Tag: 100-200

Influences of histidine-1 and azaphenylalanine-4 on the affinity, anti-inflammatory, and antiangiogenic activities of azapeptide cluster of differentiation 36 receptor modulators was written by Chignen Possi, Kelvine;Mulumba, Mukandila;Omri, Samy;Garcia-Ramos, Yesica;Tahiri, Houda;Chemtob, Sylvain;Ong, Huy;Lubell, William D.. And the article was included in Journal of Medicinal Chemistry in 2017.Name: 2-(Bromomethyl)-1,3-dimethylbenzene This article mentions the following:

Azapeptide analogs of growth hormone releasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity, and modulator activity on the cluster of differentiation 36 receptor (CD36). For example, [A¹, azaF⁴] and [azaY⁴]-GHRP-6 were previously shown to bind selectively to CD36 and exhibited resp. significant antiangiogenic and slight angiogenic activities in a microvascular sprouting assay using choroid explants. The influences of the 1- and 4-position residues on the affinity, anti-inflammatory, and antiangiogenic activity of these azapeptides have now been studied in detail by the synthesis and anal. of a set of 25 analogs featuring Ala¹ or His¹ and a variety of aromatic side chains at the aza-amino acid residue in the 4-position. Although their binding affinities differed only by a factor of 17, the analogs exhibited significant differences in ability to modulate production of nitric oxide (NO) in macrophages and choroidal neovascularization. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7Name: 2-(Bromomethyl)-1,3-dimethylbenzene).

2-(Bromomethyl)-1,3-dimethylbenzene (cas: 83902-02-7) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Name: 2-(Bromomethyl)-1,3-dimethylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The metabolic pathway catalyzed by the tyrosinase of Agaricus bisporus was written by Boekelheide, Kim;Graham, Doyle G.;Mize, Patrick D.;Jeffs, Peter W.. And the article was included in Journal of Biological Chemistry in 1980.Application of 74440-80-5 This article mentions the following:

N–tert-Butyloxycarbonyl-γ-L-glutaminyl-2-bromo-4-hydroxybenzene α-benzyl ester was synthesized as a precursor to γ-L-glutaminyl-4-hydroxybenzene-2–³H (I–2–³H). With this labeled compound and the previously synthesized I–3,5–³H₂, the stoichiometry of ring substitution was determined for the tyrosinase-catalyzed metabolic pathway of A. bisporus (mushroom). In this pathway, I is hydroxylated to γ-L-glutaminyl-3,4-dihydroxybenzene (II) which is oxidized to γ-L-glutaminyl-3,4-benzoquinone (III) and a compound of previously unknown structure, 490. The results indicated that the 490 quinone was derived from III without further ring substitution. A base-catalyzed, nonenzymic reaction of III was observed which yielded a compound with a 490 nm chromophore. γ-Glutamyl transpeptidase cleavage of II led to the release of 4-aminocatechol which air-oxidized to a compound with identical spectral properties to 490. The structure of 490 was thus determined to be 2-hydroxy-4-imino-2,5-cyclohexadiene-1-one (2-hydroxy-4-iminoquinone). The tyrosinase-catalyzed hydroxylation of I was found to be optimal at pH 8.0, whereas the enzymic oxidation of II was optimal at pH 6.0. In the experiment, the researchers used many compounds, for example, 4-Amino-3-bromophenol (cas: 74440-80-5Application of 74440-80-5).

4-Amino-3-bromophenol (cas: 74440-80-5) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 74440-80-5

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Bromide – Wikipedia,
bromide – Wiktionary

Pyrrolopyrrole-1,3-dione-Based Wide Band-Gap Polymeric Donors Exemplify High Voltage and Diminutive Energy Loss for Efficient Binary and Tandem Nonfullerene Organic Solar Cells with Efficiency Exceeding 15.7% was written by Tamilavan, Vellaiappillai;Lee, Jihoon;Jang, Soyeong;Shin, Insoo;Oh, Chang-Mok;Hwang, In-Wook;Yang, Hyun-seock;Kim, Danbi;Yang, Eunhye;Lee, Seongbeom;Kim, Jung Hwan;Lee, Bo Ram;Park, Sung Heum. And the article was included in ACS Applied Energy Materials in 2022.Synthetic Route of C4H4BrNO2 This article mentions the following:

Here, the potential of pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-dione-based polymers, namely, poly[4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)benzo[1,2-b:4,5-b’]dithiophene-alt-2,5-dioctyl-4,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-dione] (PBDPD), is tested as an electron donor in nonfullerene electron acceptor-based organic solar cells (NFA OSCs). Polymer PBDPD shows an intense absorption between 300 and 600 nm with a deeper HOMO of -5.44 eV. Noticeably, PBDPD displays good complementary absorption and well-matched energy levels with various NFAs. The binary NFA OSCs are fabricated by using PBDPD without any additive or postannealing treatment, providing a maximum power conversion efficiency (PCE) of 11.24% with an impressive open-circuit voltage (V_oc) of 1.004 V and a low energy loss (E_loss) of 0.496 eV. These results suggest that PBDPD could be a useful candidate for tandem NFA OSCs. Therefore, the tandem NFA OSCs are fabricated using PBDPD with the aim of further maximizing the V_oc of the NFA OSCs. The resp. tandem NFA OSCs provide an impressive PCE of 15.71% with a greatly improved V_oc of 1.73 V. This study suggests that the PD-based polymers are efficient candidates for NFA OSCs, and it opens a new platform for researchers planning to develop efficient wide band-gap polymers for NFA OSCs. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Synthetic Route of C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Synthetic Route of C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luminescence color regulation of carbon quantum dots by surface modification was written by Li, Jing;Wang, Wei;An, Bao-Li;Jia, Xin;Zhang, Ying-Hao;Li, Juan-Rong;Bai, Yue-Ling;Xu, Jia-Qiang. And the article was included in Journal of Luminescence in 2022.Formula: C4H4BrNO2 This article mentions the following:

Labeling various biol. mols. with multi-color carbon quantum dots (CQDs) in the same scene has great potential application for investigating the relationship between those mols. It is still a great challenge to regulate the color of CQDs. Ample -NH₂ groups on the surface of green carbon quantum dots (GCQDs) were characterized and confirmed by ¹H NMR (¹H NMR) data. As-NH₂ groups had high organic reactivity, the surface of GCQDs was designed and modified with several organic functional groups through a simple surface modification strategy of organic reactions. The surface band gap states of GCQDs were tuned gradually by the corresponding modified functional groups, and the emission colors of GCQDs were tuned from green to yellow-green, then to orange, and finally to red. All the emission spectra for these multicolor carbon quantum dots (M-CQDs) were excitation independent, and the lifetimes for the M-CQDs were mainly determined by the second electron decay process from the surface defect band states. The red-shift colors for the M-CQDs were ascribed to the emissions from their surface defect band states, and the luminescence mechanism had been investigated. This work opens up a novel synthesis strategy to regulate the emission colors of carbon quantum dots. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Formula: C4H4BrNO2).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Formula: C4H4BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carbonylative synthesis of thiochromenones via palladium-catalyzed tert-butyl isocyanide insertion was written by Zhang, Fang-Ling;Chen, Zhen-Bang;Liu, Kui;Yuan, Qing;Jiang, Qing;Zhu, Yong-Ming. And the article was included in Synlett in 2018.Category: bromides-buliding-blocks This article mentions the following:

A flexible and efficient carbonylative synthesis of thiochromenones from the com. available materials by utilizing tert-Bu isocyanide as carbonyl source has been developed. This methodol. efficiently constructs thiochromenones I (R¹ = H, 8-F, 7-Cl, etc.; R² = C₆H₅, 4-CH₃OC₆H₄, 3-thienyl, etc.; Y = C, N) in moderate to excellent yields with the advantages of wide range of substrates and being applicable to library synthesis. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-fluorotoluene (cas: 452-62-0Category: bromides-buliding-blocks).

3-Bromo-4-fluorotoluene (cas: 452-62-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Novel Pterostilbene-Based Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors with Inflammatory Activity for Colitis was written by Chen, Liu Zeng;Zhang, Xing Xing;Liu, Ming Ming;Wu, Jing;Ma, Duo;Diao, Liang Zhuo;Li, Qingshan;Huang, Yan Shuang;Zhang, Rui;Ruan, Ban Feng;Liu, Xin Hua. And the article was included in Journal of Medicinal Chemistry in 2021.Product Details of 4457-67-4 This article mentions the following:

Studies have shown that the abnormal activation of the NLRP3 inflammasome is involved in a variety of inflammatory-based diseases. In this study, a high content screening model targeting the activation of inflammasome was first established and pterostilbene was discovered as the active scaffold. Based on this finding, total of 50 pterostilbene derivatives were then designed and synthesized. Among them, compound 47 was found to be the best one for inhibiting cell pyroptosis [inhibitory rate (IR) = 73.09% at 10μM], showing low toxicity and high efficiency [against interleukin-1β (IL-1β): half-maximal inhibitory concentration (IC₅₀) = 0.56μM]. Further studies showed that compound 47 affected the assembly of the NLRP3 inflammasomes by targeting NLRP3. The in vivo biol. activity showed that this compound significantly alleviated dextran sodium sulfate (DSS)-induced colitis in mice. In general, our study provided a novel lead compound directly targeting the NLRP3 protein, which is worthy of further research and structural optimization. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Product Details of 4457-67-4).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 4457-67-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Selective alkylation of phenylhydrazine: a facile and efficient synthesis of 1-alkyl-1-phenylhydrazines was written by Lerch, Ulrich;Koenig, Johann. And the article was included in Synthesis in 1983.Computed Properties of C5H11BrO This article mentions the following:

Hydrazines 4-RC₆H₄NR¹NH₂ [R = H, Me, Cl; R¹ = C_1-8 alkyl, allyl, (CH₂)₄OMe, PhCH₂] were prepared Thus, MeI was added to PhNHNH₂ and NaNH₂ in THF at 10-14° in 2.5 h, and the mixture was stirred 1.5 h and worked up to give 89% PhNMeNH₂. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-methoxybutane (cas: 4457-67-4Computed Properties of C5H11BrO).

1-Bromo-4-methoxybutane (cas: 4457-67-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Computed Properties of C5H11BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Indolactam dipeptides as nanomolar Gli inhibitors was written by Mendoza, Manuel;Tran, UyenPhuong;Zhang, Grace C.;Leister, Jeffrey;To, Kyle;Malepeai-Tofaeono, Theodore;Ondrus, Alison E.;Billingsley, Kelvin L.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Recommanded Product: 128-08-5 This article mentions the following:

The Gli transcription factors within the Hedgehog (Hh) signaling pathway play essential roles in human development. However, the reactivation of Gli proteins in adult tissue is tumorigenic and drives the progression of several cancers, including the majority of basal cell carcinomas. Here we describe a novel set of indolactam dipeptides that target protein kinase C (PKC), exploiting the unique capacity of PKC isoenzymes to act as regulators of Gli. We devised an efficient synthetic route for the indolactam-based natural product (-)-pendolmycin and a series of analogs, and we evaluated these analogs in mechanistically distinct Gli reporter assays. The lead compound from these studies, N-hexylindolactam V (I), exhibits superior Gli suppression relative to clin. inhibitors and blocks the growth of Gli-dependent basal cell carcinoma cells. More broadly, our structure-activity studies provide inroads for the development of novel Gli antagonists and new avenues for combating Gli-driven cancers. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Recommanded Product: 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Polymeric ionic liquid absorbents for n-butanol recovery from aqueous solution was written by Biro, Robert;Daugulis, Andrew J.;Parent, J. Scott. And the article was included in AIChE Journal in 2022.Related Products of 128-08-5 This article mentions the following:

A wide-ranging study of imidazolium-based polymeric ionic liquids (PILs) as absorbents in two-phase partitioning bioreactor applications is presented, with a particular focus on the removal of n-butanol from dilute aqueous solutions The study begins with a description of the synthesis and phase transition temperatures of poly(1-vinyl-3-alkylimidazolium) bromides bearing alkyl groups of different lengths, architecture, and composition, as well as analogs bearing various inorganic and carboxylate anions. Knowledge of polymer structure is used to generate insight into the solute affinity of each PIL, as quantified by the measurements of n-butanol partition coefficient (PC_BuOH) and n-butanol/water selectivity (α_b/w). These equilibrium experiments are extended to create a complete P[(VC_12-linIm)(Br)]/n-BuOH/water ternary phase diagram that is used to propose a streamlined n-butanol recovery process. In the experiment, the researchers used many compounds, for example, 1-Bromopyrrolidine-2,5-dione (cas: 128-08-5Related Products of 128-08-5).

1-Bromopyrrolidine-2,5-dione (cas: 128-08-5) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 128-08-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reduction of sulfur with borohydride exchange resin in methanol: application to rapid and selective synthesis of disulfides was written by Bandgar, B. P.;Uppalla, L. S.;Sadavarte, V. S.. And the article was included in Tetrahedron Letters in 2001.Safety of 1-Bromo-6-methoxyhexane This article mentions the following:

A convenient and rapid method for the synthesis of sym. disulfides from alkyl or aryl alkyl halides using sulfurated borohydride exchange resin under anhydrous conditions is described. Selective transfer of sulfur to an alkyl group rather than an aryl group is achieved using this methodol. The anion exchange resin-bound borohydride was prepared as reported previously, by stirring sodium borohydride with Tulsion A-27 (anion exchange resin). In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Safety of 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary