Tag: 100-200

Application of 401-55-8On May 15, 2020 ,《Acylation of Aryl Halides and α-Bromo Acetates with Aldehydes Enabled by Nickel/TBADT Cocatalysis》 appeared in Organic Letters. The author of the article were Fan, Pei; Zhang, Chang; Zhang, Linchuan; Wang, Chuan. The article conveys some information:

In this protocol aryl halides and α-bromo esters were efficiently cross-coupled with an array of aromatic and aliphatic aldehydes under the cooperative catalysis of nickel and tetrabutylammonium decatungstate as a hydrogen-atom-transfer photocatalyst. This method provided a concise approach to a variety of ketones with high compatibility of various functional groups. In the part of experimental materials, we found many familiar compounds, such as Ethylbromofluoroacetate(cas: 401-55-8Application of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《SNP discrimination by tolane-modified peptide nucleic acids: application for the detection of drug resistance in pathogens》 was written by Takagi, Kenji; Hayashi, Tenko; Sawada, Shinjiro; Okazaki, Miku; Hori, Sakiko; Ogata, Katsuya; Kato, Nobuo; Ebara, Yasuhito; Kaihatsu, Kunihiro. Name: Methyl 3-bromopropanoateThis research focused onzanamivir oseltamivir antiviral agent PNA drug resistance SNP influenza; drug resistance; influenza virus; peptide nucleic acid; single nucleotide polymorphism; tolane. The article conveys some information:

During the treatment of viral or bacterial infections, it is important to evaluate any resistance to the therapeutic agents used. An amino acid substitution arising from a single base mutation in a particular gene often causes drug resistance in pathogens. Therefore, mol. tools that discriminate a single base mismatch in the target sequence are required for achieving therapeutic success. Here, we synthesized peptide nucleic acids (PNAs) derivatized with tolane via an amide linkage at the N-terminus and succeeded in improving the sequence specificity, even with a mismatched base pair located near the terminal region of the duplex. We assessed the sequence specificities of the tolane-PNAs for single-strand DNA and RNA by UV-melting temperature anal., thermodn. anal., an in silico conformational search, and a gel mobility shift assay. As a result, all of the PNA-tolane derivatives stabilized duplex formation to the matched target sequence without inducing mismatch target binding. Among the different PNA-tolane derivatives, PNA that was modified with a naphthyl-type tolane could efficiently discriminate a mismatched base pair and be utilized for the detection of resistance to neuraminidase inhibitors of the influenza A/H1N1 virus. Therefore, our mol. tool can be used to discriminate single nucleotide polymorphisms that are related to drug resistance in pathogens. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 539-74-2In 2019 ,《Synthesis of a Variety of Activated Pyrrolo[3,2,1- ij ]quinolines》 appeared in Synthesis. The author of the article were Jumina, Jumina; Wenholz, Daniel S.; Kumar, Naresh; Black, David StC.. The article conveys some information:

A range of 7,9-dimethoxypyrrolo[3,2.1- ij]quinolines have been prepared by the cyclization of 7-formyl-1-diethylcarbethoxyindoles. The functionality at C5 has been varied by the conversion of the carbethoxy group into carboxy, azidocarbonyl and isocyanate groups. The hydroboration of a previously reported pyrroloquinolone gave a related 5-hydroxypyrrolo[3,2,1- ij]quinolone, and the hydroxyl group was sequentially converted into tosylate, azido and amino groups. In the experiment, the researchers used Ethyl 3-bromopropanoate(cas: 539-74-2Recommanded Product: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Recommanded Product: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C6H11BrO2In 2020 ,《gamma-tocotrienol and a-tocopherol ether acetate enhance docetaxel activity in drug-resistant prostate cancer cells》 appeared in Molecules. The author of the article were Asay, Spencer; Graham, Andrew; Hollingsworth, Sydney; Barnes, Bradley; Oblad, Richard V.; Michaelis, David J.; Kenealey, Jason D.. The article conveys some information:

Prostate cancer is the second most commonly diagnosed cancer in men, and metastatic prostate cancer is currently incurable. Prostate cancer frequently becomes resistant to standard of care treatments, and the administration of chemotherapeutic drugs is often accompanied by toxic side effects. Combination therapy is one tool that can be used to combat therapeutic resistance and drug toxicity. Vitamin E (VE) compounds and analogs have been proposed as potential non-toxic chemotherapeutics. Here we modeled combination therapy using mixture design response surface methodol. (MDRSM), a statistical technique designed to optimize mixture compositions, to determine whether combinations of three chemotherapeutic agents: gamma-tocotrienol (gamma-T3), a-tocopherol ether acetate (a-TEA), and docetaxel (DOC), would prove more effective than docetaxel alone in the treatment of human prostate cancer cells. Response surfaces were generated for cell viability, and the optimal treatment combination for reducing cell viability was calculated We found that a combination of 20 uM gamma-T3, 30 uM a-TEA, and 25 nm DOC was most effective in the treatment of PC-3 cells. We also found that the combination of gamma-T3 and a-TEA with DOC decreased the amount of DOC required to reduce cell viability in PC-3 cells and ameliorated therapeutic resistance in DOC-resistant PC-3 cells. After reading the article, we found that the author used Ethyl 4-bromobutyrate(cas: 2969-81-5COA of Formula: C6H11BrO2)

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.COA of Formula: C6H11BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Louwsma, Jeroen; Carvalho, Alain; Lutz, Jean-Francois; Joly, Stephane; Chan-Seng, Delphine published an article in 2021. The article was titled 《Adsorption of phenylalanine-rich sequence-defined oligomers onto Kevlar fibers for fiber-reinforced polyolefin composite materials》, and you may find the article in Polymer.Recommanded Product: 4-Bromobutanoic acid The information in the text is summarized as follows:

Oligomers comprising four or sixteen phenylalanine residues with regularly intercalated aliphatic chains of different lengths prepared by solid-phase synthesis exhibit sufficient thermal stability to be used as interfacial agents and processed for the preparation of poly(propylene-co-ethylene)-based composite materials. The investigation of their adsorption on Kevlar fibers by SEM is difficult due to the surface heterogeneity of the bare Kevlar fibers. However, oligomers with four successive phenylalanine residues have been clearly observed suggesting their better adsorption on the fiber. The quantification of those oligomers adsorbed on the fibers performed gravimetrically on pellets of fibers has however revealed no significant impact of the length of the aliphatic chain.4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Efforts towards Rh(II)-catalyzed N-alkoxyazomethine ylide generation: Disparate reactivities of O-tethered α-diazo keto and -β-ketoester oximes》 was published in Tetrahedron in 2020. These research results belong to Chen, Doris; Jones, Elizabeth V.; Rocke, Benjamin N.; Flick, Andrew C.; Wright, Stephen W.; Trujillo, John I.; France, Stefan. COA of Formula: C4H7BrO2 The article mentions the following:

Herein, dirhodium-catalyzed intramol. N-alkoxyazomethine ylide generation from α-diazo keto and -β-ketoester oximes and the disparate reactivities observed was described. After reading the article, we found that the author used Methyl 3-bromopropanoate(cas: 3395-91-3COA of Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.COA of Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Du, Juan; Wang, Xing; Wang, Hongling; Wei, Jinhu; Huang, Xuan; Song, Jun; Zhang, Junmin published their research in Organic Letters in 2021. The article was titled 《Photoinduced Palladium-Catalyzed Intermolecular Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl Bromides》.Formula: C4H7Br The article contains the following contents:

A mild visible-light-induced Pd-catalyzed intermol. radical cascade reaction of N-arylacrylamides with unactivated alkyl bromides was disclosed. Photoexcited Pd complexes transfer a single electron in this protocol, and hybrid alkyl Pd-radical species were involved as the key reaction intermediates. Sophisticated bioactive oxindole derivatives bearing various substituents and substitution patterns were efficiently afforded through this approach. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Dong; Chen, Jiaming; Huang, Yanping; Pan, Huiquan; Shi, Jingqi; Zhang, Yingyue; Wang, Fang; Li, Ziyuan published their research in ACS Catalysis in 2021. The article was titled 《Room-temperature Formal Aza-Wacker Cyclization through Synergistic Copper/TEMPO-catalyzed Radical Relay》.Recommanded Product: 2623-87-2 The article contains the following contents:

A formal aza-Wacker cyclization of alkenylated carbamates or amides through a synergistic Cu/TEMPO-catalyzed radical relay pathway using N-fluorobenzenesulfonimide (NFSI) as an external oxidant afforded oxazolidinones, pyrrolidones I [R= Cl, Br, F, R1 = Me, Et, n-Pr; R2 = H, Me, Et; R1R2 = cyclohex-1-en-1-yl; X = CH2, O] and isoindolinones II [R3 = Ph, 4-MeOC6H4, OBn, etc.] under mild conditions. In this efficient cyclization of alkenylated carbamates or amides at room temperature, the imidyl nitrogen-centered radical (NCR) generated by NFSI induced carbamate or amido NCR from the substrate via N-H homolysis to realize the radical relay process, which was supported by results of control experiments In the experiment, the researchers used 4-Bromobutanoic acid(cas: 2623-87-2Recommanded Product: 2623-87-2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Recommanded Product: 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-Catalyzed Intermolecular trans-Selective Carbofunctionalization of Internal Alkynes to Highly Functionalized Alkenes》 was written by Lv, Weiwei; Liu, Shihan; Chen, Yanhui; Wen, Si; Lan, Yu; Cheng, Guolin. Formula: C9H11Br And the article was included in ACS Catalysis in 2020. The article conveys some information:

A palladium/DPEphos-catalyzed intermol. trans-selective carbofunctionalization of internal alkynes was established herein. This method proceeds through a formal anti-carbopalladation, forming trans-alkenyl palladium species, which was trapped by aryl boronic acids to provide all-carbon tetrasubstituted alkenes in 32-92% yields. The trans-selective arylsilylation/remote C-H silylation and hydroarylation/remote C-H borylation of internal alkynes were also achieved by using hexamethyldisilane and bis(pinacolato)diboron as trapping reagents, resp. The reaction features good regio- and stereoselectivity and high functional group tolerance. A preliminary mechanistic study and DFT calculations show that a cis to trans isomerization of cis-alkenyl palladium species was involved in this transformation. In addition to this study using 1-Bromo-2-isopropylbenzene, there are many other studies that have used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Formula: C9H11Br) was used in this study.

1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Formula: C9H11Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-Catalyzed Three-Component Coupling Reaction of o-Bromobenzaldehyde, N-Tosylhydrazone, and Methanol》 was published in Organic Letters in 2020. These research results belong to Zhu, Lei; Ren, Xiaojian; Yu, Yinghua; Ou, Pengcheng; Wang, Zhi-Xiang; Huang, Xueliang. Application of 6630-33-7 The article mentions the following:

A ligand-controlled palladium-catalyzed three-component reaction of o-bromoaryl aldehydes, N-tosylhydrazones and methanol was described for the synthesis of aryl esters such as I [R = H, 3-OMe, 4-F, etc.; Ar = Ph, 3-MeC6H4, 2-thienyl, etc.]. This reaction used readily available compounds as starting materials while displaying a broad substrate scope and good functional group compatibility. This methodol. was also extended to the synthesis of [methoxy(aryl)methyl]benzaldehydes II [R1 = H, 4-Me, 5-Cl, etc.; R2 = H, Me, OMe, etc.]. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary