Bromides-buliding-blocks

Electric Literature of 10269-01-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10269-01-9, name is (3-Bromophenyl)methanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[0241] 1-(3-Bromobenzyl)-2,2,5,5-tetramethyl-1,2,5-azadisilolidine (3.1). The procedure developed by Magnus et al. was followed.5 To a solution containing 2.228 g (11.98 mmol) of 3-bromobenzylamine in 10 mL of dichloromethane was added 3.4 mL (24 mmol) of triethylamine. The solution was stirred for 30 min and then treated with a solution containing 2.579 g (11.98 mmol) of 1,1,4,4-tetramethyl-1,4-dichlorosilethylene in 5 mL of dichloromethane. The reaction mixture was stirred for 3 h and then poured into 100 mL of saturated sodium dihydrogen phosphate. The reaction mixture was extracted with three 50 mL portions of dichloromethane, then dried (MgSO4), and concentrated under reduced pressure. The residue was distilled at 160 C. to give 3.1 as a clear colourless oil: yield 2.510 g (64%). 1H NMR (200 MHz, acetone-d6): delta 0.00 (s, 12H), 0.78 (s, 4H), 4.06 (s, 2H), 7.20-7.48 (m, 4H). 13C NMR (50.3 MHz, Acetone-d6): delta -0.26, 8.01, 45.59, 122.15, 126.10, 129.35, 129.53, 130.69, 146.01. IR (thin film): 3388, 2953, 1666, 1251, and 1132 cm-1. MS (CI): m/z=312.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (3-Bromophenyl)methanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Valliant, John F.; Dorff, Peter N.; Chirakal, Raman; US2004/260073; (2004); A1;,
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Related Products of 40787-48-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40787-48-2 as follows.

Finally, the final product d was obtained by Suzuki coupling reaction: 9 mmol of 9-benzoquinone-10 borate was obtained.1.5 mmol of 1,4-dibromo-2,5-diethylbenzene, 0.36 mmol of tetrakis(triphenylphosphine)palladium, 60 mL of toluene,15 mL of ethanol, 333 mmol of K2CO, (formed as a solution with 15 mL of water), and added to the reaction flask.The system was then evacuated under reflux of nitrogen at 110 C for 24 hours.After completion of the reaction, the methanol was subjected to hot-washing suction filtration, toluene to recrystallization, and sublimation to obtain the final product d, yield 42%.

According to the analysis of related databases, 40787-48-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shaanxi Normal University; Hu Jianyong; Zhang Jiali; (19 pag.)CN108383693; (2018); A;,
Bromide – Wikipedia,
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Reference of 626-88-0, A common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Entry 7: 3,7-dimethyloctan-2-one (0.5 mmol, 78.1 mg). The remote product was 7-hydroxy-3,7-dimethyloctan-2-one (21), and the proximal product was 3-hydroxy-3,7-dimethyloctan-2-one. Purification by flash chromatography (35% EtOAc/hexanes), run 1 (46.0 mg, 0.267 mmol, 53%), run 2 (43.1 mg, 0.250 mmol, 50%). Average: 52%. Recovered starting material (rSM): 14.2 mg, 0.183 mmol, 18%. [Remote:Proximal]>99:1. Authentic proximal oxidation product was obtained by treating 1-bromo-4-methylpentane (1 equiv.) with Mg turnings (1 equiv.), followed by 2,3-butandione (1 equiv.) at -78 C. The reaction was quenched H2O, extracted with CH2Cl2 and purified by column chromatography (15% EtOAc/hexanes) to yield 3-hydroxy-3,7-dimethyloctan-2-one.

The synthetic route of 626-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Board of Trustees of the University of Illinois; US2011/15397; (2011); A1;,
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Some common heterocyclic compound, 65896-11-9, name is 2-Bromo-6-fluoroaniline, molecular formula is C6H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 65896-11-9

General procedure: To a solution of o-haloaniline (4.63 mmol) in dry DCM (20 mL) at room temperature was dropped acyl chloride (5.09 mmol). The reaction mixture was stirred for 24 hours then poured into water, extracted with DCM, washed with saturated NaHCO3, brine, dried over MgSO4, filtered and concentrated. The product was carried on to next step without any further purification in most cases.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 65896-11-9, its application will become more common.

Reference:
Article; Shi, Yajie; Zhou, Qifan; Du, Fangyu; Fu, Yang; Du, Yang; Fang, Ting; Chen, Guoliang; Tetrahedron Letters; vol. 60; 40; (2019);,
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16518-62-0, These common heterocyclic compound, 16518-62-0, name is 3-Bromo-N,N-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of N,N-dimethylaniline 1 (2.0 mmol), indole 2 (1.0mmol), K2S2O8 (1.5 equiv), and CH3CN (3 mL) was taken in aflask and stirred at r.t. for 2?4 h (Scheme 2). After completion ofthe reaction (monitored by TLC), water (5 mL) was added andthe mixture was extracted with ethyl acetate (3 ¡Á 5 mL). Thecombined organic phase was dried over anhydrous Na2SO4, filtered,and evaporated under reduced pressure. The resultingcrude product was purified by silica gel chromatography using amixture of hexane/ethyl acetate (4:1) as eluent to afford an analyticallypure sample of product 3.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16518-62-0.

Reference:
Article; Singh, Manjula; Yadav, Arvind K.; Yadav, Lal Dhar S.; Singh, Rana Krishna Pal; Synlett; vol. 29; 17; (2018); p. 2306 – 2310;,
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Adding a certain compound to certain chemical reactions, such as: 1083181-43-4, name is 6-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1083181-43-4, 1083181-43-4

The title compound is prepared according to General Procedure 8 described for Intermediate 14, using 6-bromo-1-methyl-1 H-1 ,2,3-benzotriazole (Intermediate 80, 45 mg; 0.21 mmol; 1 eq.), bis(pinacolato)diboron (108 mg; 0.42 mmol; 2 eq.), potassium acetate (125 mg; 1.27 mmol; 6 eq.), Pd(dppf)CI2 (27 mg; 0.03 mmol; 0.15 eq.) in DMSO (2 mL). Conditions: 90 C overnight. The crude 1-methyl-6-(tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 – – 1 ,2,3-benzotriazole (80 mg; 0.10 mmol; 45%; brown solid; UPLC purity: 85%) is used in the next step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Malgorzata; GUZIK, Pawel Szczepan; BIA?AS, Arkadiusz Kacper; PAWLIK, Henryk Edward; BOUTARD, Nicolas Felix Pierre; (439 pag.)WO2016/180537; (2016); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2635-13-4, name is 5-Bromobenzo[d][1,3]dioxole belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 2635-13-4

Benzo[1,3]dioxole-5-carbaldehyde (1.80 g, 11.96 mmol), 5-bromobenzo[1,3]dioxole (2.65 g, 13.16 mmol), and n-butyl lithium (5.26 ml, 13.16 mmol) were treated in the same manner as described above for the synthesis of (2,3-dihydrobenzo[1,4]dioxin-6-yl)-(3,5-dimethoxyphenyl)methanol. The crude material was purified via flash column chromatography (5% EtOAc in hexane gradient to 40% EtOAc in hexane in about 40 min.) to give bis-benzo[1,3]dioxol-5-yl-methanol as a light brown oil (2.69 g, 83%): 1H-NMR (CDCl3) 6.86-6.74 (m, 6H, Ar), 5.93 (s, 4H, 2CH2), 5.68 (d, J=3 Hz, 1H, CHOH), 2.16 (d, J=3 Hz, 1H, OH). The product was carried over to the next step.

The synthetic route of 2635-13-4 has been constantly updated, and we look forward to future research findings.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 615-59-8

(1) 2,5-dibromotoluene (10 mmol, 2.5 g), 4-methoxycarbonylbenzeneboronic acid (24 mmol, 4.33 g) under N2 protection.caesium fluoride (40 mmol, 6.0 g) was placed in a 250 mL three-necked flask, and 5% (1.2 to 2.0 g) of Pd (PPh3) catalyst was added.100 mL of anhydrous THF was used as a solvent, and refluxed at 67 C.After completion of the reaction, the product was isolated by silica gel column chromatography (petroleum ether, dichloromethane) to give a pink solid 2.91 g, yield 81%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 615-59-8, its application will become more common.

Reference:
Patent; Shandong Normal University; Dong Yubin; Wang Jiancheng; Liu Congxue; Hu Yuhong; (14 pag.)CN108640906; (2018); A;,
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4766-33-0, These common heterocyclic compound, 4766-33-0, name is 5-Bromonaphthalen-1-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The substituted 1-naphthylamine (10 mmol), 2-picolinic acid (12.5 mmol) and Et3N (20 mmol,2.8 mL) were dissolved in DCM (40 mL) followed by dropwise addition of POCl3 (1.88 mL) at 0C. The resulting mixture was stirred at 0C for 0.5 h and warmed to room temperature for 2 h. Then the reaction mixture was cooled to 0C. Ice water was added slowly to quench the reaction. The organic layer was collected, and the aqueous phase was extracted with DCM. The combined organic phase was washed by saturated NaHCO3 and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was recrystallized from i-propyl alcohol to give desired product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4766-33-0.

Reference:
Article; Guan, Dinghui; Han, Lu; Wang, Lulu; Song, He; Chu, Wenyi; Sun, Zhizhong; Chemistry Letters; vol. 44; 6; (2015); p. 743 – 745;,
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Some common heterocyclic compound, 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline, molecular formula is C7H5BrF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 57946-63-1

2-Bromo-4-(trifluoromethyl)aniline (3. 5g, 14.58 mmol), 1H-pyrazole (1 .98g, 29.2 mmol), N1,N2-dimethylethane-1,2-diamine (0.78 ml, 7.29 mmol), cesium carbonate (10.45g, 32.1 mmol) was added to degassed 1,4-dioxane (15 ml) in a sealed tube and copper(i) iodide (0.55g, 2.92 mmol) was added. The tube was sealed and heated at 120 ¡ãC for 72h. After the solution was cooled, the mixture was passed through a pad of celite and the filtrate was extracted with ethyl acetate. The ethyl acetate layer was washed withbrine, dried over Na2SO4 and concentrated. The crude was purified by column chromatography to obtain the product as off white solid (2.7g, 83percent). LCMS (ESI): mlz 228.39(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57946-63-1, its application will become more common.

Reference:
Patent; LUPIN LIMITED; RAMDAS, Vidya; LORIYA, Rajeshkumar, Maganlal; BANERJEE, Moloy; PATIL, Pradeep, Rangrao; JOSHI, Advait, Arun; DATRANGE, Laxmikant, Shamlal; WALKE, Deepak, Sahebrao; KHAN, Talha, Hussain; DAS, Amit, Kumar; GOTE, Ganesh, Navinchandra; KALHAPURE, Vaibhav, Madhukar; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; (234 pag.)WO2017/37682; (2017); A1;,
Bromide – Wikipedia,
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