Category: bromides-buliding-blocks

Wang, Li-Jun published the artcileSynthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(10), 3473-3479, database is CAplus and MEDLINE.

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds I (R = 4-iodobenzyl), I (R = 4-(trifluoromethyl)benzyl), I (R = 4-nitrobenzyl), I (R = (2-methylthiazol-4-yl)methyl) exhibited significantly inhibitory activities against HBV DNA replication with IC₅₀ values of 5.71, 5.36, 8.90 and 9.08 μM, resp. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C17H18N3NaO3S, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kolycheva, M. T. published the artcileFluorinated benzaldehydes in Leuckart and Rodionov reactions, Computed Properties of 21101-63-3, the publication is Zhurnal Organicheskoi Khimii (1989), 25(11), 2367-72, database is CAplus.

Difluoromethylating RCOR¹ [I; R = 2-HOC₆H₄, R¹ = Me; R = 3,4-(HO)₂C₆H₃, R¹ = H] with ClCHF₂ in Me₂CHOH containing KOH at 70° gave 27-82% I [R = 2-CHF₂OC₆H₄, 3,4-(CHF₂O)₂C₆H₃; same R¹]. These and I (R = 2-CF₃C₆H₄, 2- and 4-CHF₂OC₆H₄; R¹ = H) reacted with HCONH₂ at 150-180° to give 57-82% RCHR¹NHCHO, which were hydrolyzed with concentrated HCl in MeOH to give 25-86% RCHR¹NH₂.HCl (II), and reduced with LiAlH₄ in THF to give 30-52% RCH₂NHMe.HCl (R = 4-CHF₂OC₆H₄, 2-CF₃C₆H₄). RCH₂Br (R = 4-CF₃SC₆H₄, 4-C₂F₅OC₆H₄) reacted with urotropine in CHCl₃ and then with aqueous-alc. HCl to give the corresponding II in 25-74% yield. RCHO (R = 2- and 4-CHF₂OC₆H₄) condensed with CH₂(CO₂H)₂ in EtOH containing NH₄OAc to give 40-52% RCH(NH₂)CH₂CO₂H and 18-35% RCH:CHCO₂H. Analogous treatment of PhCOCF₃ gave 56% CF₃CPh(OH)CH₂CO₂H.

Zhurnal Organicheskoi Khimii published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Computed Properties of 21101-63-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grollier, Kevin published the artcileElectrochemical Trifluoromethylselenolation of Activated Alkyl Halides, Recommanded Product: 1-Bromododecane, the publication is European Journal of Organic Chemistry (2022), 2022(19), e202200123, database is CAplus.

A practical electrochem. method for the generation of CF₃Se^– anion from a shelf-stable reagent (TsSeCF₃) is reported allowing the metal-free trifluoromethylselenolation of activated alkyl halides RCH₂X (X = Br, Cl; R = 4-F-Ph, pyridin-2-yl, 5-nitrofuran-2-yl, undecyl, etc.). Trifluoromethylselenolated compounds RCH₂SeCF₃ have been obtained in modest to excellent yields under the optimized reaction conditions. Finally, cyclic voltammetric and ¹⁹F NMR studies are presented and allowed to gain insight into the reaction mechanism.

European Journal of Organic Chemistry published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Shaohui published the artcileEffect of Decarboxylation on the Photoinitiation Behavior of Nitrocarbazole-Based Oxime Esters, Computed Properties of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(7), 2475-2485, database is CAplus.

A series of 50 oxime esters bearing various substituents were designed and synthesized as photoinitiators (48 of them were never synthesized before and only B1 and B10 were reported). Good light absorption properties in the visible range were observed for these oxime esters. Some structures exhibited better photoinitiation abilities than diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) upon exposure to a LED@405 nm. Interestingly, PIs with Me substituent on the oxime ester group have better photoinitiation performance than the others. Substituent effects were investigated through MOs calculations, the detection of CO₂, and the investigation of the generated free radicals. The results demonstrate that the substituents on the oxime ester group exert major effects on the photoinitiation ability via the decarboxylation reaction. In addition, a chem. mechanism was proposed. 3D printed objects were successfully obtained by using the most reactive oxime ester as photoinitiator, and their thermal initiation behaviors of several oxime esters were also studied (dual thermal/photochem. initiator behavior).

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Computed Properties of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mansour, Mounir published the artcileActivation of aryl halides by Cu⁰/1,10-phenanthroline: Cu⁰ as precursor of Cu^I catalyst in cross-coupling reactions, Quality Control of 25753-84-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2008), 6051-6053, database is CAplus and MEDLINE.

The activation of aryl iodides and bromides by Cu⁰/1,10-phenanthroline in acetonitrile (S) generates Cu^I(phenanthroline)S₂⁺ which can be a catalyst for cross-coupling reactions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 25753-84-8. 25753-84-8 belongs to bromides-buliding-blocks, auxiliary class Copper, name is Bromo(1,10-phenanthroline)(triphenylphosphine)copper(I), and the molecular formula is C30H24BrCuN2P, Quality Control of 25753-84-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhong, Yongliang published the artcileFunctionalized Polyesters via Stereoselective Electrochemical Ring-Opening Polymerization of O-Carboxyanhydrides, Recommanded Product: Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is ACS Macro Letters (2020), 9(8), 1114-1118, database is CAplus and MEDLINE.

Ring-opening polymerization is used to prepare polyesters with precisely controlled mol. weights, mol. weight distributions, and tacticities. Herein, we report a Co/Zn catalytic system that can be activated by an elec. current to mediate efficient ring-opening polymerization of enantiopure O-carboxyanhydrides, allowing for the synthesis of isotactic functionalized polyesters with high mol. weights (>140 kDa) and narrow mol. weight distributions (M_w/M_n < 1.1). We also demonstrate that these catalysts can be used for stereoselective ring-opening polymerization of racemic O-carboxyanhydrides to synthesize syndiotactic or stereoblock copolymers with different glass transition temperatures compared with their atactic counterparts.

ACS Macro Letters published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C18H10F3NO3S2, Recommanded Product: Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Tang, Wei-Ke published the artcileVisible-Light-Enabled Decarboxylative Mono- and Difluoromethylation of Cinnamic Acids under Metal-Free Conditions, Category: bromides-buliding-blocks, the publication is Organic Letters (2017), 19(20), 5501-5504, database is CAplus and MEDLINE.

Several new mono- and difluoromethylation reactions of cinnamic acids using an Eosin Y catalytic system are reported. An efficient alkene fluoromethylation of α,β-unsaturated carboxylic acids, e.g., I, II, and III, was accomplished under ambient temperature and metal-free conditions, with a wide range of functional group tolerance. A mechanism that involves a radical process is proposed for this reaction.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C14H10O4S2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Penglei published the artcileDual functions of a novel low-gap polymer for near infra-red photovoltaics and light-emitting diodes, Safety of 2,5-Dibromo-3,4-dinitrothiophene, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(31), 8820-8822, database is CAplus and MEDLINE.

We have synthesized and characterized a new low-gap conjugated polymer, with a broad absorption profile. In blends with a C₇₀ derivative we demonstrate power conversion efficiencies of 0.76%. We show electroluminescence from the polymer peaking at 956 nm, and quantum efficiency of 0.02% in a blend.

Chemical Communications (Cambridge, United Kingdom) published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Safety of 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Riente, Paola published the artcileShedding light on the nature of the catalytically active species in photocatalytic reactions using Bi₂O₃ semiconductor, COA of Formula: C4H6BrFO2, the publication is Nature Communications (2021), 12(1), 625, database is CAplus and MEDLINE.

The importance of discovering the true catalytically active species involved in photocatalytic systems allows for a better and more general understanding of photocatalytic processes, which eventually may help to improve their efficiency. Bi₂O₃ has been used as a heterogeneous photocatalyst and is able to catalyze several synthetically important visible-light-driven organic transformations. However, insight into the operative catalyst involved in the photocatalytic process is hitherto missing. Herein, we show through a combination of theor. and exptl. studies that the perceived heterogeneous photocatalysis with Bi₂O₃ in the presence of alkyl bromides involves a homogeneous BinBrm species, which is the true photocatalyst operative in the reaction. Hence, Bi₂O₃ can be regarded as a precatalyst which is slowly converted in an active homogeneous photocatalyst. This work can also be of importance to mechanistic studies involving other semiconductor-based photocatalytic processes.

Nature Communications published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, COA of Formula: C4H6BrFO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sorci, Mirco published the artcileVirucidal N95 Respirator Face Masks via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, HPLC of Formula: 143-15-7, the publication is ACS Applied Materials & Interfaces (2022), 14(22), 25135-25146, database is CAplus and MEDLINE.

N95 respirator face masks serve as effective phys. barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration media materials, such as nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability of face masks to protect against infection can be likely improved by incorporating components that deactivate viruses on contact. We present a facile method for covalently attaching antiviral quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics that are commonly used as active filtration materials in N95 respirators via UV-initiated grafting of biocidal agents. Here, C₁₂-quaternized benzophenone is simultaneously polymerized and grafted onto melt-blown or spunbond polypropylene fabric using 254 nm UV light. This grafting method generated ultrathin polymer coatings which imparted a permanent cationic charge without grossly changing the fiber morphol. or air resistance across the filter. For melt-blown polypropylene, which comprises the filtration layer of N95 respirator masks, filtration efficiency was neg. impacted from 72.5 to 51.3% for uncoated and coated single-ply samples, resp. Similarly, directly applying the antiviral polymer to full N95 masks decreased the filtration efficiency from 90.4 to 79.8%. This effect was due to the exposure of melt-blown polypropylene to organic solvents used in the coating process. However, N95-level filtration efficiency could be achieved by wearing coated spunbond polypropylene over an N95 mask or by fabricating N95 masks with coated spunbond as the exterior layer. Coated materials demonstrated broad-spectrum antimicrobial activity against several lipid-enveloped viruses and Escherichia coli bacteria. For example, a 4.3-log reduction in infectious MHV-A59 virus and a 3.3-log reduction in infectious SuHV-1 virus after contact with coated filters were observed, although the level of viral deactivation varied significantly depending on the virus strain and protocol for assaying infectivity.

ACS Applied Materials & Interfaces published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C11H10O, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary