well as hydroxamic acid (15a-b), carboxylic acid (16a-b), carboxamide (17a-b) and boronic acid (22a-b and 26) functionalities, which act as human carbonic anhydrase (hCA, EC 4.2.1.1) inhibitors. The newly synthesized benzimidazole derivatives were evaluated against 4 physiol. relevant CA isoforms (hCA I, II, IX, and XII), and especially the sulfonamide-containing benzimidazoles demonstrated intriguing inhibitory activity against tumor associated CA IX and XII with K_I values in the range of 5.2-29.3 nM and 9.9-41.7 nM, resp. Notably, compound 4c was the most potent and selective CA IX (K_I = 6.6 nM) and XII (K_I = 9.9 nM) inhibitor with a significant selectivity ratio over cytosolic CA I and II isoforms in the range of 3.4-25.2. In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with K_I values in lower micromolar potency (K_Is = 0.36-0.85μM for CA IX/XII).

Bioorganic Chemistry published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C7H6Cl2, Recommanded Product: 4-Bromo-N-methyl-2-nitroaniline.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary