Category: bromides-buliding-blocks

Chang, Suae-Chen published the artcileAttempt to observe neighboring group participation in hydrogen abstraction from β-(substituted phenyl)-ethyl bromides, Safety of 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is Journal of Organic Chemistry (1975), 40(25), 3800-1, database is CAplus.

A series of β-(substituted phenyl)-ethyl bromides are reacted with bromotrichloromethane at 70°. Benzylic hydrogen abstraction comprises the only reaction. The exptl. ρ value for this process is -0.83 ± 0.02. A ρ value is calculated to have the range of -0.84 to -0.90. The negligible difference between these two ρ values is indicative of no anchimeric assistance in this reaction by the neighboring bromine atom under the conditions utilized.

Journal of Organic Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Safety of 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, D. published the artcileN-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors, Computed Properties of 76283-09-5, the publication is Pharmazie (2007), 62(8), 636-637, database is CAplus and MEDLINE.

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, resp., were synthesized and evaluated as aldose reductase inhibitors.

Pharmazie published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, Dietmar published the artcileSynthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors, COA of Formula: C7H5Br2F, the publication is European Journal of Pharmaceutical Sciences (2006), 27(2-3), 188-193, database is CAplus and MEDLINE.

In the course of our ongoing studies several substituted benzyloxyphenylacetic acids were prepared Comparison of their aldose reductase inhibition with the biol. activity obtained for recently evaluated benzoic acid analogs revealed the critical role of a methylene spacer between the aromatic core and the acidic function. Starting from the most potent derivative (i.e. 5d, IC₅₀ = 20.9 μM) further structural modifications were performed and their influence on the inhibitory effect was established.

European Journal of Pharmaceutical Sciences published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lee, Jungho published the artcileInsights into constitutional isomeric effects on donor-acceptor intermolecular arrangements in non-fullerene organic solar cells, COA of Formula: C7H5Br2F, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2019), 7(31), 18468-18479, database is CAplus.

Donor-acceptor intermol. interactions and/or arrangements are key factors determining the performance of organic solar cells (OSCs). Herein, two ITIC-based isomeric acceptors (o-F-ITIC and m-F-ITIC) with fluorine atoms at ortho and meta positions within the side chains were developed. The developed acceptors showed different interactions and/or arrangements with the donor counterpart (PBDB-T), which caused a significant variation in the power conversion efficiency (PCE) of OSCs. The PCE of the PBDB-T:o-F-ITIC device was 11.11% vs. 8.90% of the PBDB-T:m-F-ITIC device. A detailed theor. anal. of the intermol. complexes formed between F-ITICs and PBDB-T allows a determination of how the two isomeric acceptors interact differently with PBDB-T. Relative to PBDB-T:m-F-ITIC with a preferential DCI-BDD complex, PBDB-T:o-F-ITIC showed a closer donor-acceptor interaction, with a tightly packed parallel-like DCI-BDT complex, resulting in larger interfacial areas. These behavioral characteristics explain in detail the exptl. results obtained from the comparison of the two blend systems relating to elec. and morphol. properties. Moreover, transient absorption spectroscopy of PBDB-T:o-F-ITIC revealed superior hole/electron transfer and separation processes, providing further evidence of the presence of beneficial intermol. complexes. This study facilitates the understanding of the role of constitutional isomerism both in intermol. interactions and in promoting the development of high-performance OSCs.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rao, P. Suryachandra published the artcileKinetics and mechanism of the oxidation of phosphinic, phenylphosphinic and phosphorous acids by benzyltrimethylammonium tribromide, SDS of cas: 111865-47-5, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1998), 37B(11), 1129-1132, database is CAplus.

The oxidation of phosphorus-(I) and -(III) oxyacids by benzyltrimethyl ammonium tribromide (BTMAB), in 9:1 (volume/volume) acetonitrile-acetic acid, leads to the formation of corresponding phosphorus-(III) and -(V) oxyacids. The reaction is first order with respect to each of the BTMAB and oxyacid. There is no effect of benzyltrimethylammonium chloride or bromide ion on the reaction rate. The oxidation of deuterated phosphinic and phosphorous acids exhibit the presence of a substantial kinetic isotope effect. The rate decreases with an increase in the proportion of acetic acid in the solvent. It has been shown that the reactive reducing species is the penta-coordinated form of the oxyacid. Tribromide ion has been postulated as the reactive oxidizing species. A mechanism involving a hydride-ion transfer in the rate-determining step has been proposed.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, SDS of cas: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Eseola, Abiodun Omokehinde published the artcileImportance of monodentate mono-ligand designs in developing N-stabilized palladium catalysts for efficient ambient temperature C-C coupling: Donor strengths and steric features, Synthetic Route of 89694-44-0, the publication is Molecular Catalysis (2019), 110398, database is CAplus.

Unfriendly temperature profiles and costs of carbon coupling catalysis, which pose challenge to both synthetic organic chemists as well as industrial applicability, motivated our design of new monodentate N-donors as support ligands for the purpose of constructing ambient temperature precatalysts that are molecularly close to the hypothetical active forms. Therefore, a series of sterically varied monodentate N-donor imidazoles (1-7) and oxazoles (8-9) have been synthesized and their N-donor strengths, which were estimated as pK_as, are systematically varied from 0.9 to 8.5 by substituent variations. Eleven target mono-ligand complexes (1-PdCl₂MeCN – 9-PdCl₂MeCN, 6-PdCl₂PhCN and 7-PdCl₂PhCN) and six trans-bis-ligand complexes (1₂-PdCl₂, 2₂-PdCl₂, 3₂-PdCl₂, 6₂-PdCl₂, 1₂-Pd(OAc)₂ and 2₂-Pd(OAc)₂) were isolated and catalytically studied along with PdI₂(PPh₃)₂. Results of coupling reactions, which were conducted both via in situ ‘Pd(II) salt + ligand’ approach and by use of the precatalysts, show that the mono-ligand precatalyst designs (1-PdCl₂MeCN – 9-PdCl₂MeCN, 6-PdCl₂PhCN and 7-PdCl₂PhCN) represent a true catalyst improvement initiative among the phosphine-free catalyst community; i.e. yields approaching 100% (TOF ≈ 2000) at 0.2 mol % catalyst loading, 45°C and within 15 min. On the other hand, the complexes with trans-bis-ligand coordination were inactive at ambient temperatures Therefore, it was concluded that coordinative saturation, which results from implementing two or more ligand equivalent or use of polydentate ligands on palladium, should be strongly discouraged. Such saturation necessitates the undesirable and avoidable high temperature necessities, long reflux durations and needlessly high catalyst loadings. Correlation between catalyst activity and donor strengths or steric properties were analyzed leading to important conclusions. The catalyst design also supported coupling of activated aryl chlorides from 60°C while Heck coupling activities were observed only at the early minutes of reactions.

Molecular Catalysis published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Synthetic Route of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mercanton, Roger published the artcileBromonaphthalenesulfonic acids, Category: bromides-buliding-blocks, the publication is Helvetica Chimica Acta (1945), 533-9, database is CAplus.

4-Amino-2-naphthalenesulfonic acid gives by the Sandmeyer reaction 71% Na 4-bromo-2-naphthalenesulfonate (I) (Ag salt, 86% yield, Me ester m. 132° (all m.ps. corrected), Et ester m. 90°, acid chloride m. 112.5°, amide m. 183-5°, anilide m. 172°). Similarly is obtained 74% Na 5-bromo-2-naphthalenesulfonate (II) (Ag salt, 96% yield, Me ester m. 110°, Et ester m. 125°, acid chloride m. 100°, amide m. 225°, anilide m. 207.5°). All derivatives of II are less soluble than those of I. The reaction gives 61% K 8-bromo-2-naphthalenesulfonate (III) (Ag salt, 88% yield, Me ester m. 97°, Et ester m. 92.5°, acid chloride m. 120-1.5°, amide m. 193°, anilide m. 170°), and 70% K 2-bromo-1-naphthalenesulfonate (IV) (Ag salt, 87% yield, Me ester m. 93°, Et ester m. 65.5°, acid chloride m. 98°, amide m. 145°, anilide m. 144°). Treatment of the acid chlorides with NaHSO₃ and NaOH gives bromonaphthalenesulfinic acids which with HgCl₂ form bromonaphthylmercuric chlorides. When these are refluxed with Br and KBr in EtOH they form dibromonaphthalenes, I giving the 1,3-, II the 1,6-, III the 1,7-, and IV the 1,2-dibromides.

Helvetica Chimica Acta published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fortuna, Andreia published the artcileSynthesis and Exploitation of the Biological Profile of Novel Guanidino Xylofuranose Derivatives, Name: 1-Bromododecane, the publication is ChemMedChem (2022), 17(14), e202200180, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of novel guanidino sugars as iso-nucleoside analogs is described. 5-Guanidino xylofuranoses containing 3-O-saturated/unsaturated hydrocarbon or aromatic-containing moieties were accessed from 5-azido xylofuranoses via reduction followed by guanidinylation with N,N’-bis(tert-butoxycarbonyl)-N”-triflylguanidine. Mols. comprising novel types of iso-nucleosidic structures including 5-guanidino 3-O-methyl-branched N-benzyltriazole iso-nucleosides and a guanidinomethyltriazole 3′-O-dodecyl xylofuranos-5′-yl iso-nucleoside were accessed. The guanidinomethyl triazole derivative and a 3-O-dodecyl (N-Boc)guanidino xylofuranose were revealed as selective inhibitors of acetylcholinesterase (K_i=22.87 and 7.49μM, resp.). The latter also showed moderate antiproliferative effects in chronic myeloid leukemia (K562) and breast cancer (MCF-7) cells. An aminomethyltriazole 5′-iso-nucleoside was the most potent mol. with low micromolar GI₅₀ values in both cells (GI₅₀=6.33μM, 8.45μM), similar to that of the drug 5-fluorouracil in MCF-7 cells. Moreover, the most bioactive compounds showed low toxicity in human fibroblasts, further indicating their interest as promising lead mols.

ChemMedChem published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Name: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qi, Zhigang published the artcileSynthesis and characterization of acid-base polyimides bearing pendant sulfoalkoxy groups for direct methanol fuel cell applications, Product Details of C3H6BrNaO3S, the publication is Journal of Applied Polymer Science (2015), 132(29), 42238/1-42238/8, database is CAplus.

A series of acid-base polyimides with sulfonic acid groups in the side chains have been prepared, based on a new synthesized sulfonated diamine monomer containing pyridine functional group. The effect of the introduction of pyridine groups into copolymer backbone on the properties of membrane were evaluated through the investigation of membrane parameters. The copolymers produced flexible, tough, and transparent membranes by solvent casting method. All the prepared membranes displayed high thermal stability, great oxidative stability and good mech. properties. They exhibited appropriate water uptake (15.8-30.2 wt % at 80°C) and remarkable dimensional stability (2.5-6.9% at 80°C). The proton conductivity of SPI-80 was 1.01 × 10^-2 S cm^-1 at room temperature Moreover, the methanol permeability of SPI-80 membrane was 1.22 × 10^-7 cm² s^-1, which was lower than 23.8 × 10^-7 cm² s^-1 of Nafion 117. Therefore, these acid-base polyimides materials have a promising prospect for direct methanol fuel cell applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42238.

Journal of Applied Polymer Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Product Details of C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhegalova, Natalia G. published the artcileSynthesis of nitric oxide probes with fluorescence lifetime sensitivity, Quality Control of 53484-26-7, the publication is Organic & Biomolecular Chemistry (2013), 11(47), 8228-8234, database is CAplus and MEDLINE.

The authors present the rationale, synthesis and evaluation of the 1st activatable fluorescent probe that uses fluorescence lifetime change for detection of nitric oxide. The new probe I (R = R’ = H) features a near-IR polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

Organic & Biomolecular Chemistry published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C8H7NaO4S, Quality Control of 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary