Bromides-buliding-blocks

Polycyclic heteroaromatics via hydrazine-catalyzed ring-closing carbonyl-olefin metathesis was written by Cho, Eun Kee;Quach, Phong K.;Zhang, Yunfei;Sim, Jae Hun;Lambert, Tristan H.. And the article was included in Chemical Science in 2022.Application of 85118-24-7 This article mentions the following:

The use of hydrazine-catalyzed ring-closing carbonyl-olefin metathesis (RCCOM) to synthesize polycyclic heteroaromatic (PHA) compounds is described. In particular, substrates bearing Lewis basic functionalities such as pyridine rings and amines, which strongly inhibit acid catalyzed RCCOM reactions, are shown to be compatible with this reaction. Using 5 mol% catalyst loadings, a variety of PHA structures can be synthesized from biaryl alkenyl aldehydes, which themselves are readily prepared by cross-coupling. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7Application of 85118-24-7).

2-Bromo-4-(trifluoromethyl)benzaldehyde (cas: 85118-24-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application of 85118-24-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

GC-MS analysis of fatty acids of Irvingia gabonensis seed fat was written by Okore, V. C.;Udeala, O. K.. And the article was included in Nigerian Journal of Natural Products and Medicine in 1997.Quality Control of 15-Bromopentadecanoic acid This article mentions the following:

Dika fat is the name given to the waxy material obtained from the seeds of Irvingia gabonensis (Fam. Irvingiaceae). The fat has been a subject of research in recent years, and it has been evaluated as a component of different drug delivery systems . Despite the impressive properties of this wax as have been established in the earlier studies, information on its chem. composition is rather scanty. Chem. characterization of the wax was done by GC-MS technique. The dika fat was obtained by solvent extraction, using the method described by Udeala et al (1980). A Fisons Trio 200 Quadrupole GC-MS instrument fitted with a 30m 鑴?0.32mm (i.d.) OV-1 capillary column, was used for the anal. The column temperature was programmed to rise from 100鎺矯 to 280鎺矯 at the rate of 5鎺?min. The carrier gas was helium flowing at the rate of 1.5ml/min. Ionization voltage of 70eV was applied. The solvent for dika fat was n-hexane. The identity of the components of dika fat was confirmed by a combination of computer-aided identification, the eight peak index of mas spectra as well as co-chromatog. The gas chromatogram of dika fat reveals seven peaks representing major components and about the same number of peaks for the minor components. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Quality Control of 15-Bromopentadecanoic acid).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Quality Control of 15-Bromopentadecanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formation of C(sp²)-boronate esters by borylative cyclization of alkynes using BCl₃ was written by Warner, Andrew J.;Lawson, James R.;Fasano, Valerio;Ingleson, Michael J.. And the article was included in Angewandte Chemie, International Edition in 2015.Computed Properties of C9H11BrO This article mentions the following:

Arylpropargyl compounds R¹C₆H₄YCH₂C椤氬挵R² undergo cyclization in a reaction with BCl₃ and pinacol, yielding cyclic alkenylboronates I (2, R¹ = H, Me, MeO, Cl; Y = CH₂, NTs, O; R² = Ph, ClC₆H₄, C₆F₅, 3-CF₃C₆H₄, 4-NCC₆H₄, MeC₆H₄, Br, Me, 1-naphthyl, PhCH:CH, 4-NO₂C₆H₄, 4-EtO₂CC₆H₄). Diynes R³C椤氬挵CH₂YCH₂C椤氬挵R³ gave boronates II (R³ = Ph, 10a,b; Y = CH₂, NTs) or III (11, R³ = H, Y = CH₂). BCl₃ is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp²)-boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermol. 1,2-carboboration of alkynes Ar¹C椤氬挵Me is also achieved using BCl₃ and arene Ar²H to generate trisubstituted vinyl boronate esters Ar¹Ar²C:CMe(Bpin) (12, Ar¹ = Ph, Ar² = 5-methyl-2-thienyl). In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Computed Properties of C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Equivalent Loading of Directed Arenes in Pd(II)-Catalyzed Oxidative Cross-Coupling of Aryl C-H Bonds at Room Temperature was written by Mei, Chong;Zhao, Mengdi;Lu, Wenjun. And the article was included in Journal of Organic Chemistry in 2021.Category: bromides-buliding-blocks This article mentions the following:

Here, in a palladium/oxidant/acid catalytic system at room temperature, one arene could highly selectively couple with the other one to afford the target unsym. biaryls just by controlling the directing groups and the substituted groups on their Ph rings was reported. The utility of this one-one cross-coupling was also demonstrated by synthesis of a few bioactive mols. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Category: bromides-buliding-blocks).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Inhibition of tyrosine phenol-lyase by tyrosine homologues was written by Do, Quang;Nguyen, Giang T.;Phillips, Robert S.. And the article was included in Amino Acids in 2016.Formula: C9H11BrO This article mentions the following:

The authors designed, synthesized, and evaluated tyrosine homologs and their O-Me derivatives as potential inhibitors for tyrosine phenol-lyase (TPL; EC 4.1.99.2). Recently, the authors reported that homologs of tryptophan were potent inhibitors of tryptophan indole-lyase (tryptophanase; TIL, EC 4.1.99.1), with K_i values in the low micromolar range. As the structure and mechanism for TPL is very similar to that of TIL, the authors postulated that tyrosine homologs could also be potent inhibitors of TPL. However, the authors found that homotyrosine, bishomotyrosine, and their corresponding O-Me derivatives were competitive inhibitors of TPL, which exhibited K_i values in the range of 0.8-1.5 mM. Thus, these compounds were not potent inhibitors, but instead bound with affinities similar to common amino acids, such as phenylalanine or methionine. Pre-steady-state kinetic data were very similar for all compounds tested and demonstrated the formation of an equilibrating mixture of aldimine and quinonoid intermediates upon binding. Interestingly, the authors also observed a blue-shift for the absorbance peak of external aldimine complexes of all tyrosine homologs, suggesting possible strain at the active site due to accommodating the elongated side-chains. In the experiment, the researchers used many compounds, for example, 1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0Formula: C9H11BrO).

1-(2-Bromoethyl)-4-methoxybenzene (cas: 14425-64-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C9H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Condensed isoquinolines. Part 9. Alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones was written by Kisel, V. M.;Potikha, L. M.;Kovtunenko, V. A.. And the article was included in Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2000.Safety of 3-(Bromomethyl)benzoic acid This article mentions the following:

The alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one proceeds at N(6) or C(7) depending on the type of alkylating agent and reaction conditions. C(7)-alkylation occurs in the presence of base. The secondary alkylation of the 7-alkyl derivatives occurs at the same position under these conditions. Depending on the conditions, the reaction with ortho-xylylene dibromide leads to spiro[5H-isoquino-[2,3-a]quinazolin-7(12H),2′-indane]-5-one or 11-oxo-4b,5,10,16-tetrahydro-11H-10a-azonia-15b-azadibenzo[a,e]pleiadene bromide. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Safety of 3-(Bromomethyl)benzoic acid).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Safety of 3-(Bromomethyl)benzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design of Potent and Proteolytically Stable Biaryl-Stapled GLP-1R/GIPR Peptide Dual Agonists was written by Yang, Yifang;Lee, Candy;Reddy, Reddy Rajasekhar;Huang, David J.;Zhong, Weixia;Nguyen-Tran, Van T. B.;Shen, Weijun;Lin, Qing. And the article was included in ACS Chemical Biology in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Recent clin. trials have revealed that the chimeric peptide hormones simultaneously activating glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) demonstrate superior efficacy in glycemic control and body weight reduction, better than those activating the GLP-1R alone. However, the linear peptide-based GLP-1R/GIPR dual agonists are susceptible to proteolytic cleavage by common digestive enzymes present in the gastrointestinal tract and thus not suitable for oral administration. Here, we report the design and synthesis of biaryl-stapled peptides, with and without fatty diacid attachment, that showed potent GLP-1R/GIPR dual agonist activities. Compared to a linear peptide dual agonist and semaglutide, the biaryl-stapled peptides displayed drastically improved proteolytic stability against the common digestive enzymes. Furthermore, two stapled peptides showed excellent efficacy in an oral glucose tolerance test in mice, owing to their potent receptor activity in vitro and good pharmacokinetics exposure upon s.c. injection. By exploring a more comprehensive set of biaryl staplers, we expect that this stapling method could facilitate the design of the stapled peptide-based dual agonists suitable for oral administration. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reductive coupling of benzyl oxalates with highly functionalized alkyl bromides by nickel catalysis was written by Yan, Xiao-Biao;Li, Chun-Ling;Jin, Wen-Jie;Guo, Peng;Shu, Xing-Zhong. And the article was included in Chemical Science in 2018.Application In Synthesis of 1-Bromo-4-methoxybutane This article mentions the following:

Coupling reactions involving non-sulfonated C-O electrophiles provide a promising method for forming C-C bonds, but the incorporation of functionalized or secondary alkyl groups remains a challenge due to the requirement for well-defined alkylmetal species. In this study, a reductive nickel-catalyzed cross-coupling of benzyl oxalates with alkyl bromides, using oxalate as a new leaving group is reported. A broad range of highly functionalized alkyl units (such as functional groups: alkyl chloride, alc., aldehyde, amine, amide, boronate ester, ether, ester, heterocycle, phosphonate, strained ring) were efficiently incorporated at the benzylic position. The utility of this synthetic method was further demonstrated by late-stage modification of complex bioactive compounds Preliminary mechanistic experiments revealed that a radical process might be involved in the reaction. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Application In Synthesis of 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application In Synthesis of 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Development of C₂-Symmetric Chiral Spirocyclic Phase-Transfer Catalysts: Synthesis and Application to Asymmetric Alkylation of Glycinate Schiff Base was written by Xu, Changming;Qi, Yinsheng;Yang, Xinshuang;Li, Xiangfan;Li, Zhenpeng;Bai, Lei. And the article was included in Organic Letters in 2021.Quality Control of 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

A class of C₂-sym. chiral spirocyclic phase-transfer catalysts based on the tetramethyl-1,1′-spirobiindane scaffold such as I璺疊r^– was synthesized from com. available bisphenol A in 12 steps in 22-25% total yields; the scaffold features a more rigid and stable backbone and smaller dihedral angles and can be easily modified. These catalysts show high catalytic performance in the asym. alkylation of tert-Bu glycinate Schiff base Ph₂C:NCH₂CO₂t-Bu at only 2 mol % catalyst loading, giving nonracemic protected 浼?amino acid esters such as (R)-Ph₂C:NCH(CH₂Ph)CO₂t-Bu in up to 92% yield and 98% ee. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Quality Control of 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Theoretical study of a few 2D polymer networks and MOFs formed by chiral mTBPB molecules was written by Xiang, Zhihao;Kang, Shuangyu;Feng, Xuyang;Mu, Huijing;Cai, Yingxiang. And the article was included in Materials Chemistry and Physics in 2020.Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl This article mentions the following:

Two-dimensional (2D) materials have become the most popular research targets due to their unique structural characteristics, novel phys. properties and potential applications such as photovoltaics, semiconductors, electrodes and water purification In this study, a few 2D polymer networks and their corresponding metal organic frameworks (MOFs) formed by the debromination (also including dehydrogenation) of mTBPB mols. were investigated based on first-principles calculations It was found that L-C₄₈H₃₀, LR-C₄₈H₃₀ and achiral-C₁₂H₆ were direct-bandgap semiconductors but L-C₄₈H₃₀Cr₃, LR-C₄₈H₃₀Cr₃ and achiral-C₄₈H₂₄Cr₆ 2D MOFs were ferromagnetic semiconductors. The origin of ferromagnetism in three 2D MOFs was mainly attributed to the contribution of Cr-d and C-p_z orbitals. Furthermore, anisotropic carrier effective masses were determined and the reaction energy barriers to form these 2D polymer networks and MOFs were evaluated. In the experiment, the researchers used many compounds, for example, 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl).

3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl (cas: 96761-85-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: 3,3”-Dibromo-5′-(3-bromophenyl)-1,1′:3′,1”-terphenyl

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary