Category: bromides-buliding-blocks

Wang, Shan; Zhang, Rong-Hong; Zhang, Hong; Wang, Yu-Chan; Yang, Dan; Zhao, Yong-Long; Yan, Guo-Yi; Xu, Guo-Bo; Guan, Huan-Yu; Zhou, Yan-Hua; Cui, Dong-Bing; Liu, Ting; Li, Yong-Jun; Liao, Shang-Gao; Zhou, Meng published the artcile< Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities>, Formula: C7H8BrN, the main research area is diamino pyrimidine preparation SAR antitumor antiangiogenesis FAK inhibitor human; Anti-angiogenesis; Antitumor; DAPY; FAK inhibitor; Structure-activity relationship.

A series of 2,4-diamino pyrimidine (DAPY) derivatives I (R1 = 2-ClC6H4, 4-MeOC6H4, 4-BrC6H4, etc.), II (R2 = 4-H2NC6H4, 4-MeOC6H4, 2-O2NC6H4, etc.) were designed, synthesized, and evaluated as inhibitors of focal adhesion kinase (FAK) with antitumor and anti-angiogenesis activities. Most compounds effectively suppressed the enzymic activities of FAK, and the IC50s of I (R1 = 2-ClC6H4) and II (R2 = 2-MeOC6H4) were 2.75 and 1.87 nM, resp. They exhibited strong antiproliferative effects against seven human cancer cells, with IC50 values against two FAK-overexpressing pancreatic cancer cells (PANC-1 and BxPC-3) of 0.98μM, 0.55μM, and 0.11μM, 0.15μM, resp. Moreover, the above two compounds obviously suppressed the colony formation, migration, and invasion of PANC-1 cells in a dose-dependent manner. Meanwhile, these two compounds could induce the apoptosis of PANC-1 cells and arrest the cell cycle in G2/M phase according to the flow cytometry assay. Western blot revealed that these compounds effectively inhibited the FAK/PI3K/Akt signal pathway and significantly decreased the expression of cyclin D1 and Bcl-2. In addition, the above compounds potently inhibited the antiproliferative of HUVECs and obviously altered the cell morphol and also significantly inhibited the migration, tube formation of HUVECs and severely impaired the angiogenesis in the zebrafish model. Overall, these results revealed the potential of these compounds as promising candidates for further preclin. studies.

European Journal of Medicinal Chemistry published new progress about Angiogenesis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dong, Guangping; Iyamu, Iredia D.; Vilseck, Jonah Z.; Chen, Dongxing; Huang, Rong published the artcile< Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1>, Category: bromides-buliding-blocks, the main research area is peptidomimetic inhibitor preparation antitumor mol docking protein terminal methyltransferase; cell-permeable inhibitor; peptidomimetic inhibitor; protein N-terminal methyltransferase; structure-based drug design.

A series of new peptidomimetic inhibitors I (R = 3-bromophenyl, cyclohexylmethyl, 2-(4-phenylphenyl)ethyl, etc.) was designed and synthesized. Through a focused optimization of DC113, a new cell-potent peptidomimetic inhibitor GD562 (IC50 = 0.93 ± 0.04μM) is discovered. GD562 exhibited improved inhibition of the cellular N-terminal methylation levels of both the regulator of chromosome condensation 1 and the oncoprotein SET with an IC50 value of ∼50μM in human colorectal cancer HCT116 cells. Notably, the inhibitory activity of GD562 for the SET protein increased over 6-fold compared with the previously reported cell-potent inhibitor DC541. Furthermore, GD562 also exhibited over 100-fold selectivity for NTMT1 against several other methyltransferases. Thus, this study provided a valuable probe to investigate the biol. functions of NTMT1.

Molecules published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fan, Xiao-Nan; Ou, Hui-Dan; Deng, Wei; Yao, Zi-Jian published the artcile< Air-Stable Half-Sandwich Iridium Complexes as Aerobic Oxidation Catalysts for Imine Synthesis>, Product Details of C7H8BrN, the main research area is iridium half sandwich iminoketone complex preparation oxidation catalyst; imine preparation aerobic oxidation amine iridium iminoketone catalyst; benzyl alc amine coupling preparation benzylideneaniline iridium iminoketone catalyst; crystal structure iridium half sandwich iminoketone complex; mol structure iridium half sandwich iminoketone complex.

Several N,O-coordinate half-sandwich iridium complexes I (1-5, R = H, 4-MeO, 4-Cl, 2-Me, 3-Br) containing constrained bulky β-enaminoketonato ligands were prepared and clearly characterized. Single-crystal X-ray diffraction characterization of these complexes indicates that the iridium center adopts a distorted octahedral geometry. Complexes 1-5 showed good catalytic efficiency in the oxidative homocoupling of primary amines, dehydrogenation of secondary amines, and the oxidative cross-coupling of amines and alcs., which furnished various types of imines in good yields and high selectivities using O2 as an oxidant under mild conditions. No distinctive substituent effects of the iridium catalysts were observed in these reactions. The diverse catalytic activity, broad substrate scope, mild reaction conditions, and high yields of the products made this catalytic system attractive in industrial processes. Half-sandwich iridium complexes were synthesized which exhibited high catalytic activity for oxidative homocoupling of primary amines, dehydrogenation of secondary amines, and oxidative cross-coupling of alcs. and amines under mild conditions using clean O2 as the oxidative reagent. The broad substrate scope, mild reaction conditions, and high yields of the products made this catalytic system attractive in industrial processes.

Inorganic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pearce-Higgins, Robert; Hogenhout, Larissa N.; Docherty, Philip J.; Whalley, David M.; Chuentragool, Padon; Lee, Najung; Lam, Nelson Y. S.; McGuire, Thomas M.; Valette, Damien; Phipps, Robert J. published the artcile< An Enantioselective Suzuki-Miyaura Coupling To Form Axially Chiral Biphenols>, COA of Formula: C7H7BrO2, the main research area is arylbromide phenylboronate ester palladium sSPhos catalyst Suzuki Miyaura coupling; arylphenol enantioselective preparation.

The use of enantiopure, sulfonated SPhos (sSPhos), an existing ligand that has until now been used only in racemic form and that derived its chirality from an atropisomeric axis that was introduced through sulfonation. The attractive noncovalent interactions involving the ligand sulfonate group was responsible for the high levels of asym. induction that we obtain in the 2,2′-biphenol products of Suzuki-Miyaura coupling, and a highly practical resolution of sSPhos via diastereomeric salt recrystallization was developed.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, COA of Formula: C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Singh, Sudhir K.; Ruchelman, Alexander L.; Li, Tsai-Kun; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J. published the artcile< Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity>, Application of C7H4BrNO4, the main research area is methylenedioxydibenzonaphthyridinone preparation topoisomerase inhibiting activity cytotoxicity; structure methylenedioxydibenzonaphthyridinone topoisomerase inhibiting activity cytotoxicity; nitro amino substitution methylenedioxydibenzonaphthyridinone topoisomerase targeting activity cytotoxicity.

Methylenedioxydibenzo[c,h][1,6]naphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et) are prepared as potential inhibitors of human topoisomerase I. Coupling of 2-bromobenzoic acids to amino(methylenedioxy)quinolines [prepared by displacement of 4-chloro-6,7-(methylenedioxy)quinoline] followed by palladium-catalyzed intramol. Heck arylation reactions and reduction of the pendant nitro groups (if present) yields methylenedioxydibenzonaphthyridinones I (R, R1, R2 = H, H2N, O2N; R3 = Me2N, Et). I (R = H; R1 = H, O2N; R2 = O2N, H; R3 = Me2N) inhibit topoisomerase I-mediated DNA cleavage more effectively and are more cytotoxic than camptothecin; I have topoisomerase I inhibiting activities comparable to dimethoxydibenzonaphthyridinone I (R = H; R1 = R2 = MeO; R3 = Me2N).

Journal of Medicinal Chemistry published new progress about Cytotoxic agents. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application of C7H4BrNO4.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Peiqi; Guo, Zhifen; Liu, Xin; Lv, Hui; Che, Yan; Bai, Rong; Chi, Yanhong; Xing, Hongzhu published the artcile< A visible-light-responsive metal-organic framework for highly efficient and selective photocatalytic oxidation of amines and reduction of nitroaromatics>, Application of C7H8BrN, the main research area is metal organic framework photooxidation photoreduction catalyst.

Photocatalysis is a green synthetic method for organics transformation. We present here the synthesis of a novel visible-light-responsive metal-organic framework and its photocatalytic application. The prepared MOF is highly efficient for the self-coupling of primary amines and oxidative dehydrogenation of secondary amines to selectively produce imines assisted by the green and economic oxidant of mol. oxygen. Studies reveal that both energy transfer and electron transfer from the photoexcited MOF to mol. oxygen are important for amine oxidation, where the highly reactive species of superoxide radicals and singlet oxygen together account for the high catalytic performance. The photogenerated electrons of the MOF have also been utilized for the reduction of aromatic nitroarenes. Results show that they are highly selective for the reduction of nitroarenes to produce anilines in the presence of hydrazine hydrate. The work demonstrates the enormous potential of photoactive MOFs for converting organic substrates into valuable chems.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Coupling reaction catalysts. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Crosignani, Stefano; Pretre, Adeline; Jorand-Lebrun, Catherine; Fraboulet, Gaele; Seenisamy, Jeyaprakashnarayanan; Augustine, John Kallikat; Missotten, Marc; Humbert, Yves; Cleva, Christophe; Abla, Nada; Daff, Hamina; Schott, Olivier; Schneider, Manfred; Burgat-Charvillon, Fabienne; Rivron, Delphine; Hamernig, Ingrid; Arrighi, Jean-Francois; Gaudet, Marilene; Zimmerli, Simone C.; Juillard, Pierre; Johnson, Zoe published the artcile< Discovery of Potent, Selective, and Orally Bioavailable Alkynylphenoxyacetic Acid CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases>, Product Details of C7H4BrF3O, the main research area is alkynylphenoxyacetic acid preparation CRTH2 receptor antagonist; DP2 receptor antagonist alkynylphenoxyacetic acid structure activity.

New phenoxyacetic acid antagonists of CRTH2 are described. Following the discovery of a hit compound, I, by a focused screening, high protein binding was identified as its main weakness. Optimization aimed at reducing serum protein binding led to the identification of several compounds that showed not only excellent affinities for the receptor (41 compounds with Ki < 10 nM) but also excellent potencies in a human whole blood assay (IC50 < 100 nM; PGD2-induced eosinophil shape change). Addnl. optimization of the pharmacokinetic characteristics led to the identification of several compounds suitable for in vivo testing. Of these, II (R1 = n-Pr, R2 = Me; R1 = n-Pr, R2 = F) were tested in two different pharmacol. models (acute FITC-mediated contact hypersensitivity and ovalbumin-induced eosinophilia models) and found to be active after oral dosing (10 and 30 mg/kg). Journal of Medicinal Chemistry published new progress about Allergic asthma. 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wei, Hao; Zhang, Yong Jian; Wang, Feijun; Zhang, Wanbin published the artcile< Novel atropisomeric bisphosphine ligands with a bridge across the 5,5'-position of the biphenyl for asymmetric catalysis>, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate, the main research area is biphenyl diphosphine atropisomeric preparation chiral ligand asym hydrogenation; cinnamic acid acetamido asym hydrogenation; phenylalanine substituted asym synthesis.

A new type of atropisomeric bisphosphine ligand I [X = (CH2)8, (CH2)10] with a bridge across the 5,5′-position of the biphenyl has been developed. The axial chirality of this type of ligands can be retained by macrocyclic ring strain produced from 5,5′-linkage of the biphenyl even without 6,6′-substituents on the biphenyls. Ligand (R)-I [X = (CH2)8] showed good catalytic activity and enantioselectivity for Rh(I)-catalyzed asym. hydrogenation of (Z)-α-acetamidocinnamic acids RCH:C(COOH)NHAc.

Tetrahedron: Asymmetry published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Recommanded Product: Methyl 2-bromo-4-methoxybenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Feriancova, Lucia; Cigan, Marek; Gmucova, Katarina; Kozisek, Jozef; Nadazdy, Vojtech; Putala, Martin published the artcile< Effect of electron-withdrawing groups on molecular properties of naphthyl and anthryl bithiophenes as potential n-type semiconductors>, Safety of 5-Bromo-2,2′-bithiophene, the main research area is naphthylbithiophene anthrylbithiophene preparation semiconductor.

A series of ten 2-naphthyl and 2-anthrylbithiophene derivatives with electron acceptor groups were synthesized using the Negishi or Suzuki cross-coupling reaction as a key step. We present a comparison of theor. and exptl. values of the LUMO and gap energies of these derivatives and the effect of the various electron-withdrawing groups on their optical and electrochem. properties. DFT-calculated frontier orbital energy differences have shown a trend following the exptl. determined values. The participation of the electron-withdrawing group in π-conjugation decreases the LUMO level and narrows the energy gap in the order of perfluoroalkyl, acyl, perfluoroacyl, nitro ≈ dicyanovinyl in both series. TD-DFT calculations allowed better understanding of electronic transitions. X-ray structure anal. of naphthalene hexanoyl and perfluorooctanoyl derivatives revealed their herringbone or sandwich herringbone mol. packing, resp., having a planar naphthalene-bithiophene moiety with opposite (s-trans vs. s-cis) conformation of bithiophene.

New Journal of Chemistry published new progress about Absorption spectra. 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, Safety of 5-Bromo-2,2′-bithiophene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zhipeng; He, Zhiqin; Xie, Yuxing; He, Tiantong; Fu, Yaofeng; Yu, Yang; Huang, Fei published the artcile< Bronsted acid-catalyzed homogeneous O-H and S-H insertion reactions under metal- and ligand-free conditions>, Related Products of 81107-97-3, the main research area is alkoxy acetate preparation; alc diazo compound OH bond insertion Bronsted acid catalyzed; phenylethylidene amino oxy acetate preparation; oximes with diazo compound OH insertion Bronsted acid catalyzed; thio aryl acetate preparation; thiol diazo compound SH insertion Bronsted acid catalyzed.

Under metal- and ligand-free conditions, the economical and accessible CF3SO3H successfully catalyzed homogeneous O-H bond insertion reactions between hydroxyl compounds and diazo compounds to afford alkoxy acetates. Including phenols, alcs., water and oximes, these O-H bond insertion reactions were very general and functional-group tolerant. Here, the O-H bond insertion of oximes (ketoximes and aldoximes) to gave phenylethylidene(amino(oxy)acetates) was reported and their structures were characterized by X-ray crystallog. Moreover, a simple and effective method for S-H insertion reactions of thiols to gave thio(aryl)acetates was also developed, delivering the desired C-S bond products with good to excellent yields. It was worth noting that the efficacy of the developed methodol. could be further shown by the expeditious synthesis of the PPAR agonist MBX-102 acid.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Related Products of 81107-97-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary