Tag: 100-200

Synthesis of Sexithiophene-Bridged Cage Compound: A New Class of Three-Dimensionally Expanded Oligothiophenes was written by Adachi, Kazuhiko;Hirao, Yasukazu;Matsumoto, Kouzou;Kubo, Takashi;Kurata, Hiroyuki. And the article was included in Organic Letters in 2014.Computed Properties of C5H3BrOS This article mentions the following:

A bicyclo-type cage-shaped compound I [R = hexyl] consisting of three sexithiophenes was successfully synthesized and characterized by NMR, HRMS, and X-ray crystallog. anal. The strained cage architecture was reflected in the blue-shifted absorption spectrum relative to its linear analog. Intramol. interaction between three-dimensionally fixed sexithiophenes was suggested by electrochem. anal. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Computed Properties of C5H3BrOS).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Computed Properties of C5H3BrOS

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Enhanced efficiency of polymer solar cells via simple fluorination on the π-bridge of polymer donors was written by Liao, Junxu;Weng, Fubiao;Zheng, Peijin;Xu, Gengbiao;Zeng, Langxian;Huang, Zhangen;Deng, Tianjiao;Pang, Yiqi;Wu, Siyang;Chen, Jianhao;Zhao, Hongbin;Xu, Yongjun. And the article was included in Organic Electronics in 2022.Formula: C4H4BrNO2 This article mentions the following:

In this contribution, a novel fluorinated polymer based on the well-known J52, using the newly developed 3-fluorothiophene as π bridges on the conjugated main chain, named J52-FTh, was synthesized and was used as polymer solar cells (PSCs) donor material. The effects of fluorinated π bridge on the polymer′s thermal stability, light absorption, energy level, mol. configuration and photovoltaic performance were systematically studied. It demonstrated that J52-FTh exhibited an enhanced absorption, a narrower optical band gap, a low-lying the highest occupied MOs (HOMO) energy level and better coplanar compared with J52 without any fluorine substituent on its π bridges. The non-fullerene PSCs based on J52-FTh:ITIC (1:0.8, weight/weight) achieved a high PCE of 13.32% with a V_OC of 0.92 V, a J_SC of 21.29 mA cm^-2 and an FF of 68%, which was much better than the PSCs based on J52:ITIC with a PCE of 5.51%. The results indicated that fluorination on the polymer′s main chain was a simple and efficient strategy toward high efficiency. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nucleophilic and Radical Heptafluoroisopropoxylation with Redox-Active Reagents was written by Tong, Chao-Lai;Xu, Xiu-Hua;Qing, Feng-Ling. And the article was included in Angewandte Chemie, International Edition in 2021.Computed Properties of C3H4BrN3 This article mentions the following:

The practical and efficient heptafluoroisopropoxylation reactions through the invention of a series of redox-active N-OCF(CF₃)₂ reagents e.g., I were described. These reagents were readily prepared from the oxidative heptafluoroisopropylation of hydroxylamines e.g., II with AgCF(CF₃)₂. The substitutions on the nitrogen atom significantly affected the properties and reactivities of N-OCF(CF₃)₂ reagents. Accordingly, two types of N-OCF(CF₃)₂ reagents including I and III were used as OCF(CF₃)₂ anion and radical precursors, resp. This protocol enables the direct heptafluoroisopropoxylation of a range of substrates, delivering the corresponding products in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5Computed Properties of C3H4BrN3).

4-Bromo-1-methyl-1H-1,2,3-triazole (cas: 13273-53-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Computed Properties of C3H4BrN3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tachykinin NK-1 receptor probed with constrained analogs of substance P was written by Sagan, Sandrine;Josien, Hubert;Karoyan, Philippe;Brunissen, Alie;Chassaing, Gerard;Lavielle, Solange. And the article was included in Bioorganic & Medicinal Chemistry in 1996.Reference of 83902-02-7 This article mentions the following:

The action of rotameric probes introduced either in position 7 or 8 in the sequence of substance P (SP) was investigated. i.e., L-tetrahydroisoquinoleic acid (Tic), L-fluorenylglycine (Flg), L-diphenylalanine (Dip), the diastereoisomers of L-1-indanylglycine (Ing) and L-benz[f]indanylglycine (Bfi), the Z- and E-isomers of dehydrophenylalanine and dehydronaphthylalanine (Δ^ZPhe, Δ^EPhe, Δ^ZNal, Δ^ENal) and L-o,o’-dimethylphenylalanine (Dmp). The aim this study was the topog. characterization of the binding subsites of human NK-1 receptor expressed in CHO cells, especially the S₇ and S₈ subsites, corresponding to residues Phe⁷ and Phe⁸ of substance P. According to the binding potencies of these substituted-SP analogs, the S₇ binding subsite is smaller than the S₈ subsite: the S₇ subsite accepts only one aromatic nucleus, while the S₈ can accommodate three coplanar nuclei altogether. These findings are compatible with the idea that the S₈ binding subsite may reside in the extracellular loops of the hNK-1 receptor. NK-1 agonists bind to human NK-1 receptor and activate the production of both inositol phosphates and cAMP. As already quoted for septide, [pGlu⁶, Pro⁹]SP(6-11), discrepancies are observed between affinity (K_i) and activity (EC₅₀) values for IPs production While a weak correlation between K_i and EC₅₀ values for IPs production could be found (r= 0.70), an excellent correlation could be demonstrated between their affinities (K_i) and their potencies (EC₅₀) for cAMP production (r= 0.97). The high potency (EC₅₀) observed for “septide-like” mols. on PI hydrolysis, compared to their affinity is not an artifact related to the high level of NK-1 receptors expressed on CHO cells since a good correlation was found between EC₅₀ values obtained for PI hydrolysis and those measured for spasmogenic activity in guinea pig ileum bioassay (r= 0.94). In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Reference of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Reference of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sequentially Fluorinated Polythiophene Donors for High-Performance Organic Solar Cells with 16.4% Efficiency was written by Jeong, Dahyun;Kim, Geon-U.;Lee, Dongchan;Seo, Soodeok;Lee, Seungjin;Han, Daehee;Park, Hyeonjung;Ma, Biwu;Cho, Shinuk;Kim, Bumjoon J.. And the article was included in Advanced Energy Materials in 2022.Safety of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

Polythiophenes (PTs) have attracted considerable interest for application in organic solar cells (OSCs) owing to their simple mol. structures and low-cost synthesis. However, the power conversion efficiencies (PCEs) of PT-based OSCs are lower than those of state-of-the-art OSCs. Herein, the development of two sequentially fluorinated PT donors (PT-2F and PT-4F) is reported for realizing highly efficient OSCs. PT-2F and PT-4F are designed to contain two and four fluorine atoms, resp., per repeating unit to decrease their HOMO energy levels and increase the open-circuit voltages of the OSCs. Importantly, the PT-4F polymers exhibit high backbone rigidity and the desired temperature-dependent aggregation behavior, affording well-developed crystalline structures in thin films for efficient charge transport. These beneficial features promote the construction of an optimal blend morphol. of PT-4F:small-mol. acceptor with a suitable energy offset and low energetic disorder. Thus, the PT-4F-based binary and ternary OSCs achieve high PCEs of 15.6% and 16.4%, resp. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Safety of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Safety of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Imidazole-Functionalized Multiquaternary Side-Chain Polyethersulfone Anion-Exchange Membrane for Fuel Cell Applications was written by Li, Songsong;Du, Shenghua;Xie, Ning;Zhang, Tong;Xu, Yaoyao;Ning, Xingming;Chen, Pei;Chen, Xinbing;An, Zhongwei. And the article was included in ACS Applied Energy Materials in 2022.Name: 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A series of rPES(x/y)-MI membranes with different rigid side chains and high-d. imidazole cationic groups have been prepared for anion-exchange membrane (AEM) fuel cells (AEMFC). These AEM rPES(x/y)-MIs with IEC values of 1.91-2.31 mequiv g^-1 exhibit high conductivities of 92.92-142.69 mS cm^-1 at 80 °C, acceptable water uptake, and dimensional change. D. functional theory (DFT) was used to demonstrate the excellent alkali stability of this class of copolymers, which is consistent with exptl. results. In addition, the degradation mechanism of this type of AEM has also been investigated. Significantly, rPES(1/4)-MI-based AEMFC has the maximum power d. of 195 mW cm^-2 at a c.d. of 525 mA cm^-2, which is much higher than com. reference membrane FAS-30 measured in the same environment. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Name: 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Ipso/Ortho Difunctionalization of Aryl Bromides with Alkynes and Alkyl Bromides via a Vinyl-to-Aryl 1,4-Hydride Shift was written by He, Yuli;Borjesson, Marino;Song, Huayue;Xue, Yuhang;Zeng, Daning;Martin, Ruben;Zhu, Shaolin. And the article was included in Journal of the American Chemical Society in 2021.Name: 1-Bromo-4-methoxybutane This article mentions the following:

Polysubstituted arenes are ubiquitous structures in a myriad of medicinal agents and complex mols. Herein, a new catalytic blueprint that merges the modularity of nickel catalysis for bond formation with the ability to enable a rather elusive 1,4-hydride shift at arene sp² C-H sites, thus allowing access to ipso/ortho-difunctionalized arenes from readily available aryl halides under mild conditions and exquisite selectivity profile is reported. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Name: 1-Bromo-4-methoxybutane).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Name: 1-Bromo-4-methoxybutane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Asymmetric synthesis of all six regioisomers of N-BOC-dimethylphenylalanines was written by Ouchi, Hidekazu;Kumagai, Midori;Sakurada, Shinobu;Takahata, Hiroki. And the article was included in Heterocycles in 2004.Product Details of 83902-02-7 This article mentions the following:

All possible regioisomers of dimethyl-substituted (S)-phenylalanine were efficiently synthesized by reacting the Ni(II)-complex of the chiral Schiff base of glycine with (S)-2-N-(N-benzylprolyl)(amino)benzophenone [i.e., [N-[phenyl[2-[[[(1R,2S)-1-(phenylmethyl)-2-pyrrolidinyl-κN]carbonyl]amino-κN]phenyl]methylene]glycinato(2-)-κN,κO]nickel]. The ligand could effectively be recovered. Phenylalanine isomers, such as N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-phenylalanine, etc. were all prepared In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Product Details of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Product Details of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Alkenylcopper reagents. 26. Carbocupration of alkynes by organocopper reagents bearing a protected hydroxy or thiol function was written by Gardette, M.;Alexakis, A.;Normant, J. F.. And the article was included in Tetrahedron in 1985.Name: 1-Bromo-6-methoxyhexane This article mentions the following:

Halohydrins, protected as ethers, acetals, or chloro-magnesium alcoholates were sequentially transformed to Li or Mg reagents, and then to copper or cuprate derivatives Addition of the copper reagents with alkynes was studied. Thus, treating Y(CH₂)_nX(Y = LiO, Me₃SiO, Me₃O, PhS, tetrahydropyranyl, etc.; X = Br, Cl; n = 3,4,6,8,10) with Li in Et₂O gave Y(CH₂)_nLi. Treating the last with CuBr·Me₂S in Et₂O, followed by reaction with HCCH at -50°, followed by acid hydrolysis gave Y(CH₂)_nCH:CH₂. Reactions of the copper or cuprate reagents with electrophiles was investigated. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Name: 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Name: 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Orally active and potent inhibitors of γ-aminobutyric acid uptake was written by Ali, Fadia E.;Bondinell, William E.;Dandridge, Penelope A.;Frazee, James S.;Garvey, Eleanor;Girard, Gerald R.;Kaiser, Carl;Ku, Thomas W.;Lafferty, John J.. And the article was included in Journal of Medicinal Chemistry in 1985.Electric Literature of C5H11BrO This article mentions the following:

GABA  [56-12-2]-uptake inhibitors that are more potent, more lipophilic, and in limited testing, at least as selective as the parent amino acids were obtained by alkylation of the appropriate butyric-, cyclohexane- and piperidinecarboxylic and pyrrolinidineacetic acids. The ability of these alkylated amino acids to inhibit Na-dependent, high-affinity GABA uptake was measured after preincubation for 15 min with rat brain synaptosomes. N-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid (I) [85375-85-5] is a specific GABA-uptake inhibitor more potent, more lipophilic and, as selective as the nonalkylated parent; I and its analogs also exhibited anticovulsant activity in rodents. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Electric Literature of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Electric Literature of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary