Bromides-buliding-blocks

Vinyl Azides as Radical Acceptors in the Vitamin B₁₂-Catalyzed Synthesis of Unsymmetrical Ketones was written by Dworakowski, Krzysztof R.;Pisarek, Sabina;Hassan, Sidra;Gryko, Dorota. And the article was included in Organic Letters in 2021.HPLC of Formula: 57293-19-3 This article mentions the following:

Vitamin B₁₂ catalyzed the reaction of vinyl azides with electrophiles under light irradiation to afforded unsym. carbonyl compounds R¹C(O)CH₂R² [R¹ = Ph, 4-t-BuC₆H₄, 4-ClC₆H₄, etc.; R² = (CH₂)₃CN, (CH₂)₃Ph, (CH₂)₃C(O)OEt, etc.] in decent yields. Mechanistic studies revealed that alkyl radicals were key intermediates in this transformation. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of cadiolide analogues as inhibitors of bacterial biofilm formation was written by Mairink, Simone Z.;Barbosa, Luiz C. A.;Boukouvalas, John;Pedroso, Silvia H. S. P.;Santos, Simone G.;Magalhaes, Paula P.;Farias, Luiz M.. And the article was included in Medicinal Chemistry Research in 2018.Computed Properties of C8H6Br2O2 This article mentions the following:

Bacterial biofilm infections pose a major clin. challenge due to the ability of biofilms to resist high levels of conventional antibiotics. In the present study, we describe the synthesis and biofilm inhibiting properties of nine new butenolides related to the cadiolide family of marine antibiotics. Eight new cadiolide analogs were synthesized using oxazole-ynone Diels-Alder cycloaddition/cycloreversion as the key step. Their effects on bacterial growth and biofilm formation were investigated against a range of Gram-pos. and Gram-neg. bacteria, namely Staphylococcus aureus, Enterococcus faecalis, Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. The cadiolide analogs strongly inhibited biofilm formation of the two Gram-pos. bacteria (S. aureus and E. faecalis) at concentrations as low as 0.3 娓璯 mL^-1 and 0.5 娓璯 mL^-1, resp. The identification of synthetic cadiolides with potent biofilm-inhibiting capabilities opens a new avenue for therapeutic interventions and highlights the potential of this class of compounds for antimicrobial drug development. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1Computed Properties of C8H6Br2O2).

3,5-Dibromo-4-methoxybenzaldehyde (cas: 108940-96-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C8H6Br2O2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa was written by Batt, Douglas G.;Qiao, Jennifer X.;Modi, Dilip P.;Houghton, Gregory C.;Pierson, Deborah A.;Rossi, Karen A.;Luettgen, Joseph M.;Knabb, Robert M.;Jadhav, P. K.;Wexler, Ruth R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Application of 6515-58-8 This article mentions the following:

Structural features of the 5-amidinoindole inhibitor I of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa. Several analogs of I with greatly diminished factor Xa selectivity were prepared and the structural features favorable for factor IXa activity were identified. In the experiment, the researchers used many compounds, for example, 3-(Bromomethyl)benzoic acid (cas: 6515-58-8Application of 6515-58-8).

3-(Bromomethyl)benzoic acid (cas: 6515-58-8) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 6515-58-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives was written by Muimhneachain, Eoin O.;Pardo, Leticia M.;Bateman, Lorraine M.;Rao Khandavilli, U. B.;Lawrence, Simon E.;McGlacken, Gerard P.. And the article was included in Advanced Synthesis & Catalysis in 2017.HPLC of Formula: 61150-57-0 This article mentions the following:

A synthesis of tricyclic oxoisochromene derivatives via an intramol. direct arylation of cycloalkyl-1,3-diketone-derived 浼?灏?unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0HPLC of Formula: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The bromination of the silver salts of organic acids in trichloroethylene was written by Stoll, M.;Rouve, A.. And the article was included in Helvetica Chimica Acta in 1951.Name: 15-Bromopentadecanoic acid This article mentions the following:

Formation of bromides from Ag salts and Br goes best in solvents which react with Br. Ag mono-Me thapsate treated with Br in CCl₄ gives 65-75% Me 15-bromopentadecanoate and 18-25% free acid. When the reaction is carried out under N in C₂HCl₃ the yield is 78-85%, with 9-11% free acid and about 8% of a neutral compound b¹⁵ 90-5鎺? The solvent probably takes part in the reaction. In the experiment, the researchers used many compounds, for example, 15-Bromopentadecanoic acid (cas: 56523-59-2Name: 15-Bromopentadecanoic acid).

15-Bromopentadecanoic acid (cas: 56523-59-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 15-Bromopentadecanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

N-Phthalimidoalkyl derivatives of 2灏?carbomethoxy-3灏?(4′-iodophenyl)tropane (灏?CIT): brain monoamine transporter affinity was written by Tamagnan, Gilles;Neumeyer, John L.;Gao, Yigong;Wang, Shaoyin;Kula Nora;Baldessarini, Ross J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1997.Recommanded Product: N-(5-Bromopentyl)phthalimide This article mentions the following:

A series of novel N-phthalimidoalkyl analogs I (n = 2-5, 8) for the stable phenyltropane 灏?CIT were synthesized and evaluated by selective radioligand binding assays for affinity to transporters for dopamine (DA), serotonin (5-HT) and norepinephrine (NE) in corpus striatum tissue from rat forebrain. 灏?CIT and I (n = 4, 5, 8) showed similarly greater affinity at 5-HT than DA transporters; this affinity was lost with I (n = 2, 3). These results are consistent with interference at a critical binding site for the tropane nitrogen on the transporter proteins and indicate that the tropane nitrogen atom can be substituted with large substituted alkyl moieties without loss of affinity or selectivity for amine transporters. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4Recommanded Product: N-(5-Bromopentyl)phthalimide).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: N-(5-Bromopentyl)phthalimide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Isomeric thermally activated delayed fluorescence emitters based on a quinolino[3,2,1-de]acridine-5,9-dione multiple resonance core and carbazole substituent was written by Liu, Jing-Feng;Zou, Sheng-Nan;Chen, Xing;Yang, Sheng-Yi;Yu, You-Jun;Fung, Man-Keung;Jiang, Zuo-Quan;Liao, Liang-Sheng. And the article was included in Materials Chemistry Frontiers in 2022.Related Products of 100189-84-2 This article mentions the following:

The color purity of the pixels is an essential indicator in organic light-emitting diode (OLED) com. displays. Since the two important parameters of high color purity and efficiency can be achieved simultaneously, multiple resonance thermally activated delayed fluorescence (MR-TADF) emitters have achieved rapid development. Recently, there has been a lot of research work on connecting various donor (D) moieties to the existing MR core, but few studies on how the linking moiety affects the efficiency of MR-TADF emitters. To figure out the influence of substituents on the MR-TADF system, we developed three isomers QAOCz1, QAOCz2, and QAOCz3, which are constructed with the same moieties of 3,11-diphenylquinolino[3,2,1-de]acridine-5,9-dione and 9-phenyl-9H-carbazole (PhCz) by different site connections. Through reasonable adjustments of the substitution site, the donor-acceptor (D-A) interaction of the isomers gradually weakened and mol. rigidity gradually increased. As a result, their singlet-triplet energy gap (铻朎ST) gradually decreased and their photoluminescence quantum yield (PLQY) gradually rose. QAOCz3 with the weakest D-A interaction successfully achieves a much higher PLQY of 98.9% and a smaller 铻朎ST of 0.16 eV. The QAOCz3 based OLED not only realizes the best maximum external quantum efficiency (EQE) of 21.1% but also has the narrowest full-width at half maximum (FWHM) of 40 nm. This work shows that weakening the D-A interaction between the substituents and the MR core by a spacer group is of great significance for the construction of efficient MR-TADF emitters. In the experiment, the researchers used many compounds, for example, 2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2Related Products of 100189-84-2).

2,5-Dibromo-1,3-dimethylbenzene (cas: 100189-84-2) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 100189-84-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Copper-Catalyzed Formal Dehydration Polymerization of Propargylic Alcohols via Cumulene Intermediates was written by Wu, Bin;Su, Hao-Ze;Wang, Zi-Yuan;Yu, Zi-Di;Sun, Han-Li;Yang, Fan;Dou, Jin-Hu;Zhu, Rong. And the article was included in Journal of the American Chemical Society in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

Here we report a copper-catalyzed formal dehydration polymerization of propargylic alcs. Copper catalysis allows for efficient in situ generation of [n]cumulenes (n = 3, 5) by a soft deprotonation/灏?elimination pathway and subsequent polymerization via organocopper species. Alkyne polymers (M_n up to 36.2 kg/mol) were produced with high efficiency (up to 95% yield) and excellent functional group tolerance. One-pot synthesis of semiconducting head-to-head poly(phenylacetylene) was demonstrated through a polymerization-isomerization sequence. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of aryl sulfonyl fluorides from aryl sulfonyl chlorides using sulfuryl fluoride (SO₂F₂) as fluoride provider was written by Song, Xuyan;He, Yunlu;Wang, Bo;Peng, Sanwen;Pan, Xi;Wei, Min;Liu, Qiang;Qin, Hua-Li;Tang, Haolin. And the article was included in Tetrahedron in 2022.Product Details of 454-65-9 This article mentions the following:

A highly efficient method for the synthesis of aryl sulfonyl fluorides ArSO₂F [Ar = 4-MeC₆H₄, 4-PhC₆H₄, 4-ClC₆H₄, etc.] was developed from aryl sulfonyl chlorides using SO₂F₂ as fluoride source in up to 98% isolated yield under mild conditions. Gram scale experiments were also conducted, revealing the good practicality of this new protocol. In the experiment, the researchers used many compounds, for example, 3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9Product Details of 454-65-9).

3-Bromobenzene-1-sulfonyl fluoride (cas: 454-65-9) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Product Details of 454-65-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Design and Synthesis of [(2,3-Dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as Novel Ligands Selective for the Dopamine D₃ Receptor Subtype was written by Robarge, Michael J.;Husbands, Stephen M.;Kieltyka, Andrzej;Brodbeck, Robbin;Thurkauf, Andrew;Newman, Amy Hauck. And the article was included in Journal of Medicinal Chemistry in 2001.HPLC of Formula: 954-81-4 This article mentions the following:

The dopamine D₃ receptor subtype has been recently targeted as a potential neurochem. modulator of the behavioral actions of psychomotor stimulants, such as cocaine. However, definitive behavioral investigations have been hampered by the lack of highly selective D₃ agonists and antagonists. In an attempt to design a novel class of D₃ ligands with which to study this receptor system, a series of chem. divergent compounds that possessed various structural features that exist within several classes of reputed D₃ agents was screened and compared to the recently reported NGB 2904. On the basis of these results, a novel series of compounds was designed that included functional moieties that were required for high-affinity and selective binding to D₃ receptors. All the compounds in this series included an aryl-substituted piperazine ring, a varying alkyl chain linker (C₃-C₅), and a terminal aryl amide. The compounds were synthesized and evaluated in vitro for binding in CHO cells transfected with human D₂, D₃, or D₄ receptor cDNAs. D₃ binding affinities ranged from K_i = 1.4 to 1460 nM. The most potent analog in this series, I, demonstrated a D₃/D₂ selectivity of 64 and a D₃/D₄ selectivity of 1300. Structure-activity relationships for this class of ligands at D₃ receptors will provide new leads toward the development of highly selective and potent mol. probes that will prove useful in the elucidation of the role D₃ receptors play in the psychomotor stimulant and reinforcing properties of cocaine. In the experiment, the researchers used many compounds, for example, N-(5-Bromopentyl)phthalimide (cas: 954-81-4HPLC of Formula: 954-81-4).

N-(5-Bromopentyl)phthalimide (cas: 954-81-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.HPLC of Formula: 954-81-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary