Tag: 100-200

Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals was written by Ul Lah, Hafiz;Mir, Shabir Ahmad;Hussain, Gulzar;Wani, Rafiq Ahmad;Yousuf, Syed Khalid. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.Name: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A highly chemo- and diastereoselective vic-dibromination of olefins was developed. The process employed a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Name: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of a novel fluoropyrrole derivative as a potassium-competitive acid blocker with long duration of action was written by Nishida, Haruyuki;Arikawa, Yasuyoshi;Hirase, Keizo;Imaeda, Toshihiro;Inatomi, Nobuhiro;Hori, Yasunobu;Matsukawa, Jun;Fujioka, Yasushi;Hamada, Teruki;Iida, Motoo;Nishitani, Mitsuyoshi;Imanishi, Akio;Fukui, Hideo;Itoh, Fumio;Kajino, Masahiro. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: 881676-32-0 This article mentions the following:

With the aim to find a novel long-lasting potassium-competitive acid blocker (P-CAB) that would perfectly overcome the limitations of proton pump inhibitors (PPIs), we tried various approaches based on pyrrole derivative I as a lead compound As part of a comprehensive approach to identification of a new drug, we explored excellent compounds that have low lipophilicity by introducing a polar hetero-aromatic group at position 5 of the pyrrole ring. Among the compounds synthesized, fluoropyrrole derivativeII, which has a 2-fluoro-3-pyridyl group at the fifth position, lower pK_a, and much lower C log P and log D values than I does, showed potent gastric-acid suppressive action resulting from gastric H⁺,K⁺-ATPase inhibition in animal models. Its maximum intragastric pH elevation effect was strong in rats, and its duration of action was much longer than that of either lansoprazole or lead compound I in dogs. Therefore, compound II can be considered a promising new P-CAB with long duration of action. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Host-guest supramolecular amphiphile enhanced photodecomposition with responsive room-temperature phosphorescence signals was written by Li, Teng;Ma, Xiang. And the article was included in Dyes and Pigments in 2018.Recommanded Product: 4457-67-4 This article mentions the following:

Photolyzable matric belongs to photo-responsive system that experiences irreversible decomposition after irradiation While the self-aggregation of photosensitizers in aqueous media often results in lower photosensitizing ability. In this work, an enhanced photolyzable system is constructed through host-guest recognition between amphiphilic 6-bromoisoquinoline functionalized alkoxyanthracene (AnBq) and cucurbit[7]uril (CB[7]). In addition, a visible room-temperature phosphorescence (RTP) signal occurs along with the photolysis reaction as the suppression of intramol. photoinduced electron transfer (PET) process from the anthracene moiety to phosphorous 6-bromoisoquinoline moiety. The formation of the host-guest assembly and the photolysis of AnBq are clearly corroborated through UV-Vis, NMR and MS spectroscopy. This photo-responsive host-guest assembly provides some hints for the design of photodegradable materials. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Stacked Reticular Frame Boosted Circularly Polarized Luminescence of Chiral Covalent Organic Frameworks was written by Du, Cong;Zhu, Xuefeng;Yang, Chenchen;Liu, Minghua. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Chiral covalent organic frameworks (COFs) with circularly polarized luminescence (CPL) are intriguing as advanced chiroptical materials but have not been reported to date. We constructed chiroptical COF materials with CPL activity through the convenient Knoevenagel condensation of formyl-functionalized axially chiral linkers and C3-sym. 1,3,5-benzenetriacetonitrile. Remarkably, the as-prepared chiral COFs showed high absorption and luminescent dissym. factors up to 0.02 (g_abs) and 0.04 (g_lum), resp. In contrast, the branched chiral polymers from the same starting monomers were CPL silent. Structural and spectral characterization revealed that the reticular frame was indispensable for CPL generation via confined chirality transfer. Moreover, reticular stacking boosted the CPL performance significantly due to the interlayer restriction of frame. This work demonstrates the first example of a CPL-active COF and provides insight into CPL generation through covalent reticular chem., which will play a constructive role in the future design of high-performance CPL materials. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Safety of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Study on synthesis technology of sodium ozagrel was written by Wang, Yuting. And the article was included in Jinzhou Yikedaxue Xuebao in 2022.Application of 128-08-5 This article mentions the following:

Objective In response to the deficiency of existing synthesis process, to explore an industrial preparation of sodium ozagrel, which features safe and environmental protection, low production cost, easy operation, and recycle of solvent. Methods Me cinnamate and sodium imidazolate were used resp. as the starting materials. The reaction material ratio, solvent selection, reaction temperature, reaction time, post-treatment method and product purification and other conditions were studied. Results The sodium ozagrel prepared by this method can meet the quality standard Conclusion The production process has been determined to be reasonable and feasible, and the optimal production conditions have been obtained, which are convenient for production In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Application of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Cross-Electrophile C(sp³)-Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes was written by Duan, Jicheng;Wang, Yuquan;Qi, Liangliang;Guo, Peng;Pang, Xiaobo;Shu, Xing-Zhong. And the article was included in Organic Letters in 2021.Recommanded Product: 1-Bromo-4-methoxybutane This article mentions the following:

Cross-electrophile C-Si coupling has emerged as a promising tool for the construction of organosilanes, but the potential of this method remains largely unexplored. Herein, we report a C(sp³)-Si coupling of unactivated alkyl bromides with vinyl chlorosilanes. The reaction proceeds under mild conditions, and it offers a new approach to alkylsilanes. Functionalities such as Grignard-sensitive groups (e.g., acid, amide, alc., ketone, and ester), acid-sensitive groups (e.g., ketal and THP protection), alkyl fluoride and chloride, aryl bromide, alkyl tosylate and mesylate, silyl ether, and amine were tolerated. Incorporation of the -Si(vinyl)R₂ moiety into complex mols. and the immobilization of a glass surface by formed organosilanes were demonstrated. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ni-Catalyzed reductive arylalkylation of unactivated alkenes was written by Jin, Youxiang;Wang, Chuan. And the article was included in Chemical Science in 2019.SDS of cas: 4457-67-4 This article mentions the following:

In this protocol Ni-catalyzed reductive arylalkylation of unactivated alkenes tethered to aryl bromides with primary alkyl bromides was accomplished, which provided a new path to construct diverse benzene-fused carbo- and heterocyclic cores including indanes, tetrahydroisoquinolines, indolines and isochromanes I [R¹ = Me, Et, i-Pr, cyclohexyl; R² = H, Me, Et; R³ = 5-OMe, 5-F, 4-Cl, etc.; R⁴ = CN, OAc, F, etc.; X = CH₂, NH, NMe, O; m = 0,3,4,5,6; n = 0,1]. Notably, this new method circumvented the pregeneration of organometallics and demonstrated high tolerance to a wide range of functional groups. The preliminary mechanistic investigations suggested a reaction pathway with an intermediate reduction In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4SDS of cas: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.SDS of cas: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zirconium-Catalyzed Remote Defunctionalization of Alkenes was written by Matt, Christof;Kern, Christoph;Streuff, Jan. And the article was included in ACS Catalysis in 2020.Synthetic Route of C5H11BrO This article mentions the following:

This work introduces a catalytic zirconium chain-walk reaction that in combination with a β-heteroatom elimination step enables the cleavage of remote nonactivated carbon-heteroatom bonds. The result is a controlled defunctionalization reaction, which takes place with excellent site selectivity and can be applied to sym. and unsym. alkene chains with ether, amine, and thioether groups. The approach can be used for remote functional group substitution as well, and a preliminary investigation indicates a dissociative chain-walk mechanism. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Synthetic Route of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-based design of high-affinity fluorescent probes for the neuropeptide Y Y₁ receptor was written by Mueller, Christoph;Gleixner, Jakob;Tahk, Maris-Johanna;Kopanchuk, Sergei;Laasfeld, Tonis;Weinhart, Michael;Schollmeyer, Dieter;Betschart, Martin U.;Luedeke, Steffen;Koch, Pierre;Rinken, Ago;Keller, Max. And the article was included in Journal of Medicinal Chemistry in 2022.Recommanded Product: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The recent crystallization of the neuropeptide Y Y₁ receptor (Y₁R) in complex with the argininamide-type Y₁R selective antagonist UR-MK299 (2) opened up a new approach toward structure-based design of nonpeptidic Y₁R ligands. We designed novel fluorescent probes showing excellent Y₁R selectivity and, in contrast to previously described fluorescent Y₁R ligands, considerably higher (~100-fold) binding affinity. This was achieved through the attachment of different fluorescent dyes to the diphenylacetyl moiety in 2 via an amine-functionalized linker. The fluorescent ligands exhibited picomolar Y₁R binding affinities (pK_i values of 9.36-9.95) and proved to be Y₁R antagonists, as validated in a Fura-2 calcium assay. The versatile applicability of the probes as tool compounds was demonstrated by flow cytometry- and fluorescence anisotropy-based Y₁R binding studies (saturation and competition binding and association and dissociation kinetics) as well as by widefield and total internal reflection fluorescence (TIRF) microscopy of live tumor cells, revealing that fluorescence was mainly localized at the plasma membrane. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Recommanded Product: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-catalyzed C-H alkylation of 2-phenylpyridines with alkyl iodides was written by Wang, Xiaoling;Ji, Xiaoming;Shao, Changdong;Zhang, Yu;Zhang, Yanghui. And the article was included in Organic & Biomolecular Chemistry in 2017.Synthetic Route of C5H11BrO This article mentions the following:

Palladium-catalyzed C-H alkylation reaction of 2-phenylpyridines with alkyl iodides was successfully developed. The palladacycles obtained from 2-phenylpyridines act as the key intermediates in the alkylation reaction. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Synthetic Route of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Synthetic Route of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary