Category: bromides-buliding-blocks

In 2018,Journal of Medicinal Chemistry included an article by Hao, Meixi; Hou, Siyuan; Xue, Lingjing; Yuan, Haoliang; Zhu, Lulu; Wang, Cong; Wang, Bin; Tang, Chunming; Zhang, Can. Computed Properties of C4H7BrO2. The article was titled 《Further Developments of the Phenyl-Pyrrolyl Pentane Series of Nonsteroidal Vitamin D Receptor Modulators as Anticancer Agents》. The information in the text is summarized as follows:

The vitamin D3 receptor (VDR), which belongs to the nuclear-receptor superfamily, is a potential mol. target for anticancer-drug discovery. In this study, a series of nonsteroidal vitamin D mimics with phenyl-pyrrolyl pentane skeletons with therapeutic potentials in cancer treatment were synthesized. Among them, 11b (N-(3-(diethylamino)propyl)-1-ethyl-5-(3-(4-((3-ethyl-3-hydroxypentyl)oxy)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxamide) and 11g (1-ethyl-5-{1-ethyl-1-[4-(3-ethyl-3-hydroxypentyloxy)-3-methylphenyl]propyl}-1H-pyrrole-2-carboxylic acid (3-morpholin-4-yl-propyl)amide) were identified as the most effective agents in reducing the viability of four cancer-cell lines, particularly those of breast-cancer cells, with IC50 values in the submicromolar-concentration range. In addition, 11b and 11g possessed VDR-binding affinities and displayed significant partial VDR-agonistic activities determined by dual-luciferase-reporter assays and human-leukemia-cell-line (HL-60)-differentiation assays. Furthermore, 11b and 11g inhibited tumor growth in an orthotopic breast-tumor model via inhibition of cell proliferation and induction of cell apoptosis. More importantly, 11b and 11g exhibited favorable pharmacokinetic behavior in vivo and did not increase serum calcium levels or cause any other apparent side effects. In summary, 11b and 11g act as novel VDR modulators and may be promising candidates for cancer chemotherapy. In the experimental materials used by the author, we found Methyl 3-bromopropanoate(cas: 3395-91-3Computed Properties of C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Organometallics included an article by Martinez, Gabriel Espinosa; Nugent, Joseph W.; Fout, Alison R.. Category: bromides-buliding-blocks. The article was titled 《Simple Nickel Salts for the Amination of (Hetero)aryl Bromides and Iodides with Lithium Bis(trimethylsilyl)amide》. The information in the text is summarized as follows:

Recent developments in the chem. of C-N bond formation and the synthesis of anilines have allowed for the use of 1st-row transition metals to catalyze these transformations. Much of the progress in this area was driven by comprehensive screening for privileged/tailored ligands, which can be costly and not readily available in a research laboratory setting. The authors report a protocol in which simple Ni salts catalyze the C-N cross-coupling reaction between (hetero)aryl bromides and iodides with Li bis(trimethylsilyl)amide without the need for any additive ligand. This method is amenable to low Ni catalyst loadings (1%) as well as gram-scale reactions. Because of the good functional group tolerance and compatibility with heterocyclic moieties, this method is useful for academic laboratory settings where access to tailored ligands and noble-metal catalysts could be challenging. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Category: bromides-buliding-blocks)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: Ethyltriphenylphosphonium bromideIn 2021 ,《Highly efficient and reversible low-concentration SO2 absorption in flue gas using novel phosphonium-based deep eutectic solvents with different substituents》 was published in Journal of Molecular Liquids. The article was written by Zhao, Yongqi; Dou, Jinxiao; Wei, Aoran; Khoshkrish, Salman; Yu, Jianglong. The article contains the following contents:

Four hydrogen bond acceptors (HBAs) with different carbon chain length substituents, including methyl-triphenyl phosphonium bromide (MTPB), ethyl-tri-Ph phosphonium bromide (ETPB), propyl-triphenyl phosphonium bromide (PTPB), and butyl-tri-Ph phosphonium bromide (BTPB), combined with ethylene glycol (EG) were developed to synthesize four low-viscosity deep eutectic solvents (DESs). In this study, the effect of different substituents in DESs on low-concentration SO2 absorption was systematically studied at 30-70°C. Exptl. results show that the EG-MTPB DES has a higher SO2 absorption capacity and a lower viscosity than other DESs. The reason for the higher SO2 absorption capacity of EG-MTPB DES was described by viscosity experiments and quantum chem. calculations It was shown that the strong polarization ability of the CH3- group promotes the absorption of SO2 by DESs. 1H NMR and FTIR results indicated that chem. interactions primarily exist between the S of SO2 and Br, and the O of SO2 and the H atom of EG form hydrogen bonds. The d. functional theory (DFT) results also confirm that the charge of the Br atom migrated to the S atom. Also, thermostability and regeneration experiments showed that the EG-MTPB DES exhibits good stability and can thus be used for industrial flue gas desulfurization. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Name: Ethyltriphenylphosphonium bromide)

Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Name: Ethyltriphenylphosphonium bromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetateIn 2019 ,《Synthesis and characterization of stanozolol N-glucuronide metabolites》 was published in Monatshefte fuer Chemie. The article was written by Kratena, Nicolas; Enev, Valentin; Gmeiner, Guenter; Gaertner, Peter. The article contains the following contents:

The preparation, separation, and anal. of two regioisomeric N-glucuronides of the common doping agent stanozolol are described in this manuscript. Glucuronidation was carried out using modified Koenigs-Knorr conditions developed specifically for pyrazoles. After preparative HPLC separation both isomers could be isolated in a pure form. Global cleavage of protecting groups furnished the putative human phase II metabolites STN1 and STN2 which were compared with human excretion studies. The results came from multiple reactions, including the reaction of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Recommanded Product: (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C12H7Br2NIn 2022 ,《Effects of 3,6-Dibromocarbazole on Soil Health-Based on Soil Enzymes and the Biolog-ECO Test》 was published in Water, Air, & Soil Pollution. The article was written by Du, Zhongkun; Zhang, Ji; Cheng, Chao; Shi, Baihui; Zhu, Lusheng; Wang, Jun; Wang, Jinhua; Li, Bing. The article contains the following contents:

Polyhalogenated carbazoles (PHCZs) are a kind of emerging contaminants with doxin-like toxicity, potential bioaccumulation capability, and persistence. Data about the risks of PHCZs on soil ecosystem are scarce to date, although PHCZs have been detected with high concentrations in the soil. The present study performed a preliminary investigation of 3,6-dibromocarbazole (36-DBCZ, a PHCZ with a high detection rate, and concentration in the environment) at concentrations of 0.1, 1.0, 10, and 100 mg/kg on the soil health, based on soil enzyme test and Biolog-ECO assay. Results showed that 36-DBCZ could inhibit the activity and diversity of soil microbes, even at the environment-relevant concentration (0.1 mg/kg). But, the inhibition lasted only about 10 days. As time passed, slight increases in microbe activity and diversity were found in 36-DBCZ-treated groups. We hypothesized that the degradation products of 36-DBCZ provided extra nutrients to the soil microbes, which required further verification. Activities of urease, β-glucosidase, and acid phosphatase were increasingly increased, in contrast to the microbial activity. The present study provides valuable data on the effects of PHCZs on the soil ecosystem, and we suggest that the degradation of PHCZs, as well as their influences on the structure and functions of the soil microbial community, should be investigated in future studies. In the experiment, the researchers used many compounds, for example, 3,6-Dibromo-9H-carbazole(cas: 6825-20-3Synthetic Route of C12H7Br2N)

3,6-Dibromo-9H-carbazole(cas: 6825-20-3) is used as a pharmaceutical intermediate, and also an important intermediate of synthesizing optoelectronic materials. It has been used in the preparation of N-(2-hydroxyethyl)-3,6-dibromocarbazole.Synthetic Route of C12H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5437-45-6In 2021 ,《Enantioselective Rauhut-Currier Reaction with β-Substituted Acrylamides Catalyzed by N-Heterocyclic Carbenes》 appeared in Organic Letters. The author of the article were Pitchumani, Venkatachalam; Breugst, Martin; Lupton, David W.. The article conveys some information:

β-Substituted acrylamides have low electrophilicity and are yet to be exploited in the enantioselective Rauhut-Currier reaction. Exploiting electron-withdrawing protection of the amide, and moderate nucleophilicity N-heterocyclic carbenes (NHCs), such substrates have been converted to enantioenriched quinolones. The reaction proceeds with complete diastereoselectivity, good yield, and modest enantioselectivity. Derivatizations are reported, as are computational studies, supporting decreased amide bond character with electron-withdrawing protection of the nitrogen. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Application of 5437-45-6

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 76006-33-2In 2020 ,《Nickel-catalyzed dual C(sp2)-H activation of arenes: a new route to diaryl ethers》 appeared in Organic Chemistry Frontiers. The author of the article were Lv, Ningning; Chen, Zhengkai; Yu, Shuling; Liu, Zhanxiang; Zhang, Yuhong. The article conveys some information:

Diaryl ethers were synthesized directly from simple arenes for the first time through dual C(sp2)-H activation with the aid of a bidentate auxiliary by nickel catalysis. The anion of the additive is crucial to the transformation, and the control experiments revealed that the acyloxylated benzamide was the key intermediate. The results came from multiple reactions, including the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Related Products of 76006-33-2)

3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Some of these compounds are identical to man-made organobromine compounds, such as methyl bromide, bromoform, and bromophenols, but many others are entirely new moleclar entities, often possessing extraordinary and important biological properties. Related Products of 76006-33-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 21085-72-3In 2021 ,《Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates》 appeared in Bioconjugate Chemistry. The author of the article were Chuprakov, Stepan; Ogunkoya, Ayodele O.; Barfield, Robyn M.; Bauzon, Maxine; Hickle, Colin; Kim, Yun Cheol; Yeo, Dominick; Zhang, Fangjiu; Rabuka, David; Drake, Penelope M.. The article conveys some information:

Although peptide motifs represent the majority of cleavable linkers used in clin.-stage antibody-drug conjugates (ADCs), the sequences are often sensitive to cleavage by extracellular enzymes, such as elastase, which leads to systemic release of the cytotoxic payload. This action reduces the therapeutic index by causing off-target toxicities that can be dose-limiting. For example, a common side-effect of ADCs made using peptide-cleavable linkers is myelosuppression, including neutropenia. Only a few reports describe methods for optimizing peptide linkers to maintain efficient and potent tumor payload delivery while enhancing circulating stability. Herein, the authors address these critical limitations through the development of a tandem-cleavage linker strategy, where two sequential enzymic cleavage events mediate payload release. The authors prepared dipeptides that are protected from degradation in the circulation by a sterically encumbering glucuronide moiety. Upon ADC internalization and lysosomal degradation, the monosaccharide is removed and the exposed dipeptide is degraded, which liberates the attached payload inside the target cell. The authors used CD79b-targeted monomethyl auristatin E (MMAE) conjugates as the model system and compared the stability, efficacy, and tolerability of ADCs made with tandem-cleavage linkers to ADCs made using standard technol. with the vedotin linker. The results, where rat studies showed dramatically improved tolerability in the hematopoietic compartment, highlight the role that linker stability plays in efficacy and tolerability and also offer a means of improving an ADC’s therapeutic index for improved patient outcomes. The experimental part of the paper was very detailed, including the reaction process of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Application of 21085-72-3)

(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Application of 21085-72-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhu, Hong; Liu, Zhichao; Xu, Chenbo; Chen, Caiqi; Wen, Jinxuan; Yang, Keqin; Chen, Suqin; Pan, Yuexiao published an article in Journal of Alloys and Compounds. The title of the article was 《Large red shift from blue to green in the photoluminescence of pure CsPbBr3 nanoplatelets triggered by the cooperative effect of ligands combination》.Recommanded Product: 4-Bromobutanoic acid The author mentioned the following in the article:

A viable design strategy toward cubic CsPbBr3 (CPB) nanoplatelet (NPs) with blue emission at 450-467 nm and a large red shift to the green region at 500-512 nm occurs was developed through a cooperative effect of the ligands 4-bromobutyric acid (BBA) and oleylamine (OLA). The influence of the mol. ratio of BBA/OLA, reaction time and temperature on the transformation from blue to green was studied systematically. The red shift in the PL of CPB NPs is ascribed to the growth of the crystals with decreased quantum confinement. The luminescence quantum yields (PLQYs) of the blue and green luminescence of the obtained CPB NPs reach 94.4 and 84.4%, resp. This proposed strategy not only exptl. fabricates size-adjustable CPB NPs but also helps to reveal in depth the mechanisms of the large variation of quantum confinement in pure cubic CPB NPs. The results came from multiple reactions, including the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wu, Lipeng; Zhang, Kaiming; Shi, Jiaoyan; Wu, Fan; Zhu, Xufei; Dong, Wei; Xie, Aming published an article in Composites, Part B: Engineering. The title of the article was 《Metal/nitrogen co-doped hollow carbon nanorods derived from self-assembly organic nanostructure for wide bandwidth electromagnetic wave absorption》.HPLC of Formula: 523-27-3 The author mentioned the following in the article:

Converting carbonaceous material into heteroatom-doped hollow nanomaterial is a promise route to realize lightweight and high-performance electromagnetic wave absorption (EMA). In this work, a series of metal/nitrogen co-doped hollow carbon nanorods (M-NHCRs, M represent as Fe, Co, Ni) were successfully fabricated via a facile self-assembly template strategy, which refers to self-assembling of 9,10-dibromoanthracene (DBA), surficial modification with polydopamine (PDA) and metal ions, and controlled pyrolysis. Among these M-NHCRs, Co-NHCR exhibits remarkable EMA performance, where the optimal reflection loss (RL) reaches -58.6 dB at a loading ratio of 5 wt%. Moreover, the effective absorption bandwidth (EAB) gets to 7.65 GHz. It is considered that the high-performance EMA should be attributed to the unique hollow structure, excellent conductance loss and improved polarization relaxation. This research not only provides a new idea for the design of lightweight electromagnetic absorbents with broadband efficient absorption, but also broadens the way of synthesizing hollow nanomaterials.9,10-Dibromoanthracene(cas: 523-27-3HPLC of Formula: 523-27-3) was used in this study.

9,10-Dibromoanthracene(cas: 523-27-3) is synthesized by the bromination of anthracene. The bromination reaction is carried out at room temperature using carbon tetrachloride as a solvent. Using 80-85% anthracene as raw material, adding bromine to react for half an hour, the yield is 83-88%.HPLC of Formula: 523-27-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary