Category: bromides-buliding-blocks

Kelso, Robert G. published the artcileThe synthesis and properties of 1,1,2-trimethylcyclopropane, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (1952), 287-92, database is CAplus.

The reaction between Me₂CBrCH₂CHBrMe and Zn in aqueous PrOH at 0° carried out on a large scale permitted a thorough study of the reaction products. 1,1,2-Trimethylcyclopropane (I) comprised 68% of the hydrocarbon mixture obtained in 67% yield. Me₂CHPr, CH₂:CMePr (II), b₇₆₀ 61°, n_D²⁵ 1.3916, and Me₂C:CHEt, b₇₆₀ 64.5-5.5°, n_D²⁵ 1.3987-1.3995, were also obtained; MeCH:CHCHMe₂ was present in minor amount Com. Me₂C(OH)CH₂CH(OH)Me (18 moles) and PBr₃ yielded 4112 g. crude Me₂CBrCH₂CHBrMe (III), b₅ 65-70°, n_D²⁰ 1.496-1.498. (CMe:CH₂)₂, and anhydrous HBr yielded 70% H₂CBrCHMeCBrMe₂, b₁₀ 76°, and 30% (CBrMe)₂, m. 160-4°, b₁₀ 78°. The product of AcII and Me₂CH₂CHO reduced over Raney Ni at 70° and 1500 lb./sq. in. yielded 13% MeCH(OH)CMe₂CH₂OH (IV), b₂₀ 121°, n_D²⁰ 1.4408; IV with PBr₃ at 0° yielded MeCHBrCH₂CBrMe₂. The following constants were determined: for I, f.p., -138.27°, m.p. -138.30°, b₇₆₀ 52.55, dt/dp 0.039, d₄²⁰ 0.6947, n_D²⁰ 1.3864, dn_D/dt 0.00054, n_D²⁵ 1.3834; for CH₂:CMeCHMe₂, b₇₆₀ 55.6°, n_D²⁵ 1.3874; for (Me₂C:)₂, b₇₆₀ 73.3°, n_D²⁵ 1.4070.

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Elgendy, Bahaa published the artcileSynthesis and structure activity relationship of the first class of LXR inverse agonists, HPLC of Formula: 1997-80-4, the publication is Bioorganic Chemistry (2022), 105540, database is CAplus and MEDLINE.

Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play significant role in lipid and cholesterol metabolism Moreover, they are key regulators of several inflammatory pathways. Pharmacol. modulation of LXRs holds great potential in treatment of metabolic diseases, neurodegenerative diseases, and cancer. We were the first group to identify LXR inverse agonists SR9238 and SR9243 and demonstrate their potential utility in treating liver diseases and cancer. Here, we present the results of structure-activity relationship (SAR) studies, based around SR9238 and SR9243. This study led to identification of I, II, III and IV which were more potent inverse agonists than SR9238 and SR9243 and inhibited expression of the fatty acid synthase gene in DU145 cells. We previously demonstrated that inhibition of FASN is correlated to the anticancer activity of SR9243 and this suggests that new inverse agonists have great potential as anticancer agents. We identified compounds with distinct selectivity toward both LXR isoforms, which can be excellent tools to study the pharmacol. of both isoforms. We employed mol. dynamic (MD) simulations to better understand the mol. mechanism underlying inverse agonist activity and to guide our future design.

Bioorganic Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, HPLC of Formula: 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lutter, Ferdinand H. published the artcileCobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides, Product Details of C7H13BrSi, the publication is Angewandte Chemie, International Edition (2020), 59(14), 5546-5550, database is CAplus and MEDLINE.

A combination of 10% CoCl₂ and 20% 2,2′-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents RZnY (R = 3-phenylpropyl, 3-(2,5-dimethyl-1H-pyrrol-1-yl)propyl, cyclopropyl, etc.; Y = Cl, Br) with various (hetero)aryl halides R¹X (R¹ = 5-cyanopyridin-2-yl, quinolin-2-yl, pyrimidin-2-yl, etc.; X = Cl, Br). Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents R²ZnI (R² = 3-methylcyclohexyl, 4-(1H-pyrrol-1-yl)cyclohexyl, (4R,4aS,6R,8aR)-4,4a-dimethyl-6-(propan-2-yl)-decahydronaphthalen-2-yl, etc.) proceeded diastereoselectively leading to functionalized heterocycles R¹R² with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides R³CCBr (R³ = Ph, tris(propan-2-yl)silyl) react with primary and secondary alkylzinc reagents RZnY (R = 2-(1,3-dioxan-2-yl)ethyl, 4-phenylcyclohexyl; Y = Cl, I) providing the alkylated alkynes RCCR³.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Foster, G. E. published the artcileAssay of 2,7-diamino-9-phenyl-10-methylphenanthridinium bromide, Quality Control of 518-67-2, the publication is Analyst (1946), 287-8, database is CAplus.

The organic compound mentioned in the title of this paper, which is more commonly known as dimidium bromide or as phenanthridium 1553 [3,8-diamino-5-methyl-6-phenylphenanthridinium bromide (C.A. numbering)], has been tested for its trypanocidal activity in the treatment of T. congolense and T. brucei infections in mice and cattle. The Br content can be easily determined by treating about 0.25 g. of sample with a little dilute HNO₃ and titrating electrometrically, with AgNO₃. To determine the C₂₀H₁₈N₃⁺, dissolve 1 g. in 200 ml. of warm water and to the solution add 5 g. of NaOAc and 200 ml. of 0.1 M K₄Fe(CN)₆ with vigorous shaking. After 5 min. filter and wash the precipitate with two 25-ml. portions of water. To the filtrate add 5 ml. of concentrated HCl + 5 g. of NaCl + 2 g. KI + 3 g. ZnSO₄.7-H₂O. Wait for each salt to dissolve before adding the next one. After 5 min. titrate with 0.1 N Na₂S₂O₃. After allowing for a blank, each ml. of 0.1 N K₄Fe(CN)₆ = 0.1141 g. of C₂₀H₁₈N₃Br.

Analyst published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Quality Control of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Magagnano, G. published the artcilePhotocatalytic ATRA reaction promoted by iodo-Bodipy and sodium ascorbate, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(10), 1591-1594, database is CAplus and MEDLINE.

Using ascorbate as a sacrificial reductant, iodo-Bodipy dye 1b is able to promote the ATRA reaction between bromoderivatives and alkenes. This finding expands the possibility of using Bodipy dyes to promote photocatalytic reactions in efficient ways.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ji, Jian published the artcileBase-Induced Highly Regioselective Synthesis of N²-Substituted 1,2,3-Triazoles under Mild Conditions in Air, Recommanded Product: 1-Bromododecane, the publication is Organic Letters (2022), 24(1), 132-136, database is CAplus and MEDLINE.

A highly regioselective base-induced synthesis of N²-substituted 1,2,3-triazoles from N-sulfonyl-1,2,3-triazoles and alkyl bromides/alkyl iodides at room temperature is reported. An S_N2-like mechanistic pathway to explain the high N₂-regioselectivity is proposed. The protocol features a broad substrate scope and generates products in good to excellent yields (72-90%).

Organic Letters published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Zui published the artcileManipulated and Improved Photoinduced Deformation Property of Photoresponsive Liquid Crystal Elastomers by Copolymerization, Category: bromides-buliding-blocks, the publication is Macromolecular Rapid Communications (2022), 43(6), 2100717, database is CAplus and MEDLINE.

Photoresponsive liquid crystal elastomers (LCEs) have aroused much attention due to their unique structures, properties, and potential applications. However, many reported photoresponsive LCEs show small photoinduced deformation with a slow deformation speed, which limits their application to a certain extent. In this article, multiple hydrogen bond component and biphenyl component was introduced into photoresponsive LCEs bearing cyanostilbene by copolymerization, and prepared a series of LCEs CSm-BPn (CS and BP means cyanostilbene and biphenyl component, resp.; m, n means the content ratio of CS and BP). All uniaxially oriented CSm-BPn fibers show photoinduced deformation behavior under 365 nm UV light except for CS0-BP5. The introduction of hydrogen bond and the decrease of glass transition temperature realize large deformation and fast deformation speed. Besides, the properties of LCEs are successfully regulated by changing the content ratio of each component. What’s more interesting is that the addition of appropriate amount of biphenyl can significantly improve and manipulate the deformation property of the CSm-BPn fibers. The maximum bending angle can reach 175°, and the whole photoinduced deformation process only takes 11 s. The photoresponsive LCEs with such large bending angle and fast deformation rate are rarely reported.

Macromolecular Rapid Communications published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Shaoxiang published the artcileThe enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading, HPLC of Formula: 76283-09-5, the publication is Journal of Fluorine Chemistry (2013), 19-29, database is CAplus.

A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

Journal of Fluorine Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mei, Wenwen published the artcileSynthesis and protein-tyrosine phosphatase 1B inhibitory activity evaluation of indolepropyl based 1,3,4-oxadiazole derivatives, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Youji Huaxue (2016), 36(3), 533-539, database is CAplus.

A series of indolepropyl based 1,3,4-oxadiazole derivatives were synthesized by esterification, hydrazidation, cyclization and substitution using indolebutyric acid as starting material. The inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was evaluated. The results indicated that five compounds displayed obviously inhibitory effect against PTP1B in vitro, for instance, compound 5g exhibited the strongest PTP1B inhibitory activity with an IC₅₀ value of 6.74 μg·mL^-1. It was the first example of indolealkyl based oxadiazole derivatives showing PTP1B inhibitory activity.

Youji Huaxue published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Xin published the artcilePillared Metal-Organic Framework Initiating Intermolecular Atom-Transfer Radical Addition via Visible-Light-Induced Electron Transfer Activation of Haloalkanes, Recommanded Product: Ethylbromofluoroacetate, the publication is ACS Applied Materials & Interfaces (2021), 13(29), 34114-34123, database is CAplus and MEDLINE.

Herein, a novel metal-organic framework (MOF) with a pillared-layer structure was rationally synthesized to initiate intermol. atom-transfer radical addition (ATRA) via photoinduced electron transfer activation of haloalkanes. The MOF synthesized via the controllable pillared-layer method is of excellent visible-light absorption and high chem. stability. Photocatalytic experiments show the atom transfer of various alkyl halides (R-X, X = Cl/Br/I) onto diverse olefins was successfully achieved to produce functional ATRA products. The mechanism and exptl. investigations reveal the prepared MOF serves as an efficient photocatalyst with strong reduction potential to activate haloalkane substrates via photoinduced electron transfer, generating a highly reactive alkyl radical to trigger the ATRA reaction. Key events in the ATRA reaction, including alkyl radical photogeneration as well as halide transfer, have been further regulated to achieve preferable photocatalytic performance with higher yields, shorter reaction time, and desirable cycling capability. It is notable that the work is the first report on photoinduced electron transfer activation of halides by a MOF photocatalyst for the ATRA reaction, providing a new blueprint for MOFs to develop photoinduced radical reactions.

ACS Applied Materials & Interfaces published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary