Tag: 100-200

Kim, Mingi; Ryu, Chan Hee; You, Dong Kyun; Hong, Ju Hyun; Lee, Kang Mun published an article in 2022. The article was titled 《Crucial Factors Regulating Intramolecular Charge-Transfer-Based Radiative Efficiency in ortho-Carboranyl Luminophores: Planarity between Substituted Biphenyl Rings》, and you may find the article in ACS Omega.Name: 1-Bromo-2-isopropylbenzene The information in the text is summarized as follows:

O-Carboranyl compounds contain specific geometries, ranging from planar to orthogonally distorted biphenyl rings. Herein, 13 o-carboranyl compounds, 1HF-13PP, were synthesized and fully characterized to determine the impact of structural formation of the aromatic group appended with the o-carborane to estimate the efficiency of their radiative decay process. All the compounds exhibited significant intramol. charge transfer (ICT)-based emission in the crystalline state at 298 K. Remarkably, increasing the distorted dihedral angles between biphenyl rings gradually decreased the emission efficiencies. Also, their radiative decay constants decreased linearly with increasing dihedral angles, which demonstrated the inversely proportional relation between these two factors. These findings distinctly suggest that the planar or distorted geometry of substituted aryl groups can strongly affect the efficiency of the ICT-based radiative process in o-carboranyl luminophores.1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Name: 1-Bromo-2-isopropylbenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Structure-activity relationships and biological evaluation of 7-substituted harmine analogs for human β-cell proliferation》 was written by Kumar, Kunal; Wang, Peng; Swartz, Ethan A.; Khamrui, Susmita; Secor, Cody; Lazarus, Michael B.; Sanchez, Roberto; Stewart, Andrew F.; DeVita, Robert J.. Product Details of 3395-91-3 And the article was included in Molecules in 2020. The article conveys some information:

Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure-activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell proliferation based on our related previous structure-activity relationship studies of harmine in the context of diabetes and β-cell specific targeting strategies. Thirty three harmine analogs of the 7-position substituent were synthesized and evaluated for biol. activity. Two novel inhibitors were identified which showed DYRK1A inhibition and human β-cell proliferation capability. The DYRK1A inhibitor, compound 3-(7-oxy-1-methyl-9-H-b-carbolin)propionic acid Me ester, induced β-cell proliferation half that of harmine at three times higher concentration From these studies we can draw the inference that 7-position modification is limited for further harmine optimization focused on β-cell proliferation and cell-specific targeting approach for diabetes therapeutics. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Product Details of 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Product Details of 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Degradable PE-Based Copolymer with Controlled Ester Structure Incorporation by Cobalt-Mediated Radical Copolymerization under Mild Condition》 was published in iScience in 2020. These research results belong to Zeng, Tianyou; You, Wei; Chen, Guang; Nie, Xuan; Zhang, Ze; Xia, Lei; Hong, Chunyan; Chen, Changle; You, Yezi. Related Products of 2623-87-2 The article mentions the following:

Polyethylene (PE) is one of the most widely used materials in the world, but it is virtually undegradable and quickly accumulates in nature, which may contaminate the environment. We utilized the cobalt-mediated radical copolymerization (CMRP) of ethylene and cyclic ketene acetals (CKAs) to effectively incorporate ester groups into PE backbone as cleavable structures to make PE-based copolymer degradable under mild conditions. The content of ethylene and ester units in the produced copolymer could be finely regulated by CKA concentration or ethylene pressure. Also, the copolymerization of ethylene and CKA with other functional vinyl monomers can produce functional and degradable PE-based copolymer. All the formed PE-based copolymers could degrade in the presence of trimethylamine (Et3N). In the part of experimental materials, we found many familiar compounds, such as 4-Bromobutanoic acid(cas: 2623-87-2Related Products of 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Related Products of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy》 were Chen, Yang; Yang, Cejun; Mao, Juan; Li, Haigang; Ding, Jinsong; Zhou, Wenhu. And the article was published in RSC Advances in 2019. Computed Properties of C5H9BrO2 The author mentioned the following in the article:

Tumor targeting delivery of chemotherapeutic drugs by nanocarriers has been demonstrated to be a promising strategy for cancer therapy with improved therapeutic efficacy. In this work, we reported a novel type of active targeting micelle with pH-responsive drug release by using biodegradable poly(lactide)-poly(2-ethyl-2-oxazoline) di-block copolymers functionalized with spermine (SPM). SPM has been considered as a tumor binding ligand through its specific interaction with the polyamine transport system (PTS), a transmembrane protein overexpressed on various types of cancer cell, while its application in nano-drug delivery systems has rarely been explored. The micelles with spherical shape (~110 nm) could load hydrophobic paclitaxel (PTX) with high capacity, and release the payload much faster at acidic pH (4.5-6.5) than at pH 7.4. This pH-responsive property assisted the rapid escape of drug from the endo/lysosome after internalization as demonstrated by confocal laser scanning microscopy images using coumarin-6 (Cou-6) as a fluorescent probe. With surface SPM modification, the micelles displayed much higher cellular uptake than SPM lacking micelles in various types of cancer cells, demonstrating tumor targeting ability. The uptake mechanism of SPM modified micelles was explored by flow cytometry, which suggested an energy-consuming sag vesicle-mediated endocytosis pathway. As expected, the micelles displayed significantly enhanced anti-cancer activity. This work demonstrates that SPM modified pH-sensitive micelles may be potential drug delivery vehicles for targeting and effective cancer therapy. In the experimental materials used by the author, we found Ethyl 3-bromopropanoate(cas: 539-74-2Computed Properties of C5H9BrO2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Computed Properties of C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ACS Catalysis included an article by Zhu, Kai; Xu, Kai; Fang, Qi; Wang, Yi; Tang, Bencan; Zhang, Fengzhi. SDS of cas: 2623-87-2. The article was titled 《Enantioselective Synthesis of Axially Chiral Biaryls via Cu-Catalyzed Acyloxylation of Cyclic Diaryliodonium Salts》. The information in the text is summarized as follows:

We report here a Cu-catalyzed enantioselective acyloxylation of cyclic diaryliodonium salts. With readily available cyclic diaryliodonium salts and ubiquitous aliphatic or (hetero)aromatic carboxylic acids as the starting materials, various axially chiral acyloxylated 2-iodobiaryls were prepared in excellent yield and with excellent enantioselectivity (mostly 99% yield and 99% ee). D. functional theory calculations were conducted to reveal the stereo- and regioselectivities. This simple reaction protocol can be employed for the late-stage modification of some drug mols. Finally, by diversity-oriented transformations, these acyloxylated 2-iodobiaryl products can be easily transformed into diverse valuable functionalized biaryls that could be used as chiral ligands or functional materials.4-Bromobutanoic acid(cas: 2623-87-2SDS of cas: 2623-87-2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).SDS of cas: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Molecules included an article by Qin, Shu-Qin; Li, Lian-Chun; Song, Jing-Ru; Li, Hai-Yun; Li, Dian-Peng. Recommanded Product: 2969-81-5. The article was titled 《Structurally simple phenanthridine analogues based on nitidine and their antitumor activities》. The information in the text is summarized as follows:

A series of novel structurally simple analogs based on nitidine was designed and synthesized in search of potent anticancer agents. The antitumor activity against human cancer cell lines (HepG2, A549, NCI-H460, and CNE1) was performed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay in vitro. The results showed that some of them had good anticancer activities, especially derivatives with a [(dimethylamino)ethyl]amino side chain in the C-6 position. Planar conjugated compounds 15a, 15b, and 15c, with IC50 values of 1.20 μM, 1.87 μM, and 1.19 μM against CNE1 cells, resp., were more active than nitidine chloride. Compound 15b and compound 15c with IC50 values of 1.19 μM and 1.37 μM against HepG2 cells and A549 cells demonstrated superior activities to nitidine. Besides, compound 5e which had a phenanthridinone core displayed extraordinary cytotoxicity against all test cells, particularly against CNE1 cells with the IC50 value of 1.13 μM.Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: 2969-81-5) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: 2969-81-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 401-55-8On September 24, 2021 ,《The serendipitous effect of KF in Ritter reaction: Photo-induced amino-alkylation of alkenes》 was published in iScience. The article was written by Guan, Yu-Qing; Min, Xiang-Ting; He, Gu-Cheng; Ji, Ding-Wei; Guo, Shi-Yu; Hu, Yan-Cheng; Chen, Qing-An. The article contains the following contents:

The Ritter reaction has been recognized as an elegant strategy to construct the C-N bond. Its key feature is forming the carbocation for nucleophilic attack by nitriles. Herein, authors report a complementary visible-light-induced three-component Ritter reaction of alkenes, nitriles, and α-bromo nitriles/esters, thereby providing mild and rapid access to various γ-amino nitriles/acids. Mechanistic studies indicated that traceless fluoride relay, transforming KF into imidoyl fluoride intermediate, is critical for the efficient reaction switch from atom transfer radical addition (ATRA) to the Ritter reaction. This approach to amino-alkylation of alkenes is chemoselective and operationally simple. In addition to this study using Ethylbromofluoroacetate, there are many other studies that have used Ethylbromofluoroacetate(cas: 401-55-8Product Details of 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Product Details of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Direct synthesis of N-functionalized dipropargylamine linkers as models for use in peptide stapling》 were Renzetti, Andrea; Rutherford, Ryan N.; Fukumoto, Kozo; Kunciw, Dominique; Sore, Hannah F.; Spring, David R.. And the article was published in Synlett in 2019. SDS of cas: 539-74-2 The author mentioned the following in the article:

N-Substituted dipropargylamines that are suitable as functionalized linkers for peptide stapling can be synthesized in one step under mild conditions from com. available starting materials (41% to quant. yield). The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-bromopropanoate(cas: 539-74-2SDS of cas: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. SDS of cas: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Full-spectrum fluoromethyl sulfonation via modularized multicomponent coupling》 was published in CCS Chemistry in 2022. These research results belong to Li, Kejie; Wang, Ming; Jiang, Xuefeng. Name: Ethylbromofluoroacetate The article mentions the following:

Modular free-assembly construction of mono-, di-, and tri-fluoromethyl sulfones was comprehensively achieved by a combination of halides, a sulfur dioxide surrogate, and halofluorocarbons. The industrial raw material thiourea dioxide served as the sulfur dioxide source, combined with readily available fluorocarbon sources such as 2-bromo-2-fluoroacetate and chlorodifluoromethane employed as fluoromethyl reagents. Notably, four Me sulfone-containing pharmaceuticals were modified into three types of fluoromethyl sulfones, displaying their great potential for drug discovery via the current strategy. Mechanistic studies further demonstrated that C-F···H-N interactions between thiourea dioxide and halofluorocarbons play a key role in stabilizing monofluoromethyl electrophiles and difluorocarbene species. The results came from multiple reactions, including the reaction of Ethylbromofluoroacetate(cas: 401-55-8Name: Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Name: Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: EthylbromofluoroacetateOn November 20, 2020 ,《Copper-Catalyzed Decarboxylative Functionalization of Conjugated β,γ-Unsaturated Carboxylic Acids》 appeared in ACS Catalysis. The author of the article were Zhang, Wei; Wang, Chengming; Wang, Qiu. The article conveys some information:

Copper-catalyzed decarboxylative coupling reactions of conjugated β,γ-unsaturated carboxylic acids have been achieved for allylic amination, alkylation, sulfonylation, and phosphinoylation. This approach was effective for a broad scope of amino, alkyl, sulfonyl, and phosphinoyl radical precursors as well as various conjugated β,γ-unsaturated carboxylic acids. These reactions also feature high regioselectivity, good functional group tolerance, and simple operation procedure. Mechanistic studies show that the reaction proceeds via copper-catalyzed electrophilic addition onto an olefin followed by decarboxylation, with radical intermediates involved. These insights present a modular and powerful strategy to access versatilely functionalized allyl-containing skeletons from readily available and stable carboxylic acids. In the part of experimental materials, we found many familiar compounds, such as Ethylbromofluoroacetate(cas: 401-55-8Name: Ethylbromofluoroacetate)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Name: Ethylbromofluoroacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary