Tag: 100-200

In 2019,Organic Letters included an article by Liu, Qianyi; Hong, Junting; Sun, Beiqi; Bai, Guangcan; Li, Feng; Liu, Guoquan; Yang, Yang; Mo, Fanyang. Name: (Bromomethyl)cyclopropane. The article was titled 《Transition-Metal-Free Borylation of Alkyl Iodides via a Radical Mechanism》. The information in the text is summarized as follows:

The authors describe an operationally simple transition-metal-free borylation of alkyl iodides. This method uses com. available diboron reagents as the B source and exhibits excellent functional group compatibility. Also, a diverse range of primary and secondary alkyl iodides could be effectively transformed to the corresponding alkylboronates in excellent yield. Mechanistic studies suggest that this borylation reaction proceeds through a single-electron transfer mechanism featuring the generation of an alkyl radical intermediate. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Name: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Name: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Science included an article by Ding, Feng; Chen, Zhao; Kim, Won Young; Sharma, Amit; Li, Chonglu; Ouyang, Qingying; Zhu, Hua; Yang, Guangfu; Sun, Yao; Kim, Jong Seung. Application In Synthesis of Methyl 3-bromopropanoate. The article was titled 《A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum(II) metallacycle for efficient cancer imaging and therapy》. The information in the text is summarized as follows:

The scarcity of efficient imaging technologies for precise cancer treatment greatly drives the development of new nanotheranostic based platforms that enable both diagnostic and therapeutic functions, together in a single formulation. Owing to the complicated physiol. microenvironment, nanosystems designed with the possibility of noninvasive real-time monitoring of therapeutic progression in the second near-IR channel (NIR-II, 1000-1700 nm) could substantially improve the current cancer therapies. Herein, we design a novel NIR-II theranostic nanoprobe, PSY (size ∼110 nm), by incorporating organoplatinum(II) metallacycles P1 and an organic NIR-II mol. dye, SY1030, into the FDA-approved polymer Pluronic F127. Preliminary in vitro and in vivo studies suggest that PSY is capable of being internalized into glioma U87MG-cells with no significant internalization in non-cancerous tissues. In addition, it shows excellent photostability and minimal background for real-time monitoring the process of therapy in the NIR-II region. Furthermore, in U87MG xenografts and orthotopic breast tumor, PSY demonstrat significantly improved anticancer efficacy compared to a clin. approved Pt(II)-based anticancer drug, cisplatin. The engineered nano-cocktail PSY offers a simple strategy for delivering the organoplatinum(II) macrocycle P1 and NIR-II fluorophore SY1030 as a cocktail of diagnostic and therapeutic functions and highlights its promising capacity for future cancer treatment. In addition to this study using Methyl 3-bromopropanoate, there are many other studies that have used Methyl 3-bromopropanoate(cas: 3395-91-3Application In Synthesis of Methyl 3-bromopropanoate) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Application In Synthesis of Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Green Chemistry included an article by Li, Zhuofei; Song, He; Guo, Rui; Zuo, Minghui; Hou, Chuanfu; Sun, Shouneng; He, Xin; Sun, Zhizhong; Chu, Wenyi. Formula: C7H5BrO. The article was titled 《Visible-light-induced condensation cyclization to synthesize benzimidazoles using fluorescein as a photocatalyst》. The information in the text is summarized as follows:

A mild strategy for visible-light-induced synthesis of benzimidazoles I (R = Ph, cyclohexyl, furan-2-yl, etc.; R1 = H, Me, Cl) was developed using aldehydes RCHO and o-phenylenediamines 2-NH2-4-R1C6H3NH2 as substrates. The use of an organic dye, fluorescein, as an innoxious photocatalyst provided a mild and inexpensive catalytic system to synthesize a series of benzimidazoles I in moderate to excellent yields. It was originally applied to this system to obtain benzimidazoles I. Besides, the catalytic system does not require an addnl. oxidant or metal which was good for the environment.o-Bromobenzaldehyde(cas: 6630-33-7Formula: C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Formula: C7H5BrOIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Kundu, Subrata; Nagapradeep, N.; Mohapatra, Balaram; Biswas, Sourav; Verma, Sandeep; Chandrasekhar, Vadapalli published 《Organostannoxane-supported nucleobase arrays: synthesis and supramolecular structures of polymeric and molecular organotin complexes containing guanine, uracil and 2-aminopurine》.CrystEngComm published the findings.Name: Methyl 3-bromopropanoate The information in the text is summarized as follows:

The reaction of L1H {L1H = 3-(N9-guaninyl)propionic acid} with Me3SnCl or (n-Bu3Sn)2O afforded the 1D coordination polymers, [Me3Sn(L1)]n (1) and [n-Bu3Sn(L1)]n (2) resp. A reaction between L2H {L2H = 3-(N7-guaninyl)propionic acid} with Me3SnCl also afforded a 1D coordination polymer, [Me3Sn(L2)]n (3). A similar reaction between L3H [uracil-6-carboxylic acid] with (Ph3Sn)2O in a 2 : 1 ratio afforded a dimer [(n-Bu3SnL3)2·H2O] (4). A mononuclear compound [Me3Sn(L4)·H2O] (5) was obtained in a 1 : 1 reaction of 3-{N9-(2-aminopurinyl)}propanoic acid (L4H) with Me3SnCl. Complexes 1-5 show rich supramol. structures in the solid state as a result of several intermol. interactions. Thus, in the one-dimensional coordination polymer 3, triple hydrogen bonding (GG), between inter-chain guanine units has been observed Similarly a homo orotate quartet has been observed in 4 as a result of intermol. interactions. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Name: Methyl 3-bromopropanoate)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.Name: Methyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A “”turn-on”” fluorescent probe based on V-shaped bis-coumarin for detection of hydrazine》 was written by Jiang, Xingzong; Shangguan, Mingqin; Lu, Zhen; Yi, Sili; Zeng, Xiaoyang; Zhang, Yongle; Hou, Linxi. Electric Literature of C4H7BrO2 And the article was included in Tetrahedron in 2020. The article conveys some information:

Hydrazine (N2H4) has been classified as an environmental contaminant and human carcinogen owing to its high toxicity. Exposed to high concentration of hydrazine can cause irreversible damage to human bodies. Hence, it is significant to explore an effective anal. method to selectively recognize and detect it. In this work, an intramol. charge transfer (ICT) based probe 1 (I) was designed and synthesized by condensation of V-shaped bis-coumarin and 4-bromobutyric acid. The V-shaped bis-coumarin with π-expanded system endowed the probe 1 larger stokes shift and superior tolerance to photobleaching. This “”turn-on”” probe exhibited a high selectivity towards hydrazine over other common ions and amine-containing species with a distinct fluorescent enhancement at 555 nm. It could rapidly detect hydrazine over a wide pH range and the detection limit was as low as 4.2 ppb. The large shift of absorption spectrum enabled it to detect hydrazine in real water samples and gas-state hydrazine by “”naked-eyes””. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Development of novel amides as noncovalent inhibitors of immunoproteasomes》 were Ettari, Roberta; Cerchia, Carmen; Maiorana, Santina; Guccione, Manuela; Novellino, Ettore; Bitto, Alessandra; Grasso, Silvana; Lavecchia, Antonio; Zappala, Maria. And the article was published in ChemMedChem in 2019. SDS of cas: 3395-91-3 The author mentioned the following in the article:

The development of immunoproteasome-selective inhibitors is a promising strategy for treating hematol. malignancies, autoimmune and inflammatory diseases. In this context, we report the design, synthesis, and biol. evaluation of a new series of amide derivatives as immunoproteasome inhibitors. Notably, the designed compounds act as noncovalent inhibitors, which might be a promising therapeutic option because of the lack of drawbacks and side effects associated with irreversible inhibition. Among the synthesized compounds, we identified a panel of active inhibitors with Ki values in the low micromolar or sub-micromolar ranges toward the β5i and/or β1i subunits of immunoproteasomes. One of the active compounds was shown to be the most potent and selective inhibitor with a Ki value of 21 nM against the single β1i subunit. Docking studies allowed us to determine the mode of binding of the mols. in the catalytic site of immunoproteasome subunits.Methyl 3-bromopropanoate(cas: 3395-91-3SDS of cas: 3395-91-3) was used in this study.

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 3395-91-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Li, Xinwei; Cheng, Zengrui; Liu, Jianzhong; Zhang, Ziyao; Song, Song; Jiao, Ning published an article in Chemical Science. The title of the article was 《Selective desaturation of amides: A direct approach to enamides》.Application of 7051-34-5 The author mentioned the following in the article:

C(sp3)-H bond desaturation has been an attractive strategy in organic synthesis. Enamides are important structural fragments in pharmaceuticals and versatile synthons in organic synthesis. However, the dehydrogenation of amides usually occurs on the acyl side benefitting from enolate chem. like the desaturation of ketones and esters. Herein, the authors demonstrate an Fe-assisted regioselective oxidative desaturation of amides, which provided an efficient approach to enamides, e.g., I [R1 = Me, Ph, 4-BrC6H4, cyclopropyl, etc., R2 = R3 = H, X = (CH2)n, n = 1, 2, 3, 9], and β-halogenated enamides I [R1 = n-Pr, Ph, 4-MeC6H4, etc., R2 = Br, I, R3 = H, Me, Ph]. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Kai; Ye, Ya-Xi; Jiang, Cheng-Yan; Guo, Meng-Ya; Zhang, Xiang-Yang; Jiang, Ai-Qin; Yang, Yu-Shun; Jiao, Qing-Cai; Zhu, Hai-Liang published an article in 2021. The article was titled 《Design and synthesis of a novel “”turn-on”” fluorescent probe based on benzofuran-3(2H)-one for detection of hydrazine in water samples and biological systems》, and you may find the article in Dyes and Pigments.Reference of 4-Bromobutanoic acid The information in the text is summarized as follows:

Hydrazine is a very important industrial chem. with high toxicity to the human body. In this work, a fluorescent probe HZ (I), based on the substitution-cyclization-elimination cascade which initiated by hydrazine, was designed and synthesized. HZ had various characteristics such as high selectivity, high sensitivity, fast detection speed, wide application range, and so on. After treating with hydrazine, the fluorescence signal of HZ at 520 nm in aqueous solution was significantly enhanced. Furthermore, HZ had the linear range of 1-10 equiv for monitoring hydrazine, and the solution showed a colorless to yellow color change. In practical application, the detection limit of HZ for the detection of hydrazine was only 0.75μM, which could be utilized for trace detection of hydrazine in different water samples. These indicated that HZ had a broad application prospect in the fields of environmental protection and water treatment. This work not only provided a useful instrument for the detection of the ecol. environment but also supplied important information for the system optimization of other ecol. environment detectors. In addition, HZ could monitor endogenous and exogenous hydrazine in MCF-7 cells successfully, which demonstrated its potential for practical application in complex biol. systems. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Reference of 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Reference of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Morera, Ludovica; Roatsch, Martin; Fuerst, Michael C. D.; Hoffmann, Inga; Senger, Johanna; Hau, Mirjam; Franz, Henriette; Schuele, Roland; Heinrich, Markus R.; Jung, Manfred published 《4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A》.ChemMedChem published the findings.Formula: C4H7BrO2 The information in the text is summarized as follows:

Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathol. of several human cancers. We found that a previously reported hydroxamate-based histone deacetylase (HDAC) inhibitor (SW55) was also able to weakly inhibit this demethylase with an IC50 value of 25.4 μm. Herein we report the synthesis and biochem. evaluations, with two orthogonal in vitro assays, of a series of derivatives of this lead structure. With extensive chem. modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low-micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. Cell-permeable derivatives clearly showed a demethylase-inhibition-dependent antiproliferative effect against HL-60 human promyelocytic leukemia cells. In the experiment, the researchers used Methyl 3-bromopropanoate(cas: 3395-91-3Formula: C4H7BrO2)

Methyl 3-bromopropanoate(cas: 3395-91-3) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Formula: C4H7BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tang, Wei-Ke; Xu, Zhuo-Wei; Xu, Jun; Tang, Fei; Li, Xiao-Xuan; Dai, Jian-Jun; Xu, Hua-Jian; Feng, Yi-Si published an article in Organic Letters. The title of the article was 《Irradiation-Induced Cobaloxime-Catalyzed C-H Monofluoroalkylation of Styrenes at Room Temperature》.Application of 401-55-8 The author mentioned the following in the article:

A cobaloxime-catalyzed photochem. synthesis of allyl monofluorides from styrenes is described herein. This method is characterized by mild reaction conditions, low-cost catalyst, and broad substrate scope. Furthermore, this convenient method will provide a facile synthesis toward novel monofluoroalkylated natural product and pharmaceutical derivatives Mechanistic investigations indicate that a monofluoroalkyl radical is involved in the catalytic cycle. The experimental process involved the reaction of Ethylbromofluoroacetate(cas: 401-55-8Application of 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Application of 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary