Category: bromides-buliding-blocks

Mistry, Shailesh N. published the artcile4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M₁ Muscarinic Acetylcholine Receptor, Computed Properties of 76283-09-5, the publication is Journal of Medicinal Chemistry (2016), 59(1), 388-409, database is CAplus and MEDLINE.

Pos. allosteric modulators (PAMs) of the M₁ muscarinic acetylcholine receptor (M₁ mAChR) are a promising strategy for the treatment of the cognitive deficits associated with diseases including Alzheimer’s and schizophrenia. Herein, we report the design, synthesis, and characterization of a novel family of M₁ mAChR PAMs. The most active compounds of the 4-phenylpyridin-2-one series exhibited comparable binding affinity to the reference compound, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (BQCA), but markedly improved pos. cooperativity with acetylcholine, and retained exquisite selectivity for the M₁ mAChR. Furthermore, the pharmacol. characterization revealed ligands with a diverse range of activities, including modulators that displayed both high intrinsic efficacy and PAM activity, those that showed no detectable agonism but robust PAM activity and ligands that displayed robust allosteric agonism but little modulatory activity. Compound I was found to have the best pharmacol. profile. Thus, the 4-phenylpyridin-2-one scaffold offers an attractive starting point for further lead optimization.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kale, Someshwar B. published the artcileRongalite as a Sulfone Source: Sulfonylation of para-Quinone Methides and Alkyl/allyl Halides, Product Details of C8H17Br, the publication is Chemistry – An Asian Journal (2022), 17(16), e202200408, database is CAplus and MEDLINE.

A one-pot three-component reaction using p-quinone methides, rongalite and alkyl/allyl halides has been described. The corresponding unsym. sulfones were obtained in good yields under mild reaction conditions in the absence of any metal, base or any other additive.

Chemistry – An Asian Journal published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Product Details of C8H17Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cavieres, Jenifer published the artcileIonanofluids based on ionic liquid mixtures, a new approach as an alternative material for solar energy storage, Recommanded Product: 1-Bromooctane, the publication is Journal of Molecular Liquids (2022), 118677, database is CAplus.

Hybrid materials based on ionic liquids (ILs) known as Ionanofluids (INFs) have shown exciting improvements in their thermophys. properties compared to their base fluids (BF). Within this group, INFs obtained using mixtures of ionic liquids as BFs have been virtually ignored until now. In this work, INFs composed of two equimolar mixtures of ILs, [Omim][PF₆] + [Odmim][PF₆] and [Omim][PF₆] + [Odmim][BF₄] as base fluids and Multiwalled Carbon Nanotubes (MWCNTs) with weight percentages of 0.04, 0.06, 0.08, and 0.1 wt% were elaborated. Furthermore, the thermophys. properties of our proposed new materials were evaluated and compared to conventional materials currently used in solar energy storage systems. It was shown that the heat capacity (Cp) reaches increases of up to 3.7 and 3.2 times that of nitrated salts and the com. fluid Therminol VP-1, which translates into a 9.4% and 284% higher thermal storage d. (E), resp., and even lower thermal diffusivity (α), which supports the preliminary idea of using these new materials for energy storage.

Journal of Molecular Liquids published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Saraswathi, Sajena K. published the artcileThymine-Induced Dynamic Switching of Self-Assembled Nanofibers in Diaminotriazine-Functionalized Tetraphenylethylene Derivatives: Implications for One-Dimensional Molecular Devices, Quality Control of 143-15-7, the publication is ACS Applied Nano Materials (2022), 5(2), 3018-3027, database is CAplus.

One-dimensional (1D) supramol. polymers of aggregation-induced emission (AIE)-active chromophores belong to an in-demand group of functional materials because of their potential applications in optoelectronic devices like optical waveguides, lasers, displays, photodetectors, field-effect transistors, and solar cells. Herein, we report the hydrogen (H)-bondingdirected self-assembly of diaminotriazine-appended tetraphenylethylene derivatives (TPE-DAT) into 1D-fibers, hierarchical organogels and their thymine-induced structural transitions. The intermol. H-bonding ability of diaminotriazine (-DAT=DAT-) leads to the formation of TPE dimers, which upon subsequent cooperative self-assembly via π-π stacking forms micrometer-long, blue-emissive, bundled nanofibers. Further, we exploit the mol. recognition property of thymine nucleobase toward the diaminotriazine unit to tune the properties of this 1D assembly. In the presence of a thymine derivative (T-C12), the blue-emissive, bundled nanofibers of TPE-DAT having a width of 70-80 nm changes to green-emissive nanofibers of TPE-DATT-C12 with 30-40 nm width. This transition from blue- to green-emissive nanofibers and hierarchical gels was ascribed to the change in monomeric units, their mol. planarity, and packing in the self-assembly, which was further probed by UV-visible absorption, at. force microscopy (AFM), transmission electron microscopy (TEM), and fluorescence properties. In addition, to gain more insights into the mechanism of these 1D-assemblies, we explored the self-assembly properties of chiral and racemic derivatives of TPE-DAT and the gelation properties of TPE-DAT and TPE-DATT-C12. In short, this work demonstrates the use of the mol. recognition property of nucleobase and nucleobase analogs in constructing and controlling the formation of rarely reported 1D-assemblies of AIE-active TPE chromophores.

ACS Applied Nano Materials published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Quality Control of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Huber, Johannes published the artcileNanoparticles of Low Optical Band Gap Conjugated Polymers, Computed Properties of 52431-30-8, the publication is Macromolecules (Washington, DC, United States) (2012), 45(19), 7799-7805, database is CAplus.

Sonogashira coupling of 9,9-bis(2-ethylhexyl)-2,7-diethynyl-9H-fluorene (1) with 2,7-dibromo-9,9-bis(2-ethylhexyl)-9H-fluorene (2) and dibromo-substituted electron accepting arylenes 5,7-bis(5-bromothiophen-2-yl)-2,3-dihexylthieno[3,4-b]pyrazine (3), 4,7-bis(5-bromo-4-(2-ethylhexyl)thiophene-2-yl)bis(benzothiadiazole) (4) or 4,9-bis(5-bromo-4-(2-ethylhexyl)thiophen-2-yl)-6,7-dihexylthiadiazolo[3,4-g]quinoxaline (5), resp., in a miniemulsion polymerization process afforded colloidally stable dispersions of poly(arylene ethynylene) nanoparticles with an average size in the range of 50 to 120 nm. For these poly[1-alt-(2-co-X)] (X = 3, 4, or 5), poly(1-alt-3), poly(1-alt-4), and poly(1-alt-5) aqueous nanoparticle dispersions absorption occurs increasingly in the red and NIR regime with increasing incorporation of acceptor monomer, with a strong absorption up to λ_abs = 1 μm for poly(1-alt-4) dispersions. For poly[1-alt-(2-co-3)] nanoparticles fluorescence is also observed at λ_em = ca. 700 nm, which occurs at this long wavelength exclusively even at an incorporation of only 1 mol % of 3 due to energy transfer to the low-energy chromophores. An alternative postpolymn. approach by change of solvent quality yielded dilute aqueous dispersions of self-stabilized nanoparticles from an amphiphilic block copolymer, poly(ethylene glycol)-block-poly(1-alt-6)-block-poly(ethylene glycol) generated from alkyne-terminated poly(1-alt-6) via azide-alkyne coupling (6 = 4,7-bis(5-bromo-4-(2-ethylhexyl)thiophene-2-yl)benzothiadiazole), which fluoresce at λ_em max = 672 nm.

Macromolecules (Washington, DC, United States) published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Computed Properties of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lee, Junghun published the artcileDiscovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents, Name: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Bioorganic & Medicinal Chemistry (2018), 26(8), 1628-1637, database is CAplus and MEDLINE.

A series of 4-aryl-thieno[1,4]diazepin-2-one were synthesized and evaluated for their antiproliferative activities against the A375P melanoma and U937 hematopoietic cell lines. Several compounds showed very potent antiproliferative activities toward both cell lines and the activities were better than that of sorafenib, the reference standard Derivatives were made as amide (8a-8i, 9a-9m) and urea (10a-10d, 11a-11d) with diverse hydrophobic moieties. One of the most potent inhibitor 10d, 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno [3,4-b][1,4]diazepin-4-yl)phenyl)urea was found to be very potent inhibitor of multi-protein kinases including FMS kinase (IC₅₀=3.73nM) and is a promising candidate for further development in therapeutics for cancer.

Bioorganic & Medicinal Chemistry published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Name: 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nganga, Joseph B. published the artcileDibromorhodamine-based photoredox catalysis under visible light for the colorimetric detection of Hg(II) ion, COA of Formula: C20H18BrN3, the publication is Bulletin of the Korean Chemical Society (2022), 43(7), 946-950, database is CAplus.

We demonstrated a colorimetric readout of Hg(II) ion through visible-light-induced polymerization, initiated by an Hg(II)-responsive photoredox initiator/catalyst under aerobic conditions. Thiosemicarbazide-functionalized 4â€?5â€?dibromorhodamine was synthesized as a stimuli-responsive photoredox catalyst. The rhodamine derivatives bearing thiosemicarbazide have been known as fluorogenic probes of Hg(II) ion with excellent sensitivity and selectivity. In this work, we incorporated a heavy halogen atom (i.e., Br) onto the xanthene core ring of the rhodamine derivative to improve the photoredox catalytic performance of rhodamine 6G, which exhibits a low catalytic performance, presumably due to the poor quantum yield of intersystem crossing. Thus, this photoredox catalyst led to the formation of a hydrogel with Hg(II) ion in a concentration of 10 μM, as the catalyst initiated free-radical polymerization of poly(ethylene glycol) diacrylate and N-vinylpyrrolidone with triethanolamine under visible light for 1 min.

Bulletin of the Korean Chemical Society published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, COA of Formula: C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ploypradith, Poonsakdi published the artcileUtility of Polymer-Supported Reagents in the Total Synthesis of Lamellarins, Related Products of bromides-buliding-blocks, the publication is Journal of Organic Chemistry (2005), 70(13), 5119-5125, database is CAplus and MEDLINE.

Four solid-supported reagents have been utilized in the multistep synthesis of lamellarins. The use of Amberlyst A-26 Br₃^– and polymer bound pyridine hydrobromide perbromide (PVPHP) for keto α-bromination of the less studied ortho-substituted acetophenone derivatives selectively furnished the corresponding monobromination products (phenacyl bromide derivatives), which were used directly in condensation reactions with benzyldihydroisoquinoline mediated by Amberlyst A-26 NaCO₃^–. The 2H-pyrrole carbonates subsequently underwent intramol. Friedel-Crafts transacylation followed by lactonization to provide the lamellarin skeleton (e.g. I). Alternatively, Amberlyst A-26 NaCO₃^– effectively served as base in condensation reaction of benzyldihydroisoquinoline with α-nitrocinnamate derivatives to provide the corresponding 2-ethoxycarbonyl pyrroles, which smoothly underwent O-debenzylation reaction followed by lactonization to furnish the lamellarin skeleton. The novel Amberlyst-15 mediated lactonization reactions effectively combined the otherwise two sep. steps into a single transformation.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileBromination and oxidation with benzyltrimethylammonium tribromide, Computed Properties of 111865-47-5, the publication is Industrial Chemistry Library (1995), 29-48, database is CAplus.

A review with 42 references Our recent studies on effective bromination and oxidation using benzyltrimethylammonium tribromide (BTMA Br₃), stable solid, are described. Those involve electrophilic bromination of aromatic compounds such as phenols, aromatic amines, aromatic ethers, acetanilides, arenes, and thiophene, α-bromination of arenes and acetophenones, and also bromo-addition to alkenes by the use of BTMA Br₃. Furthermore, oxidation of alcs., ethers, 1,4-benzenediols, hindered phenols, primary amines, hydrazo compounds, sulfides, and thiols, haloform reaction of Me ketones, N-bromination of amides, Hofmann degradation of amides, and preparation of acylureas and carbamates by the use of BTMA Br₃ are also presented.

Industrial Chemistry Library published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Computed Properties of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kajigaeshi, Shoji published the artcileHalogenation and oxidation with benzyltrimethylammonium polyhalides, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Yuki Gosei Kagaku Kyokaishi (1993), 51(5), 366-76, database is CAplus.

A review with 55 references on preparations and properties of PhCH₂NMe₃Br₃, PhCH₂NMe₃ICl₂, and PhCH₂NMe₃ICl₄ and electrophilic halogen substitution (bromination, iodination, and chlorination) of aromatic compounds, halogen-addition of alkenes, oxidation, haloform reaction of Me ketones, and Hofmann degradation of amides by the use of the benzyltrimethylammonium polyhalides.

Yuki Gosei Kagaku Kyokaishi published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary