Bromides-buliding-blocks

Discovery of novel 1-arylmethylpyrrolidin-2-ylethanolamines as calcium-sensing receptor antagonists was written by Gavai, Ashvinikumar V.;Vaz, Roy J.;Mikkilineni, Amarendra B.;Roberge, Jacques Y.;Liu, Yalei;Lawrence, R. Michael;Corte, James R.;Yang, Wu;Bednarz, Mark;Dickson, John K.;Ma, Zhengping;Seethala, Ramakrishna;Feyen, Jean H. M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Product Details of 6515-58-8 This article mentions the following:

A 3D quant. structure-activity relationship study for inhibition of the calcium-sensing receptor in the aryloxypropanolamine series predicted that these mols. adopt a U-shaped conformation with pi-stacking between the two aromatic rings. This hypothesis led to the discovery of novel 1-arylmethylpyrrolidin-2-ylethanolamines capable of antagonizing the calcium-sensing receptor with potency comparable to that of NPS-2143. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Product Details of 6515-58-8).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 6515-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Towards rigid-rod polyelectrolytes via well-defined precursor poly(p-phenylene)s substituted by 6-iodohexyl side chains was written by Rau, I. U.;Rehahn, M.. And the article was included in Acta Polymerica in 1994.Quality Control of 1-Bromo-6-methoxyhexane This article mentions the following:

A synthetic strategy is presented to prepare readily soluble poly-p-phenylene (PP) electrolytes of well-defined mol. constitution and conveniently determinable d.p. PP having 6-phenoxyhexyl pendant groups is treated with Me₃SiI to give 6-iodohexyl pendant groups; condensation with EtO₂C-p-C₆H₄ONa followed by hydrolysis gives the desired rigid-rod polyelectrolytes. Under appropriate reaction conditions all steps occur highly selectively and almost quant.; no degradation of the polymer backbone occurs as verified by high resolution NMR spectroscopy and osmometric investigations. Thus, structurally homogeneous carboxy-containing PP of well-known d.p. are prepared In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Quality Control of 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Quality Control of 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Photochemical Nickel-Catalyzed Reductive Migratory Cross-Coupling of Alkyl Bromides with Aryl Bromides was written by Peng, Long;Li, Zheqi;Yin, Guoyin. And the article was included in Organic Letters in 2018.Synthetic Route of C10H13BrO This article mentions the following:

A method to access 1,1-diarylalkanes from readily available, nonactivated alkyl bromides and aryl bromides via visible-light-driven nickel and iridium dual catalysis, wherein diisopropylamine (iPr₂NH) is used as the terminal stoichiometric reductant, is reported. Both primary and secondary alkyl bromides can be successfully transformed into the migratory benzylic arylation products with good selectivity. Addnl., this method showcases tolerance toward a wide array of functional groups and the presence of bases. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Synthetic Route of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Diastereo- and enantioselective conjugate addition of α-ketoesters to nitroalkenes catalyzed by a chiral Ni(OAc)2 complex under mild conditions was written by Nakamura, Ayako;Lectard, Sylvain;Hashizume, Daisuke;Hamashima, Yoshitaka;Sodeoka, Mikiko. And the article was included in Journal of the American Chemical Society in 2010.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

A highly efficient, catalytic, diastereo- and enantioselective conjugate addition of α-ketoesters to nitroalkenes has been devised. The reaction was applicable to various substrates. Notably, the combination of endogenous and exogenous bases was effective, allowing a small amount of the catalyst (0.1-1 mol % Ni) to promote the reaction efficiently. The synthetic utility of this reaction was demonstrated in the synthesis of substituted pyrrolidine derivatives, whose stereochem. is closely related to biol. important natural products such as kainic acid. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification, characterization, synthesis of major metabolites biotransformed from vonoprazan fumarate was written by Lin, Biyue;Kou, Jingping;Xiao, Qingbo;Wu, Shuming;Hu, Ji’an;Li, Jianbing;Zhu, Zhu;Zhou, Xinglin;Xin, Libo;Li, Yanhua;Wang, Zhongqing. And the article was included in Tetrahedron in 2022.Formula: C5H4BrNO This article mentions the following:

A first synthetic research concerning four observed metabolites and their deuterium-labeled analogs of reflux esophagitis drug vonoprazan fumarate was reported. Among which the synthetic methods of three metabolites M – I, M-III, M-IV-Sul, and four stable isotop labeled analogs M-I-d₄, M-II-d₄, M-III-d₄, M-IV-Sul-d₄ was not yet been reported before. The structures of these compounds were elucidated on the basis of MS and NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Formula: C5H4BrNO).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Formula: C5H4BrNO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Novel inhibitors of bacterial virulence: Development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression was written by Yestrepsky, Bryan D.;Xu, Yuanxi;Breen, Meghan E.;Li, Xiaoqin;Rajeswaran, Walajapet G.;Ryu, Jenny G.;Sorenson, Roderick J.;Tsume, Yasuhiro;Wilson, Michael W.;Zhang, Wenpeng;Sun, Duxin;Sun, Hongmin;Larsen, Scott D.. And the article was included in Bioorganic & Medicinal Chemistry in 2013.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene This article mentions the following:

Resistance to antibiotics is an increasingly dire threat to human health that warrants the development of new modes of treating infection. The authors recently identified CCG-2979 as an inhibitor of the expression of streptokinase, a critical virulence factor in Group A Streptococcus that endows blood-borne bacteria with fibrinolytic capabilities. The authors describe the synthesis and biol. evaluation of a series of novel 5,6-dihydrobenzo[h]quinazolin-4(3H)-one analogs of CCG-2979 undertaken with the goal of improving the modest potency of the lead. In addition to achieving an over 35-fold increase in potency, the authors identified structural modifications that improve the solubility and metabolic stability of the scaffold. The efficacy of two new compounds CCG-203592 and CCG-205363 against biofilm formation in Staphylococcus aureus represents a promising addnl. mode of action for this novel class of compounds In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Application In Synthesis of 1-(2-Bromoethyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors was written by Tasker, Nikhil R.;Rastelli, Ettore J.;Blanco, Isabella K.;Burnett, James C.;Sharlow, Elizabeth R.;Lazo, John S.;Wipf, Peter. And the article was included in Organic & Biomolecular Chemistry in 2019.Category: bromides-buliding-blocks This article mentions the following:

A continuous flow photooxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones to produce 7-iminothieno[3,2-c]pyridine-4,6(5H,7H)-diones has been developed, utilizing ambient air as the sole reactant. N-H Imines are formed as the major products, and excellent functional group tolerance and conversion on gram-scale without the need for chromatog. purification allow for facile late-stage diversification of the aminothienopyridinone scaffold. Several analogs exhibit potent in vitro inhibition of the cancer-associated protein tyrosine phosphatase PTP4A3, and the SAR supports an exploratory docking model. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Category: bromides-buliding-blocks).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of monosubstituted [1.1.1]propellanes was written by Bothe, Harald;Schlueter, Arnulf Dieter. And the article was included in Chemische Berichte in 1991.Related Products of 4457-67-4 This article mentions the following:

Wittig reaction of (ClCH₂)₂CO with RCH:PPh₃ [R = Me(CH₂)_n, MeO(CH₂)_m; n = 4, 6, 10; m = 3, 5] in Et₂O-hexane gave 32-48% RCH:C(CH₂Cl)₂, which underwent cycloaddition with :CBr₂ to give 20-57% bis(chloromethyl)dibromocyclopropanes I. Treating I with MeLi in Et₂O gave 21-64% title propellanes II, which polymerized spontaneously at room temperature in the absence of inhibitors. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Related Products of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Poly(phenylene oxide)-Based Anion Exchange Membranes Having Linear Cross-Linkers or Star Cross-Linkers was written by Han, Juanjuan;Zhang, Yangyang;Kang, Fei;Liu, Chifeng;Song, Wenfeng;Zheng, Xiumeng;Liu, Xia;Wang, Minhao;Zhou, Xiaorong;Ren, Zhandong;Hu, Meixue;Xiao, Li;Zhuang, Lin. And the article was included in ACS Applied Energy Materials in 2022.Computed Properties of C4H4BrNO2 This article mentions the following:

Linear crosslinked and star crosslinked anion exchange membranes (AEMs) are reported in this work, namely, lcQPPO (linear crosslinked quaternized poly(2,4-dimethyl-1,4-phenylene oxide) (PPO)) and scDQPPO (star crosslinked quaternized PPO). Compared with original quaternized PPO (QPPO), crosslinked AEMs show a restrained swelling degree. But, due to the hindrance of a crosslinking polymer matrix, lcQPPO membranes show decreased ionic conductivity For scDQPPO, its wide and connective ion channels are beneficial to the conduction of OH^–, exhibiting increased ionic conductivity Besides, the aggregated and crosslinked polymer networks in scDQPPO enhance the chem. stability and mech. properties of the AEMs. Specifically, for scDQPPO-40, a high OH^– conductivity of 100.7 mS cm^-1 and a low swelling degree of 20.7% are achieved at 80°C. The tensile strength and elongation at break of wet scDQPPO-40 at 25°C are 16.7 MPa and 18.0%. After immersing in 1 M NaOH at 80°C for 30 days, the loss of ionic conductivity and weight for scDQPPO-40 is 24.2 and 14.8%, with the degradation of tensile strength and elongation at break of 22.2% and 26.7%, resp. On the basis of the membrane, a fuel cell performance of 0.577 W cm^-2 is demonstrated at 60°C, while, for QPPO-40 and lcQPPO-60, their fuel cell peak power densities are only 0.250 and 0.215 W cm^-2. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Computed Properties of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary