Category: bromides-buliding-blocks

Mederski, WWKR published the artcileNovel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridines. Potent angiotensin II receptor antagonists with high affinity for both the AT₁ and AT₂ subtypes, Product Details of C7H5Br2F, the publication is European Journal of Medicinal Chemistry (1997), 32(6), 479-491, database is CAplus.

The synthesis and pharmacol. activity of balanced high affinity non-peptide angiotensin II antagonists of the AT₁ and AT₂ subtype receptors have been presented. A series of previously prepared AT₁ selective 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]-pyridines were modified at four different positions in order to increase the AT₂ binding affinity by maintaining the nanomolar activity for the AT₁ receptor. The targeted AT₂/AT₁ IC₅₀ binding ratio of ∼ 1 was achieved with a number of compounds possessing a small alkyl chain at C-2, different acetamide groups at N-5 and a 3-fluoro and 2′-carboxamidosulfonyl substituent at the biphenylmethyl moiety. These modifications led to an analog which exhibited an AT₂/AT₁ ratio of 0.74, a subnanomolar AT₁ antagonistic potency (0.18 nM) and a high metabolic stability in rat and monkey liver microsomes in vitro. After oral administration of 3 mg/kg to cynomolgus monkeys, EMD 90423 (potassium salt of the active analog) demonstrated good efficacy and a long duration of action as an antihypertensive agent.

European Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Taylor, Edward C. published the artcileReplacement of the 1′,4′-Phenylene Region in 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF) by 4,5,6,7-Tetrahydrobenzo[c]thiophene and 4,5,6,7-Tetrahydroisobenzofuran Nuclei, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Organic Chemistry (1997), 62(6), 1599-1603, database is CAplus.

Two new analogs of DDATHF, in which the 1′,4′-phenylene unit is replaced by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisobenzofuran nuclei, have been prepared and evaluated for in vitro cytotoxicity, glycinamide ribonucleotide formyltransferase (GARFT) inhibition, and folyl polyglutamate synthetase (FPGS) affinity as potential antitumor agents.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C8H8O3, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Pels, Kevin published the artcileSolvent-free phase-vanishing reactions with PTFE (Teflon) as a phase screen, Synthetic Route of 594-81-0, the publication is Beilstein Journal of Organic Chemistry (2009), No pp. given, NO. 75, database is CAplus and MEDLINE.

In a solvent-free phase-vanishing reaction with PTFE (polytetrafluoroethylene, Teflon) tape as the phase screen, a thermometer adapter is utilized to insert a PTFE-sealed tube into the vapor phase above the substrate. Besides avoiding use of solvents, the exptl. design is not dependent upon the densities of the reactants and the procedure generates little or no waste while providing the reaction products in high yield and in high purity.

Beilstein Journal of Organic Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Synthetic Route of 594-81-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Windmon, Nicole published the artcileThe role of neat substrates in phase-vanishing and tandem phase-vanishing reactions, Product Details of C6H12Br2, the publication is Tetrahedron Letters (2008), 49(46), 6543-6546, database is CAplus.

Phase-vanishing reactions are triphasic reactions, which involve a reagent, a liquid perfluoroalkane as a phase screen, and a substrate. Aromatization, isomerization, and halogenation of neat substrates under phase-vanishing conditions gave the expected products in good to excellent yields. In tandem single-phase-phase-vanishing reaction, two reactants, placed in the top phase, afforded the intermediate, which in a subsequent phase-vanishing reaction reacted with the reagent from the bottom phase to give the final product. The reaction worked well under solvent-free conditions on liquid substrates and intermediates. With solids, results were better if an addnl. solvent was employed.

Tetrahedron Letters published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C9H6N2O2, Product Details of C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qi, Ji published the artcileSimultaneously boosting the conjugation, brightness and solubility of organic fluorophores by using AIEgens, Recommanded Product: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Chemical Science (2020), 11(32), 8438-8447, database is CAplus and MEDLINE.

Organic near-IR (NIR) emitters hold great promise for biomedical applications. Yet, most organic NIR fluorophores face the limitations of short emission wavelengths, low brightness, unsatisfactory processability, and the aggregation-caused quenching effect. Therefore, development of effective mol. design strategies to improve these important properties at the same time is a highly pursued topic, but very challenging. Herein, aggregation-induced emission luminogens (AIEgens) are employed as substituents to simultaneously extend the conjugation length, boost the fluorescence quantum yield, and increase the solubility of organic NIR fluorophores, being favorable for biol. applications. A series of donor-acceptor type compounds with different substituent groups (i.e., hydrogen, Ph, and tetraphenylethene (TPE)) are synthesized and investigated. Compared to the other two analogs, MTPE-TP3 with TPE substituents exhibits the reddest fluorescence, highest brightness, and best solubility Both the conjugated structure and twisted conformation of TPE groups endow the resulting compounds with improved fluorescence properties and processability for biomedical applications. The in vitro and in vivo applications reveal that the NIR nanoparticles function as a potent probe for tumor imaging. This study would provide new insights into the development of efficient building blocks for improving the performance of organic NIR emitters.

Chemical Science published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Recommanded Product: 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Yang published the artcileEffect of Alkanolamide on Interfacial Tension and Loss of Petroleum Sulfonates for Enhanced Oil Recovery, Recommanded Product: Dimidium bromide, the publication is Journal of Dispersion Science and Technology (2010), 31(6), 722-726, database is CAplus.

Exptl. studies are conducted in order to elucidate the mechanisms of monoethanolamide responsible for synergism on lowering interfacial tension and decreasing loss due to adsorption on surface of reservoir sand and precipitation with multivalent cations in model oil/water/surfactants/brine systems. The interfacial tensions between solutions containing crude oil and monoethanolamide, petroleum sulfonates, or mixture of monoethanolamide and petroleum sulfonates at different ratios are studied without any alkali added in the solution The results show significant synergic effect between monoethanolamide and petroleum sulfonates can reduce the interfacial tension to ultralow. Adsorption isotherms of monoethanolamide, petroleum sulfonates and mixture solution are determined to assess the effect of monoethanolamide on reducing the loss of petroleum sulfonates in formation. Static adsorption experiments indicate that the loss of petroleum sulfonates for adsorption and precipitation can be reduced on a great degree when monoethanolamide is mixed with petroleum sulfonates. The core-flooding tests show that the enhanced oil recovery with the formulation of surfactants of 0.3 wt% petroleum sulfonates and 0.2 wt% monoethanolamide can be increased by 26.6% without any alkali added in the flooding solution

Journal of Dispersion Science and Technology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Yang published the artcileInfluence of polymer on oil displacement efficiency of petroleum sulfonates system, Safety of Dimidium bromide, the publication is Xinan Shiyou Daxue Xuebao, Ziran Kexueban (2009), 31(5), 135-138, database is CAplus.

The effect of polymer, such as partially hydrolyzed polyacrylamide, on the dynamic and equilibrium interfacial tension of petroleum sulfonates and oil/water systems is examined It is testified that polymer added in a certain concentration scope in the system only prolongs the time which the system needs to reach at the equilibrium interfacial tension, but the ability of the system for washing oil is not influenced. The simulation test by changing the injection sequence or injection mode of polymer and petroleum sulfonate indicates that the maximum oil displacement efficiency is acquired by the injection mode in which the petroleum sulfonate solution is injected after polymer flooding. The main reason is the decrease of adsorption site on the surface of rock for the adsorption of partially hydrolyzed polyacrylamide by hydrogen bond and the reduction of association body formed by polar group, so the loss of petroleum sulfonate in the core is decreased, as a result, the oil displacement efficiency of petroleum sulfonate for enhanced oil recovery is relatively increased.

Xinan Shiyou Daxue Xuebao, Ziran Kexueban published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Jixin published the artcileSalt-Stabilized Silylzinc Pivalates for Nickel-Catalyzed Carbosilylation of Alkenes, Product Details of C7H5Br2F, the publication is Angewandte Chemie, International Edition (2022), 61(17), e202202379, database is CAplus and MEDLINE.

The authors herein report the preparation of solid and salt-stabilized silylzinc pivalates from the corresponding silyllithium reagents via transmetalation with Zn(OPiv)₂. These resulting organosilylzinc pivalates show enhanced air and moisture stability and unique reactivity in the silylative difunctionalization of alkenes. Thus, a practical chelation-assisted Ni-catalyzed regioselective alkyl and benzylsilylation of alkenes was developed, which provides an easy method to access alkyl silanes with broad substrate scope and wide functional group compatibility. Kinetic experiments highlight that the OPiv-coordination is crucial to improve the reactivity of silylzinc pivalates. Also, late-stage functionalizations of druglike mols. and versatile modifications of the products illustrate the synthetical utility of this protocol.

Angewandte Chemie, International Edition published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C12H16N2O2, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Azizov, Ilgar published the artcileStudying droplet retention in porous media by novel microfluidic methods, Synthetic Route of 143-15-7, the publication is Chemical Engineering Science (2022), 248(Part_A), 117152, database is CAplus.

Transport of oil drops through porous media is an important topic in the oil and gas industry. Oil drops that are present in produced water contribute to injectivity decline during re-injection due to retention in pores. In the literature, the retention phenomenon is typically studied by means of core/packed bed flooding, which struggles to provide a simple and inexpensive way to visualize retention events at the pore scale. This paper demonstrates a microfluidic method for studying the transport of dilute oil-in-water emulsions through porous media. The method allows identification of every single retention event at the capillary level and quant. anal. of the spatial distribution of the retained drops over pore volumes injected. Experiments were carried out for monodisperse and tailored polydisperse emulsions. Moreover, several drop sizes, flow rates, and dispersed phase concentrations were tested. The results showed that the drop size has a dramatic effect on the pore clogging. Drops that are larger than pore throats underwent complete retention, while drops that are smaller than pore throats showed little to no retention in the monodisperse emulsion experiments Addnl., the experiments with polydisperse emulsions showed that the larger drops are facilitators for the retention of the smaller drops, and the latter are unlikely to experience significant retention independently of the former. The flow rates affected flow re-entry mechanisms of the larger drops, while for the smaller drops it affected only the number of retention events. It was identified that dispersed phase concentration has a significant effect in experiments with limited pore volumes injected. At low concentration, the obtained statistical sample was not sufficiently large to unravel the trends. The developed method presents a solid foundation for further experiments and developments in microfluidic studies of the emulsion transport.

Chemical Engineering Science published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Synthetic Route of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rudler, H. published the artcileTungsten(0) alkylidene complexes stabilized as pyridinium ylides: new aspects of their synthesis and reactivity, Recommanded Product: (2-Bromoethyl)cyclopentane, the publication is Journal of Organometallic Chemistry (2001), 571-587, database is CAplus.

The interaction of dihydropyridines with alkoxycarbene complexes of tungsten has been shown to lead to pyridinium ylide complexes: this transformation has now been applied to the synthesis of a hydroxyl-containing ylide complex by ring-opening of the pentacarbonyl (2-oxacyclopentylidene)tungsten(0) complex and to the synthesis of a series of chiral ylide complexes both from chiral and non-chiral carbene complexes by the use of dihydropyridines and dihydronicotines, resp. The transfer of the alkylidene moiety of these complexes to nucleophilic olefins will be outlined and discussed. Especially relevant is the interaction of these pyridinium ylide complexes with unsaturated substrates such as dihydropyridines, enamines, and β-alkoxy bis(trimethylsilyl) ketene acetals. This latter reaction leads to conjugated carboxylic acids, and has been be applied to a new synthesis of a honey bee pheromone, the queen substance.

Journal of Organometallic Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Recommanded Product: (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary