Tag: 100-200

Syntheses of 3-furyl, 3-thienyl and 3-selenienyl propenoic acids and esters. A route to substituted thienothiophenes and selenolothiophenes was written by Capron, Bernard;Paulmier, Claude;Pastour, Paul. And the article was included in Bulletin de la Societe Chimique de France in 1975.Safety of 5-Bromothiophene-3-carbaldehyde This article mentions the following:

3-(Furyl, thienyl, or selenienyl)propenoic acids were prepared by modified Wittig reaction of the heterocyclic aldehydes and were cyclized with SOCl2 to give condensed thiophenes. In the experiment, the researchers used many compounds, for example, 5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2Safety of 5-Bromothiophene-3-carbaldehyde).

5-Bromothiophene-3-carbaldehyde (cas: 18791-79-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 5-Bromothiophene-3-carbaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Meso-π-extended/deficient BODIPYs and low-band-gap donor-acceptor copolymers for organic optoelectronics was written by Can, Ayse;Choi, Gi-Seok;Ozdemir, Resul;Park, Soyoon;Park, Jin Su;Lee, Yongchul;Deneme, Ibrahim;Mutlugun, Evren;Kim, Choongik;Kim, Bumjoon J.;Usta, Hakan. And the article was included in ACS Applied Polymer Materials in 2022.Quality Control of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The realization of π-deficient acceptors and their donor-acceptor copolymers has become a key research focus for the realization of versatile organic optoelectronic materials and devices. Herein, we demonstrate the theor. design, synthesis, and physicochem./optoelectronic characterization of two meso-π-extended/deficient BODIPY building blocks (2OD-T2BDY and 2OD-TTzBDY) and a library of donor-acceptor copolymers with low band gap (E_g = 1.30-1.35 eV) based on these building blocks. These building blocks, to the best of our knowledge, are the first examples of BODIPYs with meso-π-extension. A library of BODIPY building blocks with varied meso units/substituents is studied to reveal the meso effects on the semiconducting BODIPY′s optoelectronic properties. The building blocks showed favorable π-acceptor electronic/structural properties with meso-π-delocalized and stabilized LUMOs (ca. -3.6 eV) and large ground-state dipole moments of 4.9-5.5 D. Consistent with the theor./exptl. π-electronic structures, all copolymers functioned as p-type semiconductors in field-effect transistors and as donor materials in the bulk heterojunction organic photovoltaics. Power conversion efficiencies of up to 4.4% with a short-circuit current of 12.07 mA cm^-2 were achieved. This study demonstrates a unique meso-π-extension strategy to realize BODIPYs with favorable π-acceptor properties, and our findings could open up future materials design avenues in various organic optoelectronic applications. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Quality Control of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Quality Control of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Influence of Chain Rigidity and Dielectric Constant on the Glass Transition Temperature in Polymerized Ionic Liquids was written by Bocharova, V.;Wojnarowska, Z.;Cao, Peng-Fei;Fu, Y.;Kumar, R.;Li, Bingrui;Novikov, V. N.;Zhao, S.;Kisliuk, A.;Saito, T.;Mays, Jimmy W.;Sumpter, B. G.;Sokolov, A. P.. And the article was included in Journal of Physical Chemistry B in 2017.Formula: C5H11BrO This article mentions the following:

Polymerized ionic liquids (PolyILs) are promising candidates for a wide range of technol. applications due to their single ion conductivity and good mech. properties. Tuning the glass transition temperature (T_g) in these materials constitutes a major strategy to improve room temperature conductivity while controlling their mech. properties. In this work, we show exptl. and simulation results demonstrating that in these materials T_g does not follow a universal scaling behavior with the volume of the structural units V_m (including monomer and counterion). Instead, T_g is significantly influenced by the chain flexibility and polymer dielec. constant We propose a simplified empirical model that includes the electrostatic interactions and chain flexibility to describe T_g in PolyILs. Our model enables design of new functional PolyILs with the desired T_g. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Formula: C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Formula: C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinylogous Nitro-Haloform Reaction Enables Aromatic Amination was written by Monasterolo, Claudio;Adamo, Mauro F. A.. And the article was included in Organic Letters in 2022.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione This article mentions the following:

The first example of an aromatic haloform reaction was reported, defining a conceptually new haloform-type approach to the metal-free functionalization of arenes I [R¹ = Ph, i-Pr, cyclobutane, etc.; R ² = H; R¹R² = -(CH₂)₄-, -(CH₂)₅-, -(CH₂)₂O- (CH₂)₂, etc.]. The heteroarenes bearing a vinylogous nitromethane system, via the stage of a trichloromethane derivative II, could undergo aromatic amination to produce N-functionalized arenes I in quant. yields and without the need for transition-metal catalysis. The haloform-type amination was implemented in the development of effective orthogonal N-protection strategies, establishing a new promising N-protecting reagent. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Application In Synthesis of 1-Bromopyrrolidine-2,5-dione).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of 1-Bromopyrrolidine-2,5-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Scope and limitations of lithium-ethylenediamine-THF-mediated cleavage at the α-position of aromatics: deprotection of aryl methyl ethers and benzyl ethers under mild conditions was written by Shindo, Takeyuki;Fukuyama, Yasuaki;Sugai, Takeshi. And the article was included in Synthesis in 2004.COA of Formula: C9H11Br This article mentions the following:

The scope and limitations of lithium-ethylenediamine-THF-mediated reductive bond cleavage at the α-position of aromatics were examined Very mild conditions such as lithium metal and ethylenediamine, in oxygen-free THF, were quite effective for the demethylation of aromatic ethers even at as low as -10°C. Allyl benzyl ethers were also deprotected under these conditions with very little change of the allylic alc. moiety. 2,6-Dimethylbenzyl ether was developed as an alternative to benzyl ether, which was readily cleaved under these conditions. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7COA of Formula: C9H11Br).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.COA of Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and Antitumor Activity of Staurosporine Derivatives was written by Li, Gang;Wu, Dan;Xu, Yanchao;He, Wenwen;Wang, Dongyang;Zhu, Weiming;Wang, Liping. And the article was included in Natural Product Communications in 2022.Related Products of 128-08-5 This article mentions the following:

Twenty-four derivatives of staurosporine were synthesized by modification at the 3â€?N, 3- and 7-positions. Of these compounds, 16 were synthesized for the first time and their structures were determined by NMR spectroscopy, ECD, and HRESIMS. Their inhibitory activities against seven tumor cell lines, MV4-11 (leukemia), MCF-7 (breast carcinoma), HCT-116 (colon cancer), TE-1 (esophageal carcinoma), PATU8988 T (pancreatic cancer), HOS (osteosarcoma) and GBC-SD (gallbladder cancer), and human normal liver cell L-02 were evaluated using a Cell Counting Kit-8. The IC₅₀ values for 7-oxo-3â€?N-benzoylstaurosporin (4) on MV4-11 and PATU8988 T cells were 0.078 and 0.666 μmol/L, and the selection indexes were 1254 and 147, resp. The IC₅₀ values of 7-oxo-3-chloro-3â€?N-benzoylstaurosporine (5) and (7R)-7-hydroxy-3-bromo-3 â€?N-acetylstaurosporine (24) on MCF-7 cells were 0.029 and 0.021 μmol/L, and the selection indexes were 102 and 221, resp. The above compounds have the potential to be developed further into antitumor drugs due to the advantages of high efficiency and low toxicity. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Related Products of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Related Products of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity was written by Das, Bhaskar C.;McCartin, Kellie;Liu, Ting-Chun;Peterson, Randall T.;Evans, Todd. And the article was included in PLoS One in 2010.Category: bromides-buliding-blocks This article mentions the following:

Background: Retinoids regulate key developmental pathways throughout life, and have potential uses for differentiation therapy. It should be possible to identify novel retinoids by coupling new chem. reactions with screens using the zebrafish embryonic model. Principal Findings: We synthesized novel retinoid analogs and derivatives by amide coupling, obtaining 80-92% yields. A small library of these compounds was screened for bioactivity in living zebrafish embryos. We found that several structurally related compounds significantly affect development. Distinct phenotypes are generated depending on time of exposure, and we characterize one compound (BT10) that produces specific cardiovascular defects when added 1 day post fertilization. When compared to retinoic acid (ATRA), BT10 shows similar but not identical changes in the expression pattern of embryonic genes that are known targets of the retinoid pathway. Reporter assays determined that BT10 interacts with all three RAR receptor sub-types, but has no activity for RXR receptors, at all concentrations tested. Conclusions: Our screen has identified a novel retinoid with specificity for retinoid receptors. This lead compound may be useful for manipulating components of retinoid signaling networks, and may be further derivatized for enhanced activity. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Category: bromides-buliding-blocks).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Poly(3-hexylthiophene)-stat-poly(3-dodecylselenophenes): Conjugated Statistical Copolymers and Their Gels was written by Li, Sheng;Cranston, Rosemary;Lessard, Benoit H.;Seferos, Dwight S.. And the article was included in ACS Applied Polymer Materials in 2022.Category: bromides-buliding-blocks This article mentions the following:

The mol. weight of conjugated polymers plays an important role in polymer self-assembly, which has a significant influence on their application in electronics. In this work, we report the self-assembly behavior of poly(3-hexylthiophene)-stat-poly(3-dodecylselenophenes) as both thin films and organogels at low, medium, and high ds.p. Different self-assembly behaviors are observed in pristine copolymer films, annealed copolymer films, and copolymer gels. We found that through cycle-doping, a process by which the sample is gelled and repetitively doped by solution, conjugated statistical copolymer gels have greater conductivities compared to thin films of the same polymers and maintain high conductivities after seven cycles of doping. Statistical copolymer gels at medium and high ds.p. show the greatest conductivity, which is likely due to their unique morphol. from that of the low d.p. Grazing incident wide-angle x-ray scattering suggests an inter charge transfer doping mechanism takes place between the polymer and dopant. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Category: bromides-buliding-blocks).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of the selective sphingomyelin synthase 2 inhibitors with the novel structure of oxazolopyridine was written by Qi, Xiang-Yu;Cao, Yang;Li, Ya-Li;Mo, Ming-Guang;Zhou, Lu;Ye, De-Yong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Recommanded Product: 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

Sphingomyelin synthase (SMS) is a key enzyme in sphingomyelin biosynthetic pathway, whose activity is highly related to the atherosclerosis progression. SMS2 could serve as a promising therapeutic target for atherosclerosis. Based on the structure of lead compound I, a series of oxazolopyridine derivatives were designed, synthesized, and their inhibitory activities against purified SMS1 and SMS2 enzymes were evaluated, resp. The representative mols. 2-(2-((3-chlorobenzyl)oxy)phenyl)oxazolo[5,4-b]pyridine and 2-(2-((3-methoxybenzyl)oxy)phenyl)oxazolo[5,4-b]pyridine possess micromolar inhibitory activities against SMS2 and excellent isoform preferences over SMS1, qualified to be selected as potential mols. in further discovery of specific SMS2 inhibitors. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Recommanded Product: 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Anodic Oxidation of Dithiane Carboxylic Acids: A Rapid and Mild Way to Access Functionalized Orthoesters was written by Garcia, Anthony D.;Leech, Matthew C.;Petti, Alessia;Denis, Camille;Goodall, Iain C. A.;Dobbs, Adrian P.;Lam, Kevin. And the article was included in Organic Letters in 2020.COA of Formula: C5H11BrO This article mentions the following:

A new electrochem. methodol. has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives The new methodol. also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4COA of Formula: C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. COA of Formula: C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary