Category: bromides-buliding-blocks

Singh, Avineesh; Patel, Vijay K.; Rajak, Harish published the artcile< Appraisal of pyrrole as connecting unit in hydroxamic acid based histone deacetylase inhibitors: Synthesis, anticancer evaluation and molecular docking studies>, Reference of 3893-18-3, the main research area is pyrrole hydroxamic acid preparation SAR antitumor mol docking human; histone deacetylase inhibitor.

SAHA and its synthetic analogs has demonstrated potent antitumor activity against numerous human cancer lines and different classes of HDACs. The objective of present studies was to incorporate pyrrole as connecting unit in hydroxamic acid based HDAC inhibitors for their anticancer evaluation and mol. docking studies. A series of novel 4-substituted Me 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)hexanoate I (R = Ph, 4-ClC6H4, 4-BrC6H4, etc.) and 4-substituted 6-(3-acetyl-2-methyl-1H-pyrrol-1-yl)-N-hydroxyhexanamide II were synthesized and were evaluated for their anticancer activity using in-vitro method against leukemia (K-562), lung (A-549), breast (MCF-7), and cervical (HeLa) human cancer cell lines using Sulforhodamine B (SRB) assay method, HDAC1 and HDAC6 inhibitory assay and binding mode anal. using mol. docking studies. Interestingly, p-nitro-substituted mol. produced a most active derivative in the series. The in-vitro anticancer study of synthesized compounds indicated that the unsubstituted Ph derivative, II (R = Ph) have moderate antitumor activity against K-562 human leukemia cell line. Substitution at 4-Ph ring with weak and moderate electron withdrawing groups, such as fluoro, chloro, and bromo potentiated the cytotoxic activity. Compounds II were docked against different HDAC proteins to determine the exact binding mode and orientation. These studies can be further employed for the design and development of novel SAHA analogs with promising anticancer activity.

Journal of Molecular Structure published new progress about Antitumor agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Reference of 3893-18-3.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ke, Da; Zhou, Shaodong published the artcile< General Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters>, Quality Control of 3959-07-7, the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Quality Control of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Long, Solida; Loureiro, Joana B.; Carvalho, Carla; Gales, Lu Is; Saraiva, Lucilia; Pinto, Madalena M. M.; Puthongking, Ploenthip; Sousa, Emilia published the artcile< Semi-synthesis of small molecules of aminocarbazoles: tumor growth inhibition and potential impact on p53>, Recommanded Product: 4-Bromobenzylamine, the main research area is aminocarbazole derivative preparation antitumor p53 activator; alkaloids; aminocarbazoles; heptaphylline; mutant; p53; tumor.

The tumor cell growth inhibitory activity of aminocarbazole derivatives, I [R = H, OMe; R1 = H, CH2CHC(Me)2; R2 = NH(CH2)3N(Me)2, pipridin-1-yl, 4-ClC6H4NH, etc.] as well as their potential activation of p53 was reported. Compounds I was synthesized from naturally-occurring carbazoles II [R3 = H, OMe; R4 = H, CH2CHC(Me)2] with amine precursors and isolated from Clausena harmandiana, using a reductive amination protocol. Compounds I and II were evaluated for their potential effect on wild-type and mutant p53 activity using a yeast screening assay and on human tumor cell lines. Naturally-occurring carbazoles II showed the most potent growth inhibitory effects on wild-type p53-expressing cells, being heptaphylline II [R3 = H; R4 = CH2CHC(Me)2] the most promising in all the investigated cell lines. However, compound II [R3 = H; R4 = CH2CHC(Me)2] also showed growth inhibition against non-tumor cells. Conversely, semi-synthetic aminocarbazole I [R = H; R1 = CH2CHC(Me)2; R2 = 4-FC6H4NH] showed an interesting growth inhibitory activity in tumor cells expressing both wild-type and mutant p53, exhibiting low growth inhibition on non-tumor cells. The yeast assay showed a potential reactivation of mutant p53 by heptaphylline derivatives, including compound I [R = H; R1 = CH2CHC(Me)2; R2 = 4-FC6H4NH].

Molecules published new progress about Amines Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carullo, Gabriele; Mazzotta, Sarah; Giordano, Francesca; Aiello, Francesca published the artcile< Green synthesis of new pyrrolo [1,2-a] quinoxalines as antiproliferative agents in GPER-expressing breast cancer cells>, Computed Properties of 51605-97-1, the main research area is pyrroloquinoxaline GPER breast cancer antiproliferative activity.

4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biol. properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, the synthesis and preliminary antiproliferative activity of a small set of new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) and pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known antiproliferative agents (G-1, G-15, and G-36). The synthesis of the pyrroloquinoxalinic core was employed following the Pictet-Spengler reaction, using the surfactant p-dodecylbenzene sulfonic acid (p-DBSA), as catalyst. It demonstrated efficiency in the catalysis of the 4-phenylpyrrole [1,2-a] quinoxaline type compound formation in mild solvents such as water, ethanol, and hydroalcoholic solutions In addition, the reactions proceeded in a short time (between 15 and 120 min) at room temperature and with high yields. The in vitro MTT assays showed that the presence of iso-Pr groups furnished promising antiproliferative compounds Although, the acetyl group provided also antiproliferative effects, breaking down its responsibility in the GPER transactivation. Nevertheless, it is possible to conclude that the 4,5-dihydropyrrolo[1,2-a]quinoxalines remain a feasible scaffold to develop anticancer agents against GPER-expressing cells.

Journal of Chemistry published new progress about Antiproliferative agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Computed Properties of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Wei; Wang, Biyun; Ji, Xinfei; Cao, Song published the artcile< Direct copper-catalyzed oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3>, Application of C7H4BrF3S, the main research area is arylboronic acid silver trifluoromethylthiolate copper catalyst trifluoromethylthiolation; aryl trifluoromethyl thioether preparation.

A copper-catalyzed direct oxidative trifluoromethylthiolation of aryl boronic acids with AgSCF3 was developed. This approach provided straightforward and efficient access to a variety of aryl trifluoromethyl sulfides from an easily prepared and stable nucleophilic trifluoromethylthiolation reagent AgSCF3, and readily available nucleophilic arylboronic acids, thus avoiding the preparation of electrophilic trifluoromethylthiolating reagents in advance. Preliminary mechanistic experiments indicated that AgSCF3 served as both a source of SCF3 and an oxidant.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 2252-45-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3S, Application of C7H4BrF3S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Martinelli, Joseph R.; Freckmann, Dominique M. M.; Buchwald, Stephen L. published the artcile< Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure>, SDS of cas: 639520-70-0, the main research area is Weinreb amide preparation; palladium catalyst aminocarbonylation aryl bromide; phosphine ligand palladium catalyst aminocarbonylation; benzamide methoxymethyl preparation.

The direct transformation of aryl bromides into the corresponding Weinreb amides via Pd-catalyzed aminocarbonylation at atm. pressure was reported. Thus, reaction of 3-BrC6H4CN and MeNHOMe.HCl with CO in toluene containing Pd(OAc)2, the bidentate P ligand Xantphos, and Na2Co3 at 80° gave 88% 3-BrC6H4CONMeOMe.

Organic Letters published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, SDS of cas: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Huang, Wanqiao; Zhang, Ruzhong; Zhang, Ruxue; Yu, Jianxin; Wang, Mang published the artcile< Radical hydrotrifluoromethylation of ynamides: a route toward β-CF3 enamides>, Synthetic Route of 3959-07-7, the main research area is aryl trifluoromethyl amine preparation; trifluoromethyl enamide preparation diastereoselective deprotection reduction reaction; ynamide chlorophenyl trifluoromethyliodane radical hydrotrifluoromethylation reaction.

Radical hydrotrifluoromethylation of ynamides RNR2CCR1 (R = Ph, 3-chlorophenyl, benzodioxol-5-yl, etc.; R1 = H, cyclopropyl, Ph, etc.; R2 = Boc, Ac, Cbz) to provide an alternative route toward (E)-β-CF3 enamides RNR2CH=C(CF3)R1 was reported. By using PhICF3Cl as the CF3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature Further reduction of the resulting β-CF3 enamides efficiently delivered β-CF3 amines RNHCH2CH(CF3)R1. Gram-scale synthesis was conducted to demonstrate the practicability of the method.

Organic Chemistry Frontiers published new progress about Diastereoselective synthesis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nazarahari, Maryam; Azizian, Javad published the artcile< FeCl2-PPh3 as an efficient catalytic system for the acceptorless dehydrogenation of amines into imines>, Product Details of C7H8BrN, the main research area is benzylamine iron chloride triphenylphosphine catalyst diastereoselective dehydrogenative coupling; phenylmethanimine preparation.

A novel and simple catalytic system including FeCl2, PPh3 and potassium tert-butoxide were employed for the synthesis of imines from amines. In order to prove the catalytic acceptorless dehydrogenation pathway for this transformation, the liberated H2 gas was detected by NMR spectroscopy. By utilizing this protocol, a variety of arylamines were used successfully for the preparation of corresponding imines in good to excellent yields (on a 1 mmol scale, 73-91% yield for homocoupling, 71 and 91% for heterocoupling).

Chemical Papers published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Product Details of C7H8BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jorgensen, P. Fischer published the artcile< A mathematical-statistical analysis of titration errors in the determination of ascorbic acid of serum by use of the 2,6-dichlorophenolindophenol method>, Computed Properties of 82-73-5, the main research area is .

373 determinations of ascorbic acid in serum were made, using a slight modification of the method of Farmer and Abt (cf. C.A. 30, 8273.5). The results are divided into 6 groups and the standard deviation determined for each group. The possible sources of error are investigated. Two types of errors can be distinguished: Group (a) comprises the exptl. errors. In this group the standard deviation is constant Group (b) is associated with the chemistry of the analytical method, and the standard deviation is found to be directly proportional to the ascorbic acid concentration The chem. significance of these errors is discussed.

Dansk Tidsskrift for Farmaci published new progress about Blood. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Computed Properties of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thorve, Pradip Ramdas; Maji, Biplab published the artcile< Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst>, Electric Literature of 3959-07-7, the main research area is quinazolinone preparation kinetic mechanistic study; amine aminobenzamide cascade aerobic oxidative coupling copper catalyst.

Herein, a bioinspired catalytic system for the one-pot cascade oxidation of a native primary amine and an in situ generated non-native secondary amine is reported. The catalyst consists of an o-quinone cofactor phd (1,10-phenanthroline-5,6-dione) and a copper ion and operates under ambient air conditions. Quinazolin-4(3H)-ones, which are common pharmacophores present in numerous pharmaceuticals and bioactive compounds, were synthesized in high yields. A detailed kinetic and mechanistic study elucidates the role of the catalyst in the multi-step oxidative cascade reaction.

Catalysis Science & Technology published new progress about Benzamides Role: RCT (Reactant), RACT (Reactant or Reagent) (amino). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Electric Literature of 3959-07-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary