Category: bromides-buliding-blocks

Cabre, Albert published the artcileHighly Enantioselective Iridium-Catalyzed Hydrogenation of 2-Aryl Allyl Phthalimides, Recommanded Product: (R)-tert-Butyl (2-(4-bromophenyl)propyl)carbamate, the main research area is beta aryl methyl amine preparation enantioselective; aryl allyl phthalimide hydrogenation iridium catalyst.

The iridium-catalyzed asym. hydrogenation of 2-aryl allyl phthalimides to afford enantioenriched β-aryl-β-Me amines is presented. Recently developed Ir-MaxPHOX catalysts are used for this enantioselective transformation. The mild reaction conditions and the feasible removal of the phthalimido group makes this catalytic method easily scalable and of great interest to afford chiral amines. The importance of this new methodol. is exemplified by the formal synthesis of (R)-Lorcaserin, OTS514, and enantiomerically enriched 3-Me indolines.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 211315-53-6 belongs to class bromides-buliding-blocks, name is (R)-tert-Butyl (2-(4-bromophenyl)propyl)carbamate, and the molecular formula is C14H20BrNO2, Recommanded Product: (R)-tert-Butyl (2-(4-bromophenyl)propyl)carbamate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ambartsumova, R. F. published the artcileOn interaction of 2-aminobenzothiazoles with halohydrins, Application of 1-Bromo-3-(3-bromopropoxy)propane, the main research area is benzothiazolamine halohydrin alkylation oxidation dimerization; iminobenzothiazoline preparation; benzothiazolylideneammonium chloride preparation.

On heating on a boiling water bath, 2-aminobenzothiazoles react with Cl(CH2)2OH to yield mainly the corresponding 3-(2-chloroethyl)benzothiazolin-2-ones. Reducing the reaction temperature increases the fraction of 2-imino-3-(2-hydroxyethyl)benzothiazolines. In both instances, formation of bis[3-(2-hydroxyethyl)benzothiazol-2-ylidene]ammonium chlorides is observed The reaction of 2-aminobenzothiazole with Br(CH2)3OH gives only the corresponding amino alcs. The anomalous products from the reaction of β-chloroethyl derivatives of benzothiazolinones result from a dominating side-reaction of the starting 2-aminobenzothiazoles with the Cl(CH2)2OH thermolysis products that are formed on boiling.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Halohydrins Role: RCT (Reactant), RACT (Reactant or Reagent). 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Application of 1-Bromo-3-(3-bromopropoxy)propane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xu, Liangxuan published the artcileMomentary click nitrile synthesis enabled by an aminoazanium reagent, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene, the main research area is nitrile preparation selective Schmidt reaction aminoazanium reagent.

Momentary and selective Schmidt-type nitrile synthesis was reported. The success of this achievement was ascribed to the employment of the stable and robust aminoazanium reagent H2N-DABCO. A broad range of functionalized aldehydes were efficiently converted to nitriles within 5 min at room temperature in air. The robustness and speed of the protocol allow the CHO group to be regarded as a CN equivalent in organic synthesis. Moreover, the synthetic advantage of this developed protocol is further highlighted via the direct cyanation of a diversity of aldehyde precursors (carboxylic acids, aromatics, aryl halides, alkenes and alkynes) in a cyanide-free process. Addnl., this protocol can not only be used for rapid access to a wide range of ligands and material precursors, but it can also be used in the late-stage modification of complex bioactive mols.

Organic Chemistry Frontiers published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 452-63-1 belongs to class bromides-buliding-blocks, name is 1-Bromo-4-fluoro-2-methylbenzene, and the molecular formula is C7H6BrF, Recommanded Product: 1-Bromo-4-fluoro-2-methylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Qian published the artcileIsoquinolone-4-Carboxylic Acids by Ammonia-Ugi-4CR and Copper-Catalyzed Domino Reaction, Category: bromides-buliding-blocks, the main research area is carboxy isoquinolone preparation green chem; benzoylaminoacetamide preparation green chem keto ester heterocyclization copper catalyst; halobenzoic acid aldehyde isocyanide ammonia multicomponent Ugi reaction.

Highly substituted isoquinolone-4-carboxylic acid I (R1 = H, 7-Me, 6-OMe, 6-NO2, etc.; R2 = H, Me, cyclopentyl, Ph, etc.; R3 = tert-Bu, 2-ethylphenyl, cyclopropylmethyl, benzyl, etc.; R4 = Me, iso-Pr, Pr, phenyl) is an important bioactive scaffold; however, it is challenging to access it in a general and short way. A Cu-catalyzed cascade reaction was successfully designed involving the Ugi postcyclization strategy by using ammonia and 2-halobenzoic acids 2-X-(R5)C6H3C(O)OH (R5 = H, 4-OMe, 5-Me, etc.; X = Br, I) as crucial building blocks. Privileged polysubstituted isoquinolin-1(2H)-ones I were constructed in a combinatorial format with generally moderate to good yields. The protocol, with a ligand-free catalytic system, shows a broad substrate scope and good functional group tolerance toward excellent mol. diversity. Free 4-carboxy-isoquinolone is now for the first time generally accessible by a convergent multicomponent reaction protocol.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Qian published the artcileCopper-Catalyzed Modular Assembly of Polyheterocycles, Name: 2-Bromo-4-methoxybenzoic acid, the main research area is indenoisoquinolinone preparation; indenedione benzamide preparation cyclization copper catalyst; carboxylic acid isocyanide aldehyde ammonia Ugi reaction.

Easy operation, readily accessible starting materials, and short synthesis of the privileged scaffold indeno[1,2-c]isoquinolinones I (R1 = H, 3-MeO, 2-Me, 2-NO2, etc.; R2 = H, Me, cyclopentyl, 4-chlorophenyl, etc.; R3 = tert-Bu, benzyl, 2-methoxy-2-oxoethyl, 2-ethylphenyl, etc.; R4 = H, 8,9-dimethoxy) were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodol. allows an efficient construction of a wide variety of indenoisoquinolinones I in just two steps.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Name: 2-Bromo-4-methoxybenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cristau, Henri-Jean published the artcileSynthesis of diphosphine dioxides for extraction of actinides using supported liquid membranes technology, COA of Formula: C6H12Br2O, the main research area is diphosphine dioxide preparation extraction actinide; organophosphorus extractant diphosphine dioxide preparation; radioactive liquid waste treatment organophosphorus extractant; plutonium extraction diphosphine dioxide; neptunium extraction diphosphine dioxide; supported liquid membrane actinide extraction organophosphorus.

A recurrent method for synthesis of diphosphine dioxides to be used for extraction of actinides from acidic aqueous solution is described. Selective phosphonium salt formation and cleavage permits the stepwise introduction of different bridges between the P atoms as well as various chains on them. The influence of the structural parameters on liquid-liquid extraction properties of Pu, Np, and Am was studied. Pu and Np can be efficiently removed from radioactive contaminated liquid wastes, using the supported liquid membranes technol. with the more lipophilic organophosphorus extractants, e.g., I.

Heteroatom Chemistry published new progress about Actinides Role: REM (Removal or Disposal), PROC (Process). 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, COA of Formula: C6H12Br2O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yu, Lin published the artcileFe3O4 nanoparticle-supported copper(I): magnetically recoverable and reusable catalyst for the synthesis of quinazolinones and bicyclic pyrimidinones, Category: bromides-buliding-blocks, the main research area is quinazolinone bicyclic pyrimidinone preparation; amidine halobenzoic acid bromocycloalkenecarboxylic acid cyclocondensation; ferrous ferric oxide nanoparticle supported copper catalyst.

A highly efficient, easily recoverable and reusable Fe3O4 magnetic nanoparticle-supported Cu(I) catalyst has been developed for the synthesis of quinazolinones I(R1 = H, 6-F, 7-MeO, 8-Me, 7-NO2, R2 = Me, Ph, cyclopropyl)and bicyclic pyrimidinones II(R = Me, Ph, cyclopropyl). In the presence of supported Cu(I) catalyst (10 mol%), amidines reacted with substituted 2-halobenzoic acids and 2-bromocycloalk-1-enecarboxylic acids to generate the corresponding N-heterocycle products in good to excellent yields at room temperature in DMF. In addition, the supported Cu(I) catalyst could be recovered at least 10 times without significant loss of its catalytic activity.

Applied Organometallic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yun published the artcileChiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct, Related Products of bromides-buliding-blocks, the main research area is chiral phosphoric acid catalyzed asym Ugi dynamic kinetic resolution; enantioselective synthesis aryloxoisoindolinecarboxamide; formylbenzoic acid aniline isonitrile asym Ugi reaction; asymmetric synthesis; kinetic resolution; multicomponent reaction; organocatalysis; reaction mechanisms.

Reaction of isonitriles with 3-(arylamino)isobenzofuran-1(3H)-ones in the presence of a catalytic amount of an octahydro (R)-binol-derived chiral phosphoric acid afforded 3-oxo-2-arylisoindoline-1-carboxamides in high yields with good to high enantioselectivities [e.g., I + tert-BuNC → II (93% yield, 87% ee)]. An enantioselective Ugi four-center three-component reaction of 2-formylbenzoic acids, anilines, and isonitriles was subsequently developed for the synthesis of the same heterocycle. Mechanistic studies indicate that the enantioselectivity results from the dynamic kinetic resolution of the primary Ugi adduct, rather than from the C-C bond-forming process. The resulting heterocycle products are of significant medicinal importance.

Angewandte Chemie, International Edition published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lindsay, Karl B. published the artcileFormal Total Synthesis of the Potent Renin Inhibitor Aliskiren: Application of a SmI2-Promoted Acyl-like Radical Coupling, Category: bromides-buliding-blocks, the main research area is renin inhibitor aliskiren total synthesis; samarium diiodide radical addition phenylalanine thioester acrylate.

A formal total synthesis of the potent renin inhibitor aliskiren is disclosed exploiting an alternative coupling strategy recently developed by the authors for the preparation of the hydroxyethylene isostere-based class of protease inhibitors. The 4-pyridyl thioester derivative of amino acid, CbzNHCH(CH2Ph)COS-Pyr (Pyr = 4-pyridyl), representing the C5-C9 fragment of the aliskiren carbon skeleton underwent a carbon chain extension via a SmI2-promoted radical addition to Bu acrylate. Introduction of the C3-iso-Pr group with the correct relative configuration was accomplished via stereoselective reduction of the obtained ketone with concomitant lactonization, followed by an aldol reaction with acetone. Further functional group and protecting group manipulation culminated in a formal total synthesis of aliskiren in 10 steps from the corresponding fully protected non-natural amino acid.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 172900-69-5 belongs to class bromides-buliding-blocks, name is 2-(3-Methoxypropoxy)-4-((R)-2-(bromomethyl)-3-methylbutyl)-1-methoxybenzene, and the molecular formula is C17H27BrO3, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tsarev, A. A. published the artcileTitanium and zirconium complexes with η5:η1-4-(alkyl/arylamino)(dimethyl)silylindene ligands as catalysts for ethene polymerization, Safety of 7-Bromo-2-methyl-1H-indene, the main research area is titanium zirconium complex catalyst polyethylene polymerization.

First members of a novel family of constrained geometry complexes of titanium and zirconium containing a short bridge between the amide and inden-4-yl fragments were obtained. When activated with methylaluminoxane, these complexes can be used as highly active catalysts for ethene polymerization producing high-mol.-weight polymers.

Russian Chemical Bulletin published new progress about Aluminoxanes, Me Role: CAT (Catalyst Use), USES (Uses). 880652-93-7 belongs to class bromides-buliding-blocks, name is 7-Bromo-2-methyl-1H-indene, and the molecular formula is C10H9Br, Safety of 7-Bromo-2-methyl-1H-indene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary