Tag: 100-200

Novel metal complexes of pyridineimine derivative used as auxiliary electron acceptor of D-(A-π-A)₂ motif dye sensitizer: synthesis and photovoltaic application was written by Tian, Yong;Wang, Kaixuan;Wu, Xianming;Tang, Shiyu;Zhang, Houpeng;Zhong, Chaofan. And the article was included in Journal of Solid State Electrochemistry in 2022.Quality Control of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The auxiliary acceptors of metal complexes can easily regulate the electron-withdrawing ability of electron acceptor and adjust the balance of push-pull electron of D-A-π-A motif dye sensitizers. Two series of the D-(A-π-A)₂ motif dye sensitizer (BDTT-i.m.-Co, BDTT-i.m.-Cu, BDTT-i.m.-Zn, BDTT-i.m.-Cd and FL-i.m.-Co, FL-i.m.-Cu, FL-i.m.-Zn, FL-i.m.-Cd) which use metal complexes of pyridineimine derivative as auxiliary acceptor were designed, synthesized, and characterized. The photovoltaic test of eight complex-based dye sensitized solar cells (DSSCs) showed that the short-circuit photocurrent d. (J_SC) and the power conversion efficiency (PCE) of two series dye sensitizers are sequentially increased. BDTT-i.m.-Cd have the highest J_SC of 15.58 mA cm^-2 and the PCE of 9.13% under AM 1.5 irradiation, which may be due to that electron-withdrawing ability of the auxiliary acceptor metal complexes of pyridineimine derivative can be changed by the strength of coordination bond of the complexes. They also show good terminal stability with decomposition temperatures (T_d) higher than 300 °C. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Quality Control of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Quality Control of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Co-operative halogen bonds and nonconventional sp-C-H·O hydrogen bonds in 1:1 cocrystals formed between diethynylpyridines and N-halosuccinimides was written by Bosch, Eric;Bowling, Nathan P.. And the article was included in Acta Crystallographica, Section C: Structural Chemistry in 2022.Formula: C4H4BrNO2 This article mentions the following:

The rapid evaporation of 1:1 solutions of diethynylpyridines and N-halosuccinimides, that react together to form haloalkynes, led to the isolation of unreacted 1:1 cocrystals of the two components. The 1:1 cocrystal formed between 2,6-diethynylpyridine and N-iodosuccinimide (C₄H₄INO₂·C₉H₅N) contains an N-iodosuccinimide-pyridine I·N halogen bond and two terminal alkyne-succinimide carbonyl C-HO hydrogen bonds. The three-dimensional extended structure features interwoven double-stranded supramol. polymers that are interconnected through halogen bonds. The cocrystal formed between 3,5-diethynylpyridine and N-iodosuccinimide (C₄H₄INO₂.C₉H₅N) also features an I·N halogen bond and two C-H·O hydrogen bonds. However, the components form essentially planar double-stranded one-dimensional zigzag supramol. polymers. The cocrystal formed between 3,5-diethynylpyridine and N-bromosuccinimide (C₄H₄BrNO₂.C₉H₅N) is isomorphous to the cocrystal formed between 3,5-diethynylpyridine and N-iodosuccinimide, with a Br·N halogen bond instead of an I·N halogen bond. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors was written by Rupiani, Sebastiano;Buonfiglio, Rosa;Manerba, Marcella;Di Ianni, Lorenza;Vettraino, Marina;Giacomini, Elisa;Masetti, Matteo;Falchi, Federico;Di Stefano, Giuseppina;Roberti, Marinella;Recanatini, Maurizio. And the article was included in European Journal of Medicinal Chemistry in 2015.SDS of cas: 881676-32-0 This article mentions the following:

Glycolysis is drastically increased in tumors and it is the main route to energy production with a minor use of oxidative phosphorylation. Among the key enzymes in the glycolytic process, LDH is emerging as one of the most interesting targets for the development of new inhibitors. In this context, in the present work, we carried out a virtual screening procedure followed by chem. modifications of the identified structures according to a “hit-to-lead” process. The effects of the new mols. were preliminary probed against purified human LDH-A. The compounds active at low micromolar level were addnl. characterized for their activity on some cellular metabolic processes by using Raji human cell line. Within the series, 1 was considered the best candidate, and a more detailed characterization of its biol. properties was performed. In Raji cells exposed to compound 1 we evidenced the occurrence of effects usually observed in cancer cells after LDH-A inhibition: reduced lactate production and NAD/NADH ratio, apoptosis. The flow cytometry anal. of treated cells also showed cell cycle changes compatible with effects exerted at the glycolytic level. Finally, in agreement with the data obtained with other inhibitors or by silencing LDH-A expression, compound 1 was found to increase Raji cells response to some commonly used chemotherapeutic agents. Taken together, all these finding are in support of the LDH-A inhibiting activity of compound 1. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0SDS of cas: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.SDS of cas: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

TEMPO-Promoted Mono- and Bisimidation of Tertiary Anilines: Synthesis of Symmetric and Unsymmetric N-Mannich Bases was written by Xu, Xiu Juan;Amuti, Adila;Hu, Wen Jing;Adelibieke, Qiaerbati;Wusiman, Abudureheman. And the article was included in Journal of Organic Chemistry in 2022.HPLC of Formula: 128-08-5 This article mentions the following:

A TEMPO-promoted method was developed for the synthesis of sym. bis-N-Mannich bases R¹CH₂N(Ar)(R²) [R¹ = H, 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, etc.; R² = 2-oxopyrrolidin-1-yl, 2,5-dioxopyrrolidin-1-yl, 3-oxo-3a,4,5,6,7,7a-hexahydro-1H-isoindol-2-yl; Ar = Ph, 4-MeC₆H₄, 1-naphthyl, etc.] via sequential activation of two α,α’-amino C(sp³)-H bonds of N,N-dimethylanilines under mild conditions. This methodol. was further extended for monoimidation of α-amino-functionalized methylanilines to give unsym. N-Mannich bases in good to high yields. Several control experiments were performed, and the coupling reaction outcomes indicated that the oxoammonium (TEMPO⁺) species is involved in the reaction. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5HPLC of Formula: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Study of chemical carcinogenesis. 7. Synthesis and mutagenicity of modified chrysenes related to the carcinogen, 5-methylchrysene was written by Hecht, Stephen S.;Loy, Myrna;Mazzarese, Robert;Hoffmann, Dietrich. And the article was included in Journal of Medicinal Chemistry in 1977.SDS of cas: 452-62-0 This article mentions the following:

Eleven derivatives of 5-methylchrysene (I) and related compounds, including 1-fluoro- [64977-44-2], 3-fluoro- [64977-45-3], 6-fluoro- [64977-46-4], 7-fluoro- [64977-47-5], 9-fluoro- [64977-48-6], 11-fluoro- [64977-49-7], and 12-fluoro-5-methylchrysene [61413-38-5], 1-fluoro-4-methylchrysene [61738-08-7], 6-methoxy- [61738-09-8] and 12-methoxy-5-methylchrysene [64977-25-9], and 5-methoxychrysene [61413-39-6] were prepared by photocyclization of the appropriate diarylethylene derivative or by fluorination of the required dihydromethylchrysenediol. Mutagenicity assays in Salmonella typhimurium showed less activity than I in compounds substituted in the 1, 3, and 12 positions, indicating that these positions are involved in metabolic activation to an ultimate bacterial mutagen. Compounds substituted in positions 6, 9, and 11 were mutagenic or more mutagenic than I. Results in mouse skin tests for tumor-initiating activity showed a similar trend. Structure-activity relations and structure of an ultimate mutagen derived from I are discussed. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0SDS of cas: 452-62-0).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. SDS of cas: 452-62-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bicyclic Ligand-Biased Agonists of S1P₁: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles was written by Gilmore, John L.;Xiao, Hai-Yun;Dhar, T. G. Murali;Yang, Michael;Xiao, Zili;Yang, Xiaoxia;Taylor, Tracy L.;McIntyre, Kim W.;Warrack, Bethanne M.;Shi, Hong;Levesque, Paul C.;Marino, Anthony M.;Cornelius, Georgia;Mathur, Arvind;Shen, Ding Ren;Pang, Jian;Cvijic, Mary Ellen;Lehman-McKeeman, Lois D.;Sun, Huadong;Xie, Jenny;Salter-Cid, Luisa;Carter, Percy H.;Dyckman, Alaric J.. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 1-Bromo-4-methoxybutane This article mentions the following:

Sphingosine-1-phosphate (S1P) binds to a family of sphingosine-1-phosphate G-protein-coupled receptors (S1P_1-5). The interaction of S1P with these S1P receptors has a fundamental role in many physiol. processes in the vascular and immune systems. Agonist-induced functional antagonism of S1P₁ has been shown to result in lymphopenia. As a result, agonists of this type hold promise as therapeutics for autoimmune disorders. The previously disclosed differentiated S1P₁ modulator BMS-986104 (1) exhibited improved preclin. cardiovascular and pulmonary safety profiles as compared to earlier full agonists of S1P₁; however, it demonstrated a long pharmacokinetic half-life (T_1/2 18 days) in the clinic and limited formation of the desired active phosphate metabolite. Optimization of this series through incorporation of olefins, ethers, thioethers, and glycols into the alkyl side chain afforded an opportunity to reduce the projected human T_1/2 and improve the formation of the active phosphate metabolite while maintaining efficacy as well as the improved safety profile. These efforts led to the discovery of 12 and 24, each of which are highly potent, biased agonists of S1P₁. These compounds not only exhibited shorter in vivo T_1/2 in multiple species but are also projected to have significantly shorter T_1/2 values in humans when compared to our first clin. candidate. In models of arthritis, treatment with 12 and 24 demonstrated robust efficacy. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Recommanded Product: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Flexible and Conductive Polymer Threads for Efficient Fiber-Shaped Supercapacitors via Vapor Copolymerization was written by Hu, Jing;Gao, Bo;Qi, Qi;Zuo, Zhuang;Yan, Kai;Hou, Shaocong;Zou, Dechun. And the article was included in ACS Omega in 2022.Product Details of 128-08-5 This article mentions the following:

Flexible fiber electrodes are critical for high-performance fiber and wearable electronics. In this work, we presented a highly conductive all-polymer fiber electrode by vapor copolymerization of 2,5-dibromo-3,4-vinyldioxythiophene (DBEDOT) and 2,5-diiodo-3,4-vinyldioxythiophene (DIEDOT) monomers on commonly used polyester threads (PETs) at a temperature as low as 80°C. The poly(3,4-ethylenedioxythiophene) (PEDOT)-coated PET threads maintain excellent flexibility and show conductivity of 7.93 S cm^-1, nearly four times higher than that reported previously via homopolymerization of DBEDOT monomer. A MnO₂ active layer was embedded into the PEDOT double layers, and the flexible fiber composite electrode showed a high linear specific capacitance of 157 mF cm^-1 and improved stability, retaining 86.5% capacitance after 5000 cycles. Fiber-shaped solid-state supercapacitors (FSSCs) based on the composite electrodes were assembled, and they displayed superior electrochem. performance. This work provides a new approach to realize high-performance and stable wearable electronics. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Product Details of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Product Details of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nucleotide competing reverse transcriptase inhibitors: Discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors was written by James, Clint A.;DeRoy, Patrick;Duplessis, Martin;Edwards, Paul J.;Halmos, Teddy;Minville, Joannie;Morency, Louis;Morin, Sebastien;Simoneau, Bruno;Tremblay, Martin;Bethell, Richard;Cordingley, Michael;Duan, Jianmin;Lamorte, Louie;Pelletier, Alex;Rajotte, Daniel;Salois, Patrick;Tremblay, Sonia;Sturino, Claudio F.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Recommanded Product: 4457-67-4 This article mentions the following:

A HTS screen led to the identification of a benzofurano[3,2-d]pyrimidin-2-one core structure which upon further optimization resulted in I as a potent HIV-1 nucleotide competing reverse transcriptase inhibitor. Investigation of the SAR at N-1 allowed significant improvements in potency and when combined with the incorporation of heterocycles at C-8 resulted in potent analogs not requiring a basic amine to achieve antiviral activity. Addnl. modifications at N-1 resulted in II which demonstrated excellent antiviral potency and improved physicochem. properties. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Recommanded Product: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Study of interactions between alcohol and amine functions. Thermolysis of hydroxides and salts of ω-(trialkylammonio)-1-alkanols was written by Barbry, Didier;Hasiak, Bruno. And the article was included in Collection of Czechoslovak Chemical Communications in 1983.Reference of 50592-87-5 This article mentions the following:

Products of the thermolysis of R₃N⁺(CH₂)_nOH.OH^– (I; R = Me, Et, Pr; n = 4-8) were identified. Major products were HO(CH₂)_n-2CH:CH₂ and HO(CH₂)_nR₂. Intramol. cyclization was only important for I (R = Me, n = 4; R = Pr, n = 5) giving 91.5% THF and 21.7% tetrahydropyran, resp. RO(CH₂)_n-2CH:CH₂ and RO(CH₂)_nNR₂ (R = Me, n = 6,7) were formed in 17.6-20.6% yields. Thermal decomposition of Me₃N⁺(CH₂)_nOH.OAc^– (n = 5, 6) gave 90.6% and 82.4% HO(CH₂)_nNMe₂ (n = 5, 6) and 5.6% and 16.0% AcO(CH₂)_nNMe₂ (n = 5, 6), resp. Pyrolysis of HO(CH₂)₆N⁺Me₃.Cl^– gave 82.4% HO(CH₂)₆NMe₂ and 8.2% HO(CH₂)₆Cl. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Reference of 50592-87-5).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Reference of 50592-87-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lewis Basic Amine Catalyzed Aza-Michael Reaction of Indole- and Pyrrole-3-carbaldehydes was written by Xu, Chang-Jiang;Du, Wei;Albrecht, Lukasz;Chen, Ying-Chun. And the article was included in Synthesis in 2020.Recommanded Product: 881676-32-0 This article mentions the following:

3-Formyl substituted indoles or pyrroles can form HOMO-raised dearomative aza-dienamine-type intermediates with secondary amines, which can undergo direct aza-Michael addition to β-trifluoromethyl enones to afford N-alkylated products efficiently, albeit with low to fair enantioselectivity. In addition, similar asym. aza-Michael additions of these heteroarenes and crotonaldehyde are realized under dual catalysis of chiral amines, and the adducts are obtained with moderate to good enantioselectivity. In the experiment, the researchers used many compounds, for example, 5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0Recommanded Product: 881676-32-0).

5-Bromo-1H-pyrrole-3-carbaldehyde (cas: 881676-32-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 881676-32-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary