Category: bromides-buliding-blocks

Hansa, Raj KC.; Khan, M. M. K.; Frangie, M. M.; Gilmore, D. F.; Shelton, R. S.; Savenka, A. V.; Basnakian, A. G.; Shuttleworth, S. L.; Smeltzer, M. S.; Alam, M. A. published the artcile< 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents>, Application of C6H4BrClFN, the main research area is anilinomethyl phenyl pyrazolyl benzoic acid preparation antibacterial cytotoxicity SAR; Antibiotics; Antimicrobial; Enterococcus; MRSA; Pyrazole; Staphylococcus aureus; Toxicity.

A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl Ph derived pyrazoles I [R = HO(O)C, F3C; R1 = Ph, 3-bromophenyl, 5-iodopyridin-2-yl, etc.] was synthesized and tested for antibacterial activity. The majority of trifluoromethyl Ph derivatives are highly potent growth inhibitors of Gram-pos. bacteria and showed low toxicity to human cultured cells. In particular, two compounds I [R = F3C; R1 = 3-fluoro-5-(trifluoromethyl)phenyl, 3,5-dichloro-4-fluorophenyl] were selected for addnl. studies. These compounds were highly effective against Staphylococcus aureus as shown by a low min. inhibitory concentration (MIC), a bactericidal effect in time-kill assays, moderate inhibition of biofilm formation as well as biofilm destruction and a bactericidal effect against stationary phase cells representing non-growing persister cells. Multistep resistance assays showed a very low tendency for S. aureus and Enterococcus faecalis to develop resistance through mutation. Addnl., in vivo mouse model studies showed no harmful effects at doses up to 50 mg/kg using 14 blood plasma organ toxicity markers or TUNEL assay in liver and kidney. Investigations into the mode of action by performing macromol. synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, Application of C6H4BrClFN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Barros, Helio Lopes; Esteves, Maria Alexandra; Brites, Maria Joao published the artcile< Synthesis and photophysical properties of tetraphenylethylene derivatives as luminescent downshifting materials for organic photovoltaic applications>, HPLC of Formula: 184239-35-8, the main research area is tetraphenylethylene luminescent organic solar cell.

Luminescent Down-Shifting (LDS) is an optical approach applied in several photovoltaic (PV) technologies in which high energy solar radiation is converted to a wavelength region where the response of the photovoltaic devices is better. The use of LDS layers on organic photovoltaics (OPV) could serve two purposes: to prevent cell degradation by filtering the incident UV radiation and to improve the spectral response of PV cells at short-wavelength. This work reports, the design and synthesis of a series of tetraphenylethylene (TPE) derivatives based on TPE-A or A-π-TPE-π-A mol. structure featuring various electron-acceptor (A) groups. The photophys. properties of the new LDS compounds were systematically studied in 1,4-dioxane solution and film (Zeonex) by UV-visible absorption and fluorescence spectroscopy, and electrochem. properties studied by cyclic voltammetry. Thermal stability of the new LDS compounds was evaluated by Thermogravimetric anal. (TGA). Theor. computational studies provided evidence of existence of intramol. charge-transfer (ICT) between frontier orbitals of donor and acceptor moieties. The good photophys. and thermal properties of the synthesized TPE derivatives, associated with high molar absorption coefficients in UV spectrum and emission maximum in the range of 476-531 nm, make them promising candidates for LDS layers in OPV application.

Dyes and Pigments published new progress about Electric current-potential relationship. 184239-35-8 belongs to class bromides-buliding-blocks, and the molecular formula is C26H18Br2, HPLC of Formula: 184239-35-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zhong-Yuan; Lakmal, Hetti Handi Chaminda; Qian, Xiaolin; Zhu, Zhenyu; Donnadieu, Bruno; McClain, Sarah J.; Xu, Xue; Cui, Xin published the artcile< Ruthenium-Catalyzed Enantioselective C-H Functionalization: A Practical Access to Optically Active Indoline Derivatives>, Application In Synthesis of 188813-04-9, the main research area is hydroindolecarboxaldehyde regioselective enantioselective preparation; ruthenium catalyst enantioselective cyclization alkenylaminobenzaldehyde transient imine directing group; study mechanism ruthenium catalyzed directed enantioselective cyclization alkenylaminobenzaldehyde.

In the presence of [Ru(p-cymene)Cl2]2, nonracemic 1-(1-naphthyl)ethylamine as a transient directing group, and N-phthaloyl-L-tert-leucine, 3-(alkenylamino)benzaldehydes such as I underwent enantioselective cyclization mediated by AgBF4 and KH2PO4 in chlorobenzene/hexafluoroisopropanol to yield nonracemic dihydroindolecarboxaldehydes such as II in up to 92% yield with 96% ee. A benzindolecarboxaldehyde potentially useful for the synthesis of lysergic acid analogs was prepared using this method. The reaction mechanism was studied using the preparation of ruthenacycles related to potential reaction intermediates, mass spectrometric detection of reaction intermediates, and deuterium labeling experiments

Journal of the American Chemical Society published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (m-alkenylamino). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Application In Synthesis of 188813-04-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghorbani-Choghamarani, Arash; Mohammadi, Masoud; Taherinia, Zahra published the artcile< (ZrO)2Fe2O5 as an efficient and recoverable nanocatalyst in C-C bond formation>, Computed Properties of 401-78-5, the main research area is zirconium ferrite recoverable nanocatalyst carbon bond formation.

In this paper, the synthesis and characterization of zirconium ferrite ((ZrO)2Fe2O5) magnetic nanoparticles (MNPs) and their application as a catalyst in C-C cross-coupling reaction will be described. The structure of the catalyst was studied by Fourier transform IR spectroscopy (FT-IR), SEM, energy dispersive spectrometry (EDS), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), vibrating sample magnetometer (VSM) and ICP-OES anal. The resulting zirconium ferrite [(ZrO)2Fe2O5] was efficient for C-C coupling reactions, affording the desired products in good to excellent yields. Moreover, the catalyst could be easily recovered by magnetic separation and recycled for four times without significant loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Computed Properties of 401-78-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cha, Mi Young; Lee, Kwang-Ok; Kim, Jong Woo; Lee, Chang Gon; Song, Ji Yeon; Kim, Young Hoon; Lee, Gwan Sun; Park, Seung Bum; Kim, Maeng Sup published the artcile< Discovery of A Novel Her-1/Her-2 Dual Tyrosine Kinase Inhibitor for the Treatment of Her-1 Selective Inhibitor-Resistant Non-Small Cell Lung Cancer>, SDS of cas: 115843-99-7, the main research area is tyrosine kinase inhibitor quinazolinyl pyrrolidine preparation SAR.

A novel series of (S)-1-acryloyl-N-[4-(arylamino)-7-(alkoxy)quinazolin-6-yl]pyrrolidine-2-carboxamides were synthesized and evaluated as Her-1/Her-2 dual inhibitors. In contrast to the Her-1 selective inhibitors, our novel compounds are irreversible inhibitors of Her-1 and Her-2 tyrosine kinases with the potential to overcome clin. relevant, mutation-induced drug resistance. The selected compounds, 19c and 19d (I), showed excellent EGFR inhibition activity even toward the T790M mutation of Her-1 tyrosine kinase with excellent selectivity. The excellent pharmacokinetic profiles of these compounds in rats and their robust in vivo efficacy in an A431 xenograft model clearly demonstrate that they merit further investigation as novel therapeutic agents for EGFR-targeting treatment of solid tumors, especially Her-1 selective inhibitor-resistant non-small cell lung cancer.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 115843-99-7 belongs to class bromides-buliding-blocks, and the molecular formula is C6H4BrClFN, SDS of cas: 115843-99-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Qing; Meng, Liuwei; Zhou, Siru; Deng, Xiaoyan; Wang, Na; Ji, Yi; Peng, Yichun; Xing, Junhao; Yao, Gongmei published the artcile< Rapid generation of novel benzoic acid-based xanthine derivatives as highly potent, selective and long acting DPP-4 inhibitors: scaffold-hopping and prodrug study>, Electric Literature of 337536-14-8, the main research area is diabetes antidiabetes DPP 4 benzoic acid xanthine prodrug pharmacokinetics; Benzoic acid; DPP-4 inhibitor; Prodrug; Scaffold-hopping; Xanthine derivatives.

A series of novel xanthine derivatives 2a-l incorporating benzoic acid moieties were rapidly generated by using strategy of scaffold-hopping from our previously reported scaffold uracil to xanthine, a scaffold of approved drug linagliptin. After systematic structure-activity relationship (SAR) study around benzoic acid moieties, 5 novel DPP-4 inhibitors with low picomolar potency range (IC50 < 1 nM) and excellent selectivity against various DPP-4 homologues were identified, in which the best one, compound 2f(I), with the IC50 value of 0.1 nM for DPP-4, showed 22-fold improvement in inhibitory activity compared to lead compound uracil 1, its activity was 45-fold more potent than alogliptin. 2E, I, 2i(II) and 2k were selected for pharmacokinetic evaluation, and I and II showed the better pharmacokinetic profiles after iv administration, but poor oral bioavailability. To improve the oral pharmacokinetic profile, prodrug design approach was performed around I and II. Esters of I and II were synthesized and evaluated for stability, toxicity and pharmacokinetics. Compound 3e(III), the Me ester of compound I, was identified to demonstrate good stability, low toxicity and improved oral bioavailability, with 3-fold higher blood concentration compared to I in rats. The following in vivo evaluations revealed III provided a sustained pharmacodynamics effect for 48h, and robustly improved glucose tolerance in normal ICR and db/db mice in dose-dependent manner. Chronic treatments investigations demonstrated that III achieved more beneficial effects on fasting blood glucose levels and glucose tolerance than alogliptin in type 2 diabetic db/db mice. The overall results have shown that compound III has the potential to efficacious, safety and long-acting treatment for T2DM. European Journal of Medicinal Chemistry published new progress about Antidiabetic agents. 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, Electric Literature of 337536-14-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Kai-Wei; Hsu, Wen-Li; Chen, Cheng-Ru; Tsai, Ming-Hsien; Yen, Chia-Jung; Tseng, Chih-Hua published the artcile< Discovery of triazolyl thalidomide derivatives as anti-fibrosis agents>, Name: 4-(2-Bromoacetyl)benzoic acid, the main research area is triazolyl thalidomide derivative preparation antifibrosis activity.

Fibrosis with excessive accumulation of extracellular matrix (ECM) often causes progressive organ dysfunction and results in many inflammatory and metabolic diseases, including systemic sclerosis, pulmonary fibrosis, advanced liver disease and advanced kidney disease. The store-operated calcium entry (SOCE) pathway and the related signaling pathway were both found to be the important routes for fibrogenesis. Our aim in this study was to discover novel compounds to inhibit fibrogenesis. A number of triazolyl thalidomide derivatives were synthesized and evaluated for their anti-fibrosis activities. Compounds inhibited intracellular Ca2+ activation and showed no cytotoxicity. Among them, 6-{4-[(3-(1,3-dioxoisoindolin-2-yl)-2,6-dioxopiperidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl}hexanoic acid ( I ) with the most potent inhibitory effect was chosen for further examination The results revealed that compound I, a SOCE inhibitor, reversed the migratory ability of TGF-β1-induced myofibroblasts, dedifferentiated myofibroblasts to fibroblasts due to cytoskeleton remodeling, and restrained myofibroblast activation by targeting Orai1 and TGF-β1/SMAD2/3 signaling pathways. The in silico study indicated that compound I, with the appropriate lipophilic carbon chain and carboxylic acid, showed a good drug-likeness model score. Conclusively, the SOCE inhibitor, compound I, is used as a promising lead compound for the development of a new treatment for fibrosis.

New Journal of Chemistry published new progress about Antifibrotic agents. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Name: 4-(2-Bromoacetyl)benzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Jing; Zheng, Chunming; Li, Bryan; Hawkins, Joel M.; Scott, Susannah L. published the artcile< Efficient, continuous N-Boc deprotection of amines using solid acid catalysts>, Name: 4-Bromobenzylamine, the main research area is amine preparation; tert butyloxycarbonyl amine deprotection solid acid catalyst.

The use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, e.g., tert-Bu 2-oxopiperidine-1-carboxylate without addnl. workup steps has been described. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, e.g., 2-piperidinone often in residence times of less than a minute at 140°C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per gcat, sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines.

Reaction Chemistry & Engineering published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Name: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Xin; Ang, Esther Cai Xia; Yang, Ziqi; Kee, Choon Wee; Tan, Choon-Hong published the artcile< Synthesis of chiral sulfinate esters by asymmetric condensation>, Application of C7H7BrO2S, the main research area is alc sulfinate pentanidium catalyst enantioselective condensation; sulfinate ester preparation.

Here a straightforward access to enantioenriched sulfinate esters via asym. condensation of prochiral sulfinates and alcs. using pentanidium as an organocatalyst was reported. This study successfully coupled a wide range of sulfinates and bioactive alcs. stereoselectively. The initial sulfinates was prepared from existing sulfone and sulfonamide drugs and the resulting sulfinate esters were versatile for transformations to diverse chiral sulfur pharmacophores. Through late-stage diversification 11,12 of celecoxib and other drug derivatives, was demonstrate the viability of this unified approach towards sulfur stereogenic centers.

Nature (London, United Kingdom) published new progress about Condensation reaction catalysts (stereoselective). 5751-83-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2S, Application of C7H7BrO2S.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Zhao-Ming; Shuai, Bin; Ma, Cong; Fang, Ping; Mei, Tian-Sheng published the artcile< Nickel-Catalyzed Electroreductive Syntheses of Triphenylenes Using ortho-Dihalobenzene-Derived Benzynes>, Product Details of C7H7BrO2, the main research area is triphenylene preparation regioselective; bromobenzene electroreductive reaction nickel catalyst.

Electrochem. nickel-catalyzed syntheses of triphenylenes e.g., I, by a reductive trimerization of ortho-dibromobenzenes e.g.., 5,6-dibromoindane or ortho-bromoarylsulfurofluoridates e.g., 2-bromo-4-fluorophenyl sulfurofluoridate, or by reductive cross-coupling of ortho-dibromobenzenes to 2,2′-diiodobiphenyls, were described. The former provides a practical means for the construction of triphenylene derivatives e.g., ,I in up to 87% isolated yield at room temperature For 1,2-dihalo-3-methylbenzenes and related ortho-trisubstituted substrates, trimerizations proceed with high substrate-controlled regioselectivity for the non-C3h sym. triphenylene isomer.

Chinese Journal of Chemistry published new progress about Cross-coupling reaction. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Product Details of C7H7BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary