bromides-buliding-blocks Archives - Page 884 of 1419

Vishnumurthy, Kodumuru’s team published research in Journal of Combinatorial Chemistry in 2010-10-31 | 6942-39-8

Journal of Combinatorial Chemistry published new progress about Aromatic carboxylic acids, salts Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Reference of 6942-39-8.

Vishnumurthy, Kodumuru; Makriyannis, Alexandros published the artcile< Novel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling>, Reference of 6942-39-8, the main research area is dibenzopyranone preparation; bromoarylcarboxylate hydroxyarylboronic acid Suzuki Miyaura coupling lactonization.

Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogs from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogs bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Patel, Harun’s team published research in Bioorganic Chemistry in 2020-09-30 | 82-73-5

Bioorganic Chemistry published new progress about Drug toxicity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.

Patel, Harun; Chaudhari, Kavita; Jain, Pritam; Surana, Sanjay published the artcile< Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis>, Application In Synthesis of 82-73-5, the main research area is pyridinyl hydrazide preparation antitubercular activity SAR; Schiff base pyridinyl preparation antitubercular activity SAR; Cytotoxicity; MDR-MTB; Mycobacterium tuberculosis; Synthesis.

Synthesis and the biol. activity of isoniazid and pyridine derivatives were successfully carried out with elaborated characterization by spectral data. Amongst the synthesized compounds; I and II displayed encouraging antimycobacterial activity with IC50 of 3.2μM and 1.5μM against the H37Rv strain. The MIC of test compounds I and II were also assessed against the 5 drug resistant isolates (FQ-R1, INH-R1, INH-R2, RIF-R1 and RIF-R2) of MTB strains under aerobic conditions and compound I [MIC = 3.2μM for FQ-R1; MIC = 140μM for INH-R1; MIC = 160μM for INH-R2; MIC = 2.4μM towards RIF-R1; MIC = 4.2μM for RIF-R2] and II [MIC = 3.3μM for FQ-R1; MIC = 170μM for INH-R1; MIC = 190μM for INH-R2; MIC = 1.8μM for RIF-R1; MIC = 8.4μM for RIF-R2] have shown significant activity at non-cytotoxic concentration in comparison to the standard drug.

Bioorganic Chemistry published new progress about Drug toxicity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Xue’s team published research in Journal of Catalysis in 2019-10-31 | 3959-07-7

Journal of Catalysis published new progress about Electric capacitance. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Yang, Xue; Huang, Tao; Gao, Shuiying; Cao, Rong published the artcile< Boosting photocatalytic oxidative coupling of amines by a Ru-complex-sensitized metal-organic framework>, Category: bromides-buliding-blocks, the main research area is oxidative coupling photocatalyst metal organic framework.

Visible-light-driven selective photocatalytic organic synthesis has recently become a topic of great interest due to its environmental friendliness and sustainability. It is demanding for photocatalysis to utilize the wider range of light, such as visible light, and its performance is often plagued by the sluggish separation of photogenerated charge carriers. An approach is now reported to address these issues by incorporating light harvesting RuII-polypyridyl complexes into a semiconductor-type metal-organic framework (MIL-125). Delightedly, the obtained Ru(bpy)3@MIL-125 photocatalyst presents a remarkably stable and high photoactivity toward the selective oxidative coupling of amines under ambient air with visible light irradiation (λ > 440 nm). The mechanistic investigation unveiled that both effectively photoexcited electrons transfer from [Ru(bpy)3]Cl2 to MIL-125 and the interaction of C-H bonds with superoxide radical (O·-2) play a critical role in photo-catalyzing selective aerobic oxidative coupling of amines. This work highlights a significant role of MOFs as heterogeneous photocatalysts in photocatalytic organic transformations.

Journal of Catalysis published new progress about Electric capacitance. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Yantang’s team published research in Organic Letters in 2019-06-21 | 3959-07-7

Organic Letters published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Category: bromides-buliding-blocks.

Liang, Yantang; Tan, Zhenda; Jiang, Huanfeng; Zhu, Zhibo; Zhang, Min published the artcile< Copper-Catalyzed Oxidative Multicomponent Annulation Reaction for Direct Synthesis of Quinazolinones via an Imine-Protection Strategy>, Category: bromides-buliding-blocks, the main research area is quinazolinone preparation copper catalyst oxidative multicomponent annulation.

Via an imine-protection strategy, the authors herein present an unprecedented copper-catalyzed oxidative multicomponent annulation reaction for direct synthesis of quinazolinones. The construction of various products is achieved via formation of three C-N and one C-C bonds in conjunction with the benzylic functionalization. The merits of easily available feedstocks, naturally abundant catalyst, good functional group and substrate compatibility, and release of H2O as the byproduct make the developed chem. a practical way to access quinazolinones.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Linstad, Ethan J’s team published research in Organic & Biomolecular Chemistry in 2017 | 639520-70-0

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Synthetic Route of 639520-70-0.

Linstad, Ethan J.; Vavere, Amy L.; Hu, Bao; Kempinger, Jayson J.; Snyder, Scott E.; DiMagno, Stephen G. published the artcile< Thermolysis and radiofluorination of diaryliodonium salts derived from anilines>, Synthetic Route of 639520-70-0, the main research area is aniline diaryliodonium salt preparation radiofluorination.

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex mols., such as flutemetamol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Majumder, Adhir’s team published research in New Journal of Chemistry in 2022 | 576-83-0

New Journal of Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 576-83-0 belongs to class bromides-buliding-blocks, and the molecular formula is C9H11Br, Quality Control of 576-83-0.

Majumder, Adhir; Naskar, Rajat; Phukan, Shankab J.; Maity, Ramananda published the artcile< Bimetallic PdII complexes with NHC/Py/PCy3 donor set ligands: applications in α-arylation, Suzuki-Miyaura and Sonogashira coupling reactions>, Quality Control of 576-83-0, the main research area is palladium binuclear imidazolylidene pyridine tricyclohexylphosphine complex preparation catalyst; Suzuki Sonogashira coupling catalyst palladium binuclear imidazolylidene tricyclohexylphosphine complex; alpha arylation oxindole catalyst palladium binuclear imidazolylidene tricyclohexylphosphine complex; crystal mol structure palladium binuclear imidazolylidene pyridine tricyclohexylphosphine complex.

Palladium binuclear NHC-pyridine and NHC-tricyclohexylphosphine complexes Me2C6H2-1,4-(MeImPdI2L)2 (2-5; MeIm = 3-methyl-1-imidazolyl-2-ylidene; L = 3-ClPy, 4-ClPy, 4-MeOPy, PCy3) were prepared and evaluated as catalysts for α-arylation of oxindole, Sonogashira coupling of PhCCH and Suzuki coupling of 3-bromo- and 4-bromobenzaldehyde with arylboronic acids. Bimetallic complexes bearing NHC donor ligands are gaining immense popularity as catalysts in organometallic chem. However, such complexes with a mixed NHC/PR3 donor set ligands are still rare. We present here a series of bimetallic PdII complexes featuring mixed NHC/Py/PCy3 donor set ligands applied in α-arylation of amide, Suzuki-Miyaura coupling and Sonogashira coupling reactions. All complexes have been characterized using standard characterization techniques and one of the complexes has been structurally characterized by X-ray crystallog. anal. Catalytic outcomes clearly indicate the superior activity of PdII complex bearing mixed NHC/PCy3 donor set ligands compared to the PEPPSI-type complexes in both α-arylation of amide and Sonogashira coupling reactions, though almost similar activities were observed for all the complexes in Suzuki-Miyaura coupling reactions. This observation might be due to the involvement of Pd-NPs as an active catalyst in Suzuki-Miyaura coupling reactions, whereas the Hg-poison test suggested the homogeneous nature of the other two types of reactions. Two pyridine rings in a mixed NHC/4-OMe(Py) donor complex are oriented almost in a parallel face-to-face fashion with a centroid to centroid separation of 3.758 Å, indicating π···π interactions between two methoxypyridine rings. This interaction leads to a very short Pd···Pd distance of 5.754 Å in the aforementioned complex.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jeffs, P W’s team published research in Journal of Organic Chemistry in 1975 | 17100-65-1

Journal of Organic Chemistry published new progress about Cyclization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Synthetic Route of 17100-65-1.

Jeffs, P. W.; Hansen, J. F.; Brine, G. A. published the artcile< Photochemical synthesis of 6,7-dihydro-5H-dibenz[c,e]azepine and 5,6,7,8-tetrahydrodibenz[c,e]azocine derivatives>, Synthetic Route of 17100-65-1, the main research area is dibenzoxepine; dibenzazepine; dibenzazocine; cyclization iododibenzylamine; photolysis iododibenzylamine; benzylamine iodo cyclization; iododibenzylamine cyclization; conformation dibenzazocine.

Photolysis of several substituted 2-iododibenzylamine hydrochlorides in aqueous solution provided convenient syntheses of the corresponding 6,7-dihydro-5H-dibenz[c,e]azepines in useful yields. Thus, irradiation of o-IC6H4CH2NHCH2Pb gave 57% dibenzazepine I. Irradiation of o-IC6H4CH2NHCH2C6H3(OMe)2-3.5 yielded only 2,4,6-(MeO)2CHOCH2)C6H2C6H4CH2OH-o together with a small amount of dibenzoxepine II. Photolysis of three N-(2-halogenobenzyl)-β-phenethylamine hydrochlorides provided convenient syntheses of the corresponding 5,6,7,8-tetrahydrodibenz[c,e]azocines. Thus, irradiation of O-IC6H4CH2NHCH2CH2Pb gave 33% dibenzazocine III. NMR examination of the dibenzazocines confirmed that they existed in a skewed biphenyl conformation, and that inversion of the system by rotation through the planar biphenyl was hindered.

Journal of Organic Chemistry published new progress about Cyclization. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Synthetic Route of 17100-65-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chengcheng’s team published research in Analytica Chimica Acta in 2020-02-08 | 3893-18-3

Analytica Chimica Acta published new progress about Fluorescence imaging. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.

Wang, Chengcheng; Wang, Yang; Wang, Guanyang; Huang, Chusen; Jia, Nengqin published the artcile< A new mitochondria-targeting fluorescent probe for ratiometric detection of H2O2 in live cells>, Category: bromides-buliding-blocks, the main research area is mitochondria fluorescent probe hydrogen peroxide live cell; Hydrogen peroxide; Live cell imaging; Mitochondria; Quantitative detection; Ratiometric fluorescent probe.

With this research the authors presented a ratiometric and mitochondria-target fluorescent probe (Mito-HT) (I) for detection of H2O2 both in vitro and in live cells. Mito-HT was constructed by direct conjugation of aryl boronate to fluorophore with three synthetic steps. The borate group is cleaved from Mito-HT in the presence of H2O2, resulting in the exposure of the hydroxyl group of the electron donating group. Then the ICT mechanism was turned on, and the fluorescence emission of Mito-HT at 493 nm was red shifted to 562 nm, thereby achieving radiometric detection of H2O2. Mito-HT exhibited a highly selectivity towards H2O2, and this interaction can be completed within 40 min. Mito-HT could be used for quant. detection of H2O2 (0-200μM) through ratiometric fluorescence signal readout. And limit of detection (LOD) is ∼0.33μM. The relatively high stability and medium fluorescence quantum yield of Mito-HT (0.39) and Mito-HT-OH (0.43) enable clear mitochondria localization and dual-channel fluorescence imaging of H2O2 in live cells with confocal microscopy.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Xie, Chao’s team published research in ACS Catalysis in 2020-07-17 | 3959-07-7

ACS Catalysis published new progress about Ball milling. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Xie, Chao; Song, Jinliang; Hua, Manli; Hu, Yue; Huang, Xin; Wu, Haoran; Yang, Guanying; Han, Buxing published the artcile< Ambient-Temperature Synthesis of Primary Amines via Reductive Amination of Carbonyl Compounds>, Recommanded Product: 4-Bromobenzylamine, the main research area is primary amine preparation reductive amination titanium phosphate Ruthenium nanocatalyst.

Efficient synthesis of primary amines via low-temperature reductive amination of carbonyl compounds using NH3 and H2 as the nitrogen and hydrogen resources is highly desired and challenging in the chem. community. Herein, we employed naturally occurring phytic acid as a renewable precursor to fabricate titanium phosphate (TiP)-supported Ru nanocatalysts with different reduction degrees of RuO2 (Ru/TiP-x, x represents the reduction temperature) by combining ball milling and molten-salt processes. Very interestingly, the obtained Ru/TiP-100 had good catalytic performance for the reductive amination of carbonyl compounds at ambient temperature, resulting from the synergistic cooperation of the support (TiP) and the Ru/RuO2 with a suitable proportion of Ru0 (52%). Various carbonyl compounds could be efficiently converted into the corresponding primary amines with high yields. More importantly, the conversion of other substrates with reducible groups could also be achieved at ambient temperature Detailed investigations indicated that the partially reduced Ru and the support (TiP) were indispensable. The high activity and selectivity of Ru/TiP-100 catalyst originates from the relatively high acidity and the suitable electron d. of metallic Ru0.

ACS Catalysis published new progress about Ball milling. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reddy, Kancharla Rajendar’s team published research in Synlett in 2014 | 128577-47-9

Synlett published new progress about Aralkyl bromides Role: SPN (Synthetic Preparation), PREP (Preparation). 128577-47-9 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8BrFO2, Synthetic Route of 128577-47-9.

Reddy, Kancharla Rajendar; Rajanna, Kamatala C.; Venkateswarlu, Marri; Saiprakash, P. K. published the artcile< Mild benzylic monobromination of methyl toluates in aqueous CTAB>, Synthetic Route of 128577-47-9, the main research area is bromomethyl toluate preparation; methyl toluate cetyltrimethylammonium bromide catalyst regioselective bromination microwave irradiation; cetyltrimethylammonium bromide cationic micelle catalyst.

A strategy for the regioselective monobromination of Me toluates by using tert-butylhydrogen peroxide and potassium bromide (TBHP/KBr) in a cetyltrimethylammonium bromide (CTAB) micellar medium was developed. Ultrasonic and microwave-assisted protocols were recorded and observed high rates and product yields under mild reaction conditions, coupled with a straightforward isolation procedure.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary