Category: bromides-buliding-blocks

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application In Synthesis of 402-49-3.

Yang, Ren-Yin;Gao, Xinyan;Gong, Kehao;Wang, Juan;Zeng, Xiaojun;Wang, Mingwei;Han, Junbin;Xu, Bo research published 《 Synthesis of ArCF₂X and [¹⁸F]Ar-CF₃ via Cleavage of the Trifluoromethylsulfonyl Group》, the research content is summarized as follows. A versatile synthesis of ArCF₂X and [¹⁸F]Ar-CF₃ type compounds from readily available ArCF₂SO₂CF₃ has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (¹⁸F^–, Cl^–, Br^–, and I^–), RSH, and ROH, could react with ArCF₂SO₂CF₃ efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.

402-49-3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., Application In Synthesis of 402-49-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 823-78-9.

Yang, Ren-Yin;Gao, Xinyan;Gong, Kehao;Wang, Juan;Zeng, Xiaojun;Wang, Mingwei;Han, Junbin;Xu, Bo research published 《 Synthesis of ArCF₂X and [¹⁸F]Ar-CF₃ via Cleavage of the Trifluoromethylsulfonyl Group》, the research content is summarized as follows. A versatile synthesis of ArCF₂X and [¹⁸F]Ar-CF₃ type compounds from readily available ArCF₂SO₂CF₃ has been developed. Diverse nucleophiles, including weak nucleophiles such as halides (¹⁸F^–, Cl^–, Br^–, and I^–), RSH, and ROH, could react with ArCF₂SO₂CF₃ efficiently to give the corresponding difluoromethylene products. The control experiments and the Hammett plot indicated that the reaction might proceed through a difluorocarbocation intermediate generated from the steric hindrance-assisted cleavage of the trifluoromethylsulfonyl group.

Application In Synthesis of 823-78-9, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Electric Literature of 585-76-2.

Yang, Ruige;Han, Meiyue;Fan, Jiangping;Cheng, Wanqing;Ma, Nannan;Yan, Xiaoting;Guo, Yong research published 《 Development of Novel (+)-Nootkatone Thioethers Containing 1,3,4-Oxadiazole/Thiadiazole Moieties as Insecticide Candidates against Three Species of Insect Pests》, the research content is summarized as follows. To improve the insecticidal activity of (+)-nootkatone, a series of 42 (+)-nootkatone thioethers containing 1,3,4-oxadiazole/thiadiazole moieties were prepared to evaluate their insecticidal activities against Mythimna separata Walker, Myzus persicae Sulzer, and Plutella xylostella Linnaeus. Insecticidal evaluation revealed that most of the title derivatives exhibited more potent insecticidal activities than the precursor (+)-nootkatone after the introduction of 1,3,4-oxadiazole/thiadiazole on (+)-nootkatone. Among all of the (+)-nootkatone derivatives, compound (I) (1 mg/mL) exhibited the best growth inhibitory (GI) activity against M. separata with a final corrected mortality rate (CMR) of 71.4%, which was 1.54- and 1.43-fold that of (+)-nootkatone and toosendanin, resp.; I also displayed the most potent aphicidal activity against M. persicae with an LD₅₀ value of 0.030μg/larvae, which was closer to that of the com. insecticidal etoxazole (0.026μg/larvae); and (II) showed the best larvicidal activity against P. xylostella with an LC₅₀ value of 0.27 mg/mL, which was 3.37-fold that of toosendanin and slightly higher than that of etoxazole (0.28 mg/mL). Furthermore, the control efficacy of II against P. xylostella in the pot experiments under greenhouse conditions was better than that of etoxazole. Structure-activity relationships (SARs) revealed that in most cases, the introduction of 1,3,4-oxadiazole/thiadiazole containing halophenyl groups at the C-13 position of (+)-nootkatone could obtain more active derivatives against M. separata, M. persicae, and P. xylostella than those containing other groups. In addition, toxicity assays indicated that these (+)-nootkatone derivatives had good selectivity to insects over nontarget organisms (normal mammalian NRK-52E cells and C. idella and N. denticulata fries) with relatively low toxicity. Therefore, the above results indicate that these (+)-nootkatone derivatives could be further explored as new lead compounds for the development of potential eco-friendly pesticides.

Electric Literature of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide, Application of C2H7Br2N

Yang, Wenjun;Chernyshov, Ivan Yu.;van Schendel, Robin K. A.;Weber, Manuela;Mueller, Christian;Filonenko, Georgy A.;Pidko, Evgeny A. research published 《 Robust and efficient hydrogenation of carbonyl compounds catalysed by mixed donor Mn(I) pincer complexes》, the research content is summarized as follows. A highly efficient Mn(I)-CNP pre-catalyst I which gives rise to the excellent productivity (TOF° up to 41 000 h^-1) and stability (TON up to 200 000) in hydrogenation catalysis was reported. This system enables near-quant. hydrogenation of ketones RC(O)R¹ (R = Ph, 2,3-dihydro-1,4-benzodioxin-6-yl, pentyl, etc.; R¹ = Et, Bn, cyclopropyl, etc.; RR¹ = -(CH₂)₅-) and 1,2,3,4-tetrahydronaphthalen-1-one, imines 4-R²C₆H₄N=CHC₆H₅ (R² = H, Br, OMe), aldehydes R³CHO [R³ = Ph, 4-(dimethylamino)phenyl, 4-(benzyloxy)phenyl, furan-2-yl] and formate esters R⁴OC(O)H (R⁴ = hexyl, pentyl, 3-methylbutyl) at the catalyst loadings as low as 5-200 p.p.m. The anal. points to the crucial role of the catalyst activation step for the catalytic performance and stability of the system. While conventional activation employing alkoxide bases can ultimately provide catalytically competent species under hydrogen atm., activation of Mn(I) pre-catalyst I with hydride donor promoters, e.g., KHBEt₃, dramatically improves catalytic performance of the system and eliminates induction times associated with slow catalyst activation.

2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., Application of C2H7Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 4-Bromo-N-methylaniline.

Yan, Fachao;Huang, Zijun;Du, Chen-Xia;Bai, Jian-Fei;Li, Yuehui research published 《 Iron-catalyzed reductive strecker reaction》, the research content is summarized as follows. The FeI₂-catalyzed reductive Strecker type reaction of formamides instead of aldehydes produced amino acetonitriles was reported. The challenging capture of carbinolamine intermediates by CN^– was achieved via Fe catalysis. This approach afforded better yields than the use of Ir- or Rh-catalysts. The application ability of this methodol. was demonstrated by (1) one-pot construction of (¹³C labeled) complex mols. from CO₂ via amino acetonitrile intermediates and (2) convenient production of homologated carboxylic acids from aldehydes.

Safety of 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Reference of 1575-37-7.

Yan, Jianwei;Zheng, Linxia;Wang, Jiangfei;Liu, Xiaomin;Hu, Youhong research published 《 Indoles Oxidative Ring-Opening/Cyclization Cascade with the 1,2-Diaminoarenes: Direct Synthesis of 2-Aryl-3-(2-aminoaryl)quinoxalines》, the research content is summarized as follows. A mild oxidative sequential tandem reaction was developed to rapidly generate 2-aryl-3-(2-aminoaryl)quinoxalines. This method exploited 2-substituted indoles as substrate to form quinoxalines in a one-pot reaction. The key to this tandem reaction was the formation of 3-iodoindoles, which underwent Kornblum-type oxidation with DMSO to generate active imine 2-substitued 3H-indol-3-ones. The active imines were captured in situ by 1,2-diaminobenzenes to construct diverse quinoxalines. The transformation can be accomplished at room temperature with excellent functional group tolerance.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Reference of 1575-37-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 1575-37-7.

Yan, Liuqing;Fu, Jiaxu;Li, Shuang;Zhang, Jinlong;Wang, Shuang;Gu, Qiang;Zhang, Yumin;Lin, Feng research published 《 Microwave-assisted Synthesis and In vitro Bioactivity Evaluation of Benzimidazoles Bearing Phenolic Hydroxyl》, the research content is summarized as follows. An efficient and facile method was introduced for the synthesis of benzimidazoles in this paper. The optimum reaction conditions were determined A series of benzimidazoles bearing phenolic hydroxyl were synthesized in moderate to excellent yields starting from different substituted hydroxy benzaldehyde and 4-position substituted o-phenylenediamine via nu-cleophilic addition in the presence of catalyst Na₂S₂O₅ under microwave irradiation Herein, effects of the catalyst, molar ratio of reactants, reaction temperature and solvent were investigated. The optimal reaction condition was determined The effect of DMF and EtOH solvent on the reaction was compared. Further, the bacteriostatic activities of the synthesized compounds were evaluated with ciprofloxacin and itraconazole as a pos. control, resp. Few compounds exhibited some antibacterial activity. The lowest MIC of antibacterial activity of compound I was 32μg/mL. Meanwhile, the luminescence property of compound I was studied. The antibacterial activity of compound I, along with their good fluorescence performance highlighted the potential of these compounds as lead structures and owned fluorescence trace for further study towards the development of novel drugs and functional mechanisms in living organisms.

Quality Control of 1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Safety of 4-Bromobenzene-1,2-diamine

Yan, Qiuli;Cui, Wenwen;Li, Junxin;Xu, Guiyun;Song, Xiuyan;Lv, Jian;Yang, Daoshan research published 《 C-H benzylation of quinoxalin-2(1H)-ones via visible-light riboflavin photocatalysis》, the research content is summarized as follows. An efficient visible-light promoted riboflavin-catalyzed direct benzylation of substituted quinoxalin-2(1H)-ones for the synthesis of various C3-benzylated quinoxalin-2(1H)-one derivatives was developed under mild conditions. The present method used readily available benzyl bromides as alkylating reagents and environmentally friendly and inexpensive riboflavin (vitamin B₂) as a green organic photocatalyst. This method opened a new avenue towards C3-benzylated quinoxalin-2(1H)-ones, thus promised their broad applications in pharmaceutical chem. and synthetic chem.

Safety of 4-Bromobenzene-1,2-diamine, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. COA of Formula: C7H6Br2.

Yan, Qiuli;Cui, Wenwen;Li, Junxin;Xu, Guiyun;Song, Xiuyan;Lv, Jian;Yang, Daoshan research published 《 C-H benzylation of quinoxalin-2(1H)-ones via visible-light riboflavin photocatalysis》, the research content is summarized as follows. An efficient visible-light promoted riboflavin-catalyzed direct benzylation of substituted quinoxalin-2(1H)-ones for the synthesis of various C3-benzylated quinoxalin-2(1H)-one derivatives was developed under mild conditions. The present method used readily available benzyl bromides as alkylating reagents and environmentally friendly and inexpensive riboflavin (vitamin B₂) as a green organic photocatalyst. This method opened a new avenue towards C3-benzylated quinoxalin-2(1H)-ones, thus promised their broad applications in pharmaceutical chem. and synthetic chem.

COA of Formula: C7H6Br2, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 4897-84-1, formula is C5H9BrO2, Name is Methyl 4-bromobutanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 4897-84-1.

Yan, Wenzhong;Ling, Lijun;Wu, Yiran;Yang, Kexin;Liu, Ruiquan;Zhang, Jinfeng;Zhao, Simeng;Zhong, Guisheng;Zhao, Suwen;Jiang, Hualiang;Xie, Chengying;Cheng, Jianjun research published 《 Structure-Based Design of Dual-Acting Compounds Targeting Adenosine A_2A Receptor and Histone Deacetylase as Novel Tumor Immunotherapeutic Agents》, the research content is summarized as follows. Adenosine is an immunosuppressive factor in the tumor microenvironment mainly through activation of the A_2A adenosine receptor (A_2AR), which is a mechanism hijacked by tumors to escape immune surveillance. Small-mol. A_2AR antagonists are being evaluated in clin. trials as immunotherapeutic agents, but their efficacy is limited as standalone therapies. To enhance the antitumor effects of A_2AR antagonists, dual-acting compounds incorporating A_2AR antagonism and histone deacetylase (HDAC) inhibitory actions were designed and synthesized, based on co-crystal structures of A_2AR. Compound 24e (IHCH-3064) exhibited potent binding to A_2AR (K_i = 2.2 nM) and selective inhibition of HDAC1 (IC₅₀ = 80.2 nM), with good antiproliferative activity against tumor cell lines in vitro. I.p. administration of 24e (60 mg/kg, bid) inhibited mouse MC38 tumor growth with a tumor growth inhibition rate of 95.3%. These results showed that dual-acting compounds targeting A_2AR and HDAC are potentially immunotherapeutic agents that are worth further exploring.

HPLC of Formula: 4897-84-1, Methyl 4-bromobutyrate,also as known as 4-Bromobutyric acid methyl ester, is a useful research compound. Its molecular formula is C5H9BrO2 and its molecular weight is 181.03 g/mol. The purity is usually 95%.
4-Bromobutyric acid methyl ester is a synthetic compound that can be used to inhibit the activity of the G1 phase cyclin-dependent kinases. It has been shown to inhibit protein synthesis by alkylating the amino groups of proteins and fatty acids. 4-Bromobutyric acid methyl ester also inhibits the growth of cancer cell lines, such as renal carcinoma cells. The mechanism of action for this drug is not well understood, but it may be due to its ability to bind with monoclonal antibodies and enter kidney cells by passive diffusion., 4897-84-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary