Tag: 100-200

Designing High-Performance Nonfused Ring Electron Acceptors via Synergistically Adjusting Side Chains and Electron-Withdrawing End-Groups was written by Zhang, Yan;Zhang, Cai’e;Zhang, Andong;Wu, Hongbo;Ran, Guangliu;Zhou, Yuanyuan;Wang, Xiaodong;Li, Cuihong;Liu, Yahui;Yang, Chuluo;Tang, Zheng;Zhang, Wenkai;Bo, Zhishan. And the article was included in ACS Applied Materials & Interfaces in 2022.Formula: C4H4BrNO2 This article mentions the following:

Three nonfused ring electron acceptors, Hexyl-0F, Isopropyl-0F, and Isopropyl-2F, are designed and synthesized. Unlike Hexyl-0F, Isopropyl-0F with two sterically hindered 2,4,6-triisopropyl-Ph groups is highly soluble, which provides a good opportunity for solution processability. Compared with Isopropyl-0F, Isopropyl-2F with fluorinated end-groups exhibits red-shifted absorption. Due to these synergistic adjustment, Isopropyl-2F-based devices displayed a high power conversion efficiency of 12.55%, higher than that of Isopropyl-0F (9.49%). The result demonstrates that the introduction of large steric substituents in the π-bridge units and electron-withdrawing end-groups plays a pos. role in the construction of high-efficiency nonfused ring electron acceptors. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A modular synthesis of teraryl-based α-helix mimetics, part 4: Core fragments with two halide leaving groups featuring side chains of proteinogenic amino acids was written by Trobe, Melanie;Blesl, Julia;Vareka, Martin;Schreiner, Till;Breinbauer, Rolf. And the article was included in European Journal of Organic Chemistry in 2022.Related Products of 128-08-5 This article mentions the following:

Teraryl-based α-helix mimetics have proven to be useful compounds for the inhibition of protein-protein interactions (PPI). We have developed a modular and flexible approach for the synthesis of teraryl-based α-helix mimetics using a benzene core unit featuring two halide leaving groups of differentiated reactivity in the Pd-catalyzed cross-coupling used for teraryl assembly. The use of para-bromo iodoarene core fragments resolved the issue of hydrolysis during cross-coupling that was observed when using triflate as a leaving group. We report a complete set of para-bromoiodoarene core fragments decorated with side chains of all proteinogenic amino acids relevant for PPI (Ala, Arg, Asn, Asp, Cys, Gln, Glu, His, Ile, Leu, Lys, Met, Phe, Ser, Thr, Trp, Tyr and Val). In order to be compatible with general cross-coupling conditions, some of the nucleophilic side chains had to be provided in a protected form to serve as stable building blocks. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Related Products of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-Catalyzed Reductive Alkylation of Heteroaryl Imines was written by Turro, Raymond F.;Brandstatter, Marco;Reisman, Sarah E.. And the article was included in Angewandte Chemie, International Edition in 2022.Computed Properties of C9H11Br This article mentions the following:

The preparation of heterobenzylic amines, e.g., I [R¹ = H, 4-Cl, 5-F, 6-Me, etc.; R² = i-Pr, n-Bu, t-Bu, cyclopropyl, cyclobutyl, (R)-PhCHMe; R³ = H, Me, R⁴ = PhCH₂; R³ = H, R⁴ = 4-ClC₆H₄CH₂, 2,6-Me₂C₆H₃CH₂, etc.; R³R⁴ = (CH₂)₂X(CH₂)₂; X = CH₂, O, CO, NBoc], by a Ni-catalyzed reductive cross-coupling between heteroaryl imines, e.g., II, and C(sp³) electrophiles R³R⁴CHX¹ (X¹ = Cl, Br, I, phthalimidyloxycarbonyl) is reported. This umpolung-type alkylation proceeds under mild conditions, avoids the pre-generation of organometallic reagents, and exhibits good functional group tolerance. Mechanistic studies are consistent with the imine substrate acting as a redox-active ligand upon coordination to a low-valent Ni center. The resulting bis(2-imino)heterocycle·Ni complexes can engage in alkylation reactions with a variety of C(sp³) electrophiles, giving heterobenzylic amine products in good yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Computed Properties of C9H11Br).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Adamantane-based block poly(arylene ether sulfone)s as anion exchange membranes was written by Wang, Zhen;Zhou, Shu Feng;Zhuo, Yi Zhi;Lai, Ao Nan;Lu, You Zhong;Wu, Xiao Bin. And the article was included in Polymer in 2022.Formula: C4H4BrNO2 This article mentions the following:

Current anion exchange membranes (AEMs) for fuel cells suffer from low ionic conductivity and poor mech. property. Herein, we introduce adamantane groups onto the block poly(arylene ether sulfone)s backbone to form the selected comb-shaped structure. The structure-property relationships of the AEMs are investigated by varying the ratio of the hydrophobic to hydrophilic segments. The bulk rigid adamantane group can restrain the swelling of the AEMs thus enhancing the mech. properties and expand the spacing between the hydrophilic/hydrophobic segments of the polymer chains to promote the formation of microphase separation morphol. Consequently, as characterized by at. force microscope (AFM) and transmission electron microscopy (TEM), the resulting membranes show well-defined microphase separation between the hydrophilic/hydrophobic segments, resulting in high ionic conductivity range from 27.4 to 90.2 mS cm^-1 over a temperature range of 30-80°C. At the same time, the membranes present ultralow swelling ratio with the levels from 1.6% to 6.1% at 30°C and from 6.8% to 12.7% at 80°C, resp., and thus excellent mech. properties with the tensile strength as high as 11.52 MPa and elongation at break of 29.28%. The excellent comprehensive properties grant the prepared AEMs bright future for fuel cells. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chemoselective Rearrangement Reactions of Sulfur Ylide Derived from Diazoquinones and Allyl/Propargyl Sulfides was written by Yan, Sijia;Rao, Junxin;Zhou, Cong-Ying. And the article was included in Organic Letters in 2020.COA of Formula: C6H6BrNO This article mentions the following:

Here, we describe three types of rearrangement reactions of sulfur ylide derived from diazoquinones and allyl/propargyl sulfides. With Rh₂(esp)₂ as the catalyst, diazoquinones react with allyl/propargyl sulfides to form a sulfur ylide, which undergoes a chemoselective tautomerization/[2,3]-sigmatropic rearrangement reaction, a Doyle-Kirmse rearrangement/Cope rearrangement cascade reaction, or a Doyle-Kirmse rearrangement/elimination reaction, depending on the substituent of the sulfides. The protocol provides alkenyl and allenyl sulfides and multisubstituted phenols with moderate and high yields. Safety: caution advised in preparation, storage and use of diazoquinones. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5COA of Formula: C6H6BrNO).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.COA of Formula: C6H6BrNO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

New donor-acceptor benzotrithiophene-containing conjugated polymers for solar cells was written by Keshtov, M. L.;Kuklin, S. A.;Kochurov, V. S.;Konstantinov, I. O.;Krayushkin, M. M.;Radychev, N. A.;Khokhlov, A. R.. And the article was included in Doklady Chemistry in 2014.Recommanded Product: 5-Bromothiophene-3-carbaldehyde This article mentions the following:

This paper new donor-acceptor benzotrithiophene-containing conjugated polymers for solar cells. The large BTT structure is planar and leads to an effective intermol. package in the solid state. In this work, we have designed a new BTT containing monomer as a promising ‘building block’ and used it in synthesis of four new BTT containing narrow gap donor-acceptor conjugated polymers as an electroactive material for solar cells. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Recommanded Product: 5-Bromothiophene-3-carbaldehyde).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Recommanded Product: 5-Bromothiophene-3-carbaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A virtual screening approach to identifying the greenest compound for a task: application to switchable-hydrophilicity solvents was written by Vanderveen, J. R.;Patiny, L.;Chalifoux, C. B.;Jessop, M. J.;Jessop, P. G.. And the article was included in Green Chemistry in 2015.SDS of cas: 4457-67-4 This article mentions the following:

A virtual or in-silico screening approach makes it much easier to identify mol. structures which best combine efficacy for a specific task with safety and min. environmental or health impacts. In this approach, software generates a larger number of possible mol. structures, then quant. structure-activity relationships (QSAR) predict properties related to performance, safety, and health and environmental impact. Structures are then scored on criteria (e.g., flash point, toxicity) and given an overall score. The method identifies compounds with high scores for 3 performance criteria and 7 health, safety, and environmental criteria. This method allows for larger-scale, faster screening than can be performed using human intellect and a bench-top approach. Its success was demonstrated by using it to identify new, possibly more green switchable-hydrophilic solvents (SHS). Three SHS were identified using this method. The mol. design approach is entirely modular and can be applied to design nearly any type of chem.; however, method limitations are that it does not consider chem. production health and environmental costs. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4SDS of cas: 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.SDS of cas: 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organocatalytic Enantioselective Construction of Spiroketal Lactones Bearing Axial and Central Chirality via an Asymmetric Domino Reaction was written by Xu, Shiyu;Huang, Aima;Yang, Yang;Wang, Ying;Zhang, Ming;Sun, Zhihui;Zhao, Man;Wei, Yuanlin;Li, Guofeng;Hong, Liang. And the article was included in Organic Letters in 2022.Computed Properties of C4H4BrNO2 This article mentions the following:

The catalytic asym. synthesis of chiral compounds such as I [R = H, 7-Me, Ph, etc.; X = I, Br] with multiple stereogenic elements via a single catalytic process was challenging. This paper proposed a domino asym. electrophilic halocyclization strategy for constructing heterocycloalkenyl atropisomeric spiroketal lactones. A single catalyst was utilized to realize two independent stereodetermining steps. Various spiroketal lactones containing both chiral axes and chiral centers were prepared in excellent yields with excellent enantioselectivity and diastereoselective (up to 99% ee and >20:1 dr). In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Computed Properties of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly efficient direct visible-light-mediated oxidative esterification of aldehydes was written by Lindroth, Rickard;Bryce-Rogers, Hogan P.;Merke, Thomas P. M.;Wallentin, Carl-Johan. And the article was included in Photochemical & Photobiological Sciences in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

A very efficient one-pot procedure for the direct oxidation of aldehydes to esters RC(O)OR¹ [R = Ph, cyclohexyl, 4-MeOC₆H₄, etc.; R¹ = Me, Et, t-Bu, etc.] mediated by visible-light was presented. Utilizing a combination of indium triflate and N-bromosuccinimide, NBS, with either ortho-esters or alcs. provided rapid access to a variety of esters RC(O)OR¹. Certain substrates convert fully within a few seconds, other more challenging tert-Bu esters RC(O)OR¹ [R = 4-PhC₆H₄; R¹ = t-Bu] were formed in good yield after no more than 4 h. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Visible-Light-Driven Dearomatization Reaction toward the Formation of Spiro[4.5]deca-1,6,9-trien-8-ones was written by Dong, Wuheng;Yuan, Yao;Xie, Xiaomin;Zhang, Zhaoguo. And the article was included in Organic Letters in 2020.Application of 83902-02-7 This article mentions the following:

A visible-light-driven regioselective dearomative cyclization between 2-benzyl-2-bromomalonate and alkynes under mild conditions leading to the formation of spiro[4,5]decanes has been developed. In the presence of H₂O, a variety of 2-benzyl-2-bromomalonates smoothly undergo 5-exo-dig radical dearomative cyclization with alkynes to afford the corresponding spiro[4,5]decanes in moderate to good yield in a step-economical manner under oxidant-free conditions. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Application of 83902-02-7).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Application of 83902-02-7

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary