Category: bromides-buliding-blocks

Xia, Tingting published the artcilePalladium-Catalyzed Cross-Coupling of Ethyl Bromodifluoroacetate with Aryl Bromides or Triflates and Cross-Coupling of Ethyl Bromofluoroacetate with Aryl Iodides, Application of Ethylbromofluoroacetate, the publication is Organic Letters (2017), 19(10), 2610-2613, database is CAplus and MEDLINE.

A palladium-catalyzed Negishi cross-coupling reaction of Et bromodifluoroacetate with aryl bromides or aryl triflates to construct C(sp²)-CF₂ bonds is described. The reaction was conducted under mild reaction conditions, and no preparation of organozinc reagents is required. This is the first report encompassing the conversion of aryl triflates into products containing C-CF₂ bonds. In addition, the construction of C(sp²)-CHF bonds was achieved under mild conditions via a cross-coupling of aryl iodides with Et bromofluoroacetate.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6O3, Application of Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gong, Jing-Xu published the artcileSynthesis, spectral characterization, and antituberculosis activity of thiazino[3,2-a]benzimidazole derivatives, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2016), 191(7), 1036-1041, database is CAplus.

A series of novel thiazino[3,2-a]benzimidazole derivatives were synthesized by cyclization of (R)-2-(chloromethyl)oxirane with benzimidazole-2-thiol followed by reaction with benzyl bromides in high yield under milder conditions. The mol. structures of all compounds were confirmed by ¹H, ¹³C NMR spectroscopy and mass spectrometry. The absolute configuration of the compounds were confirmed by X-ray diffraction anal. All the synthesized compounds were evaluated in-vitro for their antituberculosis activity.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sui, Jingzhi published the artcileSynthesis of Trans-4a,12b/3,4-Dihydrodibenzo[f,h]quinolin-2(1H)-Ones and Dibenzo[f,h]quinolin-2(1H)-Ones via Irradiation of 6-Biphenylpyridine-2(1H)-Ones, Product Details of C7H8BBrO3, the publication is Advanced Synthesis & Catalysis (2021), 363(14), 3554-3559, database is CAplus.

The synthesis of trans-4a,12b-dihydrodibenzo[f,h]quinolin-2(1H)-ones, dibenzo[f,h]quinolin-2(1H)-ones and 3,4-dihydrodibenzo[f,h]quinolin-2(1H)-ones via photo-induced annulation of 6-([1,1′-biphenyl]-2-yl)pyridine-2(1H)-ones under irradiation of a 313 nm UV light was described. Trans-4a,12b-dihydrodibenzo[f,h]quinolin-2(1H)-ones were obtained in 82-95% yields when the irradiation time was 3 h. Dibenzo[f,h]quinolin-2(1H)-ones were obtained by irradiating biphenylpyridinones for 12 h in the presence of iodine. Heating the solution of trans-4a,12b-dihydrodibenzo[f,h]quinolin-2(1H)-ones in DMF at 130°C for 24 h gave 3,4-dihydrodibenzo[f,h]quinolin-2(1H)-ones via a double 1,3-H shift. The demonstrated protocols showed the diversity of photo-induced cyclization of biphenylpyridinones.

Advanced Synthesis & Catalysis published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is CBF6K, Product Details of C7H8BBrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Stensrud, Kenneth F. published the artcileFluorinated photoremovable protecting groups: the influence of fluoro substituents on the photo-Favorskii rearrangement, Synthetic Route of 1998-61-4, the publication is Photochemical & Photobiological Sciences (2008), 7(5), 614-624, database is CAplus and MEDLINE.

To further explore the nature of the photo-Favorskii rearrangement and its commitment to substrate photorelease from p-hydroxyphenacyl (pHP), an array of ten new fluorinated pHP γ-aminobutyric acid (GABA) derivatives was synthesized and photolyzed. The effects of fluorine substitution on the chromophore and the photophys. and photochem. properties of these new chromophores were shown to be derived primarily from the changes in the ground state pK_a of the phenolic groups. The quantum yields and rate constants for release are clustered around Φ_dis = 0.20 ± 0.05 and k_r = 8 ± 7 × 10⁷ s^-1 (H₂O), resp. The triplet lifetimes of the pHP GABA derivatives were concentrated in the range of 0.4-6.0 ns (H₂O). The corresponding deprotonated conjugate bases displayed reduced efficiencies by 50% or more (one exception) and exhibited a weak fluorescence in pH 8.2 buffer. Pump-probe spectroscopy studies have further defined the rates of intersystem crossing and the lifetimes of the reactive triplet state of the fluoro pHP chromophore.

Photochemical & Photobiological Sciences published new progress about 1998-61-4. 1998-61-4 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzene,Phenol, name is 4-Bromo-2,3,5,6-tetrafluorophenol, and the molecular formula is C20H12N2O2, Synthetic Route of 1998-61-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Willmann, Michael published the artcileRadiosynthesis and Biological Evaluation of [¹⁸F]R91150, a Selective 5-HT_2A Receptor Antagonist for PET-Imaging, HPLC of Formula: 957061-13-1, the publication is ACS Medicinal Chemistry Letters (2021), 12(5), 738-744, database is CAplus and MEDLINE.

Serotonergic 5-HT_2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin in the brain. They have been implicated in the etiol. of many neuropsychiatric disorders and serve as a target for antipsychotic, antidepressant, and anxiolytic drugs. Positron emission tomog. imaging using suitable radioligands can be applied for in vivo quantification of receptor densities and receptor occupancy for therapy evaluation. Recently, the radiosynthesis of the selective 5-HT_2AR antagonist [¹⁸F]R91150 was reported. However, the six-step radiosynthesis is cumbersome and time-consuming with low radiochem. yields (RCYs) of <5%. In this work, [¹⁸F]R91150 was prepared using late-stage Cu-mediated radiofluorination to simplify its synthesis. The detailed protocol enabled us to obtain RCYs of 14 ± 1%, and the total synthesis time was reduced to 60 min. In addition, autoradiog. studies with [¹⁸F]R91150 in rat brain slices revealed the typical uptake pattern of 5-HT_2A receptor ligands.

ACS Medicinal Chemistry Letters published new progress about 957061-13-1. 957061-13-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters, name is 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C18H15N3O3, HPLC of Formula: 957061-13-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Meyer, Franc published the artcileTuning the metal-metal separation in pyrazolate-based dinuclear complexes by the length of chelating side arms, Safety of Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1998), 207-214, database is CAplus.

Six dinuclear Co(II) complexes of pyrazolate ligands with multidentate chelating side arms {3,5-(R₂NCH₂)₂C₃N₂H₂; R₂N = [Me₂N(CH₂)₃]₂N (HL¹) or (Et₂NCH₂CH₂)₂N (HL²)} were prepared and characterized. The reaction of L¹ and L² with 2 equiv of [Co(MeCN)₆][BF₄]₂ and NaBPh₄ proceeds via the isolable compounds [Co₂L¹(BF₄)][BPh₄]₂ (1a) and [Co₂L²(BF₄)][BPh₄]₂ (2a) finally to afford dinuclear [Co₂L¹F][BPh₄]₂ (1b) and [Co₂L²(F)(H₂O)][BPh₄]₂ (2b), resp., where a fluoride was abstracted from the BF₄^– starting material in both cases. While the longer side arms in 1b allow for an exogenous bridging position of the fluoride, an addnl. H₂O mol. is incorporated in 2b to form an FHO(H) moiety with an unusually short F-H-O bridge between the two Co centers. Evidence is reported for the reversible extrusion of the H₂O mol. from 2b. Treatment of 2b with KBr or NaN₃ yielded the resp. bromo- and azido-bridged complexes [Co₂L²Br][BPh₄]₂ (3) and [Co₂L²(N₃)][BPh₄]₂ (4), where in the latter case the azide adopts a μ-1,3-bridging mode. The magnetic properties of 3 and 4 were studied in the temperature range 8-200 K. Complexes 1b, 2b·3MeCN, 3·0.25Et₂O and 4·Me₂CO were also characterized by x-ray crystallog.

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Safety of Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cory, Michael published the artcileInhibitors of histone methylation, SDS of cas: 518-67-2, the publication is Chemico-Biological Interactions (1974), 9(4), 253-9, database is CAplus and MEDLINE.

Two classes of inhibitors of histone methyltransferase I from calf thymus were studied. High concentrations (≥10mM) of various alkyl or aralkyl amines and polyamines were inhibitory to the enzyme. Spermine and spermidine were among the most potent compounds in this group. The best monoamine inhibitor was 2-phenylethylamine, which gave 47% inhibition at 10mM. The substituted phenanthridinium compound ethidium bromide was also an inhibitor of the enzyme. A number of analogs of ethidium bromide were tested, and the most potent compound gave 50% inhibition at 0.125mM. S-adenosyl-L-methionine showed competitive inhibition of the enzyme as determined from a Lineweaver-Burk plot, whereas ethidium bromide was noncompetitive.

Chemico-Biological Interactions published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Herberich, G. E. published the artcileDerivatives of 1,2-diborabenzene. II. (1,2-Dibora-3,5-cyclohexadiene)metal complexes. Crystal structure of (C₅Me₅)Rh(C₄H₄B₂Cl₂), Recommanded Product: Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Journal of Organometallic Chemistry (1988), 355(1-3), 473-84, database is CAplus.

The 1,2-diboratabenzene derivative Li₂[C₄H₄B₂(NMe₂)₂] reacts with various transition metal compounds to form sandwich and triple-decker complexes such as (C₆Me₆)RuL (I), (C₅Me₅)RhL (II), (μ-L)[Rh(COD)]₂ (III, COD = 1,5-cyclooctadiene), NiL₂, Fe(CO)L₂ (IV), and Co₂(CO)₄L₂ (V), where L = 1,2-bis(dimethylamino)-1,2-dibora-3,5-cyclohexadiene in all cases. Barriers to internal rotation around the B-N bond are 48(1), 56(1), and 38(1) kJ/mol for I–III, resp., while IV and V are rigid on the NMR time scale. Nucleophilic substitution reactions at B were examined for the Rh complex II. The Lewis acids BF₃·OEt₂ and BCl₃ bring about substitution to give (C₅Me₅)Rh[C₄H₄B₂F(NMe₂·BF₃)] and (C₅Me₅)Rh(C₄H₄B₂Cl₂) (II), resp. Attempted substitution with Al₂Me₆ and with AlH₃ in THF effected a novel ring contraction to produce the borole complexes (C₅Me₅)Rh(C₄H₄BR) (R = Me, H); similarly, traces of air transform VI into (C₅Me₅)Rh(C₄H₄BCl). The structure of VI, determined by x-ray diffraction confirms the η⁶-bonding mode of the diboracyclohexadiene ligand.

Journal of Organometallic Chemistry published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Recommanded Product: Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Schroer, Hans P. published the artcileBehavior of some metal halides toward dimethyl glycol ether, Name: Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Zeitschrift fuer Chemie (1967), 7(6), 238, database is CAplus.

Some metal halides (I), gave adducts with dimethyl glycol ether (II) in the absence of moisture and of air. The adducts prepared were (I, I:II molar ratio in the adduct, and color given): CoBr2, 1:1, blue; CoCl2, 1:1, blue; FeCl3, 1:1, yellow brown; FeCl2, 1:1, white; CdI2, 1:1, colorless; NiBr2, 1:2, orange; CuCl2, 1:0.5, brown; MoCl3, 1:1, red.

Zeitschrift fuer Chemie published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Name: Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rutjes, Floris P. J. T. published the artcileCyclic 1,2-dinitrogen compounds through N,N’-bis(methoxycarbonyl)hydrazinium intermediates, Product Details of C7H13BrSi, the publication is Tetrahedron Letters (1988), 29(52), 6975-8, database is CAplus.

Acid-catalyzed cyclization of methoxymethyl-substituted acyclic hydrazides provides cyclic hydrazides in moderate to good yields. E.g., MeOCH₂[N(CO₂Me)]₂(CH₂)_nCH:CH₂ (n = 1-3) were treated with TiCl₄ in CH₂Cl₂ to give 32, 80, and 15% cyclic hydrazides I (same n), resp. A mechanism involving bis(methoxycarbonyl)hydrazinium intermediates is presented.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary