Category: bromides-buliding-blocks

Zhang, Mingkai; Zou, Yong; Zhang, Sai; Qu, Yongquan published the artcile< In situ Re-construction of Pt Nanoparticles Interface for Highly Selective Synthesis of Primary Amines>, Category: bromides-buliding-blocks, the main research area is platinum nanoparticle primary amine selective synthesis.

Regulation of the catalyst interface by adsorbates has been demonstrated as an efficacious methodol. to enhance the catalytic selectivity. Herein, we demonstrated an in situ modifications induced by reactants to re-construct the local interface of Pt nanoparticles anchored on the CoFe layered double hydroxides (CoFe-LDH) supports for a highly selective synthesis of primary amines from reductive amination of aldehydes and ammonia. The strong metal-support interaction between Pt metals and CoFe-LDH supports results in the highly electron-enriched surface of Pt and thereby makes the surface of Pt nanoparticles favor the enrichment of NH4+ species and adsorption of NH3. Such a tailored interface can create an interfacial stereo-hindrance effect and effectively slug the reaction kinetics of side-reactions, further preventing the formation of side-products. We anticipate that such an in situ re-construction of metal interface by reactants and afterwards the constructed local environment of active sites may provide a new approach for the optimization of metal catalysts.

ChemCatChem published new progress about Adsorbed substances. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thorve, Pradip Ramdas; Maji, Biplab published the artcile< Deaminative Olefination of Methyl N-Heteroarenes by an Amine Oxidase Inspired Catalyst>, Reference of 3959-07-7, the main research area is diaryl olefin preparation diastereoselective; methyl heteroarene primary amine deaminative olefination phenanthrolinedione catalyst.

The bioinspired o-quinone cofactor catalyzed aerobic primary amine ArCH2NH2 (Ar = Ph, 2-chlorophenyl, furan-2-yl, etc.) dehydrogenation for a cascade olefination reaction with nine different Me N-heteroarenes, including pyrimidines such as 4-Me pyrimidine, N-benzyl-4-methylpyrimidin-2-amine and N,N-dibenzyl-4-methylpyrimidin-2-amine, 2-methylpyrazine, pyridines such as 4-methylpyridine, 5-bromo-2-methylpyridine, 2-methylpyridine, etc.; quinolines such as 2-methylquinoline, 2,6-dimethylquinoline, 6-methoxy-2-methylquinoline and 4-methylquinoline, 2-methylquinoxaline, benzimidazoles such as 1-benzyl-2-methyl-1H-1,3-benzodiazole and 1-benzyl-5,6-dichloro-2-methyl-1H-1,3-benzodiazole, 2-methyl-1,3-benzoxazole, 2-methyl-1,3-benzothiazole and 2,4,6-trimethyl-1,3,5-triazine were explored. An o-quinone catalyst phd (1,10-phenanthroline-5,6-dione) combined with a Bronsted acid such as TfOH catalyzed the reaction. N-Heteroaryl stilbenoids RCH=CHAr (R = pyridin-2-yl, pyrimidin-4-yl, 1,3-benzoxazol-2-yl, etc.) were synthesized in high yields and (E)-selectivities under mild conditions using oxygen (1 atm) as the sole oxidant without the need of transition-metal salt, ligand, stoichiometric base, or oxidant.

Organic Letters published new progress about Aryl alkenes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Reference of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhen, Cian-Jhe; Lu, Shu-Feng; Lin, Min-Hwa; Wu, Jay-Tai; Chao, Ito; Lin, Chih-Hsiu published the artcile< Singlet Biradical Versus Triplet Biradical/Zwitterion Characteristics in Isomers of C6-C5-C6-C7-C6-Fused Pentacyclic Aromatic Hydrocarbons Revealed through Reactivity Patterns>, Category: bromides-buliding-blocks, the main research area is fused pentacyclic aromatic hydrocarbon biradical zwitterion structure property relationship; biradical; polycyclic aromatic hydrocarbons; structure property relationship; zwitterion.

Among various polycyclic aromatic hydrocarbons, C6-C5-C6-C7-C6 fused pentacyclic aromatic hydrocarbons have the unique potential to adopt quinonoid, zwitterion, singlet, or triplet biradical electronic configurations. Two such hybrid structures between pentacene and azulene were synthesized and their ground state electronic configurations were deduced from the reactivity patterns they exhibit resp. Compound I, where the radicaloid carbons are linked through a para-phenylene, forms a head-to-head dimer like a singlet biradical. In contrast, isomer II, where the para-linkage was switched to meta, reacts readily with oxygen which resembles the reactivity of a triplet state. The oxidized intermediate(s) then underwent rearrangement to furnish the C6-C5-C6-C6-C6 ring contraction product 11,13-Dimesityl-13H-indeno[1,2-b]anthracene-6-carbaldehyde. Cation 12,14-Dimesityl-12,14-dihydrobenzo[5,6]cyclohepta[1,2-b]fluoren-12-ylium tetrafluoroborate, the protonated form of compound II, was synthesized, which implies compound II also reacts like a zwitterion. It was revealed the oxidative rearrangement takes place even with mesityl dibenzotropylium cation despite its perceived aromaticity. DFT calculations confirm the most stable forms of compound I and compound II are singlet and triplet diradical, which is consistent with the observed reactivity of resp. mols.

Chemistry – A European Journal published new progress about Biradicals Role: FMU (Formation, Unclassified), FORM (Formation, Nonpreparative). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Chenglong; Shi, Yafei; Li, Pengfei; Zhang, Niu; Wang, Nan; Yin, Xiaodong; Chen, Pangkuan published the artcile< Access to Highly Luminescent N-Doped Diazaborepins with Penta-, Hexa-, and Heptagon Substructures>, Safety of 2,4,6-Trimethylbromobenzene, the main research area is luminescent N doped diazaborepin.

Two diazaborepins (BNN1 and BNN2) have been accomplished via a highly efficient pathway in the step-economic transformation. Oxidative dimerization of carbazole derivatives followed by borylation reaction gave heterocyclic diazaborepin as the key building block. Replacement of carbon moiety in traditional borepins with N-N functionality led to a significant red shift of their emissions up to 585 nm with strong red color as solids. This work offered an approach to diazaborepin-based materials for applications in light-emitting field.

Organic Letters published new progress about Borylation. 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Safety of 2,4,6-Trimethylbromobenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meazza, Marta; Sitinova, Gabriela; Poderi, Cecilia; Mancinelli, Michele; Zhang, Kaiheng; Mazzanti, Andrea; Torres, Ramon Rios published the artcile< Synergistic Catalysis: Highly Enantioselective Acetyl Aza-arene Addition to Enals>, Application In Synthesis of 3893-18-3, the main research area is synergistic catalysis enantioselective addition acetyl aza arene enal; Michael addition; acetyl aza-arenes; enals; secondary amine catalysis; synergistic catalysis.

A novel catalytic enantioselective methodol. based on synergistic catalysis for the synthesis of chiral 2-acyl pyridines and pyrazines is reported. The strategy involves the metal-Lewis acid activation of acetyl aza-arenes and the secondary-amine activation of enals. The proposed mechanism is supported by DFT calculations

Chemistry – A European Journal published new progress about Addition reaction, stereoselective. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application In Synthesis of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ning, Shulin; Zheng, Lianyou; Bai, Ya; Wang, Shutao; Wang, Siyu; Shi, Lingling; Gao, Qiansong; Che, Xin; Zhang, Zhuoqi; Xiang, Jinbao published the artcile< Highly selective electroreductive linear dimerization of electron-deficient vinylarenes>, Formula: C21H22BrP, the main research area is diaryl butane preparation; vinylarene preparation regioselective electroreductive dimerization.

A direct electroreductive dimerization of electron-deficient vinylarenes R1R2C:CR3R4 (R1 = Ph, 4-NCC6H4, pyridin-4-yl, etc., R2 = R3 = R4 = H; R1 = 4-EtO2CC6H4, R2 = Me, Ph, R3 = R4 = H; R1 = 4-MeO2CC6H4, R2 = H, R3 = Me, R4 = H, Me; etc.) for the synthesis of 1,4-diarylbutanes R1R2CH-CR3R4-CR3R4-CHR1R2 as been developed using a simple undivided cell with inexpensive carbon electrodes at room temperature The control and deuterium-labeling experiments of electroreductive dimerization suggest that the hydrogen source comes from the solvent CH3CN. This protocol provides a mild and efficient route for the construction of C-C bond in moderate to good yields with high regioselectivity and broad substrate scope.

Tetrahedron published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Formula: C21H22BrP.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tyler, Jasper L.; Noble, Adam; Aggarwal, Varinder K. published the artcile< Strain-Release-Driven Friedel-Crafts Spirocyclization of Azabicyclo[1.1.0]butanes>, Recommanded Product: Isopropyltriphenylphosphonium bromide, the main research area is tertiary butoxy carbonyl azetidino spiro tetralin preparation regioselective DFT; alkylazetidine preparation Friedel Crafts spirocyclization tetrafluoroboric acid etherate catalyst; azabicyclobutane carbinol preparation alkyl halide alkylation; azabicylo[1.1.0]butanes; azetidines; dearomatization; spiro compounds; strained molecules.

The strain-release-driven Friedel-Crafts spirocyclization of azabicyclo[1.1.0]butane-tethered (hetero)aryls I (R = H, Me, Bn, allyl, triethylsilyl; R1 = Ph, 2-naphthyl, benzothiophen-2-yl, etc.) for the synthesis of a unique library of azetidine spiro-tetralins e.g., II was reported. The reaction was discovered to proceed through an unexpected interrupted Friedel-Crafts mechanism, generating a highly complex azabicyclo[2.1.1]hexane scaffold. This dearomatized intermediate, formed exclusively as a single diastereomer, can be subsequently converted to the Friedel-Crafts product upon electrophilic activation of the tertiary amine, or trapped as a Diels-Alder adduct in one-pot. The rapid assembly of mol. complexity demonstrated in these reactions highlights the potential of the strain-release-driven spirocyclization strategy to be utilized in the synthesis of medicinally relevant scaffolds.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Recommanded Product: Isopropyltriphenylphosphonium bromide.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mitsudome, Takato; Sheng, Min; Nakata, Ayako; Yamasaki, Jun; Mizugaki, Tomoo; Jitsukawa, Koichiro published the artcile< A cobalt phosphide catalyst for the hydrogenation of nitriles>, Formula: C7H8BrN, the main research area is nitrile cobalt phosphide hydrogenation catalyst.

The study of metal phosphide catalysts for organic synthesis is rare. We present, for the first time, a well-defined nano-cobalt phosphide (nano-Co2P) that can serve as a new class of catalysts for the hydrogenation of nitriles to primary amines. While earth-abundant metal catalysts for nitrile hydrogenation generally suffer from air-instability (pyrophoricity), low activity and the need for harsh reaction conditions, nano-Co2P shows both air-stability and remarkably high activity for the hydrogenation of valeronitrile with an excellent turnover number exceeding 58000, which is over 20- to 500-fold greater than that of those previously reported. Moreover, nano-Co2P efficiently promotes the hydrogenation of a wide range of nitriles, which include di- and tetra-nitriles, to the corresponding primary amines even under just 1 bar of H2 pressure, far milder than the conventional reaction conditions. Detailed spectroscopic studies reveal that the high performance of nano-Co2P is attributed to its air-stable metallic nature and the increase of the d-electron d. of Co near the Fermi level by the phosphidation of Co, which thus leads to the accelerated activation of both nitrile and H2. Such a phosphidation provides a promising method for the design of an advanced catalyst with high activity and stability in highly efficient and environmentally benign hydrogenations.

Chemical Science published new progress about Adsorption. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Formula: C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cao, Yang; Aimaiti, Abudumijiti; Zhu, Zeyun; Zhou, Lu; Ye, Deyong published the artcile< Discovery of Novel 3-Hydroxyquinazoline-2,4(1H,3H)-Dione Derivatives: A Series of Metal Ion Chelators with Potent Anti-HCV Activities>, Application In Synthesis of 20776-50-5, the main research area is hydroxyquinazoline dione preparation mol docking anti HCV SAR; metal chelator; NS5B; anti-HCV; chelator; hydroxyquinazolinedione; synthesis.

Millions of people worldwide suffer from acute or chronic liver inflammation caused by the Hepatitis C virus (HCV). Some inhibitors with metal ion chelating structures have been proven to have good inhibitory activities on non-structural protein 5B (NS5B) polymerase. However, most of the reported metal ion chelators showed poor anti-HCV potency at the cellular level. Hence, authors designed and synthesized a series of 3-hydroxyquinazoline-2,4(1H,3H)-dione derivatives with novel metal ion chelating structures. Few compounds such as compound I, [R = 4-(trifluoromethyl)phenyl, 3-nitrophenyl, benzofuran-2-yl] showed better anti-HCV activities than ribavirin with EC50 values less than 10μM. Compound I [R = benzofuran-2-yl] is currently known as one of the metal ion chelators with the best anti-HCV potency (EC50 = 2.0μM) at the cellular level and has a better therapeutic index (TI > 25) as compared to ribavirin. In the thermal shift assay, the representative compounds 3-hydroxy-7-phenylquinazoline-2,4(1H,3H)-dione and 3-hydroxy-7-(3-nitrophenyl)quinazoline-2,4(1H,3H)-dione increased the melting temperature (Tm) of NS5B protein solution by 1.6°C and 2.1°C, resp., at the test concentration, indicating that these compounds may exert an anti-HCV effect by targeting NS5B. This speculation was also supported by mol. docking studies and UV-visible (UV-Vis) spectrophotometry assay, in which the possibility of binding of 3-hydroxyquinazoline-2,4(1H,3H)-diones with Mg2+ in the NS5B catalytic center was observed

International Journal of Molecular Sciences published new progress about Alkylation. 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Application In Synthesis of 20776-50-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Ming; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published the artcile< Palladium-Catalyzed Oxidative Carbonylation of Aromatic C-H Bonds of N-Alkylanilines with CO and Alcohols for the Synthesis of o-Aminobenzoates>, Application In Synthesis of 639520-70-0, the main research area is palladium catalyzed oxidative carbonylation alkylaniline aminobenzoate preparation; alkylaniline aliphatic alc phenol monocarbonylation mild carbon monoxide pressure.

A Pd(II)-catalyzed C-H monocarbonylation of N-alkylanilines for the synthesis of o-aminobenzoates has been developed. Various aliphatic alcs. and phenol were tolerated in the reaction to afford the corresponding o-aminobenzoates in good yields under mild balloon pressure of CO.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Application In Synthesis of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary