Category: bromides-buliding-blocks

Gokalp, Faik published the artcileTheoretical study of synthesis of 1,3-dibromonaphthanlene, Quality Control of 52358-73-3, the publication is Journal of the Chemical Society of Pakistan (2018), 40(6), 1089-1092, database is CAplus.

Naphthalene derivatives have been attracted the interest for synthesis of natural products having biol. properties. Elimination reaction of tetrabromonaphthalene (1) resulted in the formation of 1,3-dibromonaphthalene (2) rather than 1,4-dibomonaphthalene (3). This phenomenon was explained by theor. investigation. The phys. properties and optimization of tetrabromonaphthalene (1), 1,3-dibromonaphthalene (2) and 1,4-dibromonaphthalene (3) were evaluated by B3lyp/6-31+G(d,p) method. Due to the HOMO-LUMO gap of 1,3-dibromonaphthalene (2) was higher than that of the 1,4-dibomonaphthalene (3), the formation of 1,3-dibromonaphthalene (2) was favorable. Moreover, Higher dipole moment of 1,3-dibromonaphthalene (2) than 1,4-dibomonaphthalene (3) supported the synthesis of 1,3-dibromonaphthalene (2) properly.

Journal of the Chemical Society of Pakistan published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Quality Control of 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

O’Connell, Kathleen M. published the artcileElectron-transfer reactions and associated conformational changes. Electrochemical reduction of some vicinal dibromides, Computed Properties of 594-81-0, the publication is Journal of the American Chemical Society (1983), 105(6), 1473-81, database is CAplus.

The effect of mol. conformation on the electrochem. reduction of derivatives of trans-1,2-dibromocyclohexane and substituted 1,2-dibromoethanes was studied by low-temperature cyclic voltammetry. Reduction via conformations with antiperiplanar Br atoms is preferred, and conformational interconversion prior to electron transfer was observed in trans-1,2-dibromo- (I) and 1,1-dimethyl-trans-3,4-dibromocyclohexane (II), meso– and dl-Ph(CHBr)₂Ph (meso– and dl–III), and Br(CMe₂)₂Br (IV). Digital simulation of the low-temperature voltammetric data provided thermodn. and kinetic information on the conformational interconversion in I, II, III, and IV. The energy barriers to conformational interconversion in meso– and dl-Me(CHBr)₂Me (meso– and dl–V) are quite small, and conformational effects in the electrochem. reduction of V could not be detected at -135°. 1-Methyl-cis-3,trans-4- (VI) and –trans-3,cis-4-dibromocyclohexane (VII) and meso– and dl-Me₂CH(CHBr)₂CHMe₂ (meso– and dl–VIII) exist almost entirely in a single conformation. Voltammetric peak potentials of VI, VII, and meso– and dl–VIII reflect the geometry of their principal conformation.

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Computed Properties of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Belyaeva, T. N. published the artcileSanguinarine cytotoxicity for transformed mouse fibroblast L-cells in culture, sensitive and resistant to ethidium bromide, as compared to that of some other DNA-complexing agents, Safety of Dimidium bromide, the publication is Tsitologiya (1989), 31(11), 1363-8, database is CAplus.

A natural DNA intercalator, the benzo[c]phenanthridine alkaloid sanguinarine, is more toxic to mouse transformed fibroblast L-cells in culture than the synthetic DNA intercalator ethidium bromide (EtB) and the alkaloid berberine. Dimidium bromide is also an inhibitor of L-cell growth. In assay conditions, growth of L-cells is stopped by 1.5 x 10^-5M sanguinarine. Lebr-625 cells, resistant to 25 μg EtB/mL, have sanguinarine sensitivity close to that of L-cells, but Lebr-625 cells are resistant to dimidium bromide. Sanguinarine is more toxic to L-cells in culture than the anticancer drug cis-Pt(NH₃)₂Cl₂. trans-Pt(NH₃)₂Cl₂ is less toxic to these cells. The strong toxicity of sanguinarine for L- and Lebr-625 cells in culture, as compared to other DNA-complexing drugs, seems to be associated with the wide range of potential cell targets for sanguinarine. Besides the inhibition of nucleic acid metabolism reactions, characteristic of DNA intercalators, and disruption of mitochondrial ATP synthesis, also characteristic of organic heterocyclic cationic DNA intercalators, sanguinarine can modify the SH groups of enzymes including SH-sensitive membrane-bound Na⁺, K⁺-ATPase of cerebral cortex and Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum.

Tsitologiya published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yang, Wenqian published the artcileThe First Fluorescent Diboronic Acid Sensor Specific for Hepatocellular Carcinoma Cells Expressing Sialyl Lewis X, Safety of 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, the publication is Chemistry & Biology (2004), 11(4), 439-448, database is CAplus and MEDLINE.

Carbohydrate antigens with subterminal fucosylation have been implicated in the development and progression of several cancers, including hepatocellular carcinoma (HCC). Fluorescent sensors targeting fucosylated carbohydrate antigens could potentially be used for diagnostic and other applications. The authors have designed and synthesized a series of 26 diboronic acid compounds as potential fluorescent sensors for such carbohydrates. Among these compounds, 7q was able to fluorescently label cells expressing high levels of sLex (HEPG2) within a concentration range of 0.5 to 10 μM. This compound (7q) did not label cells expressing Lewis Y (HEP3B), nor cells without fucosylated antigens (COS7). This represents the first example of a fluorescent compound labeling cells based on cell surface carbohydrate structures.

Chemistry & Biology published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C7H7ClN2, Safety of 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lu, Xuefeng published the artcileControlling the Charge Transfer in D-A-D Chromophores Based on Pyrazine Derivatives, SDS of cas: 52431-30-8, the publication is Journal of Organic Chemistry (2014), 79(14), 6480-6489, database is CAplus and MEDLINE.

A series of sym. donor-acceptor-donor (D-A-D) chromophores bearing various electron-withdrawing groups, such as quinoxaline (Qx), benzo[g]quinoxaline (BQ), phenazine (Pz), benzo[b]phenazine (BP), thieno[3,4-b]pyrazine (TP), and thieno[3,4-b]quinoxaline (TQ), was designed and synthesized. Intramol. charge transfer (ICT) interactions can be found for all the chromophores due to the electron-withdrawing properties of the two imine nitrogens in the pyrazine ring and the electron-donating properties of the other two amine nitrogens in the two triphenylamines. Upon the fusion of either benzene or thiophene ring on the pyrazine acceptor unit, the ICT interactions are strengthened, which results in the bathochromically shifted ICT band. Moreover, the thiophene ring is superior to the benzene ring in enlarging the ICT interaction and expanding the absorption spectrum. Typically, when a thiophene ring is fused on the Qx unit in DQxD, a near-IR dye is realized in simple chromophore DTQD, which displays the maximum absorption wavelength at 716 nm with the threshold over 900 nm. This is probably due to the enhanced charge d. on the acceptor moiety and better orbital overlap, as revealed by theor. calculation These results suggest that extending the conjugation of a pyrazine acceptor in an orthogonal direction to the D-A-D backbone can dramatically improve the ICT interactions.

Journal of Organic Chemistry published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, SDS of cas: 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Shipeng published the artcileThe remarkable role of hydrogen bond, halogen, and solvent effect on self-healing supramolecular gel, Recommanded Product: 1-Bromooctane, the publication is Materials Today Chemistry (2022), 100719, database is CAplus.

Self-healing supramol. gels of low-mol.-weight (LMW) mols. are smart soft materials; however, the development of self-healing LMW gelator is still a challenging task because of the lack of in-depth studies about self-healing mechanisms of LMW gels and the solvent effect on gel properties. Therefore, herein a different perspective was used to study a family of D-gluconic acetal-based gelators with variable structural fragments in 14 different solvents, and a more detailed understanding of self-assembly and self-healing mechanism of supramol. gels was attained. Based on the critical gelation concentration, phase transition temperature, and rheol. data, A8 bearing an amide group in side chain and two chlorine atoms linked to benzene ring was found to be an outstanding gelator, which could form gels with good self-healing ability in a variety of solvents. Interestingly, A8 gel formed in n-BuOH demonstrates high transparency, good mech. strength, self-supporting behavior, and great self-healing ability from mech. damage. Based on the Fourier transform IR spectroscopy, NMR spectroscopy, XPS, X-ray diffraction, and theor. calculation anal., the self-assembly and self-healing mechanisms of A8 gel were proposed, indicating that a combination of hydrogen bonding and halogen effect was responsible for the efficient self-healing behavior of supramol. gel. Furthermore, the anal. of solvent parameters indicated that the dispersion force of solvent favored gelators to self-assemble, hydrogen bonding donor ability of solvent mainly affected the formation of one-dimensional assembly, and hydrogen bonding receptor ability and polarity of solvent mainly influenced the supramol. interactions among assemblies, significantly intervening the self-healing ability of gels. Overall, this study provides a new perspective to the understanding of gelator structure-property correlation in solvents and sheds light for future development of self-healing supramol. gels.

Materials Today Chemistry published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Recommanded Product: 1-Bromooctane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dokla, Eman M. E. published the artcileDevelopment of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators, Product Details of C8H6BrF3S, the publication is ChemMedChem (2015), 10(11), 1915-1923, database is CAplus and MEDLINE.

Previously, the authors reported the identification of a thiazolidinedione-based adenosine monophosphate activated protein kinase (AMPK) activator, compound 1 (N-(4-((3-((1-methylcyclohexyl)methyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-4-nitro-3-(trifluoromethyl)benzenesulfonamide), which provided a proof of concept to delineate the intricate role of AMPK in regulating oncogenic signaling pathways associated with cell proliferation and epithelial-mesenchymal transition (EMT) in cancer cells. In this study, the authors used compound 1 as a scaffold to conduct lead optimization, which generated a series of derivatives Anal. of the antiproliferative and AMPK-activating activities of individual derivatives revealed a distinct structure-activity relationship and identified 59 (N-(3-nitrophenyl)-N’-(4-((3-((3,5-bis(trifluoromethyl)phenyl)methyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)urea) as the optimal agent. Relative to 1, compound 59 exhibits multifold higher potency in upregulating AMPK phosphorylation in various cell lines irresp. of their liver kinase B1 (LKB1) functional status, accompanied by parallel changes in the phosphorylation/expression levels of p70S6K, Akt, Foxo3a, and EMT-associated markers. Consistent with its predicted activity against tumors with activated Akt status, orally administered 59 was efficacious in suppressing the growth of phosphatase and tensin homolog (PTEN)-null PC-3 xenograft tumors in nude mice. Together, these findings suggest that 59 has clin. value in therapeutic strategies for PTEN-neg. cancer and warrants continued investigation in this regard.

ChemMedChem published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Product Details of C8H6BrF3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yin, Yan published the artcileSynthesis and properties of highly sulfonated proton conducting polyimides from bis(3-sulfopropoxy)benzidine diamines, Related Products of bromides-buliding-blocks, the publication is Journal of Materials Chemistry (2004), 14(6), 1062-1070, database is CAplus.

Two novel sulfonated diamine isomers, 2,2′-bis(3-sulfopropoxy)benzidine (2,2′-BSPB) and 3,3′-bis(3-sulfopropoxy)benzidine (3,3′-BSPB), were successfully synthesized and the highly sulfonated polyimides (SPIs) with sulfonic acid groups in the side chains were prepared from 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTDA) and BSPB monomers. Transmission electron microscopy (TEM) anal. revealed that these side-chain-type SPI membranes have a microphase-separated structure composed of hydrophilic side chain domains and hydrophobic polyimide main chain domains. They showed high proton conductivities similar to or higher than those of Nafion 117 in the high relative humidity range (>70% RH). The proton conducting behavior was analyzed by percolation theory. Despite their high ion exchange capacity (IEC = 2.89 meq. g^-1) and high water uptakes, they displayed much better water stability than common sulfonated polyimides with the sulfonic acid groups directly bonded to the polymer backbone. This is probably due to the microphase-separated structure of the membrane and the strong basicity of BSPB diamine moieties resulting from the electron donating effect of the propoxy groups. The sulfopropoxy groups were stable against aging in acidic aqueous solution at 373 K. Both the polyimide membranes showed good mech. strength under high moisture conditions (about 6 GPa at 90% RH) and displayed anisotropic membrane swelling.

Journal of Materials Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C11H10N4, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yin, Yan published the artcileSynthesis, proton conductivity and methanol permeability of a novel sulfonated polyimide from 3-(2′,4′-diaminophenoxy)propane sulfonic acid, HPLC of Formula: 55788-44-8, the publication is Polymer (2003), 44(16), 4509-4518, database is CAplus.

A novel sulfonated diamine monomer, 3-(2′,4′-diaminophenoxy)propane sulfonic acid (DAPPS), was successfully synthesized and the sulfonated polyimide (SPI) was prepared from 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTDA) and DAPPS. The resulting SPI, NTDA-DAPPS, was soluble in common organic solvents. The SPI membrane displayed proton conductivity σ values of 0.12-0.35 S/cm at temperatures ranging from 35 to 90 °C in liquid water, which were similar to or higher than those of Nafion 117 and sulfonated hydrocarbon polymers. The σ of the SPI membrane decreased significantly with decreasing relative humidity (RH) and became much lower than that of Nafion 117 at 30% RH. The SPI membrane displayed good water stability at 80 °C and was thermally stable up to 240 °C. It showed reasonable mech. strength of a modulus of 1.3 GPa at 90 °C and 90% RH. Its methanol permeability P_M was 0.57×10^-6 cm²/s at 30 °C and 8.6 wt% methanol in feed, which was a fourth of that of Nafion 117. As a result, its ratio of σ/P_M was 21×10⁴ S cm^-3 s, which was about 4 times larger than that of Nafion 117, suggesting potential application of the SPI membrane for direct methanol fuel cell.

Polymer published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C22H21N3O3S, HPLC of Formula: 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shi, Hang published the artcileTotal Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed Tandem Reaction, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of the American Chemical Society (2011), 133(38), 14944-14947, database is CAplus and MEDLINE.

Development of a gold-catalyzed tandem reaction of 1,7-diynes with both internal and external nucleophiles was realized, which constructed five chem. bonds, two rings, and two stereogenic centers in a single step. Based on the novel cascade transformation, we achieved a unified strategy toward the stereoselective total syntheses of C-15 oxygenated drimane-type sesquiterpenoids and their analogs, which provided the natural products kuehneromycin A, antrocin, anhydromarasmone, and marasmene as a proof-of-concept study.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C5H12O2, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary