Category: bromides-buliding-blocks

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

He, Yuting;Li, Xue;Cai, Wenyi;Lu, Huimin;Ding, Jing;Li, Hongping;Wan, Hui;Guan, Guofeng research published 《 One-Pot Multiple-Step Integration Strategy for Efficient Fixation of CO₂ into Chain Carbonates by Azolide Anions Poly(ionic liquid)s》, the research content is summarized as follows. The multiple-step transformation of CO₂ greatly enriches the diversity and value of products and provides more possibilities for the sustainable development of green chem. However, it puts forward stricter requirements for the versatility of catalysts. A series of basic porous ionic polymers incorporating azolide anions (BA-PILs) were facilely synthesized via radical polymerization followed by a successive ion-exchange strategy. A one-pot multiple-step integration strategy coupling cycloaddition and transesterification were explored to synthesize chain carbonates without the separation of intermediate products. High catalytic activity, stable recyclability, and chain carbonate compatibility were achieved in the absence of any cocatalyst. Combined with catalysts’ characterization, in situ IR anal., and d. functional theory (DFT) calculation of BA-PILs rationally explained the dual roles of azolide anions in the one-pot synthesis. The construction of functional BA-PILs as a versatile platform provides an original idea for the efficient insertion of CO₂ into chain carbonates.

Category: bromides-buliding-blocks, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 2576-47-8, formula is C2H7Br2N, Name is 2-Bromoethylamine hydrobromide. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 2576-47-8.

He, Yuting;Li, Xue;Li, Hongping;Ding, Jing;Wan, Hui;Guan, Guofeng research published 《 Understanding the Ingenious Dual Role-Playing of CO₂ in One-Pot Pressure-Swing Synthesis of Linear Carbonate》, the research content is summarized as follows. CO₂, as an engaging C1 building block, shines brightly in green conversion; besides, its unique identity as an acidic mol. is worthy of further development. Here, a novel mode of CO₂ utilization was explored to play a dual role in the one-pot pressure-swing synthesis of di-Me carbonate (DMC) over 2-hydroxypyridine anion functionalized poly(ionic liquid)s (OPy-PILs), i.e., CO₂ could act as both a raw material of coupling reaction and an acidic inhibitor of side-reaction. Specifically, OPy-PILs, constructed by free radical copolymerization followed by ion exchange, were applied to the one-pot coupling reaction of CO₂, epoxide, and CH₃OH. As an efficient heterogeneous catalyst, OPy-PILs could cover basic sites with acidic CO₂ during the insertion of activated CO₂ into epoxide by intermediate [OPy-CO₂^–] so as to reduce the yield of the epoxide alcoholysis side-reaction from 27 to 12%. Moreover, various comparative experiments fully exhibited the high activity and stability of OPy-PILs, and theor. calculations convincingly explained the dual role-playing of CO₂ in a one-pot pressure-swing reaction. This work paves a novel avenue for the deeper exploration of the CO₂ utilization potential in the catalytic process.

Reference of 2576-47-8, 2-Bromoethylamine hydrobromide is a useful building block for proteomics research.
2-Bromoethylamine hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist. It is used to construct C2-symmetric imidazolidinylidene ligands with a dioxolane backbone.
2-Bromoethylamine Hydrobromide is used in the synthesis of analogs of 5,​10,​15,​20-​tetrakis(1-​methylpyridinium-​4-​yl)​porphyrin (TMPyP4) as inhibitors of human telomerase. It is also used to prepare SB-705498, a potent, selective and orally bioavailable TRPV1 antagonist.
2-Bromoethylamine hydrobromide is a nonsteroidal anti-inflammatory drug that is used to treat inflammation and pain. It is a prodrug that is hydrolyzed in vivo to its active form, 2-Bromoethylamine hydrobromide. The bound form of this drug has been shown to inhibit the development of cell nuclei in the nucleus of cells. This drug also inhibits the production of nitric oxide, which leads to cell death by necrosis. 2-Bromoethylamine hydrobromide has been shown to have an inhibitory effect on the activity of glycol ethers, which are used as solvents for resins in coatings and adhesives., 2576-47-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 1575-37-7, formula is C6H7BrN2, The most pervasive is the naturally produced bromomethane. Recommanded Product: 4-Bromobenzene-1,2-diamine

He, Zemin;Yu, Ping;Zhao, Yuzhen;Zhang, Huimin;Zhang, Yongming;Kang, Xiaoxi;Zhang, Haiquan;Sadeghzadeh, Seyed Mohsen research published 《 PrVO₄/SnD NPs as a Nanocatalyst for Carbon Dioxide Fixation to Synthesis Benzimidazoles and 2-Oxazolidinones》, the research content is summarized as follows. Recently CO₂ stabilization has received a great deal of attention because of its probable applications as a rich C1 resource and the synthesis of several fine chems. can be accomplished through this stabilization. In this study, Sn(IV) doping dendritic fibrous nanosilica (SnD) supported PrVO₄ nanoparticles as a catalyst (PrVO₄/SnD) was synthesized by a in-situ procedure. The SnD with the ratios of Si/Sn in a variety of 6 to 40 were acquired through direct hydrothermal synthesis (DHS), and PrVO₄ NPs on the surfaces of SnD were reduced in-situ. X-Ray diffraction (XRD), Scanning electron microscope (SEM), Fourier transform IR spectroscopy (FT-IR), transmission electron microscopy (TEM), and X-ray energy dispersive spectroscopy (EDS) were deployed for identifying the PrVO₄/SnD. It is potentially a highly dynamic catalyst in the stabilization of CO₂ for the production of 2-oxazolidinones and benzimidazoles. In addition, the catalyst is very easy to recycle and reuse without significant loss of active site Cu metal.

1575-37-7, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., Recommanded Product: 4-Bromobenzene-1,2-diamine

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Formula: C9H9BrO3.

Hendrich, Christoph M.;Senn, Sebastian;Haas, Lea;Hoffmann, Marvin T.;Zschieschang, Ute;Greiner, Luca C.;Rominger, Frank;Rudolph, Matthias;Klauk, Hagen;Dreuw, Andreas;Hashmi, A. Stephen K. research published 《 “Golden” Cascade Cyclization to Benzo[c]-Phenanthridines》, the research content is summarized as follows. Herein, a gold-catalyzed cascade cyclization of Boc-protected benzylamines bearing two tethered alkyne moieties in a domino reaction initiated by a 6-endo-dig cyclization is reported. The reaction was screened intensively, and the scope was explored, resulting in nine new Boc-protected dihydrobenzo[c]phenanthridines with yields of up to 98%; even a π-extension and two bidirectional approaches were successful. Furthermore, thermal cleavage of the Boc group and subsequent oxidation gave substituted benzo[c]phenanthridines in up to quant. yields. Two bidirectional approaches under the optimized conditions were successful, and the resulting π-extended mols. were tested as organic semiconductors in organic thin-film transistors.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Formula: C9H9BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 4224-70-8, formula is C6H11BrO2, Name is 6-Bromohexanoic acid, Product Details of C6H11BrO2

Hensbergen, Albertus W.;de Kleer, Mathijs A. C.;Boutkan, Michael S.;van Willigen, Danny M.;van der Wijk, Felicia A.;Welling, Mick M.;Wester, Hans-Jurgen;Buckle, Tessa;van Leeuwen, Fijs W. B. research published 《 Evaluation of asymmetric orthogonal cyanine fluorophores》, the research content is summarized as follows. Pentamethine cyanine (Cy5) fluorophores proved to be versatile imaging agents (i.e., tracers) for a range of micro- and macroscopic imaging applications, including image-guided surgery. The relation between the structure of asym. Cy5 fluorophores and their photophys. properties was studied. To this end, seven Cy5 analogs, bearing orthogonal N-indole substituents (H, SO₃^–, or benzene), were synthesized and evaluated. In-depth anal. revealed that introduction of sulfonates enhanced the fluorescence brightness and photostability, while reducing the lipophilicity, serum binding and stacking tendency. The addition of benzene moieties induced a bathochromic shift of 10-20 nm, increased the lipophilicity (LogP = -1.56-1.23) and serum binding (67.3-93.8% bound), as well as neg. impacted the brightness (0.74-42.9 × 10³ M^-1 cm^-1), photostability (24.4-90.6% remaining), and stacking tendency. Chem. stability was uninfluenced by the substitution pattern. Addnl., the generation of a c[RGDyK]-based hybrid tracer based on one of these fluorophores in combination with a diethylenetriaminepentaacetic acid (DTPA) chelate and an ¹¹¹In-isotope is reported. This compound was evaluated in vitro using α_vβ₃-overexpressing Geβ3 cells and in vivo using a 4T1 mouse tumor model. Overall, the presented results imply that alterations of the asym. orthogonal Cy5 fluorophore structure have impact on the (photo)phys. properties. Furthermore, the orthogonal Cy5 fluorophore framework can readily be applied in tracer development.

Product Details of C6H11BrO2, 6-bromohexanoic acid is an organobromine compound comprising hexanoic acid having a bromo substituent at the 6-position. It derives from a hexanoic acid.
6-Bromohexanoic acid is a useful research compound. Its molecular formula is C6H11BrO2 and its molecular weight is 195.05 g/mol. The purity is usually 95%.
6-Bromohexanoic acid is useful for the preparation of anti-CTLA4 compounds as antitumor agents.
6-Bromohexanoic acid is a fatty acid that has been shown to be an effective agent for the treatment of cancer. It is used in gene therapy to inhibit the growth of cancer cells by binding to and then activating transcription factors. 6-Bromohexanoic acid can also be used as a chemotherapeutic agent and has been shown to cause apoptosis in monoclonal antibody-treated cells. 6-Bromohexanoic acid has pharmacokinetic properties that are similar to those of other fatty acids. The reaction solution was found to have high chemical stability, which may be due to the presence of nitrogen atoms. This reaction solution was found to adsorb onto the surface of monoclonal antibodies and cell culture, altering their properties., 4224-70-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 402-49-3, formula is C8H6BrF3, The most pervasive is the naturally produced bromomethane. Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene

Heo, Seunga;Chun, Yu Sung;Bang, Joonho;Hwang, Ho Seong;Hwang, Sanju;Kim, Sonam;Cho, Eun Jin;Kim, Sung Wng;You, Youngmin research published 《 Boosting photoredox catalysis using two-dimensional electride as persistent electron donor》, the research content is summarized as follows. Electrides, which have excess anionic electrons, are solid-state sources of solvated electrons that can be used as powerful reducing agents for organic syntheses. However, the abrupt decomposition of electrides in organic solvents makes controlling the transfer inefficient, thereby limiting the utilization of their superior electron-donating ability. Here, we demonstrate the efficient reductive transformation strategy which combines the stable two-dimensional [Gd₂C]²⁺·2e^– electride electron donor and cyclometalated Pt(II) complex photocatalysts. Strongly localized anionic electrons at the interlayer space in the [Gd₂C]²⁺·2e^– electride are released via moderate alcoholysis in 2,2,2-trifluoroethanol, enabling persistent electron donation. The Pt(II) complexes are adsorbed onto the surface of the [Gd₂C]²⁺·2e^– electride and rapidly capture the released electrons at a rate of 10⁷ s^-1 upon photoexcitation. The one-electron-reduced Pt complex is electrochem. stable enough to deliver the electron to substrates in the bulk, which completes the photoredox cycle. The key benefit of this system is the suppression of undesirable charge recombination because back electron transfer is prohibited due to the irreversible disruption of the electride after the electron transfer. These desirable properties collectively serve as the photoredox catalysis principle for the reductive generation of the benzyl radical from benzyl halide, which is the key intermediate for dehalogenated or homocoupled products.

Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 402-49-3, formula is C8H6BrF3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C8H6BrF3.

Guo, Yating;Jiang, Xiaoding;Chang, Qi;Xiao, Zhihong;Chen, Zhuo;Jiang, Dejian;Hu, Gaoyun;Li, Qianbin research published 《 Novel pyrazolo[3,4-b]pyridine derivatives: Synthesis, structure-activity relationship studies, and regulation of the AMPK/70S6K pathway》, the research content is summarized as follows. A series of novel pyrazolo[3,4-b]pyridine derivatives were designed, synthesized, and biol. evaluated for anti-lung cancer activity. Structure-activity relationship and AutoGPA models were constructed based on the in vitro antiproliferative potency of the compounds against a human lung adenocarcinoma cell line (A549). Compound 9d exhibits improved potency for A549 cell growth inhibition (3.06 ± 0.05 μM) compared with A-769662 (45.29 ± 2.14 μM). Compound 9d can elevate the phosphorylation levels of adenosine monophosphate-activated protein kinase (AMPK) and its substrate acetyl-CoA carboxylase and reduce the level of phosphorylated ribosomal S6 kinase (p-70S6K) at 1 μM, which is comparable to the activity of A-769662 at 20 μM. 9d induced G2/M cell cycle arrest, which was rescued when co-incubated with “Compound C,” a potent AMPK inhibitor. Taken together, compound 9d showed potential anti-lung cancer activity via inducing cell cycle arrest by regulation of the AMPK/70S6K pathway in A549 cells, which could provide a new lead for the discovery of anti-lung cancer agents.

COA of Formula: C8H6BrF3, 4-Trifluoromethylbenzyl bromide is a useful research compound. Its molecular formula is C8H6BrF3 and its molecular weight is 239.03 g/mol. The purity is usually 95%.
4-Trifluoromethylbenzyl bromide is a choline derivative that acts as an anticancer agent. It is structurally similar to the anticancer drug doxorubicin, which has been shown to be effective against breast cancer and leukemia. 4-Trifluoromethylbenzyl bromide interacts with cellular proteins, including choline kinase, and inhibits the mitochondrial pathway. This leads to cell death through apoptosis. The molecule also interacts with nucleotide bases such as thymine and cytosine in DNA, inhibiting transcription and replication. 4-Trifluoromethylbenzyl bromide binds strongly to the hydroxyl group of cholesterol by an electrophilic substitution mechanism to form a covalent bond with its hydroxy group. The molecule can also bind to chloride ions by an ionic bond., 402-49-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 6911-87-1.

Guo, Zhiqiang;Pang, Tengfei;Yan, Leilei;Wei, Xuehong;Chao, Jianbin;Xi, Chanjuan research published 《 CO₂-tuned highly selective reduction of formamides to the corresponding methylamines》, the research content is summarized as follows. Herein an efficient, CO₂-tuned and highly selective C-O bond cleavage of N-methylated formanilides is described. With easy-to-handle and com. available NaBH₄ as the reductant, a variety of formanilides could be turned into the desired tertiary amines in moderate to excellent yields. The role of CO₂ has been investigated in detail, and the mechanism is proposed on the basis of experiments

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 3-Bromobenzoic acid.

Gurram, Swarupa Rani;Azam, Mohammed Afzal research published 《 Design, synthesis and biological evaluation of some novel N’-(1,3-benzothiazol-2-yl)-arylamide derivatives as antibacterial agents》, the research content is summarized as follows. Hydroxybenzotriazole (HOBT) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCl)-mediated synthesis of new N’-(1,3-benzothiazol-2-yl)-arylamides, I [R = 2-thienyl, 2-fluorophenyl, 4-oxochroman-3-yl, etc.] was carried out in high yields under relatively milder reaction conditions using DMF as solvent. Synthesized compounds I were characterized by FTIR, ¹H-NMR, ¹³C-NMR and HRMS spectral data. The MIC values of synthesized compounds I were determined by the broth microdilution method using Mueller Hinton medium. Tested compounds I showed variable activity against the tested Gram-pos. and Gram-neg. bacterial strains. Compounds I [R = 2,6-dichlorophenyl, 4-chloro-3-nitrophenyl; R = 3-bromophenyl, 2-iodophenyl; R = 2-thienyl, 2-quinolyl, 1H-indol-2-ylmethyl] exhibited promising activity against Staphylococcus aureus NCIM 5021 with MIC values in the range of 19.7-24.2μM. Among all tested compounds, I [R = 2-thienyl] possessing thiophene ring attached to the benzothiazole moiety via amide linkage exhibited maximum activity against S. aureus NCIM 5022 with MIC of 13.0μM. Compound I [R = 2-thienyl] showed maximum activity against S. aureus ATCC 43300 with MIC of 15.0μM and exhibited bactericidal activity against this strain in min. bactericidal concentration determination This compound also eliminated S. aureus ATCC 43300 strain after 24-h exposure indicating its bactericidal activity. ADMET calculation showed favorable pharmacokinetic profile of synthesized compounds I.

Recommanded Product: 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 823-78-9, formula is C7H6Br2, Name is 1-Bromo-3-(bromomethyl)benzene. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of C7H6Br2.

Gurusingha Arachchige, Harshani S.;Herath Mudiyanselage, Poornima D. H.;VanHecke, Garrett C.;Patel, Kush;Cheaito, Hassan A.;Dou, Q. Ping;Ahn, Young-Hoon research published 《 Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors》, the research content is summarized as follows. The ubiquitin-proteasome system (UPS) plays an important role in maintaining protein homeostasis by degrading intracellular proteins. In the proteasome, poly-ubiquitinated proteins are deubiquitinated by three deubiquitinases (DUBs) associated with 19S regulatory particle before degradation via 20S core particle. Ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) is one of three proteasome-associated DUBs that control the fate of ubiquitinated substrates implicated in cancer survival and progression. In this study, we have performed virtual screening of an FDA approved drug library with UCHL5 and discovered tiaprofenic acid (TA) as a potential binder. With mol. docking anal. and in-vitro DUB assay, we have designed, synthesized, and evaluated a series of TA derivatives for inhibition of UCHL5 activity. We demonstrate that one TA derivative, TAB2, acts as an inhibitor of UCHL5.

Application of C7H6Br2, 3-Bromobenzyl bromide undergoes reduction with diethylzinc in the presence of Pd(PPh3)4 to yield corresponding hydrocarbon.

3-Bromobenzyl bromide is a useful research compound. Its molecular formula is C7H6Br2 and its molecular weight is 249.93 g/mol. The purity is usually 95%.

3-Bromobenzyl bromide is a molecule that has been synthesized and shown to have anticancer activity. It inhibits the activity of cancer cells by binding to amines in these cells and preventing the formation of hydrogen bonds between these molecules. 3-Bromobenzyl bromide has also been shown to selectively inhibit the activity of NS5B polymerase, an enzyme that is important in the replication of the hepatitis C virus. The synthetic nature of this molecule makes it an attractive target for analytical methods such as nuclear magnetic resonance spectroscopy. This molecule also shows significant cytotoxicity against cancer cell lines in vitro, as well as inducing tumor necrosis factor-alpha (TNF-α) production in lps-stimulated murine macrophages., 823-78-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary