Category: bromides-buliding-blocks

Bai, Peng; Tong, Xinli; Gao, Yiqi; Guo, Pengfei published the artcile< Oxygen-free water-promoted selective photocatalytic oxidative coupling of amines>, SDS of cas: 3959-07-7, the main research area is imine synthesis water promoted photocatalytic oxidative coupling amine; oxygen free water promoted photocatalytic oxidative coupling amine.

A novel photocatalytic selective oxidative transformation of amines to imines using water as a primary oxidant is achieved under oxygen-free conditions. In the presence a single 1%Pt@TiO2-500 catalyst, the photocatalytic oxidative coupling of benzylamine to N-benzylidenebenzylamine has been efficiently performed using water as an oxidant, in which a 99.8% conversion and a 92.5% selectivity were obtained at room temperature; meanwhile, a certain amount of hydrogen was detected that confirms the simultaneous occurrence of water splitting reaction. Further investigations revealed that the introduction of the Pt element facilitates the formation of O-holes on the surface of TiO2, which efficiently promotes the generation of active oxygen species from water and the following oxidative coupling of benzylamine. Then, the photocatalytic oxidative coupling of various aromatic and aliphatic amines with water as the primary oxidant were also studied, and excellent conversion and high selectivities to corresponding products were attained. Based on the control experiment and the catalytic principle, a possible reaction mechanism is proposed for the oxidative coupling of benzylamine with water as the primary oxidant.

Catalysis Science & Technology published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, SDS of cas: 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sun, Jufeng; Ambrus, Joey I.; Russell, Cecilia C.; Baker, Jennifer R.; Cossar, Peter J.; Pirinen, Melanie J.; Sakoff, Jennette A.; Scarlett, Christopher J.; McCluskey, Adam published the artcile< Targeting the S100A2-p53 Interaction with a Series of 3,5-Bis(trifluoromethyl)benzenesulfonamides: Synthesis and Cytotoxicity>, Safety of 4-Bromobenzylamine, the main research area is benzenesulfonamide aminoalkyl trifluoromethyl preparation antitumor pancreatic cancer; S100A2; focuse libraries; p53; pancreatic cancer; protein-protein interaction.

In silico approaches identified N-(6-((4-bromobenzyl)amino)hexyl)-3,5-bis(trifluoromethyl)benzenesulfonamide I [X = (CH2)4; R1 = 4-BrC6H4; R2 = H] as a potential inhibitor of the S100A2-p53 protein-protein interaction, a validated pancreatic cancer drug target. Subsequent cytotoxicity screening revealed it to be a 2.97μM cell growth inhibitor of the MiaPaCa-2 pancreatic cell line. This is in keeping with the hypothesis that inhibiting this interaction would have an anti-pancreatic cancer effect with S100A2, the validated PC drug target. A combination of focused library synthesis [24 compounds I (X = nothing, CH2, CH2CH2; R1 = 4-BrC6H4, 3,4-Cl2C6H3, 1-naphthyl, etc.; R2 = H, Me)] and cytotoxicity screening identified a Pr alkyl diamine spacer as optimal; the nature of the terminal Ph substituent had limited impact on observed cytotoxicity, whereas N-methylation was detrimental to activity. In total 15 human cancer cell lines were examined, with most analogs showing broad-spectrum activity. Near uniform activity was observed against a panel of six pancreatic cancer cell lines: MiaPaCa-2, BxPC-3, AsPC-1, Capan-2, HPAC and PANC-1. In all cases there was good to excellent correlation between the predicted docking pose in the S100A2-p53 binding groove and the observed cytotoxicity, especially in the pancreatic cancer cell line with high endogenous S100A2 expression. This supports S100A2 as a pancreatic cancer drug target.

ChemMedChem published new progress about Amino amides Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wan, Lin-Xi; Miao, Shi-Xing; He, Zhen-Xiang; Li, Xiaohuan; Zhou, Xian-Li; Gao, Feng published the artcile< Pd-Catalyzed Direct Modification of an Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of α-Aryl Donepezil Analogues>, Related Products of 401-78-5, the main research area is benzylpiperidinylmethyl dimethoxy aryldihydroindenone preparation antialzheimer mol docking.

Palladium/BuAd2P catalyzed efficiently the direct α-arylation of ketone in the anti-Alzheimer’s disease drug donepezil I (Ar = H), leading to 15 aryldonepezil analogs I (Ar = 3-methylpyridin-2-yl (II), 4-chlorophenyl, naphth-1-yl, etc.) exhibiting high selective inhibition of acetylcholinesterase (AChE). The cell-based assays revealed that the 3-methylpridinyl analog (II) shows significantly lower toxicity compared to donepezil and remarkable neuroprotective activity against H2O2-induced damage in SH-SY5Y cells. Docking results of compound II also interpreted the possible mechanism of the selective inhibition between AChE and butyrylcholinesterase.

ACS Omega published new progress about Alzheimer disease. 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Related Products of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ye, Zhi-Peng; Hu, Yuan-Zhuo; Guan, Jian-Ping; Chen, Kai; Liu, Fang; Gao, Jie; Xiao, Jun-An; Xiang, Hao-Yue; Chen, Xiao-Qing; Yang, Hua published the artcile< Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2H-pyrrol-2-one Scaffold>, Application In Synthesis of 3959-07-7, the main research area is fluoro dihydropyrrolone preparation photochem; allylbromodifluoroacetamide cyclic secondary amine tandem cyclization defluorination.

Herein an unprecedented photoinduced cyclization/defluorination domino process of N-allylbromodifluoroacetamide with cyclic secondary amines is reported. Consequently, a wide array of valuable 3-fluoro-1,5-dihydro-2H-pyrrol-2-ones I (R = Ph, 4-i-PrC6H4, Bn, etc.; X = O, N(Boc), N(COMe), etc.; R1 = H, Me) were facilely prepared from readily available starting materials under mild conditions. Preliminary mechanistic investigations suggest that a radical chain propagation and amine-promoted defluorination pathway are presumably involved in this transformation.

Organic Letters published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (N-allylbromodifluoro). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application In Synthesis of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Inder; Kumar, Rakesh; Gupta, Shiv Shankar; Sharma, Upendra published the artcile< C70 Fullerene Catalyzed Photoinduced Aerobic Oxidation of Benzylamines to Imines and Aldehydes>, Recommanded Product: 4-Bromobenzylamine, the main research area is C70 fullerene catalyzed photoinduced aerobic oxidation; benzylamine oxidation imine aldehyde preparation radical formation.

C70 fullerene catalyzed photoinduced oxidation of benzylic amines at ambient conditions has been explored here. The developed strategy’s main feature includes the additive/oxidant-free conversion of benzylic amine to corresponding imine and aldehydes. The reaction manifests broad substrate scope with excellent function group leniency and is applicable up to the gram scale. Further, sym. secondary amines can also be synthesized from benzylic amine in a one-pot two-step process. Various experiments and d. functional theory studies revealed that the current reaction involves the generation of reactive oxygen species, single electron transfer reaction, and benzyl radical formation as key steps under photocatalytic conditions.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alhijry, Ibraheem A.; El Sherbini, Ashraf M.; El Sherbini, Tharwat M. published the artcile< Measurement of deviations of transition probability of the neutral silver lines at 827.35 and 768.77 nm using OES-technique>, Synthetic Route of 82-73-5, the main research area is silver transition probability Boltzmann plot OES spectrum.

Boltzmann plot of laser produced plasma spectral emission of two Ag I-spectral lines at 827.35 and 768.77 nm was carried out. Surprisingly, two order of magnitude lower inherent transition probabilities of the two Ag I-spectral lines could be monitored using optical emission spectroscopy OES-technique. Nd: YAG laser at 532 nm and incident intensities varying from 1.76 to 3.14 GW/cm2 was used to induce plasma emission of silver targets. Six Ag I-lines were identified using echelle spectrograph facility at 546.54, 520.9, 827.35, 768.77, 328.06 and 338.28 nm in addition to the Ha-line. Corrections against optically thick plasma spectral line emission were routinely implemented while taking into consideration the sensitivity of spectrograph-ICCD combination. The new measured values of transition probabilities were verified during plasma expansion under different laser incident irradiances.

Journal of Quantitative Spectroscopy & Radiative Transfer published new progress about Absorptivity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Synthetic Route of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Sifeng; Yang, Qingjing; Wang, Jun published the artcile< Copper(II) triflate-catalyzed highly efficient synthesis of N-substituted 1,4-dihydropyridine derivatives via three-component cyclizations of alkynes, amines, and α,β-unsaturated aldehydes>, Reference of 3893-18-3, the main research area is pyridine dihydro preparation; three component reaction alkyne amine unsaturated aldehyde copper catalyst; dihydropyridine preparation.

A copper(II) triflate-catalyzed three-component cyclization of alkynes, amines, and α,β-unsaturated aldehydes was developed to give various 1,4-dihydropyridines in good to high yields. In addition, this efficient and practical protocol proceeded smoothly in gram scale even when the catalytic loading was reduced to 1 mol %.

Tetrahedron Letters published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cai, Rongbin; Zhou, Qi; Hou, Tianjiao; Li, Bing; Liu, Yunzhi; Li, Huan; Gao, Yuan; Zhu, Longyi; Luo, Jun published the artcile< Facile construction of the all-bridge-position-functionalized 2,4,6,8-tetraazaadamantane skeleton and conversion of its N-functionalities>, Safety of 4-Bromobenzylamine, the main research area is tetraazaadamantanyl tricyclic preparation.

In this article, an unusual protocol of a “”one-pot”” three-step strategy to build the special all-bridge-position-functionalized tetraazaadamantane skeletons I [R = i-Bu, Bn, CH2-2-furyl, etc.] from 2,2-dipropenyl-1,3-dioxolane via ozonation, hydrogenation with 5% Pd/BaSO4, and condensation of the in-situ generated dial intermediate with primary amines was reported for the first time. Different primary amines were compatible with this process and the corresponding 2,4,6,8-tetraalkyl-2,4,6,8-tetraazaadamantane-9,10-dione bis(ethylene ketals) were achieved in 19-46% yields. The conversion of the N-benzyl group to some other functionalities such as acetyl, benzoyl, nitroso and nitro was also investigated.

Organic Chemistry Frontiers published new progress about Condensation reaction. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shah, Akshara P.; Sharma, Anuj S.; Sharma, Vinay S.; Shimpi, Navinchandra G. published the artcile< Polyacrylonitrile Nanofibers Incorporating Silver-Decorated Graphitic Carbon Nitride for the Visible-Light-Activated Selective Oxidation of Styrene, Benzylic Methylene Groups, and Benzene>, Recommanded Product: 1-Bromo-3-ethylbenzene, the main research area is photooxidation catalyst nanofiber nanocomposite visible light.

A polyacrylonitrile nanofiber (PAN NF) supported silver nanoparticles-graphitic carbon nitride (Ag NPs/g-C3N4) nanoparticles catalyst was fabricated by electrospinning technique. Structural and morphol. studies indicate that the spherical Ag NPs present in the g-C3N4 material were well-dispersed on the surfaces of the PAN NFs or embedded in the PAN NFs without agglomerating. The catalytic potential of PAN/Ag NPs/g-C3N4 NFs was developed for oxidation of organic substrate such as styrene, -CH2 bonded mols., and benzene under visible light. The visible-light-mediated activity of the catalyst could be aided by the photoactive nature of the g-C3N4 surface. PAN/Ag NPs/g-C3N4 NFs show good selectivity toward epoxide with higher conversion (98%) in the case of styrene oxidation Further, ethylbenzene was oxidized to acetophenone with 99% conversion using H2O2. Addnl., the present material also shows excellent C-H oxidation of benzene (99%) into the desired phenol with higher selectivity. PAN/Ag NPs/g-C3N4 NFs possess mesoporous properties with excellent absorptive performance. This hybrid NFs exhibited enhanced activity, excellent stabilization, and recyclability.

ACS Applied Nano Materials published new progress about Electrospinning. 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Recommanded Product: 1-Bromo-3-ethylbenzene.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Banerji, Biswadip; Adhikary, Saswati; Majumder, Leena; Ghosh, Saswati published the artcile< A Green Synthetic Approach towards Polyarylated Oxazoles via Iodine-Catalyzed One-Pot sp3 C-H Functionalization in Water: From Natural Product Synthesis To Photophysical Studies>, Safety of 4-Bromobenzylamine, the main research area is polyaryl oxazole preparation green chem regioselective; primary amine diketone acyloin aerobic oxidative cyclization iodine catalyst.

A ‘green’ methodol. for the convenient synthesis of specific regioisomers of polysubstituted oxazoles through iodine catalyzed, water-mediated, aerobic oxidative C(sp3)-H functionalization of primary amines has been developed. This mild and regioselective domino procedure does not require toxic peroxides, transition metals and organic solvents. The versatility of this methodol. was demonstrated by preparing a natural product, texaline. It is also scalable and has a wide substrate scope. This methodol. opens up a simple avenue for the synthesis of polyarylated oxazoles from various readily available amines as well as 1,2-diketones and acyloins (α-hydroxyl ketones) in moderate to excellent yields. Furthermore, these highly substituted oxazole mols. showed excellent fluorescence properties and thus have enormous potential to be a new type of fluorescent probe for use in medicinal applications and materials science.

Asian Journal of Organic Chemistry published new progress about Diketones, 1,2-diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary