Tag: 100-200

《Broadly Applicable Directed Catalytic Reductive Difunctionalization of Alkenyl Carbonyl Compounds》 was published in Chem in 2020. These research results belong to Yang, Tao; Chen, Xianxiao; Rao, Weidong; Koh, Ming Joo. Recommanded Product: (Bromomethyl)cyclopropane The article mentions the following:

Catalytic alkene difuntionalization is a convenient platform for introducing complexity in mols. and has wide applications in organic synthesis. Yet a compelling challenge that remains to be solved is the regioselective insertion of two highly functionalized carbon-based moieties, derived from stable and readily available organohalide electrophiles without the need for pre-synthesized organometallic reagents, across C=C bonds in unactivated alkyl-substituted alkenes. That catalytic amounts of an inexpensive Ni-based catalyst, in combination with a readily recyclable 8-aminoquinoline directing group, promotes efficient and site-selective addition of two different organohalides (iodides and bromides) across aliphatic alkenes under mild reductive conditions. Compared to previous studies, this protocol exhibits broad and complementary functional group tolerance that extends to aryl-alkylation, alkenyl-alkylation, and dialkylation transformations. The utility of the strategy is demonstrated through concise synthesis of biol. active mols. Kinetic studies and other control experiments shed further light on the mechanistic underpinnings of the multicomponent reaction. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Chen, Yu; Panek, James S. published their research in Tetrahedron in 2021. The article was titled 《Highly regio- and diastereoselective synthesis of bis-triazolines》.SDS of cas: 6630-33-7 The article contains the following contents:

A highly stereo- and regioselective homodimerization of chiral azido-esters was achieved by a 1,3-dipolar cycloaddition on chiral (E)-Me 4-azido-6-methoxy-5-methyl-6-phenylhex-2-enoates. Both 4,5-syn and 4,5-anti allylic azides could be used effectively to access corresponding bis-triazoline dimers such as I [X = 2-Br, 2-I, 3-Br; n = 0, 1] by this reproducible method. Structural conformation of a representative dimer was established by X-ray crystal anal. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ChemSusChem included an article by Cao, Qun; Stark, Roderick T.; Fallis, Ian A.; Browne, Duncan L.. HPLC of Formula: 401-55-8. The article was titled 《A Ball-Milling-Enabled Reformatsky Reaction》. The information in the text is summarized as follows:

An operationally simple one-pot one-step mechanochem. Reformatsky reaction using in situ generated organozinc intermediates under neat grinding conditions has been developed. Notable features of this reaction protocol are that it requires no solvent, no inert gases, and no pre-activation of the bulk zinc source. The developed process is demonstrated to have good substrate scope (39-82 % yield) and is effective irresp. of the initial morphol. of the zinc source. In the experiment, the researchers used Ethylbromofluoroacetate(cas: 401-55-8HPLC of Formula: 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.HPLC of Formula: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dow, Nathan W.; Cabre, Albert; MacMillan, David W. C. published their research in Chem in 2021. The article was titled 《A general N-alkylation platform via copper metallaphotoredox and silyl radical activation of alkyl halides》.COA of Formula: C4H7Br The article contains the following contents:

The catalytic union of amides, sulfonamides, anilines, imines, or N-heterocycles with a broad spectrum of electronically and sterically diverse alkyl bromides has been achieved via a visible-light-induced metallaphotoredox platform. The use of a halogen abstraction-radical capture (HARC) mechanism allows for room temperature coupling of C(sp3)-bromides using simple Cu(II) salts, effectively bypassing the prohibitively high barriers typically associated with thermally induced SN2 or SN1 N-alkylation. This regio- and chemoselective protocol is compatible with >10 classes of medicinally relevant N-nucleophiles, including established pharmaceutical agents, in addition to structurally diverse primary, secondary, and tertiary alkyl bromides. Furthermore, the capacity of HARC methodologies to engage conventionally inert coupling partners is highlighted via the union of N-nucleophiles with cyclopropyl bromides and unactivated alkyl chlorides, substrates that are incompatible with nucleophilic substitution pathways. Preliminary mechanistic experiments validate the dual catalytic, open-shell nature of this platform, which enables reactivity previously unattainable in traditional halide-based N-alkylation systems. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5COA of Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.COA of Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Remote control of mechanical forces via mitochondrial-targeted magnetic nanospinners for efficient cancer treatment》 was written by Chen, Mengwei; Wu, Jiaojiao; Ning, Peng; Wang, Jingjing; Ma, Zuan; Huang, Liqun; Plaza, Gustavo R.; Shen, Yajing; Xu, Chang; Han, Yu; Lesniak, Maciej S.; Liu, Zhongmin; Cheng, Yu. Related Products of 2623-87-2 And the article was included in Small in 2020. The article conveys some information:

In cells, mech. forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mech. forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mech. force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomech. approach to treat deep-seated tumors in a spatiotemporal fashion. The experimental process involved the reaction of 4-Bromobutanoic acid(cas: 2623-87-2Related Products of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Related Products of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《New zwitterionic polyurethanes containing pendant carboxyl-pyridinium with shape memory, shape reconfiguration, and self-healing properties》 was written by Xiao, Xuan; Chen, Heng; Chen, Shaojun. Computed Properties of C4H7BrO2This research focused onzwitterionic polyurethane shape memory self healing property. The article conveys some information:

In this paper, novel zwitterionic polyurethane containing pendant carboxyl-pyridinium were successfully prepared with N,N-bis(2-hydroxyethyl) isonicotinamide (BINA) and hexamethylene diisocyanate (HDI), followed by zwitterionization with 4-bromobutyric acid. The structure, morphol. and properties, including shape memory, shape reconfiguration and self-healing properties, were carefully investigated. The obtained results showed that introduction of zwitterionic units reduced glass transition temperature The shape recovery increased with increasing carboxyl zwitterion content. Finally, good shape memory properties with 99% shape memory and 99% shape recovery was achieved. Addnl., the carboxyl-pyridinium zwitterionic polyurethane had good shape reconfiguration properties, and new permanent shapes could be reconfigured easily upon heating. Moreover, the carboxyl-pyridinium zwitterionic polyurethanes possessed moisture-induced self-healing properties, where its complex structure was self-repaired in a humidity-rich environment after inevitable damage. This study opens a new door to intelligent zwitterionic polymers, which is highly significance in the field of smart biomedical. In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2969-81-5In 2019 ,《Functional Biointerfaces Based on Mixed Zwitterionic Self-Assembled Monolayers for Biosensing Applications》 was published in Langmuir. The article was written by Wang, Yu-Sin; Yau, Shuehlin; Chau, Lai-Kwan; Mohamed, Ameen; Huang, Chun-Jen. The article contains the following contents:

Surface modification for biosensors has focused attention for improvement of their sensitivity and specificity, particularly for the detection in complex medium. In this work, we have synthesized zwitterionic carboxybetaine-thiols (CB-thiols) and sulfobetaine-thiols (SB-thiols) for modification of gold substrates to form a functional self-assembled monolayer (SAM) for the immunoassay in a surface plasmon resonance (SPR) biosensor. XPS, contact angle goniometer, and cyclic voltammetry were applied for characterizations of elemental composition, surface wettability, and packing d., resp. The antifouling properties of the SAMs were accessed by quant. anal. of protein and bacterial adsorption. The results from the SAMs with a single component indicated that the SB-thiol SAM provides better surface hydrophilicity, fouling resistance, and packing d. as compared to the CB-thiol SAM, likely due to the ionic association of CB moieties. However, the CB-thiol with the functional carboxylate group plays a critical role in postmodification of biomols. via com. available amine coupling chem. Thus, the mixed SAMs were prepared to integrate the unique characteristics from CB- and SB-thiols to control compositions and surface properties. The immunoassay was performed in the SPR biosensor, showing that the zwitterionic mixed SAM enables immobilization of biorecognition elements (BREs), and improved sensitivity and specificity. Consequently, the work reveals excellent and attractive versatility, antifouling, and functionalizable properties of zwitterionic mixed SAMs comprising CB- and SB-thiols for biosensing applications. This surface chem. is expected to be applicable to monitor specific mol. recognition events. After reading the article, we found that the author used Ethyl 4-bromobutyrate(cas: 2969-81-5Related Products of 2969-81-5)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Related Products of 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Tandem Condensation-Hydrogenation to Produce Alkylated Nitriles Using Bifunctional Catalysts: Platinum Nanoparticles Supported on MOF-Derived Carbon》 was written by Huang, Ao; Nie, Renfeng; Zhang, Biying; Pei, Yuchen; Chen, Minda; Behera, Ranjan; Yu, Jiaqi; Luan, Xuechen; Hunter, Nicholas T.; Ke, Ming; Huang, Wenyu. Product Details of 6630-33-7 And the article was included in ChemCatChem in 2020. The article conveys some information:

Tandem catalysis, which allows multiple steps of a reaction to take place without the need for separation and purification, is highly desired for the design of efficient and environmentally-friendly chem. processes. Herein, the pyrolysis of UiO-66-NH2, an amino-functionalized metal-organic framework, produces nitrogen-rich carbon-ZrO2 composite (CN-ZrO2). This composite is rich in basic sites and effectively catalyzes the Knoevenagel condensation reaction. After loading Pt nanoparticles onto this composite support, a tandem catalyst (Pt/CN-ZrO2) is produced to be capable of the one-step Knoevenagel condensation-hydrogenation reaction to produce an alpha-alkylated nitrile. The tandem catalyst exhibits >99% aldehyde conversion and >99% selectivity toward alpha-alkylated nitrile under 1 MPa H2 at 80°C. This catalyst could be reused for five times in the presence of malononitrile without significant deactivation and is versatile for one-step condensation-hydrogenation of various aldehydes. The good performance of Pt/CN-ZrO2 could be ascribed to the synergistic interaction between Pt and CN-ZrO2 composite supports that lead to the appropriate hydrogenation activity of supported Pt nanoparticles. The results came from multiple reactions, including the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C4H7BrO2In 2019 ,《A new quinoline-derived highly-sensitive fluorescent probe for the detection of hydrazine with excellent large-emission-shift ratiometric response》 appeared in Talanta. The author of the article were Wu, Qingqing; Zheng, Jianlu; Zhang, Wencui; Wang, Jianbo; Liang, Wenlang; Stadler, Florian J.. The article conveys some information:

Hydrazine is an important industrial material yet highly toxic and extremely harmful to people’s health when over-exposed in the environment, thus monitoring hydrazine is of great significance. A novel highly fluorescent fluorophore BQ-OH, based on hydroxyl- and benzo[d]oxazole-substituted quinoline structure, was synthesized and esterified with 4-bromobutyric acid to afford a fluorescent probe BQABr for the selective detection of hydrazine. The probe follows SN2(nucleophilic substitution)-cyclization sensing mechanism with remarkable response, excellent sensitivity and selectivity. Spectra experiments in aqueous solutions demonstrated that BQABr exhibited an excellent ratiometric fluorescence response toward hydrazine with 2 well separated emission bands before/after sensing reaction. Emission peak shifted over 130 nm from 387 nm to 521 nm, and unexpectedly outstanding ratio signal enhancement over 3000-fold was achieved. Due to the large spectra response, a very low detection limit of 5.8 nM (0.19 ppb) was obtained. Selectivity experiment was performed, showing BQABr had nearly no spectra response to other possible disturbing analytes. The probe-coated test papers were fabricated and successfully applied to detect gaseous hydrazine. Also, potential application for the detection of hydrazine in both environmental samples and biol. samples (living cells) was demonstrated.4-Bromobutanoic acid(cas: 2623-87-2Computed Properties of C4H7BrO2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Computed Properties of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary