Tag: 100-200

Hypervalent Chalcogenonium…π Bonding Catalysis was written by Zhang, Qingyu;Chan, Yung-Yin;Zhang, Muyin;Yeung, Ying-Yeung;Ke, Zhihai. And the article was included in Angewandte Chemie, International Edition in 2022.SDS of cas: 128-08-5 This article mentions the following:

A proof-of-concept study of hypervalent chalcogenonium…π bonding catalysis was performed. A new catalytic strategy using 1,2-oxaselenolium salts as chalcogen bond donors and alkenes as chalcogen bond acceptors is described. The feasibility of this concept is demonstrated by the use of trisubstituted selenonium salts in the metal-free catalytic hydrofunctionalization and polymerization of alkenes via unconventional seleniranium ion-like intermediates. The results indicate that counter anions have a significant effect on the catalysis based on hypervalent chalcogenonium…π bonding interactions. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5SDS of cas: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.SDS of cas: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Palladium-Catalyzed Carbonylative Synthesis of 2,3-Disubstituted Chromones was written by Shen, Chaoren;Li, Wanfang;Yin, Hongfei;Spannenberg, Anke;Skrydstrup, Troels;Wu, Xiao-Feng. And the article was included in Advanced Synthesis & Catalysis in 2016.Computed Properties of C7H6BrF This article mentions the following:

An unexpected palladium-catalyzed carbonylative synthesis of 2,3-disubstituted chromones I (R = 7-Me, 6-Cl, 6-CHF₂, etc.; R¹ = 2-Me, 4-MeO, 2,4-Cl₂, etc.; R² = 4-ClC₆H₄, 4-MeC₆H₄, CH₂C₆H₅, etc.) has been developed. Starting from 2-bromofluorobenzenes R⁴2-BrFC₆H₃ (R⁴ = 4-Me, 5-Me, 6-F, etc.) and ketones R²(O)CCH₂C₆H₄R¹, the corresponding chromones I were produced in good yields. By control experiments, this transformation was found to proceed through a sequential carbonylation/Claisen-Hasse rearrangement/intramol. nucleophilic aromatic substitution approach (SNAr). More specifically, the reaction sequence started with a palladium-catalyzed carbonylation of the ketone with o-bromofluorobenzene to give the vinyl benzoates, which subsequently transformed into 1,3-diketones via a Claisen-Hasse rearrangement. The final products were produced after an intramol. SNAr reaction of the in situ formed 1,3-diketone. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Computed Properties of C7H6BrF).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Computed Properties of C7H6BrF

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Metal free synthesis of 1,3-diynes through C_sp-C_sp homo- and hetero-coupling reaction of terminal alkynes was written by Tamuli, Kashyap J.;Bordoloi, Manobjyoti. And the article was included in Sustainable Chemistry and Pharmacy in 2022.Recommanded Product: 128-08-5 This article mentions the following:

Recent methodologies aimed at utilization of eco-friendly pathways and sustainable chem. has turned out to be a convergent point in chem. research. With an objective to derive an economical, greener approach, herein, authors report a mild and straightforward synthetic strategy to synthesize a series of substituted sym. and unsym. 1,3-diyne derivatives This metal free synthetic route catalyzed by N-Bromosuccinimide with tBuOK and KF as fluorine source at room temperature affords excellent yields up to 95% within 2 h. Such type of a greener and sustainable process was adopted for the development of organic building blocks or compounds with minimal waste afford to define the most of the green chem. principles. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Preparation of N-methyl-1,2,3-triazoles was written by Pedersen, Christian. And the article was included in Acta Chemica Scandinavica in 1959.Synthetic Route of C3H4BrN3 This article mentions the following:

The reaction of CH₂N₂ (I) and excess BrCN (II) gave 4-bromo-1,2,3-triazole; excess I with II gave 2-methyl-4-bromo-1,2,3-triazole (III), b. 161-2°, m. 22°. With I overnight at 0° 1,2,3-triazole (IV), b. 205-6°, gave a mixture of 42% 1-methyl-1,2,3-triazole, b. 223-5°, and 46% 2-methyl-1,2,3-triazole, b. 102-3°. Distillation of the product of the reaction of I and II gave 3 fractions-the largest and lowest boiling one being a mixture of BrCH₂CN (V) and 21% III. With NH₃ V gave BrH₃NCH₂CN, m. 165-7° (decomposition) (absolute EtOH). The other 2 fractions were 6% 1-methyl-5-bromo-1,2,3-triazole (VI), m. 41-2° (petr. ether), and 5.5% 1-methyl-4-bromo-1,2,3-triazole (VII), m.98-9° (C₆H₆-petr. ether), prepared from 1-methyl-4-amino-1,2,3-triazole, m. 97-9° (CHCl₃-petr. ether), in 41% yield by the Gattermann reaction. VI heated 6 h. with PhNH₂ gave 45% 1-methyl-5-anilino-1,2,3-triazole, m. 169-71° (C₆H₆-petr. ether). VI was more reactive than III or VII and gave 22% 1-methyl-5-amino-1,2,3-triazole [HCl salt m. 181-2° (absolute EtOH)] with 5% alc. NH₃ solution in a sealed tube 10 h. at 100°, whereas III and VII did not react. IV was prepared in 93% yield by decarboxylating (at 220°) 4-carboxy-1,2,3-triazole, m. 222-4° (H₂O), prepared in good (71%) yield by refluxing HCCCO₂H (VIII) 15 h. with HN₃ in boiling C₆H₆. Similarly, VIII and MeN₃ (from NaN₃ and Me₂SO₄) gave 57% 1-methyl-4-carboxy-1,2,3-triazole (IX), m. 218-19° (H₂O), free from 1-methyl-5-carboxy-1,2,3-triazole. IX via the chloride gave 93% of the azide, m. 152-4° (decomposition) (isocyanate, m. 215-17°), which on boiling 36 h. in EtOH gave 74% 1-methyl-4-carbethoxyamino-1,2,3-triazole, m. 123-4° (EtOH) (urethane m. 114-18°), which on boiling 4 h. with dilute NaOH gave 64% 1-methyl-4-amino-1,2,3-triazole, m. 88-9° (C₆H₆-petr. ether) [HCl salt m. 182-5° (absolute EtOH)]. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Synthetic Route of C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chiral Ammonium Salt Catalyzed Asymmetric Alkylation of Unactivated Amides was written by Xu, Changming;Yang, Xinshuang. And the article was included in Synlett in 2022.Product Details of 83902-02-7 This article mentions the following:

A chiral spirocyclic quaternary ammonium salt catalyzed asym. alkylation of unactivated amides under homogeneous conditions has been developed, giving the target products with up to 60% ee. This novel methodol. provides a general and concise protocol for asym. α-functionalization of unactivated amides. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Product Details of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Heteroaromatic boron compounds. XX. On the preparation of the 6,7-borazarobenzo[b]thiophene system. The preparation of some 3-(2-nitro-3-thienyl)acrylic esters and related compounds. A selective hydrogenation of a vinyl group in the presence of an aromatic nitro group was written by Gronowitz, S.;Ander, I.. And the article was included in Chemica Scripta in 1980.Recommanded Product: 18791-79-2 This article mentions the following:

Some Me 3-(2-nitro-3-thienyl)acrylic esters were prepared by nitration of the corresponding 3-(3-thienyl)acrylic esters. Nitration of 3-(3-thienyl)acrylic acid and its Me ester gave a mixture of 2- and 5-nitrated products. Reduction of the nitro groups to the corresponding 3-(2-amino-3-thienyl)acrylic esters failed. The reaction between 3-thiophenecarboxaldehyde and 5-bromo-3-thiophenecarboxaldehyde with cyanoacetic acid was investigated as to isomer distribution. Hydrogenation of 2-nitro-3-vinylthiophene with Pd/C gave 3-ethyl-2-nitrothiophene (42%) as the only detected product. 3-Nitro-2-vinylthiophene was hydrogenated to 2-ethyl-3-nitrothiophene and 3-amino-2-ethylthiophene. 2-Nitro-3-[2-(2-thienyl)ethenyl]thiophene, was converted on hydrogenation to the unstable 2-amino-3-[2-(2-thienyl)ethenyl]thiophene, which with PhBCl₂ gave 6-phenyl-5-(2-thienyl)-6,7-borazarobenzo[b]thiophene (I). Desulfurization of this compound gave 2,1-borazarene (II) and lower homologs. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Recommanded Product: 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-activity relationships of novel heteroaryl-acrylonitriles as cytotoxic and antibacterial agents was written by Saczewski, Franciszek;Stencel, Agnieszka;Bienczak, Andrzej M.;Langowska, Karolina A.;Michaelis, Martin;Werel, Wladyslaw;Halasa, Rafal;Reszka, Przemyslaw;Bednarski, Patrick J.. And the article was included in European Journal of Medicinal Chemistry in 2008.Related Products of 18791-79-2 This article mentions the following:

Eighteen new 2,6-disubstituted acrylonitriles, e. g. I, and two new (benzimidazol-1-yl)-acetamide derivatives were prepared and screened for antibacterial and cytotoxic activities on 12 human cancer cell lines. Based on the lead structure 2-(benzimidazol-2-yl)-3-(5-nitrothiophen-2-yl) acrylonitrile it was found that placement of Me groups at the 5,6 positions of the benzimidazole ring lead to a 3-fold increase in overall cytotoxic activity. Replacing the nitrothiophene for pyridine reduced cytotoxic activity as did replacing the nitro group for a methoxy group. Cytotoxic activity was only slightly reduced when the benzimidazole ring was replaced by a imidazo[4,5-b]pyridine or a benzthiazole ring but replacement by benzoxazole led to a substantial decrease in activity. Moving the acrylonitrile group from position 2 to position 1 of the benzimidazole ring also resulted in moderately active compounds Benzimidazol-1-ylacetamides showed only modest activity. The structure-activity relationships found in the cytotoxicity studies are mirrored in the results of the antibacterial experiments In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Related Products of 18791-79-2).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Related Products of 18791-79-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemical Synthesis of the Highly Sterically Hindered Core Undecasaccharide of Helicobacter pylori Lipopolysaccharide for Antigenicity Evaluation with Human Serum was written by Zou, Xiaopeng;Hu, Jing;Zhao, Ming;Qin, Chunjun;Zhu, Yuntao;Tian, Guangzong;Cai, Juntao;Seeberger, Peter H.;Yin, Jian. And the article was included in Journal of the American Chemical Society in 2022.Safety of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Here, we report a total synthesis of the core undecasaccharide of H. pylori lipopolysaccharide and its subunit antigens. The match and mismatch between the glycosyl donor and acceptor caused by the inert hydroxyl groups were addressed by a judicious choice of orthogonal protection strategies and glycosylation conditions. A combination of acyl remote participation and solvent effects has been applied for selective formation of the five 1,2-cis-glucosidic bonds. The high steric hindrance induced by the high carbon sugars and trinacriform architecture required that the core undecasaccharide was synthesized through a finely tuned linear assembly rather than convergent strategies. An antigenicity evaluation using glycan microarrays showed that an α-(1â†?)-glucan trisaccharide is recognized by IgG antibodies in sera of H. pylori-infected patients. The phosphate group of the inner core trisaccharide key epitope is very important for IgG recognition. These findings are an important step toward designing carbohydrate-based vaccines against H. pylori. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Safety of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Surface-initiated atom-transfer radical polymerization (SI-ATRP) of bactericidal polymer brushes on poly(lactic acid) surfaces was written by Kalelkar, Pranav P.;Geng, Zhishuai;Cox, Bronson;Finn, M. G.;Collard, David M.. And the article was included in Colloids and Surfaces, B: Biointerfaces in 2022.COA of Formula: C4H4BrNO2 This article mentions the following:

We have modified the surface of poly(lactic acid) (PLA) by bromination in the presence of N-bromosuccinimide (NBS) under UV irradiation This new approach to impart functionality to the surface does not effect the bulk of the material. Brominated PLA surfaces served as initiators for atom-transfer radical polymerization (SI-ATRP) of 2-(methacryloyloxy)ethyl trimethylammonium chloride, a quaternary ammonium methacrylate (QMA). Grafting of poly(QMA) brushes rendered PLA films hydrophilic and these films displayed a three-order of magnitude increase in antimicrobial efficacy against Gram-neg. bacteria such as Escherichia coli as compared to unmodified PLA. The two-step strategy described here to modify PLA surface represents a useful route to modified PLA materials for biomedical and antimicrobial packaging applications. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5COA of Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Improved resistive switching WORM memory behavior in D-π-A architectures by modifying the terminal donor units was written by Harshini, Deivendran;Angela, Varghese Maria;Devibala, Paneerselvam;Imran, Predhanekar Mohamed;Bhuvanesh, Nattamai S. P.;Nagarajan, Samuthira. And the article was included in ACS Applied Electronic Materials in 2022.Recommanded Product: 128-08-5 This article mentions the following:

A series of D-π-A, D-π-D, and A-π-A based push-pull compounds with triarylamine and benzophenone were designed and synthesized for nonvolatile memory applications. All of the compounds showed good solubility in common organic solvents, which permits solution processability. D-π-A based compounds exhibited write-once-read-many (WORM) memory applications, and the compound with a methoxyphenyl substituent exhibited switching with a low threshold voltage of -0.82 V, an ON/OFF current ratio of 10², and a long-lasting retention time of 10³ s. The effect of differently functionalized triarylamines on memory behavior was explored by optical, electrochem., and computational studies. The highest HOMO levels of around 5̃.0 eV and irreversible anodic peaks (0.7-1.3 V) obtained for the compounds facilitate charge injection and switching behavior. Besides, electrochem. and d. functional theory studies disclose the charge-transfer mechanism of the D-π-A systems, which is related to the bistability of the devices. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary