Category: bromides-buliding-blocks

Caputo, Paolino published the artcilePolyalkylated gallic esters and acids, high performant warm mix asphalt and adhesion promoters for bitumen, Quality Control of 111-83-1, the publication is International Journal of Adhesion and Adhesives (2022), 103228, database is CAplus.

The main use of bitumen is the construction of road pavements due to its role as binder in asphalt concrete. For this specific scope, it is important for bitumen to have low viscosity so that the working temperature is the lowest possible. This would allow it to be easily processed while reducing the toxic fumes emanated during coating. Furthermore, the final product must be resistant to aging phenomenon and harsh weather conditions while also having a good affinity with the stones underneath in order to avoid its peeling off the road with time. To achieve all these stipulated objectives, the addition of chem. additives to asphalt concrete is being studied. In the present study, bitumen has been modified by incorporating (1% weight/weight) alkylated gallic esters and acids of alkyl chains of different length (8, 14 and 18 carbon atoms) in low amounts with the aim of improving the rheol. properties of bitumen as well as increasing the interaction forces between bitumen and stone aggregates usually employed as underneath layer for road pavement. For this purpose, gallic ester/acid additives were tested as rheol. modifiers, adhesion activators and Warm Mix Asphalt (WMA) agents through Differential Scanning Calorimetry, Thermogravimetric measurements, Dynamic Shear Rheol. and Boiling tests. The results show that alkylated gallic acids are bad WMA candidates increasing the viscosity of bitumen while corresponding gallic Me esters are excellent for WMA showing that the shorter the chain, the better the performance. Thus, C8 alkylated Me gallate decreases the overall viscosity of bitumen of about 70 Pa s at 70°C, which is nearly 4 times better than what commonly employed com. waxes provide. Furthermore, gallic ester and acid derivatives are excellent adhesion activators showing increased efficiency as the alkyl chain length increases reaching a 95% coverage on Trentino porphyry stones obtained from the boiling test carried out on the C18 alkylated Me gallate sample.

International Journal of Adhesion and Adhesives published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, Quality Control of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Goodman, Allan J. published the artcileCB₂ selective sulfamoyl benzamides: Optimization of the amide functionality, Synthetic Route of 111865-47-5, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(2), 309-313, database is CAplus and MEDLINE.

Previous research within our laboratories identified sulfamoyl benzamides as novel cannabinoid receptor ligands. Optimization of the amide linkage led to the reverse amide 40. The compound exhibited robust antiallodynic activity in a rodent pain model when administered i.p. Efficacy after oral administration was observed only when ABT, a cytochrome P 450 suicide inhibitor, was coadministered.

Bioorganic & Medicinal Chemistry Letters published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Synthetic Route of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hagiwara, Keita published the artcileAn aqueous molecular tube with polyaromatic frameworks capable of binding fluorescent dyes, Category: bromides-buliding-blocks, the publication is Chemical Science (2015), 6(1), 259-263, database is CAplus and MEDLINE.

An aqueous mol. tube composed of polyaromatic frameworks with peripheral hydrophilic groups was prepared The new tube had a well-defined hydrophobic cavity with a diameter of 1̃ nm and quant. could bind two mols. of fluorescent coumarin dyes in aqueous solutions The bound coumarin dimers in a stacked fashion exhibited unusual excimer-like emissions in the confined space through efficient host-guest energy transfer.

Chemical Science published new progress about 401797-04-4. 401797-04-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters,Boronic acid and ester, name is 2-(3-Bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C13H18BBrO3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Uner, Osman published the artcileMicellization and thermodynamics study of n-alkyl-4-methylpyridinium bromides in water and mixed water-ethanol media, HPLC of Formula: 143-15-7, the publication is Journal of Molecular Liquids (2022), 118765, database is CAplus.

The micellization behaviors of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide were studied in water and mixed water-ethanol media by using conductivity measurements over the temperature range of 293.15-318.15 K. The critical micelle concentrations (CMC) of all n-alkyl-4-Me pyridinium bromides studied increased with increasing temperature, but they decreased with increasing hydrocarbon chain length. Their CMC values of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide in water at the temperature range of 293.15-318.15 K were determined as in the range of 43.62-46.42, 10.45-11.57, and 2.78-3.20 mM, resp. Moreover, the lowest CMC values of n-decyl-4-methylpyridinium bromide, n-dodecyl-4-methylpyridinium bromide, and n-tetradecyl-4-methylpyridinium bromide were found with 15, 5, and 5 vol% ethanol additions, resp. The calculated neg. ΔG_m⁰ and ΔH_m⁰ values proved that their micellizations in water and mixed water-ethanol media were spontaneous and exothermic. Also, ΔG_m⁰ values became the more neg. with the longer the hydrocarbon chain length. Furthermore, their micellization processes in water were determined to be entropy controlled, however enthalpic contributions in the mixed water-ethanol systems started to predominate with increasing ethanol concentrations and/or temperature

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C21H37BO, HPLC of Formula: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lutteke, Ginger published the artcileFormation of bicyclic pyrroles and furans through an enone allene photocycloaddition and fragmentation sequence, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is European Journal of Organic Chemistry (2008), 925-933, database is CAplus.

The [2 + 2] photocycloaddition of dimedone-substituted allenes was studied. Irradiation of a solution of these substrates in acetonitrile at 300 nm resulted in the clean conversion of the starting materials into a mixture of photoproducts. The major product in all cases was a bicyclic pyrrole or furan fused to an eight membered ring (43-70% yield). The formation of these products is thought to be a result of a heteroatom-induced fragmentation of the straight adduct. This is supported by irradiation of 3-(penta-3,4-dienyl)cyclohex-2-en-1-one which allowed the isolation of tricyclic adduct after catalytic hydrogenation in 27 %. The minor crossed photoproducts were isolated in 10-20% yield. The observed major/minor ratio of 4:1 was not affected by the variation of substituents on the cyclohexene ring. Introduction of a substituent on the allene had a more significant effect on the ratio which changed to 2:1.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Palmer, Wylie S. published the artcileDevelopment of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): Kinase profiling guided optimization of a 1,2,3-benzotriazole lead, SDS of cas: 16523-02-7, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(5), 1486-1492, database is CAplus and MEDLINE.

A series of amino-pyrimidines was developed based upon an initial kinase cross-screening hit from a CDK2 program. Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and selective JNK inhibitor, compound 24f (JNK1 and 2 IC₅₀ = 16 and 66 nM, resp.), with bioavailability in rats and suitable for further in vivo pharmacol. evaluation.

Bioorganic & Medicinal Chemistry Letters published new progress about 16523-02-7. 16523-02-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Sulfone,Aliphatic hydrocarbon chain, name is 2-Bromoethyl Methyl Sulfone, and the molecular formula is C3H7BrO2S, SDS of cas: 16523-02-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Martins, Nayara Silva published the artcileDibromination of alkenes with LiBr and H₂O₂ under mild conditions, Formula: C6H12Br2, the publication is New Journal of Chemistry (2018), 42(1), 161-167, database is CAplus.

Electron-rich and electron-poor alkenes, and alkenes bearing protecting groups can be efficiently and stereoselectively converted to trans-dibromides using LiBr/H₂O₂ and AcOH as a proton source in 1,4-dioxane. For most substrates addition of 0.1 mol% of PhTeTePh enhances the reaction rate and the yield of the products. Exptl. data suggest that the brominating agent prepared in situ is mol. bromine and that LiBr assists the activation of H₂O₂ allowing bromination to occur using AcOH as a mild proton source in uncatalyzed experiments Scale-up is feasible: 10.0 mmol of 1-octene was quant. converted to 1,2-dibromooctene in one hour of reaction at room temperature

New Journal of Chemistry published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Formula: C6H12Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Palais, Laetitia published the artcileCopper-Catalyzed Asymmetric Conjugate Addition with Chiral SimplePhos Ligands, Related Products of bromides-buliding-blocks, the publication is Chemistry – A European Journal (2009), 15(40), 10473-10485, S10473/1-S10473/113, database is CAplus and MEDLINE.

SimplePhos ligands, e.g., I [R = Ph, 3-(F₃C)C₆H₄, 3,5-Me₂C₆H₃], represent a novel class of monodentate chiral ligands based on a chiral amine moiety and flexible diaryl groups on the phosphorous atom. They were easily prepared by two different pathways and could be highly functionalized. Their application as ligands in the copper-catalyzed asym. conjugate addition of di-Et zinc and trialkylaluminum reagents to cyclic enones, acyclic enones and nitroalkenes was reported, and resulted in giving high enantioselectivity with up to 98.6% ee. In particular, the reaction of trialkylaluminum reagents with a wide range of 3-substituted enones allowed the formation of stereogenic quaternary carbon centers.

Chemistry – A European Journal published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Al-Hamouz, Othman Charles S. published the artcilepH-responsive polyphosphonates using butler’s cyclopolymerization, COA of Formula: C5H12BrO3P, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(17), 3580-3591, database is CAplus.

The cationic monomer, N,N-diallyl-(diethylphosphonato)methylammonium chloride, and zwitterionic monomer, Et 3-(N,N-diallylammonio)methanephosphonate, were cyclopolymd. in aqueous solutions using ammonium persulfate or t-butylhydroperoxide as initiators to afford a cationic polyelectrolyte (CPE) and a polyzwitterion ester (PZE), resp. The CPE and PZE on acidic hydrolysis of the ester functionalities afforded the same polyzwitterionic acid (PZA): poly[3-(N,N-diallylammonio)methanephosphonic acid]. The solution properties of the CPE, pH-responsive PZE, and PZA were studied in detail by potentiometric and viscometric techniques. Basicity constants of the phosphonate (P=O(OEt)O^–) and amine groups in the PZE and in the conjugate base of the PZE, resp., were found to be “apparent” and as such follow the modified Henderson-Hasselbalch equation. In contrast to many polycarbobetaines and sulfobetaines, PZE was found to be soluble in salt-free water as well as salt (including Ca²⁺, Li⁺)-added solutions, and demonstrated “antipolyelectrolyte” solution behavior. The PZA, on the other hand, was found to be insoluble in salt-free water, and on treatment with NaOH gave dianionic polyelectrolyte (DAPE) containing trivalent nitrogen and [P=O(O)₂^2-] groups. For the first time, several new phase diagrams of polyethylene glycol-DAPE aqueous two-phase systems (ATPSs) have been constructed in the presence of varying proportions of HCl. The ATPSs may find application in affinity partitioning of metal ions because DAPE is expected to be an effective chelator. © 2012 Wiley Periodicals, Inc., J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, COA of Formula: C5H12BrO3P.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qiu, Hui published the artcileDiscovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors, Quality Control of 76283-09-5, the publication is Bioorganic & Medicinal Chemistry (2021), 116163, database is CAplus and MEDLINE.

Bruton’s tyrosine kinase (BTK) is a cytoplasmic, non-receptor tyrosine kinase member of the TEC family of tyrosine kinases. Pre-clin. and clin. data have shown that targeting BTK can be used for the treatment for B-cell disorders. Here we disclose the discovery of a novel imidazo[4,5-b]pyridine series of potent, selective reversible BTK inhibitors through a rational design approach. From a starting hit mol. I, medicinal chem. optimization led to the development of a lead compound II, which exhibited 58 nM BTK inhibitory potency in human whole blood and high kinome selectivity. Addnl., the compound demonstrated favorable pharmacokinetics (PK), and showed potent dose-dependent efficacy in a rat CIA model.

Bioorganic & Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Quality Control of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary