Category: bromides-buliding-blocks

Shapiro, Robert H. published the artcileEvidence for anchimeric assistance in the expulsion of bromine from ring-substituted β-phenylethyl bromides: when is a simple cleavage a rearrangement, HPLC of Formula: 1997-80-4, the publication is Organic Mass Spectrometry (1969), 2(8), 771-80, database is CAplus.

Using the principles of the quasi-equilibrium theory, substituent effects, deuterium labeling, and comparison of compound behavior, evidence is given for aryl participation in the expulsion of Br from the mol. ion of β-phenylethyl bromide and eleven of its ring-substituted derivatives This reaction shows a kinetic behavior which is typical of rearrangements, its activation energy is lower than that of similar reactions where participation is partially or completely precluded and substituent effects are not only consistent with a participation process, but are also consistent with those predicted from solution chemistry.

Organic Mass Spectrometry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C14H20BBrO2, HPLC of Formula: 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mei, Wen-wen published the artcileSynthesis and biological evaluation of benzothiazol-based 1,3,4-oxadiazole derivatives as amyloid β-targeted compounds against Alzheimer’s disease, COA of Formula: C7H5Br2F, the publication is Monatshefte fuer Chemie (2017), 148(10), 1807-1815, database is CAplus.

A series of new benzothiazol-based 1,3,4-oxadiazole derivatives were synthesized and evaluated for their neuroprotective effects against Aβ_25-35-induced toxicity in SH-SY5Y cells. The bioassay results indicated that most of the tested compounds exhibited promising neuroprotective activity. In particular, compound 2-[[[5-[(4-bromophenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]thio]benzothiazole showed the most potent activity (95.7% of cell viability at 10 μM), better than the pos. control EGCG (90.7% of cell viability at 10 μM). Furthermore, compounds 2-[[[5-[(2-bromophenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]thio]benzothiazole, 2-[[[5-[(4-bromo-2-fluorophenylmethylyl)thio]-1,3,4-oxadiazol-2-yl]methyl]thio]benzothiazole, and 2-[[[5-[(4-methoxyphenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]thio]benzothiazole displayed neuroprotective activity similar to EGCG (87.7, 89.1, and 87.7% of cell viability, resp., at 10 μM). The preliminary SARs anal. indicated that benzene ring is the key factor for the neuroprotective activity and the bromo atom substituted at 4-position of the benzene ring favors the neuroprotective activity. In addition, the fluoro group in the benzene ring appears not beneficial for the neuroprotective activity.

Monatshefte fuer Chemie published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Juan published the artcileSynthesis and evaluation of coumarin/piperazine hybrids as acetylcholinesterase inhibitors, COA of Formula: C7H5Br2F, the publication is Medicinal Chemistry Research (2018), 27(6), 1717-1727, database is CAplus.

A series of new coumarin/piperazine hybrids were synthesized and evaluated for anticholinesterase activity. Among them, compounds I and II exhibited potent human acetylcholinesterase (hAChE) inhibitory activity with IC₅₀ values of 2.42 and 9.89 μM, resp., and 4t displayed highest selectivity toward hAChE over human butyrylcholinesterase (hBChE) by 9.8-fold. In addition, both compounds did not show observed cytotoxicity against SH-SY5Y neuroblastoma cell line at 100 μM. Kinetic anal. in tandem with mol. docking study revealed that these hybrids targeted both catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. The preliminary results highlighted II as an anti-Alzheimer’s disease lead compound worthy of further investigation.

Medicinal Chemistry Research published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C6H9N3O2S, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Xian published the artcileSynthesis of aryl triflones by insertion of arynes into C-SO₂CF₃ bonds, Application of 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is RSC Advances (2017), 7(1), 47-50, database is CAplus.

A new approach toward the synthesis of aryl triflones R-2-F₃CO₂SC₆H₃CH₂Ar (R = H, 4,5-Me₂, 4,5-F₂; Ar = 2-fluorophenyl, 3-trifluoromethylphenyl, 4-carboethoxyphenyl, etc.) was achieved by the formal insertion of arynes into C-SO₂CF₃ bonds. This reaction proceeds through addition of CF₃SO₂-containing nucleophiles to the in situ generated arynes and subsequent intramol. rearrangement.

RSC Advances published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C18H20N2O12, Application of 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gao, Yong-Chao published the artcileSulfite-Promoted C-H Fluoroalkyl Sulfuration of Imidazoheterocycles with Bromofluoroacetate and Elemental Sulfur, SDS of cas: 401-55-8, the publication is Synthesis (2020), 52(17), 2541-2550, database is CAplus.

A transition-metal-free sulfite-promoted three-component C-H sulfuration between imidazoheterocycles, elemental sulfur and bromofluoroacetate was developed. Sulfites, including Na₂S₂O₄, NaHSO₃ and Na₂S₂O₃, were able to promote the formation of two C-S bonds in one step using elemental sulfur as a green sulfurating agent, allowing the rapid introduction of the synthetically useful S-fluoroacetate group into imidazoheterocycles. These new imidazoheterocycle derivatives bearing an S-fluoroacetate group can be easily modified to produce pharmaceutically attractive compounds

Synthesis published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Berton, Mateo published the artcileOn-demand synthesis of organozinc halides under continuous flow conditions, Application of Ethylbromofluoroacetate, the publication is Nature Protocols (2018), 13(1), 324-334, database is CAplus and MEDLINE.

Organozinc reagents are versatile building blocks for introducing C(sp₂)-C(sp₃) and C(sp₃)-C(sp₃) bonds into organic structures. However, despite their ample synthetic versatility and broad functional group tolerance, the use of organozinc reagents in the laboratory is limited because of their instability, exothermicity and water sensitivity, as well as their labor-intensive preparation Herein, we describe an on-demand synthesis of these useful reagents under continuous flow conditions, overcoming these primary limitations and supporting widespread adoption of these reagents in synthetic organic chem. To exemplify this procedure, a solution of Et zincbromoacetate is prepared by flowing Et bromoacetate through a column containing metallic zinc. The temperature of the column is controlled by a heating jacket and a thermocouple in close contact with it. Advice on how to perform the procedure using alternative equipment is also given to allow a wider access to the methodol. Here we describe the preparation of 50 mL of solution, which takes 1 h 40 min, although up to 250-300 mL can be prepared with the same column setup at a rate of 30 mL per h. The procedure provides the reagent as a clean solution with reproducible concentration Organozinc solutions generated in flow can be coupled to a second flow reactor to perform a Reformatsky reaction or can be collected over a flask containing the required reagents for a batch Negishi reaction.

Nature Protocols published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Parveen, Shagufta published the artcileSelective synthesis and comparative activity of olefinic isomers of 1,2-benzothiazine-1,1-dioxide carboxylates as aldose reductase inhibitors, Formula: C7H5Br2F, the publication is RSC Advances (2014), 4(40), 21134-21140, database is CAplus.

1,2-Benzothiazine-1,1-dioxides I (R¹ = 2,4,5-F₃, 4-Br-2-F; R² = CH₃) and II were selectively synthesized via the Wittig olefination reaction under various temperature conditions. At 40 °C, esters I with high Z-stereoselectivity (83-87%) were formed, while esters II formed preferentially with moderate to excellent regioselectivity at 100-120 °C (77-96%). The acid isomers I (R² = H) and II (R² = H), formed by acid hydrolysis of the corresponding esters, were found to inhibit aldose reductase in order of activity β,γ-unsaturated > Z-α,β-unsaturated > E-α,β-unsaturated isomers. The β,γ-unsaturated isomer II (R¹ = 4-Br-2F; R² = H) exhibited the most potent inhibition activity, with an IC₅₀ value of 0.057 μM. This was further supported by docking studies.

RSC Advances published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wan, Honghe published the artcileBenzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)-Hit to Lead studies, Synthetic Route of 53484-26-7, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(17), 5063-5066, database is CAplus and MEDLINE.

Hit to Lead optimization and SAR development led to the identification of the potent and selective benzo[d]imidazole inhibitor (17b)(I) of Co-activator Associated Arginine Methyltransferase (CARM1).

Bioorganic & Medicinal Chemistry Letters published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C6H7BFNO2, Synthetic Route of 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Williams, Sierra J. published the artcileOrthogonal bioluminescent probes from disubstituted luciferins, COA of Formula: C10H16Br3N, the publication is Biochemistry (2021), 60(8), 563-572, database is CAplus and MEDLINE.

Bioluminescence imaging with luciferase-luciferin pairs is routinely used to monitor cellular functions. Multiple targets can be visualized in tandem using luciferases that process unique substrates, but only a handful of such orthogonal probes are known. Multiplexed studies require addnl. robust, light-emitting mols. In this work, we report new luciferins for orthogonal imaging that comprise disubstituted cores. These probes were found to be bright emitters with various engineered luciferases. The unique patterns of light output also provided insight into enzyme-substrate interactions necessary for productive emission. Screening studies identified mutant luciferases that could preferentially process the disubstituted analogs, enabling orthogonal imaging with existing bioluminescent reporters. Further mutational analyses revealed the origins of substrate selectivity. Collectively, this work provides insights into luciferase-luciferin features relevant to bioluminescence and expands the number of probes for multicomponent tracking.

Biochemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C6H6N2O, COA of Formula: C10H16Br3N.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

He, Yali published the artcilePyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(21), 12642-12665, database is CAplus and MEDLINE.

We report herein the design, synthesis, and pharmacol. characterization of a library of novel aryl pyrazol-1-yl-propanamides as selective androgen receptor degraders (SARDs) and pan-antagonists that exert broad-scope AR antagonism. Pharmacol. evaluation demonstrated that introducing a pyrazole moiety as the B-ring structural element in the common A-ring-linkage-B-ring nonsteroidal antiandrogens’ general pharmacophore allowed the development of a new scaffold of small mols. with unique SARD and pan-antagonist activities even compared to our recently published AF-1 binding SARDs such as UT-155 and UT-34. Novel B-ring pyrazoles exhibited potent AR antagonist activities, including promising distribution, metabolism, and pharmacokinetic properties, and broad-spectrum AR antagonist properties, including potent in vivo antitumor activity. I was able to induce an 80% tumor growth inhibition of xenografts derived from the enzalutamide-resistant (Enz-R) VCaP cell line. These results represent an advancement toward the development of novel AR antagonists for the treatment of Enz-R prostate cancer.

Journal of Medicinal Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary