Tag: 100-200

Sun, Ze-Ying; Zhou, Sen; Yang, Kai; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published their research in Organic Letters on August 7 ,2020. The article was titled 《Tetrahydroxydiboron-Promoted Radical Addition of Alkynols》.Recommanded Product: 401-55-8 The article contains the following contents:

Tetrahydroxydiboron has previously been used as a borylation or reducing reagent in organic synthesis. Herein, we present a novel tetrahydroxydiboron-promoted radical addition of internal alkynes followed by intramol. oxidation of alc. through 1,5-hydrogen atom transfer. Preliminary mechanistic studies showed that the process might be initiated through N,N-dimethylformamide-assisted homolytic cleavage of tetrahydroxydiboron. This process provides a convenient synthesis of fluoroalkyl-substituted alkenes with a pendant aldehyde or ketone moiety. In the experimental materials used by the author, we found Ethylbromofluoroacetate(cas: 401-55-8Recommanded Product: 401-55-8)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Recommanded Product: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Xuan-Yu; Li, Xiang-Rui; Zhang, Chen; Chu, Xue-Qiang; Rao, Weidong; Loh, Teck-Peng; Shen, Zhi-Liang published their research in Organic Letters on August 2 ,2019. The article was titled 《Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds》.Recommanded Product: 401-55-8 The article contains the following contents:

An efficient, economical, and practical Reformatskii reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and com. iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.Ethylbromofluoroacetate(cas: 401-55-8Recommanded Product: 401-55-8) was used in this study.

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Recommanded Product: 401-55-8

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C4H6BrFO2On November 22, 2021 ,《Cobalt-Catalyzed Addition of Ethyl Bromofluoroacetate to Alkynes》 appeared in ChemistrySelect. The author of the article were Hu, Zhaoming; Ren, Jie; Chen, Zhizhi; Yin, Siyu; Wu, Fanhong; Liu, Chao; Wu, Zhuo; Wu, Jingjing. The article conveys some information:

A cobalt-catalyzed oxidative monofluoroalkylation of alkynes with Et bromofluoroacetate was reported. This method enabled direct and facile access to Et bromomonofluoroallyl acetate EtOC(O)CCHFR1C=CBrR2 [R1 = H, Me, n-Pr, n-Bu, Ph; R2 = n-Pr, Ph, 3-pyridyl, etc.] from abundant alkynes with excellent functional group compatibility. Moreover, this cobalt/ethyl bromofluoroacetate protocol could further create a series of radical monofluoroalkylation reactions of a wide array of substrates, offering a generic and complementary platform for the construction of diversified C-CFHCOOEt bonds. In the part of experimental materials, we found many familiar compounds, such as Ethylbromofluoroacetate(cas: 401-55-8Synthetic Route of C4H6BrFO2)

Ethylbromofluoroacetate(cas: 401-55-8) is a member of organofluorine compounds. Organofluorine compounds, which have carbon-fluorine bonds, show unique features such as high thermal and chemical stability, high surface activity, no light-absorbing ability, high pharmacological effect, and so on. Owing to their specific characters, they are indispensable chemicals for industry and our daily lives.Synthetic Route of C4H6BrFO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis and cytotoxic activity of new vindoline derivatives coupled to natural and synthetic pharmacophores》 was written by Keglevich, Andras; Danyi, Leonetta; Rieder, Alexandra; Horvath, Dorottya; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Jr.; Latif, Ahmed Dhahir; Hunyadi, Attila; Zupko, Istvan; Keglevich, Peter; Hazai, Laszlo. Product Details of 2623-87-2This research focused onvindoline derivative anticancer antiproliferative agent cytotoxicity breast cervical cancer; IC50 values; Vinca alkaloids; anticancer drugs; organic synthesis; pharmacophores; vindoline. The article conveys some information:

New Vinca alkaloid derivatives were synthesized to improve the biol. activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole derivative, morpholine, piperazine and N-methylpiperazine. The structure of the new compounds was characterized by NMR spectroscopy and mass spectrometry (MS). Several compounds exhibited in vitro antiproliferative activity against human gynecol. cancer cell lines with IC50 values in the low micromolar concentration range. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Reductive Electrochemical Activation of Molecular Oxygen Catalyzed by an Iron-Tungstate Oxide Capsule: Reactivity Studies Consistent with Compound I Type Oxidants》 was written by Bugnola, Marco; Shen, Kaiji; Haviv, Eynat; Neumann, Ronny. Formula: C6H5BrO2 And the article was included in ACS Catalysis on April 3 ,2020. The article conveys some information:

The reductive activation of O2 catalyzed by Fe-based enzymes toward its use as an O donor is paradigmatic for O transfer reactions in nature. Mechanistic studies on these enzymes and related biomimetic coordination compounds designed to form reactive intermediates, almost invariably using various shunt pathways, showed that high-valent Fe(V)=O and the formally isoelectronic Fe(IV)=O porphyrin cation radical intermediates are often thought to be the active species in alkane and arene hydroxylation and alkene epoxidation reactions. Although this four decade long research effort has yielded a massive amount of spectroscopic data, reactivity studies, and a detailed, but still incomplete, mechanistic understanding, the actual reductive activation of O2 coupled with efficient catalytic transformations has rarely been exptl. studied. Recently, a completely inorganic Fe-W oxide capsule with a keplerate structure, noted as {Fe30W72}, is an effective electrocatalyst for the cathodic activation of O2 in H2O leading to the oxidation of light alkanes and alkenes. The present report deals with extensive reactivity studies of these {Fe30W72} electrocatalytic reactions showing (1) arene hydroxylation including kinetic isotope effects and migration of the ipso substituent to the adjacent C atom (NIH shift); (2) a high kinetic isotope effect for alkyl C-H bond activation; (3) dealkylation of alkylamines and alkylsulfides; (4) desaturation reactions; (5) retention of stereochem. in cis-alkene epoxidation; and (6) unusual regioselectivity in the oxidation of cyclic and acyclic ketones, alcs., and carboxylic acids where reactivity is not correlated to the bond disassocn. energy; the regioselectivity obtained is attributable to polar effects and/or entropic contributions. Collectively these results also support the conclusion that the active intermediate species formed in the catalytic cycle is consistent with a compound I type oxidant. The activity of {Fe30W72} in cathodic aerobic oxidation reactions shows it to be an inorganic functional analog of Fe-based monooxygenases. The experimental part of the paper was very detailed, including the reaction process of 2-Bromobenzene-1,4-diol(cas: 583-69-7Formula: C6H5BrO2)

2-Bromobenzene-1,4-diol(cas: 583-69-7) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Formula: C6H5BrO2 Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of o-BromobenzaldehydeIn 2019 ,《Three-Component Cascade Bis-heteroannulation of Aryl or Vinyl Methylketoxime Acetates toward Thieno[3,2-c]isoquinolines》 was published in Organic Letters. The article was written by Xu, Zhenhua; Deng, Guo-Jun; Zhang, Feng; Chen, Hongbiao; Huang, Huawen. The article contains the following contents:

A three-component cascade bis-heteroannulation reaction is described that provides access to a variety of benzo[4,5]thieno[3,2-c]isoquinoline and thieno[3,2-c]isoquinoline compounds from easily available methylketoximes, o-halobenzaldehydes, and elemental sulfur. Mechanistic studies reveal a two-step process involving a sequential copper and sulfur catalysis relay. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yu, Wan-Lei; Ren, Zi-Gang; Ma, Wei; Zheng, Haixue; Wu, Wangsuo; Xu, Peng-Fei published an article in Green Chemistry. The title of the article was 《Intramolecular dehydrogenative amination of alkenes via dual organic photoredox and cobalt catalysis without a hydrogen acceptor》.Application In Synthesis of 4-Bromobutanoic acid The author mentioned the following in the article:

A conceptually novel oxidant-free dehydrogenative amination of alkenes I (Ar = Ph, 4-Me-ph, naphthalen-1-yl, etc.; R1 = H, Me, Ph, Et, etc.; R2 = H, Me, Et; R1R2 = cyclohexyl, 1-[(tert-butoxy)(oxo)methane]piperidin-4-yl, cyclopentyl, etc.; X = CH2, O, N, S) through a synergistic photoredox and cobalt catalysis with H2 evolution has been achieved. With this approach, a wide range of five-membered N-heterocycles II and III (R3 = Ph, 2,4,6-trimethylphenyl, 2-phenylethyl, etc.) was synthesized with excellent atom-economy. The green system will address the challenges that are sensitive to traditionally oxidative conditions. Furthermore, the scope and mechanistic details of the method are discussed. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid)

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Fengze; Tong, Yi; Zou, Gang published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed, Manganese-Assisted Denitrogenative Cross-Electrophile-Coupling of Benzotriazinones with Alkyl Halides for ortho-Alkylated Benzamides》.Category: bromides-buliding-blocks The author mentioned the following in the article:

A nickel-catalyzed denitrogenative cross-electrophile-coupling of benzotriazinones with unactivated alkyl halides (X = Cl, Br, I) in the presence of manganese powder as a reductant has been developed. The reaction furnishes ortho-alkylated secondary benzamides in modest to good yields under mild conditions. The scope of the reaction is demonstrated with 25 examples, showing good tolerance of steric hindrance and common functional groups, thus providing an efficient protocol to ortho-alkylated benzamide derivatives without the use of preprepared organometallic reagents. The experimental process involved the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Category: bromides-buliding-blocks)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates》 was published in ChemistrySelect in 2020. These research results belong to Dang, Phu H.; Dao, Thien H. X.; Le, Vien T.; Nguyen, Chien M.; Ly, Tin T.; Nguyen, Hai X.; Le, Tho H.; Do, Truong N. V.; Nguyen, Mai T. T.; Sun, Sijia; Awale, Suresh; Nguyen, Nhan T.. Application In Synthesis of 4-Bromobutanoic acid The article mentions the following:

Ostruthin, isolated from Paramignya trimera, was used as a scaffold to design its alkyl triphenylphosphonium derivatives With the optimal reaction conditions in hand, five alkyl triphenylphosphonium ostruthin derivatives I [n = 3, 4, 5, etc.] were synthesized. Ostruthin and its derivatives I were tested for cytotoxicity against human PANC-1 pancreatic, HeLa cervical, and HepG2 liver cancer cell lines. Ostruthin and its hexyl and heptyl triphenylphosphonium derivatives I [n = 6, 7] showed strong preferential cytotoxicity against PANC-1 cells with the PC50 values of 10.3 and 14.4μM, resp. In addition, compounds I [n = 6, 7] also exhibited potent cytotoxicity towards HeLa cells with the IC50 values of 24.8 and 18.5μM, resp. The hexyl triphenylphosphonium group in I [n = 6] was found to slightly enhance cytotoxicity against HepG2 cells. Further, the morphol. changes and the live-cell imaging result suggested the anticancer potential against HeLa cells of the synthesized ostruthin derivative I [n = 7]. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Application In Synthesis of 4-Bromobutanoic acid) was used in this study.

4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Application In Synthesis of 4-Bromobutanoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Palladium-Catalyzed Direct Ortho-C-H Selenylation of Benzaldehydes Using Benzidine as a Transient Directing Group》 were Qiao, Huihao; Sun, Bing; Yu, Qinqin; Huang, Yi-Yong; Zhou, Yirong; Zhang, Fang-Lin. And the article was published in Organic Letters in 2019. SDS of cas: 6630-33-7 The author mentioned the following in the article:

Benzidine was found to be a novel transient directing group to enable Pd-catalyzed direct selenylation of inert C(sp2)-H bonds of benzaldehydes. Diverse diarylselenides were readily constructed in high efficiency and satisfactory yields with good functional group tolerance. The practical usage of the method was further demonstrated by enlarged reaction to gram scale and application in the facile access to two selenoxanthenes and one fluorescent probe. The experimental part of the paper was very detailed, including the reaction process of o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary